| MeSH term | MeSH ID | Detail |
|---|---|---|
| Uremia | D014511 | 33 associated lipids |
| Kidney Failure, Chronic | D007676 | 51 associated lipids |
| Diabetes Mellitus | D003920 | 90 associated lipids |
| Ketosis | D007662 | 13 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Carbon Tetrachloride Poisoning | D002252 | 12 associated lipids |
| Coronary Disease | D003327 | 70 associated lipids |
| Prostatic Neoplasms | D011471 | 126 associated lipids |
| Weight Gain | D015430 | 101 associated lipids |
| Glioma | D005910 | 112 associated lipids |
3-Methyl-2-oxobutanoic acid
3-Methyl-2-oxobutanoic acid is a lipid of Fatty Acyls (FA) class. 3-methyl-2-oxobutanoic acid is associated with abnormalities such as Maple Syrup Urine Disease and Kidney Failure, Chronic. The involved functions are known as Phosphorylation, Citric Acid Cycle, inhibitors, Process and Metabolic Control. 3-methyl-2-oxobutanoic acid often locates in Mitochondria, BL21, Cytoplasm, Ribosomes and Head. The associated genes with 3-Methyl-2-oxobutanoic acid are Genome, Homologous Gene, Operon, Alleles and Oxidoreductase Gene. The related lipids are dimyristoylphosphatidylglycerol, 9-oxononanoic acid, Valerates and alpha-ketocaproic acid.
Cross Reference
Introduction
To understand associated biological information of 3-Methyl-2-oxobutanoic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with 3-Methyl-2-oxobutanoic acid?
3-Methyl-2-oxobutanoic acid is suspected in Maple Syrup Urine Disease, Kidney Failure, Chronic and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with 3-Methyl-2-oxobutanoic acid
PubChem Associated disorders and diseases
What pathways are associated with 3-Methyl-2-oxobutanoic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with 3-Methyl-2-oxobutanoic acid?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with 3-Methyl-2-oxobutanoic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with 3-Methyl-2-oxobutanoic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with 3-Methyl-2-oxobutanoic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with 3-Methyl-2-oxobutanoic acid?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with 3-Methyl-2-oxobutanoic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| pmid: | ||||
| Puukka M et al. | Formation of 2-oxoisovalerate dehydrogenase in Pseudomonas fluorescens. | 1972 | Acta Chem Scand | pmid:4628011 |
| Brodelius P | High-performance liquid chromatographic analysis of analogous amino and oxo acids for the determination of amino acid oxidase and transaminase activities. | 1984 | Acta Chem. Scand., B, Org. Chem. Biochem. | pmid:6147057 |
| Koon N et al. | Crystallization and preliminary X-ray analysis of alpha-isopropylmalate synthase from Mycobacterium tuberculosis. | 2004 | Acta Crystallogr. D Biol. Crystallogr. | pmid:15159590 |
| Berthold CL et al. | Structure of the branched-chain keto acid decarboxylase (KdcA) from Lactococcus lactis provides insights into the structural basis for the chemoselective and enantioselective carboligation reaction. | 2007 | Acta Crystallogr. D Biol. Crystallogr. | pmid:18084069 |
| Petit-Haertlein I et al. | Incorporation of methyl-protonated valine and leucine residues into deuterated ocean pout type III antifreeze protein: expression, crystallization and preliminary neutron diffraction studies. | 2010 | Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. | pmid:20516595 |
| Takei N | Branched chain amino acid transaminase and branched chain alpha-ketoacid dehydrogenase activity in the brain, liver and skeletal muscle of acute hepatic failure rats. | 1985 | Acta Med. Okayama | pmid:3984777 |
| Gerez de Burgos NM et al. | [Alpha-hydroxy-acid dehydrogenase activity in Trypanosoma cruzi]. | 1976 | Acta Physiol Lat Am | pmid:801103 |
| WRETLIND KA | Replacement of valine in the diet by alpha-ketoisovaleric acid. | 1952 | Acta Physiol. Scand. | pmid:13050479 |
| Barve A et al. | A kinetic platform for in silico modeling of the metabolic dynamics in Escherichia coli. | 2010 | Adv Appl Bioinform Chem | pmid:21918631 |
| Engelmann JC et al. | Is gene activity in plant cells affected by UMTS-irradiation? A whole genome approach. | 2008 | Adv Appl Bioinform Chem | pmid:21918607 |
| Adams SH | Emerging perspectives on essential amino acid metabolism in obesity and the insulin-resistant state. | 2011 | Adv Nutr | pmid:22332087 |
| Mudd SH | Vitamin-responsive genetic abnormalities. | 1982 | Adv Nutr Res | pmid:7039261 |
| Severin SE et al. | Dehydrogenases of alpha-keto acids: essential groups of the active centers. | 1986 | Adv. Enzyme Regul. | pmid:3812084 |
| Harris RA et al. | Purification, characterization, regulation and molecular cloning of mitochondrial protein kinases. | 1992 | Adv. Enzyme Regul. | pmid:1496922 |
| Laouari D et al. | Efficiency of substitution of 2-ketoisocaproic acid and 2-ketoisovaleric acid in the diet of normal and uremic growing rats. | 1986 | Am. J. Clin. Nutr. | pmid:3788832 |
| Schauder P et al. | Sex-specific differences in plasma branched-chain keto acid levels in obesity. | 1987 | Am. J. Clin. Nutr. | pmid:3300251 |
| Swain LM et al. | Utilization for protein synthesis of leucine and valine compared with their keto analogues. | 1990 | Am. J. Clin. Nutr. | pmid:2309648 |
| Epstein CM et al. | Decarboxylation of alpha-ketoisovaleric acid after oral administration in man. | 1980 | Am. J. Clin. Nutr. | pmid:6774606 |
| Walser M et al. | Branched-chain-ketoacid metabolism in patients with chronic renal failure. | 1989 | Am. J. Clin. Nutr. | pmid:2801585 |
| Hutson SM and Harper AE | Blood and tissue branched-chain amino and alpha-keto acid concentrations: effect of diet, starvation, and disease. | 1981 | Am. J. Clin. Nutr. | pmid:7211722 |
| Edelmann L et al. | Maple syrup urine disease: identification and carrier-frequency determination of a novel founder mutation in the Ashkenazi Jewish population. | 2001 | Am. J. Hum. Genet. | pmid:11509994 |
| Heffelfinger SC et al. | Direct physical evidence for stabilization of branched-chain alpha-ketoacid dehydrogenase by thiamin pyrophosphate. | 1984 | Am. J. Hum. Genet. | pmid:6475955 |
| Nellis MM and Danner DJ | Gene preference in maple syrup urine disease. | 2001 | Am. J. Hum. Genet. | pmid:11112664 |
| Litwer S and Danner DJ | Mitochondrial import and processing of an in vitro synthesized human prebranched chain acyltransferase fragment. | 1988 | Am. J. Hum. Genet. | pmid:3189339 |
| Chuang DT et al. | Detection of heterozygotes in maple-syrup-urine disease: measurements of branched-chain alpha-ketoacid dehydrogenase and its components in cell cultures. | 1982 | Am. J. Hum. Genet. | pmid:7081220 |
| Raj DS et al. | Markers of inflammation, proteolysis, and apoptosis in ESRD. | 2003 | Am. J. Kidney Dis. | pmid:14655193 |
| de Sain-Van Der Velden MG et al. | Nephrotic proteinuria has No net effect on total body protein synthesis: measurements with (13)C valine. | 2000 | Am. J. Kidney Dis. | pmid:10845830 |
| May ME et al. | Effects of diabetes on oxidative decarboxylation of branched-chain keto acids. | 1980 | Am. J. Physiol. | pmid:7435556 |
| Miller RH and Harper AE | Regulation of valine and alpha-ketoisocaproate metabolism in rat kidney mitochondria. | 1988 | Am. J. Physiol. | pmid:3177634 |
| Kasperek GJ and Snider RD | Effect of exercise intensity and starvation on activation of branched-chain keto acid dehydrogenase by exercise. | 1987 | Am. J. Physiol. | pmid:3812672 |
| Aftring RP et al. | Leucine and isoleucine activate skeletal muscle branched-chain alpha-keto acid dehydrogenase in vivo. | 1986 | Am. J. Physiol. | pmid:3706523 |
| Hood DA and Terjung RL | Effect of endurance training on leucine metabolism in perfused rat skeletal muscle. | 1987 | Am. J. Physiol. | pmid:3425711 |
| Hoffer LJ et al. | Effects of leucine on whole body leucine, valine, and threonine metabolism in humans. | 1997 | Am. J. Physiol. | pmid:9227449 |
| May RC et al. | Branched-chain amino acid metabolism in rat muscle: abnormal regulation in acidosis. | 1987 | Am. J. Physiol. | pmid:3591935 |
| Kasperek GJ et al. | Activation of branched-chain keto acid dehydrogenase by exercise. | 1985 | Am. J. Physiol. | pmid:3970232 |
| Mitch WE and Chan W | alpha-Ketoisocaproate stimulates branched-chain amino acid transaminase in kidney and muscle. | 1979 | Am. J. Physiol. | pmid:443371 |
| Mitch WE and Chan W | Transamination of branched-chain keto acids by isolated perfused rat kidney. | 1978 | Am. J. Physiol. | pmid:677309 |
| Nair KS et al. | Leucine as a regulator of whole body and skeletal muscle protein metabolism in humans. | 1992 | Am. J. Physiol. | pmid:1443126 |
| Block KP et al. | Glucocorticoid-mediated activation of muscle branched-chain alpha-keto acid dehydrogenase in vivo. | 1987 | Am. J. Physiol. | pmid:3103467 |
| Kasperek GJ | Regulation of branched-chain 2-oxo acid dehydrogenase activity during exercise. | 1989 | Am. J. Physiol. | pmid:2912141 |
| Aftring RP et al. | Effects of diabetes and starvation on skeletal muscle branched-chain alpha-keto acid dehydrogenase activity. | 1988 | Am. J. Physiol. | pmid:2964788 |
| Sweatt AJ et al. | Branched-chain amino acid catabolism: unique segregation of pathway enzymes in organ systems and peripheral nerves. | 2004 | Am. J. Physiol. Endocrinol. Metab. | pmid:12965870 |
| Nellis MM et al. | Insulin increases branched-chain alpha-ketoacid dehydrogenase kinase expression in Clone 9 rat cells. | 2002 | Am. J. Physiol. Endocrinol. Metab. | pmid:12217904 |
| McKenzie S et al. | Endurance exercise training attenuates leucine oxidation and BCOAD activation during exercise in humans. | 2000 | Am. J. Physiol. Endocrinol. Metab. | pmid:10751189 |
| Lynch CJ et al. | Tissue-specific effects of chronic dietary leucine and norleucine supplementation on protein synthesis in rats. | 2002 | Am. J. Physiol. Endocrinol. Metab. | pmid:12217901 |
| She P et al. | Obesity-related elevations in plasma leucine are associated with alterations in enzymes involved in branched-chain amino acid metabolism. | 2007 | Am. J. Physiol. Endocrinol. Metab. | pmid:17925455 |
| Howarth KR et al. | Exercise training increases branched-chain oxoacid dehydrogenase kinase content in human skeletal muscle. | 2007 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | pmid:17581840 |
| Wang X and Price SR | Differential regulation of branched-chain alpha-ketoacid dehydrogenase kinase expression by glucocorticoids and acidification in LLC-PK1-GR101 cells. | 2004 | Am. J. Physiol. Renal Physiol. | pmid:14612386 |
| Schachter D | L-glutamine in vitro regulates rat aortic glutamate content and modulates nitric oxide formation and contractility responses. | 2007 | Am. J. Physiol., Cell Physiol. | pmid:17329397 |