PSYCHOSINE

PSYCHOSINE is a lipid of Sphingolipids (SP) class. Psychosine is associated with abnormalities such as Globoid cell leukodystrophy, Demyelinating Diseases, Multiple Sclerosis, nervous system disorder and Lysosomal Storage Diseases. The involved functions are known as Ionization, Pathogenesis, Demyelination, 5-(carboxyamino)imidazole ribonucleotide mutase activity and Increased Sensitivy. Psychosine often locates in Body tissue, CNS - Brain (MMHCC), Autosome, Peripheral Nervous System and Nerve Tissue. The associated genes with PSYCHOSINE are GALC gene, NTRK1 gene, JUN gene, ALPP gene and Polylysine. The related lipids are Fatty Acids, fatty aldehyde, lysophosphatidic acid, Stearic acid and stearoyl chloride. The related experimental models are Mouse Model and Streptozotocin Diabetes.

Cross Reference

Introduction

To understand associated biological information of PSYCHOSINE, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with PSYCHOSINE?

PSYCHOSINE is suspected in Globoid cell leukodystrophy, Enzyme Deficiency, Demyelinating Diseases, Multiple Sclerosis, nervous system disorder, Lysosomal Storage Diseases and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with PSYCHOSINE

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Uterine Cervical Neoplasms D002583 10 associated lipids
Leukodystrophy, Metachromatic D007966 4 associated lipids
Leukodystrophy, Globoid Cell D007965 6 associated lipids
Nerve Degeneration D009410 53 associated lipids
Encephalomyelitis, Autoimmune, Experimental D004681 26 associated lipids
Gaucher Disease D005776 13 associated lipids
Optic Atrophy D009896 2 associated lipids
Total 8

PubChem Associated disorders and diseases

What pathways are associated with PSYCHOSINE

Lipid pathways are not clear in current pathway databases. We organized associated pathways with PSYCHOSINE through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with PSYCHOSINE?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with PSYCHOSINE?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with PSYCHOSINE?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with PSYCHOSINE?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with PSYCHOSINE?

Mouse Model

Mouse Model are used in the study 'Psychosine accumulates in membrane microdomains in the brain of krabbe patients, disrupting the raft architecture.' (White AB et al., 2009).

Streptozotocin Diabetes

Streptozotocin Diabetes are used in the study 'Direct quantitation of psychosine from alkaline-treated lipid extracts with a semi-synthetic internal standard.' (Jiang X et al., 2009).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with PSYCHOSINE

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Authors Title Published Journal PubMed Link
Marshall MS et al. Analysis of age-related changes in psychosine metabolism in the human brain. 2018 PLoS ONE pmid:29481565
Kanie Y et al. Evaluation of reversed-phase nano liquid chromatography conditions by using reversed-phase thin layer chromatography based on Hansen solubility parameters for the analysis of amphiphilic glycosylsphingolipid transformations. 2018 J Chromatogr A pmid:29290400
Smith NJ et al. Reduced cerebral vascularization in experimental neuronopathic Gaucher disease. 2018 J. Pathol. pmid:28981147
Lukas J et al. Glucosylsphingosine Causes Hematological and Visceral Changes in Mice-Evidence for a Pathophysiological Role in Gaucher Disease. 2017 Int J Mol Sci pmid:29053611
Kang L et al. Successful newborn screening for Gaucher disease using fluorometric assay in China. 2017 J. Hum. Genet. pmid:28356566
Escolar ML et al. Psychosine, a marker of Krabbe phenotype and treatment effect. 2017 Mol. Genet. Metab. pmid:28579020
D'Auria L et al. Psychosine enhances the shedding of membrane microvesicles: Implications in demyelination in Krabbe's disease. 2017 PLoS ONE pmid:28531236
Taguchi YV et al. Glucosylsphingosine Promotes α-Synuclein Pathology in Mutant GBA-Associated Parkinson's Disease. 2017 J. Neurosci. pmid:28847804
Franco M et al. Effect of velaglucerase alfa enzyme replacement therapy on red blood cell properties in Gaucher disease. 2017 Am. J. Hematol. pmid:28621801
Misslin C et al. Phospholipase A2 is involved in galactosylsphingosine-induced astrocyte toxicity, neuronal damage and demyelination. 2017 PLoS ONE pmid:29095858
Lim SM et al. Patient fibroblasts-derived induced neurons demonstrate autonomous neuronal defects in adult-onset Krabbe disease. 2016 Oncotarget pmid:27780934
Murugesan V et al. Glucosylsphingosine is a key biomarker of Gaucher disease. 2016 Am. J. Hematol. pmid:27441734
Dai M et al. Progression of Behavioral and CNS Deficits in a Viable Murine Model of Chronic Neuronopathic Gaucher Disease. 2016 PLoS ONE pmid:27598339
Gramlich PA et al. A peptide-linked recombinant glucocerebrosidase for targeted neuronal delivery: Design, production, and assessment. 2016 J. Biotechnol. pmid:26795355
Watanabe H et al. Psychosine-triggered endomitosis is modulated by membrane sphingolipids through regulation of phosphoinositide 4,5-bisphosphate production at the cleavage furrow. 2016 Mol. Biol. Cell pmid:27170180
Zhu H et al. Generation of a LacZ reporter transgenic mouse line for the stereological analysis of oligodendrocyte loss in galactosylceramidase deficiency. 2016 J. Neurosci. Res. pmid:27426866
Goddard-Borger ED et al. Glycosynthase mediated synthesis of psychosine. 2016 Carbohydr. Res. pmid:27721144
Avola R et al. Krabbe's leukodystrophy: Approaches and models in vitro. 2016 J. Neurosci. Res. pmid:27638610
Del Grosso A et al. Lithium improves cell viability in psychosine-treated MO3.13 human oligodendrocyte cell line via autophagy activation. 2016 J. Neurosci. Res. pmid:27638607
Carter RL et al. Can psychosine and galactocerebrosidase activity predict early-infantile Krabbe's disease presymptomatically? 2016 J. Neurosci. Res. pmid:27638594
Nogueira-Rodrigues J et al. Axonal pathology in Krabbe's disease: The cytoskeleton as an emerging therapeutic target. 2016 J. Neurosci. Res. pmid:27638589
Bradbury AM et al. Clinical, electrophysiological, and biochemical markers of peripheral and central nervous system disease in canine globoid cell leukodystrophy (Krabbe's disease). 2016 J. Neurosci. Res. pmid:27638585
Won JS et al. Biochemical, cell biological, pathological, and therapeutic aspects of Krabbe's disease. 2016 J. Neurosci. Res. pmid:27638584
Spassieva S and Bieberich E Lysosphingolipids and sphingolipidoses: Psychosine in Krabbe's disease. 2016 J. Neurosci. Res. pmid:27638582
Belleri M and Presta M Endothelial cell dysfunction in globoid cell leukodystrophy. 2016 J. Neurosci. Res. pmid:27037626
Graziano AC et al. Krabbe disease: involvement of connexin43 in the apoptotic effects of sphingolipid psychosine on mouse oligodendrocyte precursors. 2016 Apoptosis pmid:26459425
Dasgupta N et al. Neuronopathic Gaucher disease: dysregulated mRNAs and miRNAs in brain pathogenesis and effects of pharmacologic chaperone treatment in a mouse model. 2015 Hum. Mol. Genet. pmid:26420838
Sun Y et al. Properties of neurons derived from induced pluripotent stem cells of Gaucher disease type 2 patient fibroblasts: potential role in neuropathology. 2015 PLoS ONE pmid:25822147
Burrow TA et al. CNS, lung, and lymph node involvement in Gaucher disease type 3 after 11 years of therapy: clinical, histopathologic, and biochemical findings. 2015 Mol. Genet. Metab. pmid:25219293
O'Sullivan C and Dev KK Galactosylsphingosine (psychosine)-induced demyelination is attenuated by sphingosine 1-phosphate signalling. 2015 J. Cell. Sci. pmid:26359302
Yegneswaran S et al. Lyso-Sulfatide Binds Factor Xa and Inhibits Thrombin Generation by the Prothrombinase Complex. 2015 PLoS ONE pmid:26263376
Kuai XL et al. Transplantation of mouse embryonic stem cell-derived oligodendrocytes in the murine model of globoid cell leukodystrophy. 2015 Stem Cell Res Ther pmid:25888852
Cantuti-Castelvetri L et al. Mechanism of neuromuscular dysfunction in Krabbe disease. 2015 J. Neurosci. pmid:25632136
Mirzaian M et al. Quantification of sulfatides and lysosulfatides in tissues and body fluids by liquid chromatography-tandem mass spectrometry. 2015 J. Lipid Res. pmid:25632048
Fuller M et al. Rapid, single-phase extraction of glucosylsphingosine from plasma: A universal screening and monitoring tool. 2015 Clin. Chim. Acta pmid:26232157
Mirzaian M et al. Mass spectrometric quantification of glucosylsphingosine in plasma and urine of type 1 Gaucher patients using an isotope standard. 2015 Blood Cells Mol. Dis. pmid:25842368
Hawkins-Salsbury JA et al. Mechanism-based combination treatment dramatically increases therapeutic efficacy in murine globoid cell leukodystrophy. 2015 J. Neurosci. pmid:25904800
Matthes F et al. Enzyme replacement therapy of a novel humanized mouse model of globoid cell leukodystrophy. 2015 Exp. Neurol. pmid:25956830
Ahn SH et al. Psychosine inhibits osteoclastogenesis and bone resorption via G protein-coupled receptor 65. 2015 J. Endocrinol. Invest. pmid:25841894
Turgeon CT et al. Measurement of psychosine in dried blood spots--a possible improvement to newborn screening programs for Krabbe disease. 2015 J. Inherit. Metab. Dis. pmid:25762404
Aflaki E et al. Macrophage models of Gaucher disease for evaluating disease pathogenesis and candidate drugs. 2014 Sci Transl Med pmid:24920659
Claycomb KI et al. Aberrant production of tenascin-C in globoid cell leukodystrophy alters psychosine-induced microglial functions. 2014 J. Neuropathol. Exp. Neurol. pmid:25192051
Fuss IJ et al. IL-13Rα2-bearing, type II NKT cells reactive to sulfatide self-antigen populate the mucosa of ulcerative colitis. 2014 Gut pmid:24515806
Gaspar P et al. Action myoclonus-renal failure syndrome: diagnostic applications of activity-based probes and lipid analysis. 2014 J. Lipid Res. pmid:24212238
Angka L et al. Glucopsychosine increases cytosolic calcium to induce calpain-mediated apoptosis of acute myeloid leukemia cells. 2014 Cancer Lett. pmid:24631520
Farfel-Becker T et al. Neuronal accumulation of glucosylceramide in a mouse model of neuronopathic Gaucher disease leads to neurodegeneration. 2014 Hum. Mol. Genet. pmid:24064337
Smith BR et al. Neuronal inclusions of α-synuclein contribute to the pathogenesis of Krabbe disease. 2014 J. Pathol. pmid:24415155
Snook ER et al. Innate immune activation in the pathogenesis of a murine model of globoid cell leukodystrophy. 2014 Am. J. Pathol. pmid:24316110
Miranda CO et al. Primary bone marrow mesenchymal stromal cells rescue the axonal phenotype of Twitcher mice. 2014 Cell Transplant pmid:23809254
Ribbens JJ et al. Characterization and application of a disease-cell model for a neurodegenerative lysosomal disease. 2014 Mol. Genet. Metab. pmid:24094551