| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hyperlipoproteinemia Type III | D006952 | 4 associated lipids |
| Hyperlipoproteinemias | D006951 | 15 associated lipids |
Total
2
1250-95-9
1250-95-9 is a lipid of Sterol Lipids (ST) class.
Cross Reference
There are no associated biomedical information in the current reference collection.
Current reference collection contains 303 references associated with 1250-95-9 in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.
Users can download the reference list at the bottom of this page and read the reference manually to find out biomedical information.
Here are additional resources we collected from PubChem and MeSH for 1250-95-9
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with 1250-95-9
NCBI Entrez Crosslinks
All references with 1250-95-9
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| pmid: | ||||
| Levin W et al. | Distinct rat hepatic microsomal epoxide hydrolases catalyze the hydration of cholesterol 5,6 alpha-oxide and certain xenobiotic alkene and arene oxides. | 1983 | Arch. Biochem. Biophys. | pmid:6401984 |
| Li QT and Das NP | Comparison of the effects of cholesterol and oxysterols on phospholipid bilayer microheterogeneity: a study of fluorescence lifetime distributions. | 1994 | Arch. Biochem. Biophys. | pmid:7986094 |
| Deckert V et al. | Inhibition by cholesterol oxides of NO release from human vascular endothelial cells. | 1998 | Arterioscler. Thromb. Vasc. Biol. | pmid:9672065 |
| Higley NA et al. | Comparative atherogenic effects of cholesterol and cholesterol oxides. | 1986 | Atherosclerosis | pmid:3801085 |
| Zhou Q et al. | An excess concentration of oxysterols in the plasma is cytotoxic to cultured endothelial cells. | 2000 | Atherosclerosis | pmid:10704631 |
| Baranowski A et al. | Connective tissue responses to oxysterols. | 1982 | Atherosclerosis | pmid:7066074 |
| Chang JY et al. | Establishment of two morphologically distinct PC12 cell lines resistant to 25-OH-cholesterol toxicity. | 1997 | Biochem. Biophys. Res. Commun. | pmid:9344846 |
| Watabe T et al. | Epoxidation of cholesterol by hepatic microsomal lipid hydroperoxides. | 1982 | Biochem. Biophys. Res. Commun. | pmid:7150318 |
| Raaphorst GP et al. | Effect of cholesterol alpha and beta epoxides on cell killing and transformation. | 1987 | Biochem. Pharmacol. | pmid:3606646 |
| Moody DE et al. | Effects of environmentally encountered epoxides on mouse liver epoxide-metabolizing enzymes. | 1991 | Biochem. Pharmacol. | pmid:2043152 |
| Watabe T et al. | A mechanism for epoxidation of cholesterol by hepatic microsomal lipid hydroperoxides. | 1984 | Biochim. Biophys. Acta | pmid:6466699 |
| Raicht RF and Cohen BI | Sterol metabolism in the rat. Effect of cholesterol and cholesterol-alpha-epoxide on sterol metabolism in rats fed liquid diets. | 1981 | Biochim. Biophys. Acta | pmid:7326255 |
| Sevanian A et al. | Lipid epoxide hydrolase in rat lung preparations. | 1980 | Biochim. Biophys. Acta | pmid:7407199 |
| Morisseau C | Role of epoxide hydrolases in lipid metabolism. | 2013 | Biochimie | pmid:22722082 |
| Poirot M and Silvente-Poirot S | Cholesterol-5,6-epoxides: chemistry, biochemistry, metabolic fate and cancer. | 2013 | Biochimie | pmid:22613256 |
| Ryan L et al. | The role of the mitochondria in apoptosis induced by 7beta-hydroxycholesterol and cholesterol-5beta,6beta-epoxide. | 2005 | Br. J. Nutr. | pmid:16197575 |
| Küçük O et al. | Increased plasma level of cholesterol-5 beta,6 beta-epoxide in endometrial cancer patients. | 1994 Oct-Nov | Cancer Epidemiol. Biomarkers Prev. | pmid:7827587 |
| Gruenke LD et al. | Breast fluid cholesterol and cholesterol epoxides: relationship to breast cancer risk factors and other characteristics. | 1987 | Cancer Res. | pmid:3652048 |
| Petrakis NL et al. | Cholesterol and cholesterol epoxides in nipple aspirates of human breast fluid. | 1981 | Cancer Res. | pmid:7237447 |
| Wrensch MR et al. | Breast fluid cholesterol and cholesterol beta-epoxide concentrations in women with benign breast disease. | 1989 | Cancer Res. | pmid:2702658 |
| O'Callaghan YC et al. | Comparative study of the cytotoxicity and apoptosis-inducing potential of commonly occurring oxysterols. | 2001 | Cell Biol. Toxicol. | pmid:11499696 |
| Ryan L et al. | Comparison of the apoptotic processes induced by the oxysterols 7beta-hydroxycholesterol and cholesterol-5beta,6beta-epoxide. | 2004 | Cell Biol. Toxicol. | pmid:15685934 |
| Windsor K et al. | Assay of protein and peptide adducts of cholesterol ozonolysis products by hydrophobic and click enrichment methods. | 2014 | Chem. Res. Toxicol. | pmid:25185119 |
| Arshad MA et al. | Plasma lipoprotein peroxidation potential: a test to evaluate individual susceptibility to peroxidation. | 1991 | Clin. Chem. | pmid:1914180 |
| Silvente-Poirot S and Poirot M | Cholesterol epoxide hydrolase and cancer. | 2012 | Curr Opin Pharmacol | pmid:22917620 |
| Ferderbar S et al. | Cholesterol oxides as biomarkers of oxidative stress in type 1 and type 2 diabetes mellitus. | 2007 | Diabetes Metab. Res. Rev. | pmid:16634125 |
| Müller F et al. | Visualization of a covalent intermediate between microsomal epoxide hydrolase, but not cholesterol epoxide hydrolase, and their substrates. | 1997 | Eur. J. Biochem. | pmid:9151984 |
| Jové M et al. | Human omental and subcutaneous adipose tissue exhibit specific lipidomic signatures. | 2014 | FASEB J. | pmid:24265485 |
| Meyer DJ and Ketterer B | 5 alpha,6 alpha-Epoxy-cholestan-3 beta-ol (cholesterol alpha-oxide): A specific substrate for rat liver glutathione transferase B. | 1982 | FEBS Lett. | pmid:7160489 |
| Cheng YW et al. | Cholesterol-3-beta, 5-alpha, 6-beta-triol induced genotoxicity through reactive oxygen species formation. | 2005 | Food Chem. Toxicol. | pmid:15721210 |
| Sevanian A et al. | Analysis of plasma cholesterol oxidation products using gas- and high-performance liquid chromatography/mass spectrometry. | 1994 | Free Radic. Biol. Med. | pmid:7835746 |
| Musman J et al. | Regular treadmill exercise inhibits mitochondrial accumulation of cholesterol and oxysterols during myocardial ischemia-reperfusion in wild-type and ob/ob mice. | 2016 | Free Radic. Biol. Med. | pmid:27989751 |
| Ryan L et al. | Involvement of calcium in 7beta -hydroxycholesterol and cholesterol-5beta,6beta -epoxide-induced apoptosis. | 2006 Jan-Feb | Int. J. Toxicol. | pmid:16510355 |
| Lordan S et al. | Involvement of Fas signalling in 7beta-hydroxycholesterol-and cholesterol-5beta,6beta-epoxide-induced apoptosis. | 2008 | Int. J. Toxicol. | pmid:18569169 |
| O'Sullivan AJ et al. | Toxicity of cholesterol oxidation products to Caco-2 and HepG2 cells: modulatory effects of alpha- and gamma-tocopherol. | 2003 May-Jun | J Appl Toxicol | pmid:12794941 |
| Lordan S et al. | Death-signaling pathways in human myeloid cells by oxLDL and its cytotoxic components 7beta-hydroxycholesterol and cholesterol-5beta,6beta-epoxide. | 2007 | J. Biochem. Mol. Toxicol. | pmid:17994574 |
| Sevanian A and McLeod LL | Catalytic properties and inhibition of hepatic cholesterol-epoxide hydrolase. | 1986 | J. Biol. Chem. | pmid:3941086 |
| Pulfer MK and Murphy RC | Formation of biologically active oxysterols during ozonolysis of cholesterol present in lung surfactant. | 2004 | J. Biol. Chem. | pmid:15096493 |
| Morin RJ et al. | Cholesterol oxides and carcinogenesis. | 1991 | J. Clin. Lab. Anal. | pmid:2061746 |
| Anspaugh DD and Roe RM | Regulation of JH epoxide hydrolase versus JH esterase activity in the cabbage looper, Trichoplusia ni, by juvenile hormone and xenobiotics. | 2005 | J. Insect Physiol. | pmid:15893999 |
| Björkhem I et al. | Assay of unesterified cholesterol-5,6-epoxide in human serum by isotope dilution mass spectrometry. Levels in the healthy state and in hyperlipoproteinemia. | 1988 | J. Lipid Res. | pmid:3183516 |
| Paillasse MR et al. | Surprising unreactivity of cholesterol-5,6-epoxides towards nucleophiles. | 2012 | J. Lipid Res. | pmid:22285872 |
| van den Berg JJ et al. | Hypochlorous acid-mediated modification of cholesterol and phospholipid: analysis of reaction products by gas chromatography-mass spectrometry. | 1993 | J. Lipid Res. | pmid:8263423 |
| Sevanian A et al. | Uptake, metabolism, and cytotoxicity of isomeric cholesterol-5,6-epoxides in rabbit aortic endothelial cells. | 1991 | J. Lipid Res. | pmid:2010686 |
| Staprans I et al. | Oxidized cholesterol in the diet is a source of oxidized lipoproteins in human serum. | 2003 | J. Lipid Res. | pmid:12562864 |
| Johansson P et al. | Structure of an atypical epoxide hydrolase from Mycobacterium tuberculosis gives insights into its function. | 2005 | J. Mol. Biol. | pmid:16051262 |
| Jacobson MS | Cholesterol oxides in Indian ghee: possible cause of unexplained high risk of atherosclerosis in Indian immigrant populations. | 1987 | Lancet | pmid:2887943 |
| Bascoul J et al. | Intestinal absorption and fecal excretion of 5,6 alpha-epoxy-5 alpha-cholesta-3 beta-ol by the male Wistar rat. | 1986 | Lipids | pmid:3821388 |
| Maerker G et al. | Reaction of cholesterol 5,6-epoxides with simulated gastric juice. | 1988 | Lipids | pmid:3185108 |