| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Mao J et al. | Perspective: 4β-hydroxycholesterol as an emerging endogenous biomarker of hepatic CYP3A. | 2017 | Drug Metab. Rev. | pmid:27718639 |
| Josephson F et al. | CYP3A induction and inhibition by different antiretroviral regimens reflected by changes in plasma 4beta-hydroxycholesterol levels. | 2008 | Eur. J. Clin. Pharmacol. | pmid:18458892 |
| Dutreix C et al. | Comparison of two endogenous biomarkers of CYP3A4 activity in a drug-drug interaction study between midostaurin and rifampicin. | 2014 | Eur. J. Clin. Pharmacol. | pmid:24839948 |
| Nylén H et al. | Cytochrome P450 3A activity in mothers and their neonates as determined by plasma 4β-hydroxycholesterol. | 2011 | Eur. J. Clin. Pharmacol. | pmid:21246351 |
| Hole K et al. | Impact of genetic and nongenetic factors on interindividual variability in 4β-hydroxycholesterol concentration. | 2017 | Eur. J. Clin. Pharmacol. | pmid:27975131 |
| Lütjohann D et al. | 4beta-hydroxycholesterol as a marker of CYP3A4 inhibition in vivo - effects of itraconazole in man. | 2009 | Int J Clin Pharmacol Ther | pmid:19954708 |
| Pataj Z et al. | Quantification of oxysterols in human plasma and red blood cells by liquid chromatography high-resolution tandem mass spectrometry. | 2016 | J Chromatogr A | pmid:26607314 |
| Yang Z and Rodrigues AD | Does the long plasma half-life of 4beta-hydroxycholesterol impact its utility as a cytochrome P450 3A (CYP3A) metric? | 2010 | J Clin Pharmacol | pmid:20197489 |
| Xu Y et al. | LC-ESI-MS/MS quantification of 4β-hydroxycholesterol and cholesterol in plasma samples of limited volume. | 2013 | J Pharm Biomed Anal | pmid:23948760 |
| van de Merbel NC et al. | A validated liquid chromatography-tandem mass spectrometry method for the quantitative determination of 4β-hydroxycholesterol in human plasma. | 2011 | J Pharm Biomed Anal | pmid:21507593 |
| Ngaimisi E et al. | Pharmacokinetic and pharmacogenomic modelling of the CYP3A activity marker 4β-hydroxycholesterol during efavirenz treatment and efavirenz/rifampicin co-treatment. | 2014 | J. Antimicrob. Chemother. | pmid:25096076 |
| Bodin K et al. | Antiepileptic drugs increase plasma levels of 4beta-hydroxycholesterol in humans: evidence for involvement of cytochrome p450 3A4. | 2001 | J. Biol. Chem. | pmid:11514559 |
| Bodin K et al. | Metabolism of 4 beta -hydroxycholesterol in humans. | 2002 | J. Biol. Chem. | pmid:12077124 |
| Hasan M et al. | Rapid LC-MS/MS method for the determination of 4-hydroxycholesterol/cholesterol ratio in serum as endogenous biomarker for CYP3A activity in human and foals. | 2016 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:27565568 |
| Suzuki Y et al. | Significant increase in plasma 4β-hydroxycholesterol concentration in patients after kidney transplantation. | 2013 | J. Lipid Res. | pmid:23833241 |
| Honda A et al. | Highly sensitive quantification of key regulatory oxysterols in biological samples by LC-ESI-MS/MS. | 2009 | J. Lipid Res. | pmid:18815436 |
| Breuer O | Identification and quantitation of cholest-5-ene-3 beta,4 beta-diol in rat liver and human plasma. | 1995 | J. Lipid Res. | pmid:8656065 |
| Mao J et al. | Strategy for CYP3A Induction Risk Assessment from Preclinical Signal to Human: a Case Example of a Late-Stage Discovery Compound. | 2017 | Pharm. Res. | pmid:28815392 |
| Diczfalusy U et al. | 4Beta-hydroxycholesterol is a new endogenous CYP3A marker: relationship to CYP3A5 genotype, quinine 3-hydroxylation and sex in Koreans, Swedes and Tanzanians. | 2008 | Pharmacogenet. Genomics | pmid:18300941 |
| Niemi M et al. | Effect of SLCO1B1 polymorphism on induction of CYP3A4 by rifampicin. | 2006 | Pharmacogenet. Genomics | pmid:16847425 |
4beta-Hydroxycholesterol
4beta-Hydroxycholesterol is a lipid of Sterol Lipids (ST) class. 4beta-hydroxycholesterol is associated with abnormalities such as Kidney Failure, Kidney Failure, Chronic, Respiratory Tract Infections, Immunologic Deficiency Syndromes and Infection. The involved functions are known as Selection, Genetic, Renal function, Anabolism, Inflammation and Cell division phases. 4beta-hydroxycholesterol often locates in Hepatic, Blood, Skin and Microsomes. The associated genes with 4beta-Hydroxycholesterol are CYP3A5 gene, Alleles, TERT gene, CYP3A4 gene and CYP3A7 gene. The related lipids are 4-hydroxycholesterol, Hydroxycholesterols, Promega, Pregnanes and 24-hydroxycholesterol.
Cross Reference
Introduction
To understand associated biological information of 4beta-Hydroxycholesterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with 4beta-Hydroxycholesterol?
4beta-Hydroxycholesterol is suspected in Kidney Failure, Chronic, Kidney Failure, Respiratory Tract Infections, Immunologic Deficiency Syndromes, Infection, Epilepsy and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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No disease MeSH terms mapped to the current reference collection.
PubChem Associated disorders and diseases
What pathways are associated with 4beta-Hydroxycholesterol
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with 4beta-Hydroxycholesterol?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with 4beta-Hydroxycholesterol?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with 4beta-Hydroxycholesterol?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with 4beta-Hydroxycholesterol?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with 4beta-Hydroxycholesterol?
There are no associated biomedical information in the current reference collection.