PSYCHOSINE

PSYCHOSINE is a lipid of Sphingolipids (SP) class. Psychosine is associated with abnormalities such as Globoid cell leukodystrophy, Demyelinating Diseases, Multiple Sclerosis, nervous system disorder and Lysosomal Storage Diseases. The involved functions are known as Ionization, Pathogenesis, Demyelination, 5-(carboxyamino)imidazole ribonucleotide mutase activity and Increased Sensitivy. Psychosine often locates in Body tissue, CNS - Brain (MMHCC), Autosome, Peripheral Nervous System and Nerve Tissue. The associated genes with PSYCHOSINE are GALC gene, NTRK1 gene, JUN gene, ALPP gene and Polylysine. The related lipids are Fatty Acids, fatty aldehyde, lysophosphatidic acid, Stearic acid and stearoyl chloride. The related experimental models are Mouse Model and Streptozotocin Diabetes.

Cross Reference

Introduction

To understand associated biological information of PSYCHOSINE, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with PSYCHOSINE?

PSYCHOSINE is suspected in Globoid cell leukodystrophy, Enzyme Deficiency, Demyelinating Diseases, Multiple Sclerosis, nervous system disorder, Lysosomal Storage Diseases and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with PSYCHOSINE

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Uterine Cervical Neoplasms D002583 10 associated lipids
Leukodystrophy, Metachromatic D007966 4 associated lipids
Leukodystrophy, Globoid Cell D007965 6 associated lipids
Nerve Degeneration D009410 53 associated lipids
Encephalomyelitis, Autoimmune, Experimental D004681 26 associated lipids
Gaucher Disease D005776 13 associated lipids
Optic Atrophy D009896 2 associated lipids
Total 8

PubChem Associated disorders and diseases

What pathways are associated with PSYCHOSINE

Lipid pathways are not clear in current pathway databases. We organized associated pathways with PSYCHOSINE through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with PSYCHOSINE?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with PSYCHOSINE?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with PSYCHOSINE?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with PSYCHOSINE?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with PSYCHOSINE?

Mouse Model

Mouse Model are used in the study 'Psychosine accumulates in membrane microdomains in the brain of krabbe patients, disrupting the raft architecture.' (White AB et al., 2009).

Streptozotocin Diabetes

Streptozotocin Diabetes are used in the study 'Direct quantitation of psychosine from alkaline-treated lipid extracts with a semi-synthetic internal standard.' (Jiang X et al., 2009).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with PSYCHOSINE

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Authors Title Published Journal PubMed Link
Marshall MS et al. Analysis of age-related changes in psychosine metabolism in the human brain. 2018 PLoS ONE pmid:29481565
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Lukas J et al. Glucosylsphingosine Causes Hematological and Visceral Changes in Mice-Evidence for a Pathophysiological Role in Gaucher Disease. 2017 Int J Mol Sci pmid:29053611
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Gramlich PA et al. A peptide-linked recombinant glucocerebrosidase for targeted neuronal delivery: Design, production, and assessment. 2016 J. Biotechnol. pmid:26795355
Watanabe H et al. Psychosine-triggered endomitosis is modulated by membrane sphingolipids through regulation of phosphoinositide 4,5-bisphosphate production at the cleavage furrow. 2016 Mol. Biol. Cell pmid:27170180
Zhu H et al. Generation of a LacZ reporter transgenic mouse line for the stereological analysis of oligodendrocyte loss in galactosylceramidase deficiency. 2016 J. Neurosci. Res. pmid:27426866
Goddard-Borger ED et al. Glycosynthase mediated synthesis of psychosine. 2016 Carbohydr. Res. pmid:27721144
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Del Grosso A et al. Lithium improves cell viability in psychosine-treated MO3.13 human oligodendrocyte cell line via autophagy activation. 2016 J. Neurosci. Res. pmid:27638607
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O'Sullivan C and Dev KK Galactosylsphingosine (psychosine)-induced demyelination is attenuated by sphingosine 1-phosphate signalling. 2015 J. Cell. Sci. pmid:26359302
Yegneswaran S et al. Lyso-Sulfatide Binds Factor Xa and Inhibits Thrombin Generation by the Prothrombinase Complex. 2015 PLoS ONE pmid:26263376
Kuai XL et al. Transplantation of mouse embryonic stem cell-derived oligodendrocytes in the murine model of globoid cell leukodystrophy. 2015 Stem Cell Res Ther pmid:25888852
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Ahn SH et al. Psychosine inhibits osteoclastogenesis and bone resorption via G protein-coupled receptor 65. 2015 J. Endocrinol. Invest. pmid:25841894
Turgeon CT et al. Measurement of psychosine in dried blood spots--a possible improvement to newborn screening programs for Krabbe disease. 2015 J. Inherit. Metab. Dis. pmid:25762404
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Voccoli V et al. Role of extracellular calcium and mitochondrial oxygen species in psychosine-induced oligodendrocyte cell death. 2014 Cell Death Dis pmid:25412308
Claycomb KI et al. Aberrant production of tenascin-C in globoid cell leukodystrophy alters psychosine-induced microglial functions. 2014 J. Neuropathol. Exp. Neurol. pmid:25192051
Fuss IJ et al. IL-13Rα2-bearing, type II NKT cells reactive to sulfatide self-antigen populate the mucosa of ulcerative colitis. 2014 Gut pmid:24515806
Gaspar P et al. Action myoclonus-renal failure syndrome: diagnostic applications of activity-based probes and lipid analysis. 2014 J. Lipid Res. pmid:24212238
Angka L et al. Glucopsychosine increases cytosolic calcium to induce calpain-mediated apoptosis of acute myeloid leukemia cells. 2014 Cancer Lett. pmid:24631520
Farfel-Becker T et al. Neuronal accumulation of glucosylceramide in a mouse model of neuronopathic Gaucher disease leads to neurodegeneration. 2014 Hum. Mol. Genet. pmid:24064337
Smith BR et al. Neuronal inclusions of α-synuclein contribute to the pathogenesis of Krabbe disease. 2014 J. Pathol. pmid:24415155
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Miranda CO et al. Primary bone marrow mesenchymal stromal cells rescue the axonal phenotype of Twitcher mice. 2014 Cell Transplant pmid:23809254
Ribbens JJ et al. Characterization and application of a disease-cell model for a neurodegenerative lysosomal disease. 2014 Mol. Genet. Metab. pmid:24094551
Welford RW et al. Plasma lysosphingomyelin demonstrates great potential as a diagnostic biomarker for Niemann-Pick disease type C in a retrospective study. 2014 PLoS ONE pmid:25479233
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Rolfs A et al. Glucosylsphingosine is a highly sensitive and specific biomarker for primary diagnostic and follow-up monitoring in Gaucher disease in a non-Jewish, Caucasian cohort of Gaucher disease patients. 2013 PLoS ONE pmid:24278166
Won JS et al. Role of endogenous psychosine accumulation in oligodendrocyte differentiation and survival: implication for Krabbe disease. 2013 Brain Res. pmid:23438514
Ijichi K et al. MMP-3 mediates psychosine-induced globoid cell formation: implications for leukodystrophy pathology. 2013 Glia pmid:23404611
Aribindi K et al. Cholesterol and glycosphingolipids of human trabecular meshwork and aqueous humor: comparative profiles from control and glaucomatous donors. 2013 Curr. Eye Res. pmid:23790057
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Zanfini A et al. Quantification of psychosine in the serum of twitcher mouse by LC-ESI-tandem-MS analysis. 2013 J Pharm Biomed Anal pmid:23523865
Cantuti Castelvetri L et al. The sphingolipid psychosine inhibits fast axonal transport in Krabbe disease by activation of GSK3β and deregulation of molecular motors. 2013 J. Neurosci. pmid:23761900
Chuang WL et al. Determination of psychosine concentration in dried blood spots from newborns that were identified via newborn screening to be at risk for Krabbe disease. 2013 Clin. Chim. Acta pmid:23419961
Hawkins-Salsbury JA et al. Psychosine, the cytotoxic sphingolipid that accumulates in globoid cell leukodystrophy, alters membrane architecture. 2013 J. Lipid Res. pmid:24006512
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Cantuti-Castelvetri L et al. Psychosine induces the dephosphorylation of neurofilaments by deregulation of PP1 and PP2A phosphatases. 2012 Neurobiol. Dis. pmid:22326830
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White AB et al. Psychosine accumulates in membrane microdomains in the brain of krabbe patients, disrupting the raft architecture. 2009 J. Neurosci. pmid:19439584
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Jiang X et al. Direct quantitation of psychosine from alkaline-treated lipid extracts with a semi-synthetic internal standard. 2009 J. Lipid Res. pmid:18753677
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