PSYCHOSINE is a lipid of Sphingolipids (SP) class. Psychosine is associated with abnormalities such as Globoid cell leukodystrophy, Demyelinating Diseases, Multiple Sclerosis, nervous system disorder and Lysosomal Storage Diseases. The involved functions are known as Ionization, Pathogenesis, Demyelination, 5-(carboxyamino)imidazole ribonucleotide mutase activity and Increased Sensitivy. Psychosine often locates in Body tissue, CNS - Brain (MMHCC), Autosome, Peripheral Nervous System and Nerve Tissue. The associated genes with PSYCHOSINE are GALC gene, NTRK1 gene, JUN gene, ALPP gene and Polylysine. The related lipids are Fatty Acids, fatty aldehyde, lysophosphatidic acid, Stearic acid and stearoyl chloride. The related experimental models are Mouse Model and Streptozotocin Diabetes.
To understand associated biological information of PSYCHOSINE, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
PSYCHOSINE is suspected in Globoid cell leukodystrophy, Enzyme Deficiency, Demyelinating Diseases, Multiple Sclerosis, nervous system disorder, Lysosomal Storage Diseases and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with PSYCHOSINE
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Uterine Cervical Neoplasms | D002583 | 10 associated lipids |
| Leukodystrophy, Metachromatic | D007966 | 4 associated lipids |
| Leukodystrophy, Globoid Cell | D007965 | 6 associated lipids |
| Nerve Degeneration | D009410 | 53 associated lipids |
| Encephalomyelitis, Autoimmune, Experimental | D004681 | 26 associated lipids |
| Gaucher Disease | D005776 | 13 associated lipids |
| Optic Atrophy | D009896 | 2 associated lipids |
Lipid pathways are not clear in current pathway databases. We organized associated pathways with PSYCHOSINE through full-text articles, including metabolic pathways or pathways of biological mechanisms.
| Pathway name | Related literatures |
|---|
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
| Gene | Cross reference | Weighted score | Related literatures |
|---|
Mouse Model are used in the study 'Psychosine accumulates in membrane microdomains in the brain of krabbe patients, disrupting the raft architecture.' (White AB et al., 2009).
Streptozotocin Diabetes are used in the study 'Direct quantitation of psychosine from alkaline-treated lipid extracts with a semi-synthetic internal standard.' (Jiang X et al., 2009).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Spiro RG and Spiro MJ | Studies on the biosynthesis of the hydroxylysine-liked disaccharide unit of basement membranes and collagens. I. Kidney glucosyltransferase. | 1971 | J. Biol. Chem. | pmid:11732553 |
| Whitfield PD et al. | Quantification of galactosylsphingosine in the twitcher mouse using electrospray ionization-tandem mass spectrometry. | 2001 | J. Lipid Res. | pmid:11734583 |
| Hashimoto M et al. | Versatile synthesis of phenoxydiazirine-based fatty acid analogues and photoreactive galactosylceramide. | 2002 | Bioorg. Med. Chem. Lett. | pmid:11738580 |
| Giri S et al. | Galactosylsphingosine (psychosine)-induced expression of cytokine-mediated inducible nitric oxide synthases via AP-1 and C/EBP: implications for Krabbe disease. | 2002 | FASEB J. | pmid:11978730 |
| Shen JS et al. | Establishment and characterization of spontaneously immortalized Schwann cells from murine model of globoid cell leukodystrophy (twitcher). | 2002 | J. Neurosci. Res. | pmid:12111848 |
| Zhang Y et al. | A one pot synthesis of mono- and di-lactosyl sphingosines. | 2001 | Glycoconj. J. | pmid:12151717 |
| Orvisky E et al. | Glucosylsphingosine accumulation in tissues from patients with Gaucher disease: correlation with phenotype and genotype. | 2002 | Mol. Genet. Metab. | pmid:12208131 |
| Jatana M et al. | Apoptotic positive cells in Krabbe brain and induction of apoptosis in rat C6 glial cells by psychosine. | 2002 | Neurosci. Lett. | pmid:12231442 |
| Biswas S et al. | Delayed clinical and pathological signs in twitcher (globoid cell leukodystrophy) mice on a C57BL/6 x CAST/Ei background. | 2002 | Neurobiol. Dis. | pmid:12270695 |
| Sillence DJ et al. | Glucosylceramide modulates membrane traffic along the endocytic pathway. | 2002 | J. Lipid Res. | pmid:12401882 |