3-Methyl-2-oxobutanoic acid

3-Methyl-2-oxobutanoic acid is a lipid of Fatty Acyls (FA) class. 3-methyl-2-oxobutanoic acid is associated with abnormalities such as Maple Syrup Urine Disease and Kidney Failure, Chronic. The involved functions are known as Phosphorylation, Citric Acid Cycle, inhibitors, Process and Metabolic Control. 3-methyl-2-oxobutanoic acid often locates in Mitochondria, BL21, Cytoplasm, Ribosomes and Head. The associated genes with 3-Methyl-2-oxobutanoic acid are Genome, Homologous Gene, Operon, Alleles and Oxidoreductase Gene. The related lipids are dimyristoylphosphatidylglycerol, 9-oxononanoic acid, Valerates and alpha-ketocaproic acid.

Cross Reference

Introduction

To understand associated biological information of 3-Methyl-2-oxobutanoic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with 3-Methyl-2-oxobutanoic acid?

3-Methyl-2-oxobutanoic acid is suspected in Maple Syrup Urine Disease, Kidney Failure, Chronic and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with 3-Methyl-2-oxobutanoic acid

MeSH term MeSH ID Detail
Uremia D014511 33 associated lipids
Kidney Failure, Chronic D007676 51 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Ketosis D007662 13 associated lipids
Body Weight D001835 333 associated lipids
Carbon Tetrachloride Poisoning D002252 12 associated lipids
Coronary Disease D003327 70 associated lipids
Prostatic Neoplasms D011471 126 associated lipids
Weight Gain D015430 101 associated lipids
Glioma D005910 112 associated lipids
Chemical and Drug Induced Liver Injury D056486 39 associated lipids
Proteinuria D011507 30 associated lipids
Liver Cirrhosis D008103 67 associated lipids
Maple Syrup Urine Disease D008375 5 associated lipids
Bacteriuria D001437 7 associated lipids
Starvation D013217 47 associated lipids
Liver Cirrhosis, Biliary D008105 12 associated lipids
Protein Deficiency D011488 5 associated lipids
Hyperlipoproteinemia Type II D006938 22 associated lipids
Hyperlipoproteinemia Type IV D006953 6 associated lipids
Creutzfeldt-Jakob Syndrome D007562 7 associated lipids
Anemia, Macrocytic D000748 2 associated lipids
Anemia, Megaloblastic D000749 3 associated lipids
Proteus Infections D011512 2 associated lipids
Myotonic Dystrophy D009223 5 associated lipids
Friedreich Ataxia D005621 3 associated lipids
Pregnancy in Diabetics D011254 3 associated lipids
Seizures D012640 87 associated lipids
Nerve Degeneration D009410 53 associated lipids
Nephrosis D009401 4 associated lipids
Hyperthyroidism D006980 12 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with 3-Methyl-2-oxobutanoic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with 3-Methyl-2-oxobutanoic acid?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with 3-Methyl-2-oxobutanoic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with 3-Methyl-2-oxobutanoic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with 3-Methyl-2-oxobutanoic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with 3-Methyl-2-oxobutanoic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with 3-Methyl-2-oxobutanoic acid

Download all related citations
Per page 10 20 50 100 | Total 726
Authors Title Published Journal PubMed Link
Gutsche KA et al. Production of volatile compounds by Lactobacillus sakei from branched chain α-keto acids. 2012 Food Microbiol. pmid:22202876
Li S et al. Improved 2-methyl-1-propanol production in an engineered Bacillus subtilis by constructing inducible pathways. 2012 Biotechnol. Lett. pmid:22941373
Beaudet AL Neuroscience. Preventable forms of autism? 2012 Science pmid:23087240
Novarino G et al. Mutations in BCKD-kinase lead to a potentially treatable form of autism with epilepsy. 2012 Science pmid:22956686
Zhang T et al. Cloning and characterization of a novel 2-ketoisovalerate reductase from the beauvericin producer Fusarium proliferatum LF061. 2012 BMC Biotechnol. pmid:22916830
Lamsen EN and Atsumi S Recent progress in synthetic biology for microbial production of C3-C10 alcohols. 2012 Front Microbiol pmid:22701113
Ensminger AW et al. Experimental evolution of Legionella pneumophila in mouse macrophages leads to strains with altered determinants of environmental survival. 2012 PLoS Pathog. pmid:22693450
Liu Z et al. Complete Genome of Ignavibacterium album, a Metabolically Versatile, Flagellated, Facultative Anaerobe from the Phylum Chlorobi. 2012 Front Microbiol pmid:22661972
Zhang D et al. A novel ion-pair RP-HPLC method for determination of five components in compound α-ketoacid tablets. 2012 J Pharm Biomed Anal pmid:22510314
Wang YP et al. Two novel mutations in the BCKDHB gene (R170H, Q346R) cause the classic form of maple syrup urine disease (MSUD). 2012 Gene pmid:22326532