| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Wide K et al. | Time course of the increase in 4beta-hydroxycholesterol concentration during carbamazepine treatment of paediatric patients with epilepsy. | 2008 | Br J Clin Pharmacol | pmid:18279471 |
| Gjestad C et al. | 4β-hydroxycholesterol correlates with dose but not steady-state concentration of carbamazepine: indication of intestinal CYP3A in biomarker formation? | 2016 | Br J Clin Pharmacol | pmid:26574235 |
| de Graan AJ et al. | 4β-hydroxycholesterol as an endogenous CYP3A marker in cancer patients treated with taxanes. | 2015 | Br J Clin Pharmacol | pmid:26119961 |
| Vanhove T et al. | Comparative performance of oral midazolam clearance and plasma 4β-hydroxycholesterol to explain interindividual variability in tacrolimus clearance. | 2016 | Br J Clin Pharmacol | pmid:27501475 |
| Higashi T et al. | LC/MS/MS of steroids having vicinal diol as electrospray-active boronates. | 2013 | Chem. Pharm. Bull. | pmid:23449202 |
| Goodenough AK et al. | Quantification of 4-beta-hydroxycholesterol in human plasma using automated sample preparation and LC-ESI-MS/MS analysis. | 2011 | Chem. Res. Toxicol. | pmid:21728364 |
| DeGorter MK et al. | Clinical and pharmacogenetic predictors of circulating atorvastatin and rosuvastatin concentrations in routine clinical care. | 2013 | Circ Cardiovasc Genet | pmid:23876492 |
| Jiang X et al. | An Exposure-Response Modeling Approach to Examine the Relationship Between Potency of CYP3A Inducer and Plasma 4β-Hydroxycholesterol in Healthy Subjects. | 2017 | Clin Pharmacol Drug Dev | pmid:27138546 |
| Wollmann BM et al. | 4β-Hydroxycholesterol Level in Patients With Rheumatoid Arthritis Before vs. After Initiation of bDMARDs and Correlation With Inflammatory State. | 2017 | Clin Transl Sci | pmid:27991741 |
| Kanebratt KP et al. | Cytochrome P450 induction by rifampicin in healthy subjects: determination using the Karolinska cocktail and the endogenous CYP3A4 marker 4beta-hydroxycholesterol. | 2008 | Clin. Pharmacol. Ther. | pmid:18650803 |
| Shin KH et al. | Evaluation of endogenous metabolic markers of hepatic CYP3A activity using metabolic profiling and midazolam clearance. | 2013 | Clin. Pharmacol. Ther. | pmid:23784264 |
| Tomalik-Scharte D et al. | Plasma 4beta-hydroxycholesterol: an endogenous CYP3A metric? | 2009 | Clin. Pharmacol. Ther. | pmid:19458613 |
| Oh J et al. | Effects of renal impairment on the pharmacokinetics and pharmacodynamics of a novel dipeptidyl peptidase-4 inhibitor, evogliptin (DA-1229). | 2017 | Diabetes Obes Metab | pmid:27761990 |
| Björkhem-Bergman L et al. | Serum levels of 25-hydroxyvitamin D and the CYP3A biomarker 4β-hydroxycholesterol in a high-dose vitamin D supplementation study. | 2013 | Drug Metab. Dispos. | pmid:23386704 |
| Peters J et al. | Oral absorption of clarithromycin is nearly abolished by chronic comedication of rifampicin in foals. | 2011 | Drug Metab. Dispos. | pmid:21690264 |
| Suzuki Y et al. | Association of plasma concentration of 4β-hydroxycholesterol with CYP3A5 polymorphism and plasma concentration of indoxyl sulfate in stable kidney transplant recipients. | 2014 | Drug Metab. Dispos. | pmid:24135442 |
| Li K et al. | 4β-Hydroxycholesterol as an endogenous biomarker of CYP3A activity in cynomolgus monkeys. | 2014 | Drug Metab. Dispos. | pmid:24595680 |
| Björkhem-Bergman L et al. | Comparison of endogenous 4β-hydroxycholesterol with midazolam as markers for CYP3A4 induction by rifampicin. | 2013 | Drug Metab. Dispos. | pmid:23674608 |
| Ishida T et al. | Relationship between the plasma fentanyl and serum 4β-hydroxycholesterol based on CYP3A5 genotype and gender in patients with cancer pain. | 2016 | Drug Metab. Pharmacokinet. | pmid:27236640 |
| Naito T et al. | CYP3A activity based on plasma 4β-hydroxycholesterol during the early postpartum period has an effect on the plasma disposition of amlodipine. | 2015 | Drug Metab. Pharmacokinet. | pmid:26654672 |
4beta-Hydroxycholesterol
4beta-Hydroxycholesterol is a lipid of Sterol Lipids (ST) class. 4beta-hydroxycholesterol is associated with abnormalities such as Kidney Failure, Kidney Failure, Chronic, Respiratory Tract Infections, Immunologic Deficiency Syndromes and Infection. The involved functions are known as Selection, Genetic, Renal function, Anabolism, Inflammation and Cell division phases. 4beta-hydroxycholesterol often locates in Hepatic, Blood, Skin and Microsomes. The associated genes with 4beta-Hydroxycholesterol are CYP3A5 gene, Alleles, TERT gene, CYP3A4 gene and CYP3A7 gene. The related lipids are 4-hydroxycholesterol, Hydroxycholesterols, Promega, Pregnanes and 24-hydroxycholesterol.
Cross Reference
Introduction
To understand associated biological information of 4beta-Hydroxycholesterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with 4beta-Hydroxycholesterol?
4beta-Hydroxycholesterol is suspected in Kidney Failure, Chronic, Kidney Failure, Respiratory Tract Infections, Immunologic Deficiency Syndromes, Infection, Epilepsy and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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No disease MeSH terms mapped to the current reference collection.
PubChem Associated disorders and diseases
What pathways are associated with 4beta-Hydroxycholesterol
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with 4beta-Hydroxycholesterol?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with 4beta-Hydroxycholesterol?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with 4beta-Hydroxycholesterol?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with 4beta-Hydroxycholesterol?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with 4beta-Hydroxycholesterol?
There are no associated biomedical information in the current reference collection.