| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Airway Obstruction | D000402 | 13 associated lipids |
| Uremia | D014511 | 33 associated lipids |
| Stomach Ulcer | D013276 | 75 associated lipids |
| Kidney Failure, Chronic | D007676 | 51 associated lipids |
| Diarrhea | D003967 | 32 associated lipids |
| Diabetes Mellitus | D003920 | 90 associated lipids |
| Uterine Cervical Neoplasms | D002583 | 10 associated lipids |
| Neoplasms, Experimental | D009374 | 10 associated lipids |
| Hypoxia | D000860 | 23 associated lipids |
cholesterol
cholesterol is a lipid of Sterol Lipids (ST) class. Cholesterol is associated with abnormalities such as Trypanosomiasis, Chagas Disease, Cleft Palate, Chondrodysplasia punctata 2, X-linked dominant and Child syndrome. The involved functions are known as Blood Circulation, Sterol Biosynthesis Pathway, Receptor Mediated Endocytosis, Methylation and Signal. Cholesterol often locates in Animal tissue, Blood, Membrane, Plasma membrane and peroxisome. The associated genes with cholesterol are MBD2 gene, SIM, SLC33A1 gene, Genome and NSDHL gene. The related lipids are Sterols, zymosterol, fecosterol, Total cholesterol and 7-dehydrocholesterol. The related experimental models are Mouse Model, Knock-out, Genetically Engineered Mouse and Disease model.
Cross Reference
Introduction
To understand associated biological information of cholesterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with cholesterol?
cholesterol is suspected in Atherosclerosis, Hypercholesterolemia, cholesterol gallstones, Obesity, SVEINSSON CHORIORETINAL ATROPHY, Congenital Abnormality and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with cholesterol
PubChem Associated disorders and diseases
What pathways are associated with cholesterol
Lipid pathways are not clear in current pathway databases. We organized associated pathways with cholesterol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with cholesterol?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with cholesterol?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with cholesterol?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with cholesterol?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with cholesterol?
Knock-out
Knock-out are used in the study 'Acid sphingomyelinase-deficient macrophages have defective cholesterol trafficking and efflux.' (Leventhal AR et al., 2001), Knock-out are used in the study 'On the regulatory role of side-chain hydroxylated oxysterols in the brain. Lessons from CYP27A1 transgenic and Cyp27a1(-/-) mice.' (Ali Z et al., 2013), Knock-out are used in the study 'Regulation of classic and alternative bile acid synthesis in hypercholesterolemic rabbits: effects of cholesterol feeding and bile acid depletion.' (Xu G et al., 1998), Knock-out are used in the study 'Functional redundancy of steroid C26-monooxygenase activity in Mycobacterium tuberculosis revealed by biochemical and genetic analyses.' (Johnston JB et al., 2010) and Knock-out are used in the study 'Marked reduction in bile acid synthesis in cholesterol 7alpha-hydroxylase-deficient mice does not lead to diminished tissue cholesterol turnover or to hypercholesterolemia.' (Schwarz M et al., 1998).
Mouse Model
Mouse Model are used in the study 'Fenofibrate reduces intestinal cholesterol absorption via PPARalpha-dependent modulation of NPC1L1 expression in mouse.' (Valasek MA et al., 2007), Mouse Model are used in the study 'Functional redundancy of steroid C26-monooxygenase activity in Mycobacterium tuberculosis revealed by biochemical and genetic analyses.' (Johnston JB et al., 2010), Mouse Model are used in the study 'Cholic acid aids absorption, biliary secretion, and phase transitions of cholesterol in murine cholelithogenesis.' (Wang DQ et al., 1999), Mouse Model are used in the study 'Feedback inhibition of the cholesterol biosynthetic pathway in patients with Smith-Lemli-Opitz syndrome as demonstrated by urinary mevalonate excretion.' (Pappu AS et al., 2002) and Mouse Model are used in the study 'Disorders of cholesterol biosynthesis: prototypic metabolic malformation syndromes.' (Herman GE, 2003).
Disease model
Disease model are used in the study 'Amphotericin B lipid complex or amphotericin B multiple-dose administration to rabbits with elevated plasma cholesterol levels: pharmacokinetics in plasma and blood, plasma lipoprotein levels, distribution in tissues, and renal toxicities.' (Ramaswamy M et al., 2001) and Disease model are used in the study 'Increased cholesterol 7alpha-hydroxylase expression and size of the bile acid pool in the lactating rat.' (Wooton-Kee CR et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with cholesterol
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Awad AB and Spector AA | Modification of the Ehrlich ascites tumor cell nuclear lipids. | 1976 | Biochim. Biophys. Acta | pmid:990304 |
| Krause BR and Hartman AD | Relationship between cell size, plasma cholesterol and rat adipocyte cholesterol storage. | 1976 | Biochim. Biophys. Acta | pmid:990299 |
| Shattil SJ and Cooper RA | Membrane microviscosity and human platelet function. | 1976 | Biochemistry | pmid:990246 |
| Meade TW et al. | An epidemiological study of the haemostatic and other effects of oral contraceptives. | 1976 | Br. J. Haematol. | pmid:990177 |
| Delage Y et al. | Effect of glycodihydrofuisidate on sulfobromophthalein transport maximum in the hamster. | 1976 | Am. J. Physiol. | pmid:990128 |
| Imai H et al. | Angiotoxicity and arteriosclerosis due to contaminants of USP-grade cholesterol. | 1976 | Arch. Pathol. Lab. Med. | pmid:990067 |
| Kondo K et al. | Benign desoxycorticosterone-producing adrenal tumor. | 1976 | JAMA | pmid:989580 |
| Nichols AB et al. | Independence of serum lipid levels and dietary habits. The Tecumseh study. | 1976 | JAMA | pmid:989556 |
| Shioiri T et al. | Frequency distribution of serum cholesterol levels in patients with panic disorder: comparison with normal controls. | 1998 | Psychiatry Clin. Neurosci. | pmid:9895208 |
| Byun SJ et al. | Differentially expressed genes in cultured aortic smooth muscle cells by cholesterol-loading. | 1998 | Mol. Cells | pmid:9895116 |
| Giardini O et al. | Serum lipid pattern in beta-thalassaemia. | 1978 | Acta Haematol. | pmid:98949 |
| Saia F et al. | The management of hypercholesterolaemia in patients with coronary artery disease referred for coronary angiography. | 1998 | Int. J. Cardiol. | pmid:9894706 |
| Tsoko M et al. | Hypolipidaemic effects of fenofibrate are not altered by mildronate-mediated normalization of carnitine concentration in rat liver. | 1998 | Biochimie | pmid:9893954 |
| MartÃnez-Botas J et al. | Induction of apoptosis in p53-null HL-60 cells by inhibition of lanosterol 14-alpha demethylase. | 1998 | Biochimie | pmid:9893947 |
| Papadakis JA et al. | Lipids and stroke: neglect of a useful preventive measure? | 1998 | Cardiovasc. Res. | pmid:9893719 |
| Kriesten K et al. | [Stress-induced changes in serum lipids and fatty acids in bulls]. | 1978 | Zentralbl Veterinarmed A | pmid:98937 |
| Gurrieri J et al. | Antilipidemic drugs. Part 2: Experimental study of a new potent hypolipidemic drug, isopropyl-[4'-(p-chlorobenzoyl)-2-phenoxy-2-methyl]-propionate (LF178). | 1976 | Arzneimittelforschung | pmid:989363 |
| Sornay R et al. | A systematic antilipidemic structure-activity relationship study was carried out on a series of alcoyl- and benzoyl-phenoxy-carboxylic acids. | 1976 | Arzneimittelforschung | pmid:989362 |
| Kritchevsky D et al. | Influence of four agents (tibric acid, DH 990, oxandrolone and Sch 9122) on aspects of lipid metabolism in rats). | 1976 | Arzneimittelforschung | pmid:989359 |
| Bushehri N et al. | Oral reduced B-nicotinamide adenine dinucleotide (NADH) affects blood pressure, lipid peroxidation, and lipid profile in hypertensive rats (SHR). | 1998 | Geriatr Nephrol Urol | pmid:9893217 |
| Slatopolsky EA et al. | RenaGel, a nonabsorbed calcium- and aluminum-free phosphate binder, lowers serum phosphorus and parathyroid hormone. The RenaGel Study Group. | 1999 | Kidney Int. | pmid:9893140 |
| Urdal P et al. | Monday and non-Monday concentrations of lifestyle-related blood components in the Oslo Diet and Exercise Study. | 1998 | J. Intern. Med. | pmid:9893104 |
| Friedman RJ et al. | Regression of injury-induced atheromatous lesions in rabbits. | 1976 | Arch. Pathol. Lab. Med. | pmid:989284 |
| Plehn JF et al. | Reduction of stroke incidence after myocardial infarction with pravastatin: the Cholesterol and Recurrent Events (CARE) study. The Care Investigators. | 1999 | Circulation | pmid:9892586 |
| Fuster V et al. | Atherothrombosis: mechanisms and clinical therapeutic approaches. | 1998 | Vasc Med | pmid:9892516 |
| Douillet C et al. | Effect of selenium and vitamin E supplementation on lipid abnormalities in plasma, aorta, and adipose tissue of Zucker rats. | 1998 | Biol Trace Elem Res | pmid:9892495 |
| Shaila HP et al. | Hypolipidemic activity of three indigenous drugs in experimentally induced atherosclerosis. | 1998 | Int. J. Cardiol. | pmid:9891944 |
| Akiba T et al. | Six-month repeated oral toxicity study of NK-104 in rats. | 1998 | J Toxicol Sci | pmid:9891909 |
| Brown DA and London E | Functions of lipid rafts in biological membranes. | 1998 | Annu. Rev. Cell Dev. Biol. | pmid:9891780 |
| Guliaeva NV et al. | [Parameters of free radical oxidation in blood plasma of women from the AltaÄ region]. | 1998 Nov-Dec | Izv. Akad. Nauk. Ser. Biol. | pmid:9891429 |
| Gillotte KL et al. | Apolipoprotein-mediated plasma membrane microsolubilization. Role of lipid affinity and membrane penetration in the efflux of cellular cholesterol and phospholipid. | 1999 | J. Biol. Chem. | pmid:9890960 |
| Discher BM et al. | Neutral lipids induce critical behavior in interfacial monolayers of pulmonary surfactant. | 1999 | Biochemistry | pmid:9890919 |
| James PS et al. | Lipid diffusion in the plasma membrane of ram and boar spermatozoa during maturation in the epididymis measured by fluorescence recovery after photobleaching. | 1999 | Mol. Reprod. Dev. | pmid:9890752 |
| Miller WL | Early steps in androgen biosynthesis: from cholesterol to DHEA. | 1998 | Baillieres Clin. Endocrinol. Metab. | pmid:9890062 |
| Subczynski WK and Hyde JS | Membranes. Barriers or pathways for oxygen transport. | 1998 | Adv. Exp. Med. Biol. | pmid:9889917 |
| Yokoyama S | [Cellular cholesterol efflux and HDL]. | 1998 | Seikagaku | pmid:9889598 |
| Males RG and Herring FG | A 1H-NMR study of the permeation of glycolic acid through phospholipid membranes. | 1999 | Biochim. Biophys. Acta | pmid:9889392 |
| McMullen TP et al. | Calorimetric and spectroscopic studies of the effects of cholesterol on the thermotropic phase behavior and organization of a homologous series of linear saturated phosphatidylethanolamine bilayers. | 1999 | Biochim. Biophys. Acta | pmid:9889344 |
| Dawes LG et al. | Altered gallbladder bile acidification with long-term total parenteral nutrition. | 1999 | J. Surg. Res. | pmid:9889052 |
| Marcil M et al. | Cellular cholesterol transport and efflux in fibroblasts are abnormal in subjects with familial HDL deficiency. | 1999 | Arterioscler. Thromb. Vasc. Biol. | pmid:9888879 |
| Lehtimäki T et al. | Autoantibodies against oxidized low density lipoprotein in patients with angiographically verified coronary artery disease. | 1999 | Arterioscler. Thromb. Vasc. Biol. | pmid:9888862 |
| Freeman DA et al. | Plasma membrane steroidogenic cholesterol: the relative importance of membrane internalization rate and cholesterol extraction rate of internalized membrane. | 1998 Aug-Nov | Endocr. Res. | pmid:9888549 |
| Cherradi N et al. | Regulation of mineralocorticoid biosynthesis by calcium and the StAR protein. | 1998 Aug-Nov | Endocr. Res. | pmid:9888507 |
| Kovács P et al. | Effects of quantitative trait loci for lipid phenotypes in the rat are influenced by age. | 1998 | Clin. Exp. Pharmacol. Physiol. | pmid:9887997 |
| Corey LA et al. | Effects of chorion type on variation in cord blood cholesterol of monozygotic twins. | 1976 | Am. J. Hum. Genet. | pmid:988747 |
| Turner RT et al. | Is resveratrol an estrogen agonist in growing rats? | 1999 | Endocrinology | pmid:9886806 |
| Kwon HM et al. | Ultrastructural changes of the internal elastic lamina in experimental hypercholesterolemic porcine coronary arteries. | 1998 | J. Korean Med. Sci. | pmid:9886168 |
| Williams RO et al. | Characterization of an inclusion complex of cholesterol and hydroxypropyl-beta-cyclodextrin. | 1998 | Eur J Pharm Biopharm | pmid:9885309 |
| Luoma H et al. | Seven weeks feeding of magnesium and fluoride modifies plasma lipids of hypercholesterolaemic rats in late growth phase. | 1998 | Magnes Res | pmid:9884985 |
| Elkhadrawy TM et al. | Serum cholesterol and the risk of ductal carcinoma in situ: a case-control study. | 1998 | Eur. J. Cancer Prev. | pmid:9884885 |