PSYCHOSINE is a lipid of Sphingolipids (SP) class. Psychosine is associated with abnormalities such as Globoid cell leukodystrophy, Demyelinating Diseases, Multiple Sclerosis, nervous system disorder and Lysosomal Storage Diseases. The involved functions are known as Ionization, Pathogenesis, Demyelination, 5-(carboxyamino)imidazole ribonucleotide mutase activity and Increased Sensitivy. Psychosine often locates in Body tissue, CNS - Brain (MMHCC), Autosome, Peripheral Nervous System and Nerve Tissue. The associated genes with PSYCHOSINE are GALC gene, NTRK1 gene, JUN gene, ALPP gene and Polylysine. The related lipids are Fatty Acids, fatty aldehyde, lysophosphatidic acid, Stearic acid and stearoyl chloride. The related experimental models are Mouse Model and Streptozotocin Diabetes.
To understand associated biological information of PSYCHOSINE, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
PSYCHOSINE is suspected in Globoid cell leukodystrophy, Enzyme Deficiency, Demyelinating Diseases, Multiple Sclerosis, nervous system disorder, Lysosomal Storage Diseases and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with PSYCHOSINE
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Uterine Cervical Neoplasms | D002583 | 10 associated lipids |
| Leukodystrophy, Metachromatic | D007966 | 4 associated lipids |
| Leukodystrophy, Globoid Cell | D007965 | 6 associated lipids |
| Nerve Degeneration | D009410 | 53 associated lipids |
| Encephalomyelitis, Autoimmune, Experimental | D004681 | 26 associated lipids |
| Gaucher Disease | D005776 | 13 associated lipids |
| Optic Atrophy | D009896 | 2 associated lipids |
Lipid pathways are not clear in current pathway databases. We organized associated pathways with PSYCHOSINE through full-text articles, including metabolic pathways or pathways of biological mechanisms.
| Pathway name | Related literatures |
|---|
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
| Gene | Cross reference | Weighted score | Related literatures |
|---|
Mouse Model are used in the study 'Psychosine accumulates in membrane microdomains in the brain of krabbe patients, disrupting the raft architecture.' (White AB et al., 2009).
Streptozotocin Diabetes are used in the study 'Direct quantitation of psychosine from alkaline-treated lipid extracts with a semi-synthetic internal standard.' (Jiang X et al., 2009).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Nofer JR et al. | Suppression of endothelial cell apoptosis by high density lipoproteins (HDL) and HDL-associated lysosphingolipids. | 2001 | J. Biol. Chem. | pmid:11432865 |
| Luzi P et al. | Generation of a mouse with low galactocerebrosidase activity by gene targeting: a new model of globoid cell leukodystrophy (Krabbe disease). | 2001 | Mol. Genet. Metab. | pmid:11461188 |
| Sueyoshi N et al. | Apoptosis of Neuro2a cells induced by lysosphingolipids with naturally occurring stereochemical configurations. | 2001 | J. Lipid Res. | pmid:11483620 |
| Murad S and Kishimoto Y | Alpha hydroxylation of lignoceric acid to cerebronic acid during brain development. Diminished hydroxylase activity in myelin-deficient mouse mutants. | 1975 | J. Biol. Chem. | pmid:1150661 |
| Miguel BG et al. | Sphingolipid derivatives modulate intracellular Ca2+ in rat synaptosomes. | 2001 | Acta Neurobiol Exp (Wars) | pmid:11512408 |
| Tohyama J et al. | Psychosine is as potent an inducer of cell death as C6-ceramide in cultured fibroblasts and in MOCH-1 cells. | 2001 | Neurochem. Res. | pmid:11519726 |
| Shen JS et al. | Intraventricular administration of recombinant adenovirus to neonatal twitcher mouse leads to clinicopathological improvements. | 2001 | Gene Ther. | pmid:11526455 |
| Sprong H et al. | Glycosphingolipids are required for sorting melanosomal proteins in the Golgi complex. | 2001 | J. Cell Biol. | pmid:11673476 |
| Harzer K et al. | Saposins (sap) A and C activate the degradation of galactosylsphingosine. | 2001 | FEBS Lett. | pmid:11707278 |
| Matsuda J et al. | Dramatic phenotypic improvement during pregnancy in a genetic leukodystrophy: estrogen appears to be a critical factor. | 2001 | Hum. Mol. Genet. | pmid:11726558 |