PSYCHOSINE

PSYCHOSINE is a lipid of Sphingolipids (SP) class. Psychosine is associated with abnormalities such as Globoid cell leukodystrophy, Demyelinating Diseases, Multiple Sclerosis, nervous system disorder and Lysosomal Storage Diseases. The involved functions are known as Ionization, Pathogenesis, Demyelination, 5-(carboxyamino)imidazole ribonucleotide mutase activity and Increased Sensitivy. Psychosine often locates in Body tissue, CNS - Brain (MMHCC), Autosome, Peripheral Nervous System and Nerve Tissue. The associated genes with PSYCHOSINE are GALC gene, NTRK1 gene, JUN gene, ALPP gene and Polylysine. The related lipids are Fatty Acids, fatty aldehyde, lysophosphatidic acid, Stearic acid and stearoyl chloride. The related experimental models are Mouse Model and Streptozotocin Diabetes.

Cross Reference

Introduction

To understand associated biological information of PSYCHOSINE, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with PSYCHOSINE?

PSYCHOSINE is suspected in Globoid cell leukodystrophy, Enzyme Deficiency, Demyelinating Diseases, Multiple Sclerosis, nervous system disorder, Lysosomal Storage Diseases and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with PSYCHOSINE

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Uterine Cervical Neoplasms D002583 10 associated lipids
Leukodystrophy, Metachromatic D007966 4 associated lipids
Leukodystrophy, Globoid Cell D007965 6 associated lipids
Nerve Degeneration D009410 53 associated lipids
Encephalomyelitis, Autoimmune, Experimental D004681 26 associated lipids
Gaucher Disease D005776 13 associated lipids
Optic Atrophy D009896 2 associated lipids
Total 8

PubChem Associated disorders and diseases

What pathways are associated with PSYCHOSINE

Lipid pathways are not clear in current pathway databases. We organized associated pathways with PSYCHOSINE through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with PSYCHOSINE?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with PSYCHOSINE?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with PSYCHOSINE?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with PSYCHOSINE?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with PSYCHOSINE?

Mouse Model

Mouse Model are used in the study 'Psychosine accumulates in membrane microdomains in the brain of krabbe patients, disrupting the raft architecture.' (White AB et al., 2009).

Streptozotocin Diabetes

Streptozotocin Diabetes are used in the study 'Direct quantitation of psychosine from alkaline-treated lipid extracts with a semi-synthetic internal standard.' (Jiang X et al., 2009).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with PSYCHOSINE

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Authors Title Published Journal PubMed Link
pmid:
CLELAND WW and KENNEDY EP The enzymatic synthesis of psychosine. 1960 J. Biol. Chem. pmid:13810623
TAKETOMI T and YAMAKAWA T IMMUNOCHEMICAL STUDIES OF LIPIDS. I. PREPARATION AND IMMUNOLOGICAL PROPERTIES OF SYNTHETIC PSYCHOSINE-PROTEIN ANTIGENS. 1963 J. Biochem. pmid:14089738
Spiro RG and Spiro MJ Studies on the biosynthesis of the hydroxylysine-liked disaccharide unit of basement membranes and collagens. I. Kidney glucosyltransferase. 1971 J. Biol. Chem. pmid:11732553
Murad S and Kishimoto Y Alpha hydroxylation of lignoceric acid to cerebronic acid during brain development. Diminished hydroxylase activity in myelin-deficient mouse mutants. 1975 J. Biol. Chem. pmid:1150661
Sarlieve LL et al. Arylsulphatase A and 2',3'-cyclic nucleotide 3'-phosphohydrolase activities in the brains of myelin deficient mutant mice. 1976 Neuroscience pmid:11370246
Vanier M and Svennerholm L Chemical pathology of Krabbe disease: the occurrence of psychosine and other neutral sphingoglycolipids. 1976 Adv. Exp. Med. Biol. pmid:937104
Farooqui AA Purification and properties of human placenta arylsulphatase A. 1976 Arch. Int. Physiol. Biochim. pmid:64139
Murad S and Kishimoto Y alpha-Hydroxylation of fatty acid in brain. Effects of cerebroside components on the synthesis of cerebronic acid. 1977 Biochim. Biophys. Acta pmid:889850
Pasquini JM et al. Possible presence of psychosine in brain. 1977 Adv. Exp. Med. Biol. pmid:920465
Farooqui AA and Mandel P Recent developments in the biochemistry of globoid and metachromatic leucodystrophies. 1977 Biomedicine pmid:21709
Brownstein S et al. Optic nerve in globoid leukodystrophy (Krabbe's disease). Ultrastructural changes. 1978 Arch. Ophthalmol. pmid:418756
Wiesmann UN [Pathophysiology of sulfatide metabolism in metachromatic leukodystrophy]. 1978 Bull Schweiz Akad Med Wiss pmid:27269
Nonaka G et al. Formation of lysosulfatide, 3',6'-anhydropsychosine, ceramide, and sphingosine by saponification of cerebroside sulfate. Effect of the sulfate group on the hydrolysis. 1979 J. Biochem. pmid:422543
Jóźwiak W and Kościelak J [Possibility of using antibodies to lactosylsphingosine in the diagnosis of neoplasms]. 1979 Acta Haematol Pol pmid:539355
Svennerholm L et al. Krabbe disease: a galactosylsphingosine (psychosine) lipidosis. 1980 J. Lipid Res. pmid:7354254
Jóźwiak W and Kościelak J Occurrence of lactosylsphingosine-reactive antibodies in sera of cancer patients. 1980 Jul-Sep Acta Haematol Pol pmid:7445920
Naoi M and Yagi K A sensitive assay of galactocerebroside beta-galactosidase by high-performance liquid chromatography using galactosyl-N-dansyl-sphingosine as substrate. 1981 Anal. Biochem. pmid:6795970
Dickerman LH et al. The effects of psychosine upon growth of human skin fibroblasts from patients with globoid cell leukodystrophy. 1981 J. Neurol. Sci. pmid:7229663
Svennerholm L et al. Gaucher disease of the Norrbottnian type (type III). Phenotypic manifestations. 1982 Prog. Clin. Biol. Res. pmid:6812091
Naoi M and Yagi K Effects of phospholipids on substrate specificity of beta-galactosidase purified from Aspergillus oryzae. 1982 Arch. Biochem. Biophys. pmid:6807206
Kobayashi T and Suzuki K The twitcher mouse: fate of exogenously administered [3H]galactosyl-sphingosine. 1982 Adv. Exp. Med. Biol. pmid:7136914
Jóźwiak W and Kościelak J Lactosylsphingosine-reactive antibody and CEA in patients with colorectal cancer. 1982 Eur J Cancer Clin Oncol pmid:6889963
Nilsson O and Svennerholm L Accumulation of glucosylceramide and glucosylsphingosine (psychosine) in cerebrum and cerebellum in infantile and juvenile Gaucher disease. 1982 J. Neurochem. pmid:7097276
Nilsson O et al. The occurrence of psychosine and other glycolipids in spleen and liver from the three major types of Gaucher's disease. 1982 Biochim. Biophys. Acta pmid:7126619
Igisu H and Suzuki K Progressive accumulation of toxic metabolite in a genetic leukodystrophy. 1984 Science pmid:6719111
Morell P A correlative synopsis of the leukodystrophies. 1984 Neuropediatrics pmid:6546165
Semeniuk EP and VidershaÄ­n GIa [Use of fluorescence-labelled cerebroside as a substrate for galactosylceramidase of human skin fibroblasts]. 1984 Biokhimiia pmid:6549145
Igisu H and Suzuki K Analysis of galactosylsphingosine (psychosine) in the brain. 1984 J. Lipid Res. pmid:6491533
Okada S et al. Use of a fluorescent analogue of galactocerebroside for assay of galactocerebroside beta-galactosidase activity in skin fibroblasts from patients with Krabbe's disease. 1984 Clin. Chim. Acta pmid:6692566
Suzuki K Biochemical pathogenesis of genetic leukodystrophies: comparison of metachromatic leukodystrophy and globoid cell leukodystrophy (Krabbe's disease). 1984 Neuropediatrics pmid:6152811
Naoi M et al. Alteration of the substrate specificity of Aspergillus oryzae beta-galactosidase by modification with polyethylene glycol. 1984 Feb-Apr J. Appl. Biochem. pmid:6436228
Nilsson O et al. Glycosphingolipid studies of visceral tissues and brain from type 1 Gaucher disease variants. 1985 Clin. Genet. pmid:3924448
Via DP et al. Spontaneous and plasma factor-mediated transfer of pyrenyl cerebrosides between model and native lipoproteins. 1985 Biochim. Biophys. Acta pmid:3931685
LaMarco KL and Glew RH Galactosylsphingosine inhibition of the broad-specificity cytosolic beta-glucosidase of human liver. 1985 Arch. Biochem. Biophys. pmid:3918500
Kobayashi T et al. Hydrolysis of galactosylceramide is catalyzed by two genetically distinct acid beta-galactosidases. 1985 J. Biol. Chem. pmid:3934152
Hara A and Taketomi T Chemical properties and stereoisomerism of heterogeneous long chain bases in lysosphingolipids by positive ion fast atom bombardment mass spectrometry and carbon-13 NMR spectroscopy. 1986 J. Biochem. pmid:3782058
Igisu H and Nakamura M Inhibition of cytochrome c oxidase by psychosine (galactosylsphingosine). 1986 Biochem. Biophys. Res. Commun. pmid:3013184
Strasberg P Cerebrosides and psychosine disrupt mitochondrial functions. 1986 Biochem. Cell Biol. pmid:3718715
Ichioka T et al. Hematopoietic cell transplantation in murine globoid cell leukodystrophy (the twitcher mouse): effects on levels of galactosylceramidase, psychosine, and galactocerebrosides. 1987 Proc. Natl. Acad. Sci. U.S.A. pmid:2884662
Goda S et al. Hydrolysis of galactosylsphingosine and lactosylsphingosine by beta-galactosidases in human brain and cultured fibroblasts. 1987 Biochim. Biophys. Acta pmid:3111543
Hannun YA and Bell RM Lysosphingolipids inhibit protein kinase C: implications for the sphingolipidoses. 1987 Science pmid:3101176
Kobayashi T et al. Globoid cell leukodystrophy is a generalized galactosylsphingosine (psychosine) storage disease. 1987 Biochem. Biophys. Res. Commun. pmid:3579916
Ichioka T et al. Simultaneous determination of psychosine and cerebrosides. 1987 Anal. Biochem. pmid:3674406
Shinoda H et al. Accumulation of galactosylsphingosine (psychosine) in the twitcher mouse: determination by HPLC. 1987 J. Neurochem. pmid:3585345
Igisu H et al. Inhibition of cytochrome c oxidase and hemolysis caused by lysosphingolipids. 1988 Lipids pmid:2840545
Tanaka K et al. The twitcher mouse: accumulation of galactosylsphingosine and pathology of the sciatic nerve. 1988 Brain Res. pmid:3409017
Kobayashi T et al. Free sphingoid bases in normal murine tissues. 1988 Eur. J. Biochem. pmid:3350021
Hoogerbrugge PM et al. Donor-derived cells in the central nervous system of twitcher mice after bone marrow transplantation. 1988 Science pmid:3278379
Kobayashi T et al. Infantile and fetal globoid cell leukodystrophy: analysis of galactosylceramide and galactosylsphingosine. 1988 Ann. Neurol. pmid:3239954