Bakken GA and Jurs PC |
QSARs for 6-azasteroids as inhibitors of human type 1 5alpha-reductase: prediction of binding affinity and selectivity relative to 3-BHSD. |
|
J Chem Inf Comput Sci |
pmid:11604025
|
|
|
|
|
pmid:
|
Jang S et al. |
Establishment of type II 5alpha-reductase over-expressing cell line as an inhibitor screening model. |
|
J. Steroid Biochem. Mol. Biol. |
pmid:17646096
|
Bonafè M et al. |
What studies on human longevity tell us about the risk for cancer in the oldest old: data and hypotheses on the genetics and immunology of centenarians. |
|
Exp. Gerontol. |
pmid:12470840
|
Gironés X and Carbó-Dorca R |
Molecular quantum similarity-based QSARs for binding affinities of several steroid sets. |
|
J Chem Inf Comput Sci |
pmid:12377008
|
BUCHER NL et al. |
Cholesterol biosynthesis in preparations of liver from normal, fasting, x-irradiated, cholesterol-fed, triton, or delta 4-cholesten-3-one-treated rats. |
1959 |
J. Biol. Chem. |
pmid:13630891
|
PUDLES J and BLOCH K |
Conversion of 4-hydroxymethylene-Delta 7 cholesten-3-one to cholesterol. |
1960 |
J. Biol. Chem. |
pmid:13738392
|
Schuster RE and Bennett RD |
A direct low temperature 1H and 19F nuclear magnetic resonance study of boron trifluoride complexes with 4-cholesten-3-one, 1(5beta)-androstene-3,17-dione, 5beta-androstane-3,17-dione, and obacunone. |
1973 |
J. Org. Chem. |
pmid:4733449
|
Smith AG and Brooks CJ |
The mechanism of the isomerization of Cholest-5-en-3-one to cholest-4-en-3-one by cholesterol oxidase [proceedings]. |
1977 |
Biochem. Soc. Trans. |
pmid:913789
|
Gallo LL et al. |
Enzymatic assay for cholesterol ester hydrolase activity. |
1978 |
J. Lipid Res. |
pmid:712250
|
Aringer L |
7-Hydroxylation of 3-oxygenated C27-, C28-, and C29-steroids in rat liver 18,000 g supernate. |
1978 |
J. Lipid Res. |
pmid:731128
|
Nakagawa Y et al. |
Transfer of steroids and alpha-tocopherol between liposomal membranes. |
1980 |
J. Biochem. |
pmid:6892636
|
Trinder P |
Oxidase determination of plasma cholesterol as cholest-4-en-3-one using iso-octane extraction. |
1981 |
Ann. Clin. Biochem. |
pmid:6942786
|
Skrede S and Björkhem I |
Biosynthesis of cholestanol from intestinal 7 alpha-hydroxy-4-cholesten-3-one. |
1982 |
J. Biol. Chem. |
pmid:7045120
|
MotlÃk K and Stárka L |
4-Cholesten-3-one-induced lipoid hyperplasia of the adrenal cortex in rats. |
1983 |
Acta Univ Carol Med (Praha) |
pmid:6637679
|
Stokes NA and Hylemon PB |
Characterization of delta 4-3-ketosteroid-5 beta-reductase and 3 beta-hydroxysteroid dehydrogenase in cell extracts of Clostridium innocuum. |
1985 |
Biochim. Biophys. Acta |
pmid:3861198
|
Murphy PR et al. |
Binding of oxygenated cholesterol metabolites to antiestrogen binding sites from chicken liver. |
1985 |
Biochem. Biophys. Res. Commun. |
pmid:3985957
|
Suzuki K et al. |
Characterization of cytotoxic steroids in human faeces and their putative role in the etiology of human colonic cancer. |
1986 |
Cancer Lett. |
pmid:3802059
|
Kaul HK et al. |
Genotoxicity of two fecal steroids in murine colonic epithelium assessed by the sister chromatid exchange technique. |
1987 |
Mutagenesis |
pmid:3328036
|
Yoshimoto T et al. |
Polyethylene glycol derivative-modified cholesterol oxidase soluble and active in benzene. |
1987 |
Biochem. Biophys. Res. Commun. |
pmid:3479986
|
Buchmann MS et al. |
Metabolism of the cholestanol precursor cholesta-4,6-dien-3-one in different tissues. |
1987 |
Biochim. Biophys. Acta |
pmid:3676336
|
Batta AK et al. |
Chromatographic separation of putative precursors of cholestanol. |
1988 Jul-Aug |
Steroids |
pmid:3247666
|
Sugano S et al. |
Sensitive assay of cytochrome P450scc activity by high-performance liquid chromatography. |
1989 |
Anal. Biochem. |
pmid:2610350
|
Wijnberg JB and de Groot A |
Synthesis and 13C-NMR analysis of 5 alpha- and 5 beta-cholestane-3,6-dione. |
1989 |
Steroids |
pmid:2588307
|
Liu KZ et al. |
Oxidative status of lipoproteins in coronary disease patients. |
1992 |
Am. Heart J. |
pmid:1736561
|
Contreras JA et al. |
Combination of an enzymatic method and HPLC for the quantitation of cholesterol in cultured cells. |
1992 |
J. Lipid Res. |
pmid:1512516
|
Suzuki K |
Anti-obesity effect of cholest-4-en-3-one, an intestinal catabolite of cholesterol, on mice. |
1993 |
J. Nutr. Sci. Vitaminol. |
pmid:8120678
|
Plemenitas A et al. |
Identification of progesterone binding sites in the plasma membrane of the filamentous fungus Cochliobolus lunatus. |
1993 |
J. Steroid Biochem. Mol. Biol. |
pmid:8499335
|
Molnár I et al. |
Bacterial cholesterol oxidases are able to act as flavoprotein-linked ketosteroid monooxygenases that catalyse the hydroxylation of cholesterol to 4-cholesten-6-ol-3-one. |
1993 |
Mol. Microbiol. |
pmid:8459768
|
Slotte JP and Ostman AL |
Oxidation/isomerization of 5-cholesten-3 beta-ol and 5-cholesten-3-one to 4-cholesten-3-one in pure sterol and mixed phospholipid-containing monolayers by cholesterol oxidase. |
1993 |
Biochim. Biophys. Acta |
pmid:8431456
|
Slotte JP |
Direct observation of the action of cholesterol oxidase in monolayers. |
1995 |
Biochim. Biophys. Acta |
pmid:7488639
|
Bartram HP et al. |
Effects of fish oil on fecal bacterial enzymes and steroid excretion in healthy volunteers: implications for colon cancer prevention. |
1996 |
Nutr Cancer |
pmid:8837863
|
Lin HS et al. |
Synthesis of 4 alpha-(2-propenyl)-5,6-secocholestan-3 alpha-ol, a novel B-ring seco analog of the hypocholesterolemic agent 4 alpha-(2-propenyl)-5 alpha-cholestan-3 alpha-ol. |
1998 |
Steroids |
pmid:9589554
|
Suzuki K et al. |
The cholesterol metabolite cholest-4-en-3-one and its 3-oxo derivatives suppress body weight gain, body fat accumulation and serum lipid concentration in mice. |
1998 |
Bioorg. Med. Chem. Lett. |
pmid:9873500
|
Weststrate JA et al. |
Safety evaluation of phytosterol esters. Part 4. Faecal concentrations of bile acids and neutral sterols in healthy normolipidaemic volunteers consuming a controlled diet either with or without a phytosterol ester-enriched margarine. |
1999 |
Food Chem. Toxicol. |
pmid:10566877
|
Pang L et al. |
Membrane cholesterol modulates galanin-GalR2 interaction. |
1999 |
Biochemistry |
pmid:10508403
|
Liu P et al. |
Presence of oxidized cholesterol in caveolae uncouples active platelet-derived growth factor receptors from tyrosine kinase substrates. |
2000 |
J. Biol. Chem. |
pmid:10918056
|
Sampson NS |
Dissection of a flavoenzyme active site: the reaction catalyzed by cholesterol oxidase. |
2001 |
Antioxid. Redox Signal. |
pmid:11761331
|
Yin Y et al. |
The presence of a hydrogen bond between asparagine 485 and the pi system of FAD modulates the redox potential in the reaction catalyzed by cholesterol oxidase. |
2001 |
Biochemistry |
pmid:11705367
|
Niven SJ et al. |
Investigations of cholesterol transformation during sewage treatment: relevance to estrogen formation pathways? |
2001 |
Sci. Total Environ. |
pmid:11712607
|
Shibata A et al. |
Genetic polymorphisms in the androgen receptor and type II 5 alpha-reductase genes in prostate enlargement. |
2001 |
J. Urol. |
pmid:11547131
|
Samy TS et al. |
Divergent immune responses in male and female mice after trauma-hemorrhage: dimorphic alterations in T lymphocyte steroidogenic enzyme activities. |
2001 |
Endocrinology |
pmid:11459798
|
Asada Y et al. |
5 alpha-reductase type 2 is constitutively expressed in the dermal papilla and connective tissue sheath of the hair follicle in vivo but not during culture in vitro. |
2001 |
J. Clin. Endocrinol. Metab. |
pmid:11397903
|
Stuart EB et al. |
Steroid hormone influence on brain calbindin-D(28K) in male prepubertal and ovariectomized rats. |
2001 |
Brain Res. Dev. Brain Res. |
pmid:11506857
|
Charbonneau A and The VL |
Genomic organization of a human 5beta-reductase and its pseudogene and substrate selectivity of the expressed enzyme. |
2001 |
Biochim. Biophys. Acta |
pmid:11342103
|
DellaGreca M et al. |
Solid-state photodimerization of cholest-4-en-3-one. |
2001 |
J. Org. Chem. |
pmid:11300900
|
Platz EA |
Basic Science. |
2001 |
Urology |
pmid:11273573
|
Nam RK et al. |
V89L polymorphism of type-2, 5-alpha reductase enzyme gene predicts prostate cancer presence and progression. |
2001 |
Urology |
pmid:11164181
|
Wu AH et al. |
Lifestyle determinants of 5alpha-reductase metabolites in older African-American, white, and Asian-American men. |
2001 |
Cancer Epidemiol. Biomarkers Prev. |
pmid:11352865
|
Weber KS et al. |
Dietary soy-phytoestrogens decrease testosterone levels and prostate weight without altering LH, prostate 5alpha-reductase or testicular steroidogenic acute regulatory peptide levels in adult male Sprague-Dawley rats. |
2001 |
J. Endocrinol. |
pmid:11524239
|
Melcangi RC and Panzica G |
Steroids in the nervous system: a Pandora's box? |
2001 |
Trends Neurosci. |
pmid:11421230
|
Griffin LD and Mellon SH |
Biosynthesis of the neurosteroid 3 alpha-hydroxy-4-pregnen-20-one (3 alpha hp), a specific inhibitor of FSH release. |
2001 |
Endocrinology |
pmid:11606426
|
Hsing AW et al. |
Polymorphic markers in the SRD5A2 gene and prostate cancer risk: a population-based case-control study. |
2001 |
Cancer Epidemiol. Biomarkers Prev. |
pmid:11588134
|
Riters LV et al. |
Seasonal variation in androgen-metabolizing enzymes in the diencephalon and telencephalon of the male European starling (Sturnus vulgaris). |
2001 |
J. Neuroendocrinol. |
pmid:11737557
|
Haigh WG and Lee SP |
Identification of oxysterols in human bile and pigment gallstones. |
2001 |
Gastroenterology |
pmid:11438500
|
Fritsch M et al. |
Sebocytes are the key regulators of androgen homeostasis in human skin. |
2001 |
J. Invest. Dermatol. |
pmid:11348472
|
Chaler R et al. |
Bile acids and sterols in urban sewage treatment plants. |
2001 |
J Chromatogr A |
pmid:11572384
|
Reichert W et al. |
Stable expression of human 5alpha-reductase type II in COS1 cells due to chromosomal gene integration: a novel tool for inhibitor identification. |
2001 |
J. Steroid Biochem. Mol. Biol. |
pmid:11595508
|
Coulombe R et al. |
Oxygen access to the active site of cholesterol oxidase through a narrow channel is gated by an Arg-Glu pair. |
2001 |
J. Biol. Chem. |
pmid:11397813
|
Walker BR |
Activation of the hypothalamic-pituitary-adrenal axis in obesity: cause or consequence? |
2001 |
Growth Horm. IGF Res. |
pmid:11527096
|
Shaw JC |
Hormonal therapies in acne. |
2002 |
Expert Opin Pharmacother |
pmid:12083987
|
Yin Y et al. |
Construction of a catalytically inactive cholesterol oxidase mutant: investigation of the interplay between active site-residues glutamate 361 and histidine 447. |
2002 |
Arch. Biochem. Biophys. |
pmid:12051668
|
Huynh H |
Induction of apoptosis in rat ventral prostate by finasteride is associated with alteration in MAP kinase pathways and Bcl-2 related family of proteins. |
2002 |
Int. J. Oncol. |
pmid:12012013
|
Itoh K et al. |
Mutation screening for the 5alpha-reductase type 2 gene in Japanese men with idiopathic azoospermia. |
2002 |
Fertil. Steril. |
pmid:12009375
|
Brady BM and Anderson RA |
Advances in male contraception. |
2002 |
Expert Opin Investig Drugs |
pmid:11866663
|
Malik V and Pundir CS |
Determination of total cholesterol in serum by cholesterol esterase and cholesterol oxidase immobilized and co-immobilized on to arylamine glass. |
2002 |
Biotechnol. Appl. Biochem. |
pmid:12074697
|
Wolfreys AM and Hepburn PA |
Safety evaluation of phytosterol esters. Part 7. Assessment of mutagenic activity of phytosterols, phytosterol esters and the cholesterol derivative, 4-cholesten-3-one. |
2002 |
Food Chem. Toxicol. |
pmid:11893405
|
Hiort O et al. |
A novel homozygous disruptive mutation in the SRD5A2-gene in a partially virilized patient with 5alpha-reductase deficiency. |
2002 |
Int. J. Androl. |
pmid:11869378
|
Silfen ME et al. |
5 alpha-reductase and 11 beta-hydroxysteroid dehydrogenase activity in prepubertal Hispanic girls with premature adrenarche. |
2002 |
J. Clin. Endocrinol. Metab. |
pmid:12364451
|
Nguyen DH and Taub D |
Cholesterol is essential for macrophage inflammatory protein 1 beta binding and conformational integrity of CC chemokine receptor 5. |
2002 |
Blood |
pmid:12036855
|
Azzouzi AR et al. |
Impact of constitutional genetic variation in androgen/oestrogen-regulating genes on age-related changes in human prostate. |
2002 |
Eur. J. Endocrinol. |
pmid:12370109
|
Yang C et al. |
A49T, V89L and TA repeat polymorphisms of steroid 5alpha-reductase type II and breast cancer risk in Japanese women. |
2002 |
Breast Cancer Res. |
pmid:12100746
|
Sojo MM et al. |
Rhodococcus erythropolis ATCC 25544 as a suitable source of cholesterol oxidase: cell-linked and extracellular enzyme synthesis, purification and concentration. |
2002 |
BMC Biotechnol. |
pmid:11914155
|
Ribeiro ML et al. |
Allelic frequencies of six polymorphic markers for risk of prostate cancer. |
2002 |
Braz. J. Med. Biol. Res. |
pmid:11847524
|
Schatzl G et al. |
Association of polymorphisms within androgen receptor, 5alpha-reductase, and PSA genes with prostate volume, clinical parameters, and endocrine status in elderly men. |
2002 |
Prostate |
pmid:12111704
|
Raynaud JP et al. |
Inhibition of type 1 and type 2 5alpha-reductase activity by free fatty acids, active ingredients of Permixon. |
2002 |
J. Steroid Biochem. Mol. Biol. |
pmid:12477490
|
Carmina E |
Anti-androgens for the treatment of hirsutism. |
2002 |
Expert Opin Investig Drugs |
pmid:11866665
|
Maeda Y et al. |
A simple, accurate, and sensitive assay method of dehydroepiandrosterone sulfate: application for quantitative determination in human breast cyst and duct fluids. |
2002 |
Steroids |
pmid:11958788
|
Campbell SM et al. |
Virion-associated cholesterol is critical for the maintenance of HIV-1 structure and infectivity. |
2002 |
AIDS |
pmid:12441796
|
Prager N et al. |
A randomized, double-blind, placebo-controlled trial to determine the effectiveness of botanically derived inhibitors of 5-alpha-reductase in the treatment of androgenetic alopecia. |
2002 |
J Altern Complement Med |
pmid:12006122
|
Pham H and Ziboh VA |
5 alpha-reductase-catalyzed conversion of testosterone to dihydrotestosterone is increased in prostatic adenocarcinoma cells: suppression by 15-lipoxygenase metabolites of gamma-linolenic and eicosapentaenoic acids. |
2002 |
J. Steroid Biochem. Mol. Biol. |
pmid:12589947
|
Zeigler-Johnson CM et al. |
Ethnic differences in the frequency of prostate cancer susceptibility alleles at SRD5A2 and CYP3A4. |
2002 |
Hum. Hered. |
pmid:12446983
|
Shibata A et al. |
Polymorphisms in the androgen receptor and type II 5 alpha-reductase genes and prostate cancer prognosis. |
2002 |
Prostate |
pmid:12210487
|
Suzuki Y et al. |
5Alpha-reductase type 2 genes in Japanese males do not appear to be associated with cryptorchidism. |
2002 |
Fertil. Steril. |
pmid:12137870
|
Lemonde HA et al. |
Mutations in SRD5B1 (AKR1D1), the gene encoding delta(4)-3-oxosteroid 5beta-reductase, in hepatitis and liver failure in infancy. |
2003 |
Gut |
pmid:12970144
|
Nguyen DH and Taub DD |
Inhibition of chemokine receptor function by membrane cholesterol oxidation. |
2003 |
Exp. Cell Res. |
pmid:14597406
|
Norlin M et al. |
On the substrate specificity of human CYP27A1: implications for bile acid and cholestanol formation. |
2003 |
J. Lipid Res. |
pmid:12777473
|
Martin RM et al. |
Familial hyperestrogenism in both sexes: clinical, hormonal, and molecular studies of two siblings. |
2003 |
J. Clin. Endocrinol. Metab. |
pmid:12843139
|
Johnson DC and Widlanski TS |
Cerium(III) chloride-mediated reactions of sulfonamide dianions. |
2003 |
J. Org. Chem. |
pmid:12816492
|
Shapiro J and Kaufman KD |
Use of finasteride in the treatment of men with androgenetic alopecia (male pattern hair loss). |
2003 |
J. Investig. Dermatol. Symp. Proc. |
pmid:12894990
|
Soma KK et al. |
Brain aromatase, 5 alpha-reductase, and 5 beta-reductase change seasonally in wild male song sparrows: relationship to aggressive and sexual behavior. |
2003 |
J. Neurobiol. |
pmid:12884261
|
Ntais C et al. |
SRD5A2 gene polymorphisms and the risk of prostate cancer: a meta-analysis. |
2003 |
Cancer Epidemiol. Biomarkers Prev. |
pmid:12869400
|
Gupta Y et al. |
Kinetic analysis of LDL oxidation in IHD and IHD risk subjects in Indian population. |
2003 |
Indian J Clin Biochem |
pmid:23105369
|
Torres JM et al. |
Semiquantitative RT-PCR method coupled to capillary electrophoresis to study 5alpha-reductase mRNA isozymes in rat ventral prostate in different androgen status. |
2003 |
Mol. Cell. Biochem. |
pmid:12962150
|
Fassnacht M et al. |
Beyond adrenal and ovarian androgen generation: Increased peripheral 5 alpha-reductase activity in women with polycystic ovary syndrome. |
2003 |
J. Clin. Endocrinol. Metab. |
pmid:12788885
|
Yoshida T et al. |
Origin of oxysterols in hepatic bile of patients with biliary infection. |
2003 |
Am. J. Gastroenterol. |
pmid:14572579
|
Wang GM et al. |
Effects of insulin-like growth factor I on steroidogenic enzyme expression levels in mouse leydig cells. |
2003 |
Endocrinology |
pmid:12959969
|
Wiebe JP and Lewis MJ |
Activity and expression of progesterone metabolizing 5alpha-reductase, 20alpha-hydroxysteroid oxidoreductase and 3alpha(beta)-hydroxysteroid oxidoreductases in tumorigenic (MCF-7, MDA-MB-231, T-47D) and nontumorigenic (MCF-10A) human breast cancer cells. |
2003 |
BMC Cancer |
pmid:12659654
|
Sasaki G et al. |
Micropenis and the 5alpha-reductase-2 (SRD5A2) gene: mutation and V89L polymorphism analysis in 81 Japanese patients. |
2003 |
J. Clin. Endocrinol. Metab. |
pmid:12843198
|
Faragalla J et al. |
Comparative pharmacophore development for inhibitors of human and rat 5-alpha-reductase. |
2003 |
J. Mol. Graph. Model. |
pmid:12798393
|