24(S),25-Epoxycholesterol

24(S),25-Epoxycholesterol is a lipid of Sterol Lipids (ST) class.

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There are no associated biomedical information in the current reference collection.

Current reference collection contains 285 references associated with 24(S),25-Epoxycholesterol in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.

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All references with 24(S),25-Epoxycholesterol

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Authors Title Published Journal PubMed Link
Janowski BA et al. Structural requirements of ligands for the oxysterol liver X receptors LXRalpha and LXRbeta. 1999 Proc. Natl. Acad. Sci. U.S.A. pmid:9874807
Lehmann JM et al. Activation of the nuclear receptor LXR by oxysterols defines a new hormone response pathway. 1997 J. Biol. Chem. pmid:9013544
Saucier SE et al. Hepatic uptake and metabolism of ingested 24-hydroxycholesterol and 24(S),25-epoxycholesterol. 1993 Biochim. Biophys. Acta pmid:8431485
Dollis D and Schuber F Effects of a 2,3-oxidosqualene-lanosterol cyclase inhibitor 2,3:22,23-dioxidosqualene and 24,25-epoxycholesterol on the regulation of cholesterol biosynthesis in human hepatoma cell line HepG2. 1994 Biochem. Pharmacol. pmid:8043030
Nelson JA et al. Biosynthesis of 24,25-epoxycholesterol from squalene 2,3;22,23-dioxide. 1981 J. Biol. Chem. pmid:7451488
Saucier SE et al. Identification of regulatory oxysterols, 24(S),25-epoxycholesterol and 25-hydroxycholesterol, in cultured fibroblasts. 1985 J. Biol. Chem. pmid:4055791
Spencer TA et al. 24(S),25-Epoxycholesterol. Evidence consistent with a role in the regulation of hepatic cholesterogenesis. 1985 J. Biol. Chem. pmid:4055739
Taylor FR et al. 24,25-Epoxysterol metabolism in cultured mammalian cells and repression of 3-hydroxy-3-methylglutaryl-CoA reductase. 1986 J. Biol. Chem. pmid:3771561
Gupta A et al. Modulation of regulatory oxysterol formation and low density lipoprotein suppression of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase activity by ketoconazole. A role for cytochrome P-450 in the regulation of HMG-CoA reductase in rat intestinal epithelial cells. 1986 J. Biol. Chem. pmid:3722155
Panini SR et al. Regulation of sterol biosynthesis and of 3-hydroxy-3-methylglutaryl-coenzyme A reductase activity in cultured cells by progesterone. 1987 J. Biol. Chem. pmid:3667583
Emmons GT et al. 24,25-epoxysterols. Differentiation of 24R and 24S epimers by 13C nuclear magnetic resonance spectroscopy. 1989 J. Lipid Res. pmid:2918248
Endo-Umeda K et al. 1α-Hydroxy derivatives of 7-dehydrocholesterol are selective liver X receptor modulators. 2017 J. Steroid Biochem. Mol. Biol. pmid:28736297
Hong YF et al. Lactobacillus acidophilus K301 Inhibits Atherogenesis via Induction of 24 (S), 25-Epoxycholesterol-Mediated ABCA1 and ABCG1 Production and Cholesterol Efflux in Macrophages. 2016 PLoS ONE pmid:27120199
Wang Z et al. Upregulation of hydroxysteroid sulfotransferase 2B1b promotes hepatic oval cell proliferation by modulating oxysterol-induced LXR activation in a mouse model of liver injury. 2017 Arch. Toxicol. pmid:27052460
Wang Y et al. 24S,25-Epoxycholesterol in mouse and rat brain. 2014 Biochem. Biophys. Res. Commun. pmid:24832732
Bentinger M et al. Effects of various squalene epoxides on coenzyme Q and cholesterol synthesis. 2014 Biochim. Biophys. Acta pmid:24747199
Meljon A et al. Oxysterols in the brain of the cholesterol 24-hydroxylase knockout mouse. 2014 Biochem. Biophys. Res. Commun. pmid:24491562
Mazein A et al. A comprehensive machine-readable view of the mammalian cholesterol biosynthesis pathway. 2013 Biochem. Pharmacol. pmid:23583456
Javitt NB Alzheimer's disease: neuroprogesterone, epoxycholesterol, and ABC transporters as determinants of neurodesmosterol tissue levels and its role in amyloid protein processing. 2013 J. Alzheimers Dis. pmid:23455994
Theofilopoulos S et al. Brain endogenous liver X receptor ligands selectively promote midbrain neurogenesis. 2013 Nat. Chem. Biol. pmid:23292650