3-Methyl-2-oxobutanoic acid is a lipid of Fatty Acyls (FA) class. 3-methyl-2-oxobutanoic acid is associated with abnormalities such as Maple Syrup Urine Disease and Kidney Failure, Chronic. The involved functions are known as Phosphorylation, Citric Acid Cycle, inhibitors, Process and Metabolic Control. 3-methyl-2-oxobutanoic acid often locates in Mitochondria, BL21, Cytoplasm, Ribosomes and Head. The associated genes with 3-Methyl-2-oxobutanoic acid are Genome, Homologous Gene, Operon, Alleles and Oxidoreductase Gene. The related lipids are dimyristoylphosphatidylglycerol, 9-oxononanoic acid, Valerates and alpha-ketocaproic acid.
To understand associated biological information of 3-Methyl-2-oxobutanoic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
3-Methyl-2-oxobutanoic acid is suspected in Maple Syrup Urine Disease, Kidney Failure, Chronic and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with 3-Methyl-2-oxobutanoic acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Lipid concept | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
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Zhang M et al. | C metabolic flux profiling of Pichia pastoris grown in aerobic batch cultures on glucose revealed high relative anabolic use of TCA cycle and limited incorporation of provided precursors of branched-chain amino acids. | 2017 | FEBS J. | pmid:28731268 |
Fukai K et al. | Metabolic Profiling of Total Physical Activity and Sedentary Behavior in Community-Dwelling Men. | 2016 | PLoS ONE | pmid:27741291 |
Heemskerk MM et al. | Reanalysis of mGWAS results and in vitro validation show that lactate dehydrogenase interacts with branched-chain amino acid metabolism. | 2016 | Eur. J. Hum. Genet. | pmid:26014429 |
Song Y et al. | Biotechnological production of alpha-keto acids: Current status and perspectives. | 2016 | Bioresour. Technol. | pmid:27575335 |
Kim J et al. | Calmodulin-mediated suppression of 2-ketoisovalerate reductase in Beauveria bassiana beauvericin biosynthetic pathway. | 2016 | Environ. Microbiol. | pmid:27449895 |
Shibata K et al. | High-performance liquid chromatographic method for profiling 2-oxo acids in urine and its application in evaluating vitamin status in rats. | 2016 | Biosci. Biotechnol. Biochem. | pmid:26745680 |
Chen X et al. | Production of C4 and C5 branched-chain alcohols by engineered Escherichia. coli. | 2015 | J. Ind. Microbiol. Biotechnol. | pmid:26350079 |
Lee DW et al. | Increased valinomycin production in mutants of Streptomyces sp. M10 defective in bafilomycin biosynthesis and branched-chain α-keto acid dehydrogenase complex expression. | 2015 | J. Ind. Microbiol. Biotechnol. | pmid:26335568 |
Sommer B et al. | Detailed structure-function correlations of Bacillus subtilis acetolactate synthase. | 2015 | Chembiochem | pmid:25393087 |
Lu J et al. | Characterization and modification of enzymes in the 2-ketoisovalerate biosynthesis pathway of Ralstonia eutropha H16. | 2015 | Appl. Microbiol. Biotechnol. | pmid:25081555 |