Glucosyl sphingosine is a lipid of Sphingolipids (SP) class. Glucosyl sphingosine is associated with abnormalities such as Sphingolipidoses, Globoid cell leukodystrophy, Sandhoff Disease, Tay-Sachs Disease and Fabry Disease. The involved functions are known as Apoptosis, Acetylation, Infiltration, kinase activity and energy pathways. Glucosyl sphingosine often locates in Lysosomal and Protoplasm. The associated genes with Glucosyl sphingosine are MAPT gene, GALC gene, HEXA gene, PICK1 gene and ELF3 gene. The related lipids are lysoganglioside G(M2), Ganglioside GA2, Lysophosphatidylcholines and globotriaosyl lysosphingolipid.
To understand associated biological information of Glucosyl sphingosine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Glucosyl sphingosine is suspected in Globoid cell leukodystrophy, Sphingolipidoses, Sandhoff Disease, Tay-Sachs Disease, Fabry Disease and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with Glucosyl sphingosine
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Multiple Myeloma | D009101 | 13 associated lipids |
| Leukodystrophy, Globoid Cell | D007965 | 6 associated lipids |
| Nerve Degeneration | D009410 | 53 associated lipids |
| Gaucher Disease | D005776 | 13 associated lipids |
| Parkinson Disease | D010300 | 53 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Sun Y et al. | Neuronopathic Gaucher disease in the mouse: viable combined selective saposin C deficiency and mutant glucocerebrosidase (V394L) mice with glucosylsphingosine and glucosylceramide accumulation and progressive neurological deficits. | 2010 | Hum. Mol. Genet. | pmid:20047948 |
| Lukas J et al. | Glucosylsphingosine Causes Hematological and Visceral Changes in Mice-Evidence for a Pathophysiological Role in Gaucher Disease. | 2017 | Int J Mol Sci | pmid:29053611 |
| Hara A and Taketomi T | Chemical properties and stereoisomerism of heterogeneous long chain bases in lysosphingolipids by positive ion fast atom bombardment mass spectrometry and carbon-13 NMR spectroscopy. | 1986 | J. Biochem. | pmid:3782058 |
| Yamaguchi Y et al. | The synthetic pathway for glucosylsphingosine in cultured fibroblasts. | 1994 | J. Biochem. | pmid:7852294 |
| Sasagasako N et al. | Glucosylceramide and glucosylsphingosine metabolism in cultured fibroblasts deficient in acid beta-glucosidase activity. | 1994 | J. Biochem. | pmid:8188616 |
| Deguchi H et al. | Sphingolipids as bioactive regulators of thrombin generation. | 2004 | J. Biol. Chem. | pmid:14722105 |
| Sun Y et al. | Ex vivo and in vivo effects of isofagomine on acid β-glucosidase variants and substrate levels in Gaucher disease. | 2012 | J. Biol. Chem. | pmid:22167193 |
| Lloyd-Evans E et al. | Glucosylceramide and glucosylsphingosine modulate calcium mobilization from brain microsomes via different mechanisms. | 2003 | J. Biol. Chem. | pmid:12709427 |
| Gramlich PA et al. | A peptide-linked recombinant glucocerebrosidase for targeted neuronal delivery: Design, production, and assessment. | 2016 | J. Biotechnol. | pmid:26795355 |
| Sprong H et al. | Glycosphingolipids are required for sorting melanosomal proteins in the Golgi complex. | 2001 | J. Cell Biol. | pmid:11673476 |