| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Airway Obstruction | D000402 | 13 associated lipids |
| Uremia | D014511 | 33 associated lipids |
| Stomach Ulcer | D013276 | 75 associated lipids |
| Kidney Failure, Chronic | D007676 | 51 associated lipids |
| Diarrhea | D003967 | 32 associated lipids |
| Diabetes Mellitus | D003920 | 90 associated lipids |
| Uterine Cervical Neoplasms | D002583 | 10 associated lipids |
| Neoplasms, Experimental | D009374 | 10 associated lipids |
| Hypoxia | D000860 | 23 associated lipids |
cholesterol
cholesterol is a lipid of Sterol Lipids (ST) class. Cholesterol is associated with abnormalities such as Trypanosomiasis, Chagas Disease, Cleft Palate, Chondrodysplasia punctata 2, X-linked dominant and Child syndrome. The involved functions are known as Blood Circulation, Sterol Biosynthesis Pathway, Receptor Mediated Endocytosis, Methylation and Signal. Cholesterol often locates in Animal tissue, Blood, Membrane, Plasma membrane and peroxisome. The associated genes with cholesterol are MBD2 gene, SIM, SLC33A1 gene, Genome and NSDHL gene. The related lipids are Sterols, zymosterol, fecosterol, Total cholesterol and 7-dehydrocholesterol. The related experimental models are Mouse Model, Knock-out, Genetically Engineered Mouse and Disease model.
Cross Reference
Introduction
To understand associated biological information of cholesterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with cholesterol?
cholesterol is suspected in Atherosclerosis, Hypercholesterolemia, cholesterol gallstones, Obesity, SVEINSSON CHORIORETINAL ATROPHY, Congenital Abnormality and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with cholesterol
PubChem Associated disorders and diseases
What pathways are associated with cholesterol
Lipid pathways are not clear in current pathway databases. We organized associated pathways with cholesterol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with cholesterol?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with cholesterol?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with cholesterol?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with cholesterol?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with cholesterol?
Knock-out
Knock-out are used in the study 'Acid sphingomyelinase-deficient macrophages have defective cholesterol trafficking and efflux.' (Leventhal AR et al., 2001), Knock-out are used in the study 'On the regulatory role of side-chain hydroxylated oxysterols in the brain. Lessons from CYP27A1 transgenic and Cyp27a1(-/-) mice.' (Ali Z et al., 2013), Knock-out are used in the study 'Regulation of classic and alternative bile acid synthesis in hypercholesterolemic rabbits: effects of cholesterol feeding and bile acid depletion.' (Xu G et al., 1998), Knock-out are used in the study 'Functional redundancy of steroid C26-monooxygenase activity in Mycobacterium tuberculosis revealed by biochemical and genetic analyses.' (Johnston JB et al., 2010) and Knock-out are used in the study 'Marked reduction in bile acid synthesis in cholesterol 7alpha-hydroxylase-deficient mice does not lead to diminished tissue cholesterol turnover or to hypercholesterolemia.' (Schwarz M et al., 1998).
Mouse Model
Mouse Model are used in the study 'Fenofibrate reduces intestinal cholesterol absorption via PPARalpha-dependent modulation of NPC1L1 expression in mouse.' (Valasek MA et al., 2007), Mouse Model are used in the study 'Functional redundancy of steroid C26-monooxygenase activity in Mycobacterium tuberculosis revealed by biochemical and genetic analyses.' (Johnston JB et al., 2010), Mouse Model are used in the study 'Cholic acid aids absorption, biliary secretion, and phase transitions of cholesterol in murine cholelithogenesis.' (Wang DQ et al., 1999), Mouse Model are used in the study 'Feedback inhibition of the cholesterol biosynthetic pathway in patients with Smith-Lemli-Opitz syndrome as demonstrated by urinary mevalonate excretion.' (Pappu AS et al., 2002) and Mouse Model are used in the study 'Disorders of cholesterol biosynthesis: prototypic metabolic malformation syndromes.' (Herman GE, 2003).
Disease model
Disease model are used in the study 'Amphotericin B lipid complex or amphotericin B multiple-dose administration to rabbits with elevated plasma cholesterol levels: pharmacokinetics in plasma and blood, plasma lipoprotein levels, distribution in tissues, and renal toxicities.' (Ramaswamy M et al., 2001) and Disease model are used in the study 'Increased cholesterol 7alpha-hydroxylase expression and size of the bile acid pool in the lactating rat.' (Wooton-Kee CR et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with cholesterol
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Strom R et al. | Stoichiometry of hemolysis by the polyene antibiotic lucensomycin. | 1976 | Biochim. Biophys. Acta | pmid:999947 |
| Pickard MA and Paterson AR | Fractionation of human erythrocyte membranes. Presence of the nucleoside transport complex in an insoluble residue. | 1976 | Biochim. Biophys. Acta | pmid:999942 |
| Hoffman RA et al. | Voltage-clamp experiments on oxidized cholesterol membranes modified with excitability-inducing material and comparison with a model. | 1976 | Biochim. Biophys. Acta | pmid:999940 |
| Kremmer T et al. | The lipid composition of plasma membrane subfractions originating from the three major functional domains of the rat hepatocyte cell surface. | 1976 | Biochim. Biophys. Acta | pmid:999933 |
| Van Dijck PW et al. | The preference of cholesterol for phosphatidylcholine in mixed phosphatidylcholine-phosphatidylethanolamine bilayers. | 1976 | Biochim. Biophys. Acta | pmid:999929 |
| Steck AJ et al. | Lipid-protein interactions with native and modified myelin basic protein. | 1976 | Biochim. Biophys. Acta | pmid:999919 |
| Solomon B and Miller IR | Interaction of glucose oxidase with phospholipid vesicles. | 1976 | Biochim. Biophys. Acta | pmid:999918 |
| Bayliss OB | The giant cell in cholesterol resorption. | 1976 | Br J Exp Pathol | pmid:999795 |
| Mellon WS et al. | Differential effect of clofibrate on hepatic drug oxidation and cholesterol 7alpha-hydroxylation. | 1976 | Biochem. Pharmacol. | pmid:999729 |
| Seydel JK and Wassermann O | NMR-studies on the molecular basis of drug-induced phospholipidosis--II. Interaction between several amphiphilic drugs and phospholipids. | 1976 | Biochem. Pharmacol. | pmid:999723 |
| Bardeletti G and Gautheron DC | Phospholipid and cholesterol composition of rubella virus and its host cell BHK 21 grown in suspension cultures. | 1976 | Arch. Virol. | pmid:999519 |
| Harrison GA and Boyce AJ | Associations between polymorphic variety and anthropometric and biochemical variation in two New Guinea populations. | 1976 | Ann. Hum. Biol. | pmid:999231 |
| Akinyanju PA and Akinyanju CO | Plasma and red cell lipids in sickle cell disease. | 1976 Nov-Dec | Ann. Clin. Lab. Sci. | pmid:999221 |
| Hylemon PB and Harder J | Biotransformation of monoterpenes, bile acids, and other isoprenoids in anaerobic ecosystems. | 1998 | FEMS Microbiol. Rev. | pmid:9990726 |
| Root MM et al. | Determinants of plasma retinol concentrations of middle-aged women in rural China. | 1999 | Nutrition | pmid:9990573 |
| de Lorgeril M et al. | Mediterranean diet, traditional risk factors, and the rate of cardiovascular complications after myocardial infarction: final report of the Lyon Diet Heart Study. | 1999 | Circulation | pmid:9989963 |
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| Heber D et al. | Cholesterol-lowering effects of a proprietary Chinese red-yeast-rice dietary supplement. | 1999 | Am. J. Clin. Nutr. | pmid:9989685 |
| Tsutsumi K et al. | Acceleration of development of diabetic cataract by hyperlipidemia and low high-density lipoprotein in rats. | 1999 | Biol. Pharm. Bull. | pmid:9989659 |
| Kawabe Y et al. | The physiological role of sterol regulatory element-binding protein-2 in cultured human cells. | 1999 | Biochim. Biophys. Acta | pmid:9989262 |
| Mosinger BJ | Higher cholesterol in human LDL is associated with the increase of oxidation susceptibility and the decrease of antioxidant defence: experimental and simulation data. | 1999 | Biochim. Biophys. Acta | pmid:9989258 |
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| Sviridov D | Intracellular cholesterol trafficking. | 1999 | Histol. Histopathol. | pmid:9987675 |
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| Nichols AB et al. | Daily nutritional intake and serum lipid levels. The Tecumseh study. | 1976 | Am. J. Clin. Nutr. | pmid:998550 |
| Yeung DL | Relationships between cigarette smoking, oral contraceptives, and plasma vitamins A, E, C, and plasma triglycerides and cholesterol. | 1976 | Am. J. Clin. Nutr. | pmid:998536 |
| Berdanier CD and Koh ET | Effect of anti-insulin serum on the hepatic lipid metabolism of BHE rats. | 1976 | Am. J. Clin. Nutr. | pmid:998535 |
| Anderson JT et al. | Independence of the effects of cholesterol and degree of saturation of the fat in the diet on serum cholesterol in man. | 1976 | Am. J. Clin. Nutr. | pmid:998534 |
| Crayen M and Seely S | Faults of cholesterol metabolism. | 1976 | Am. Heart J. | pmid:998492 |
| Glaumann H | Phagocytosis and intralysosomal digestion of subcellular organelles by Kupffer cells of rat liver. | 1976 | Adv. Exp. Med. Biol. | pmid:998409 |
| Strunge P and Trostmann AF | An epidemiological study of a Danish school population. I. Reference values for serum lipids based on a clinical and biochemical study of 284 girls and 268 boys. | 1976 | Acta Paediatr Scand | pmid:998228 |
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| López MartÃnez J et al. | [Parenteral feeding: pattern of plasma cholesterol and triglyceride levels]. | 1978 | Rev Clin Esp | pmid:99773 |
| Olthoff D et al. | [Determination of lipids in serum and erythrocytes during surgery with extracorporeal circulation]. | 1976 | Z Exp Chir | pmid:997686 |
| Widhalm K and Götz M | [Long-term use of medium chain triglycerides in cystic fibrosis (author's transl)]. | 1976 | Wien. Klin. Wochenschr. | pmid:997539 |
| Toikka JO et al. | Large-artery elastic properties in young men : relationships to serum lipoproteins and oxidized low-density lipoproteins. | 1999 | Arterioscler. Thromb. Vasc. Biol. | pmid:9974429 |
| Truskey GA et al. | Focal increases in vascular cell adhesion molecule-1 and intimal macrophages at atherosclerosis-susceptible sites in the rabbit aorta after short-term cholesterol feeding. | 1999 | Arterioscler. Thromb. Vasc. Biol. | pmid:9974424 |
| van den Eijnden MM et al. | Cholesterol or triglyceride loading of human monocyte-derived macrophages by incubation with modified lipoproteins does not induce tissue factor expression. | 1999 | Arterioscler. Thromb. Vasc. Biol. | pmid:9974423 |
| Li D et al. | Inhibition of arterial thrombus formation by ApoA1 Milano. | 1999 | Arterioscler. Thromb. Vasc. Biol. | pmid:9974422 |
| Petit L et al. | Tissue factor pathway inhibitor is expressed by human monocyte-derived macrophages : relationship to tissue factor induction by cholesterol and oxidized LDL. | 1999 | Arterioscler. Thromb. Vasc. Biol. | pmid:9974412 |
| Bucher HC et al. | Systematic review on the risk and benefit of different cholesterol-lowering interventions. | 1999 | Arterioscler. Thromb. Vasc. Biol. | pmid:9974397 |
| Waheed AA et al. | Decreased densities of intramembranous particles and cytochemically detectable cholesterol in microvilli of starved rat enterocytes. | 1998 | Cell Biol. Int. | pmid:9974211 |
| Bellossi A et al. | Effect of pulsed magnetic fields on triglyceride and cholesterol levels in plasma of rats. | 1998 | Panminerva Med | pmid:9973821 |
| Epand RF et al. | The ectodomain of HA2 of influenza virus promotes rapid pH dependent membrane fusion. | 1999 | J. Mol. Biol. | pmid:9973566 |