| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Williams S et al. | X-ray crystal structure of the liver X receptor beta ligand binding domain: regulation by a histidine-tryptophan switch. | 2003 | J. Biol. Chem. | pmid:12736258 |
| Wong J et al. | Statins inhibit synthesis of an oxysterol ligand for the liver x receptor in human macrophages with consequences for cholesterol flux. | 2004 | Arterioscler. Thromb. Vasc. Biol. | pmid:15514210 |
| Bjorkhem I and Diczfalusy U | 24(S),25-epoxycholesterol--a potential friend. | 2004 | Arterioscler. Thromb. Vasc. Biol. | pmid:15576644 |
| Davies JD et al. | Adipocytic differentiation and liver x receptor pathways regulate the accumulation of triacylglycerols in human vascular smooth muscle cells. | 2005 | J. Biol. Chem. | pmid:15548517 |
| Wong J et al. | SREBP-2 positively regulates transcription of the cholesterol efflux gene, ABCA1, by generating oxysterol ligands for LXR. | 2006 | Biochem. J. | pmid:16901265 |
| Li L et al. | Discovery and optimization of a novel series of liver X receptor-alpha agonists. | 2006 | Bioorg. Med. Chem. Lett. | pmid:16386417 |
| Wong J et al. | Primary human astrocytes produce 24(S),25-epoxycholesterol with implications for brain cholesterol homeostasis. | 2007 | J. Neurochem. | pmid:17956548 |
| Duniec-Dmuchowski Z et al. | Regulation of CYP3A4 and CYP2B6 expression by liver X receptor agonists. | 2007 | Biochem. Pharmacol. | pmid:17825266 |
| Heverin M et al. | Studies on the cholesterol-free mouse: strong activation of LXR-regulated hepatic genes when replacing cholesterol with desmosterol. | 2007 | Arterioscler. Thromb. Vasc. Biol. | pmid:17761942 |
| Zapata-Gonzalez F et al. | 9-cis-Retinoic acid (9cRA), a retinoid X receptor (RXR) ligand, exerts immunosuppressive effects on dendritic cells by RXR-dependent activation: inhibition of peroxisome proliferator-activated receptor gamma blocks some of the 9cRA activities, and precludes them to mature phenotype development. | 2007 | J. Immunol. | pmid:17475839 |
| Beyea MM et al. | Selective up-regulation of LXR-regulated genes ABCA1, ABCG1, and APOE in macrophages through increased endogenous synthesis of 24(S),25-epoxycholesterol. | 2007 | J. Biol. Chem. | pmid:17186944 |
| Wong J et al. | Endogenous 24(S),25-epoxycholesterol fine-tunes acute control of cellular cholesterol homeostasis. | 2008 | J. Biol. Chem. | pmid:17981807 |
| Ouimet M et al. | Epoxycholesterol impairs cholesteryl ester hydrolysis in macrophage foam cells, resulting in decreased cholesterol efflux. | 2008 | Arterioscler. Thromb. Vasc. Biol. | pmid:18369155 |
| Cheng JF et al. | Combination of virtual screening and high throughput gene profiling for identification of novel liver X receptor modulators. | 2008 | J. Med. Chem. | pmid:18324758 |
| Reschly EJ et al. | Ligand specificity and evolution of liver X receptors. | 2008 | J. Steroid Biochem. Mol. Biol. | pmid:18395439 |
| Brown AJ and Jessup W | Oxysterols: Sources, cellular storage and metabolism, and new insights into their roles in cholesterol homeostasis. | 2009 | Mol. Aspects Med. | pmid:19248801 |
| Trasino SE et al. | Ligand, receptor, and cell type-dependent regulation of ABCA1 and ABCG1 mRNA in prostate cancer epithelial cells. | 2009 | Mol. Cancer Ther. | pmid:19531574 |
| Swahn BM et al. | Liver X receptor agonists with selectivity for LXRbeta; N-aryl-3,3,3-trifluoro-2-hydroxy-2-methylpropionamides. | 2009 | Bioorg. Med. Chem. Lett. | pmid:19264481 |
| Brown AJ | 24(S),25-epoxycholesterol: a messenger for cholesterol homeostasis. | 2009 | Int. J. Biochem. Cell Biol. | pmid:18725318 |
| Morello F et al. | LXR-activating oxysterols induce the expression of inflammatory markers in endothelial cells through LXR-independent mechanisms. | 2009 | Atherosclerosis | pmid:19426978 |
24(S),25-Epoxycholesterol
24(S),25-Epoxycholesterol is a lipid of Sterol Lipids (ST) class.
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