| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Zhu HJ and Sacchetti M | Solubilization and solid-state characterization of a poorly soluble 5-alpha reductase inhibitor. | 2004 | Drug Dev Ind Pharm | pmid:15285330 |
| Chapple CR | Pharmacological therapy of benign prostatic hyperplasia/lower urinary tract symptoms: an overview for the practising clinician. | 2004 | BJU Int. | pmid:15329091 |
| Nguyen PN et al. | Increased allopregnanolone levels in the fetal sheep brain following umbilical cord occlusion. | 2004 | J. Physiol. (Lond.) | pmid:15331682 |
| Namazi MR | Further insight into the pathomechanism of acne by considering the 5-alpha-reductase inhibitory effect of linoleic acid. | 2004 | Int. J. Dermatol. | pmid:15357760 |
| Assinder SJ et al. | Regulation of 5alpha-reductase isoforms by oxytocin in the rat ventral prostate. | 2004 | Endocrinology | pmid:15358676 |
| Borst SE et al. | Inhibition of 5alpha-reductase blocks prostate effects of testosterone without blocking anabolic effects. | 2005 | Am. J. Physiol. Endocrinol. Metab. | pmid:15367394 |
| Aissaoui A et al. | Novel cationic lipids incorporating an acid-sensitive acylhydrazone linker: synthesis and transfection properties. | 2004 | J. Med. Chem. | pmid:15456264 |
| Schmidt LJ et al. | Gene expression in prostate cancer cells treated with the dual 5 alpha-reductase inhibitor dutasteride. | 2004 Nov-Dec | J. Androl. | pmid:15477368 |
| Matthiesson KL et al. | Novel male hormonal contraceptive combinations: the hormonal and spermatogenic effects of testosterone and levonorgestrel combined with a 5alpha-reductase inhibitor or gonadotropin-releasing hormone antagonist. | 2005 | J. Clin. Endocrinol. Metab. | pmid:15509637 |
| Al-Mutair A et al. | Cytogenetics and etiology of ambiguous genitalia in 120 pediatric patients. | 2004 Sep-Oct | Ann Saudi Med | pmid:15573851 |
| Palusinski R and Barud W | Proscar and propecia--a therapeutic perspective. | 2004 | J. Clin. Endocrinol. Metab. | pmid:15579805 |
| Mathur S et al. | Evaluation of cell permeation of a potent 5alpha-reductase inhibitor using MALDI-TOF MS. | 2004 | J Enzyme Inhib Med Chem | pmid:15648657 |
| Festuccia C et al. | Effects of 5 alpha reductase inhibitors on androgen-dependent human prostatic carcinoma cells. | 2005 | J. Cancer Res. Clin. Oncol. | pmid:15650886 |
| Bairamov AA and Sapronov NS | Effect of dehydroepiandrosterone on radioligand binding of [3H]-testosterone by androgen receptors in rat hypothalamus. | 2004 | Bull. Exp. Biol. Med. | pmid:15665952 |
| McVey MJ et al. | Altered testicular microsomal steroidogenic enzyme activities in rats with lifetime exposure to soy isoflavones. | 2004 | J. Steroid Biochem. Mol. Biol. | pmid:15698548 |
| Pérez-Ornelas V et al. | New 5alpha-reductase inhibitors: in vitro and in vivo effects. | 2005 | Steroids | pmid:15763601 |
| Souverein PC et al. | Treatment of benign prostatic hyperplasia and occurrence of prostatic surgery and acute urinary retention: a population-based cohort study in the Netherlands. | 2005 | Eur. Urol. | pmid:15774250 |
| Panter BU et al. | 5alpha-reductase in human embryonic kidney cell line HEK293: evidence for type II enzyme expression and activity. | 2005 | Mol. Cell. Biochem. | pmid:15792368 |
| Evans CP et al. | An evidence-based approach to understanding the pharmacological class effect in the management of prostatic diseases. | 2005 | BJU Int. | pmid:15794775 |
| Iranmanesh A and Veldhuis JD | Combined inhibition of types I and II 5 alpha-reductase selectively augments the basal (nonpulsatile) mode of testosterone secretion in young men. | 2005 | J. Clin. Endocrinol. Metab. | pmid:15811930 |
| Caldinelli L et al. | Dissecting the structural determinants of the stability of cholesterol oxidase containing covalently bound flavin. | 2005 | J. Biol. Chem. | pmid:15817448 |
| Pucadyil TJ et al. | Membrane cholesterol oxidation inhibits ligand binding function of hippocampal serotonin(1A) receptors. | 2005 | Biochem. Biophys. Res. Commun. | pmid:15850776 |
| Bratoeff E et al. | Recent advances in the chemistry and pharmacological activity of new steroidal antiandrogens and 5 alpha-reductase inhibitors. | 2005 | Curr. Med. Chem. | pmid:15853706 |
| Monte MJ et al. | Changes in the expression of genes related to bile acid synthesis and transport by the rat liver during hepatocarcinogenesis. | 2005 | Clin. Sci. | pmid:15853769 |
| Guzmán DC et al. | Effect of testosterone and steroids homologues on indolamines and lipid peroxidation in rat brain. | 2005 | J. Steroid Biochem. Mol. Biol. | pmid:15857756 |
| Wiebe JP et al. | The role of progesterone metabolites in breast cancer: potential for new diagnostics and therapeutics. | 2005 | J. Steroid Biochem. Mol. Biol. | pmid:15860263 |
| Luu-The V et al. | Quantitative appreciation of steroidogenic gene expression in mouse tissues: new roles for type 2 5alpha-reductase, 20alpha-hydroxysteroid dehydrogenase and estrogen sulfotransferase. | 2005 | J. Steroid Biochem. Mol. Biol. | pmid:15860270 |
| Rho SS et al. | The hair growth promoting effect of Asiasari radix extract and its molecular regulation. | 2005 | J. Dermatol. Sci. | pmid:15862941 |
| Papanikolaou A et al. | Cholesterol-dependent lipid assemblies regulate the activity of the ecto-nucleotidase CD39. | 2005 | J. Biol. Chem. | pmid:15890655 |
| Vallarino M et al. | Ontogeny of 3 beta-hydroxysteroid dehydrogenase and 5 alpha-reductase in the frog brain. | 2005 | Ann. N. Y. Acad. Sci. | pmid:15891098 |
| Monte MJ et al. | Transient changes in the expression pattern of key enzymes for bile acid synthesis during rat liver regeneration. | 2005 | Biochim. Biophys. Acta | pmid:15904869 |
| Rouquette-Jazdanian AK et al. | Revaluation of the role of cholesterol in stabilizing rafts implicated in T cell receptor signaling. | 2006 | Cell. Signal. | pmid:15925486 |
| Beattie ME et al. | Sterol structure determines miscibility versus melting transitions in lipid vesicles. | 2005 | Biophys. J. | pmid:15951379 |
| Gorin RE et al. | Effects of finasteride on chronic and acute ethanol withdrawal severity in the WSP and WSR selected lines. | 2005 | Alcohol. Clin. Exp. Res. | pmid:15976519 |
| Rosati F et al. | 5alpha-Reductase activity in Lycopersicon esculentum: cloning and functional characterization of LeDET2 and evidence of the presence of two isoenzymes. | 2005 | J. Steroid Biochem. Mol. Biol. | pmid:15993049 |
| Fujita R et al. | Anti-androgenic activities of Ganoderma lucidum. | 2005 | J Ethnopharmacol | pmid:16029938 |
| Hammer F et al. | Sex steroid metabolism in human peripheral blood mononuclear cells changes with aging. | 2005 | J. Clin. Endocrinol. Metab. | pmid:16091484 |
| Puglielli L et al. | Alzheimer disease beta-amyloid activity mimics cholesterol oxidase. | 2005 | J. Clin. Invest. | pmid:16127459 |
| Lewis JG et al. | Circulating levels of isoflavones and markers of 5alpha-reductase activity are higher in Japanese compared with New Zealand males: what is the role of circulating steroids in prostate disease? | 2005 | Steroids | pmid:16137729 |
| Ellis JA et al. | Androgenic correlates of genetic variation in the gene encoding 5alpha-reductase type 1. | 2005 | J. Hum. Genet. | pmid:16155734 |
| Livingstone DE et al. | Increased A-ring reduction of glucocorticoids in obese Zucker rats: effects of insulin sensitization. | 2005 | Obes. Res. | pmid:16222053 |
| Tiwari A et al. | Benign prostatic hyperplasia: an insight into current investigational medical therapies. | 2005 | Expert Opin Investig Drugs | pmid:16255676 |
| Kiyokage E et al. | Localization of 5alpha-reductase in the rat main olfactory bulb. | 2005 | J. Comp. Neurol. | pmid:16261538 |
| Ordyan NE and Pivina SG | Effects of prenatal stress on the activity of an enzyme involved in neurosteroid synthesis during the "critical period" of sexual differentiation of the brain in male rats. | 2005 | Neurosci. Behav. Physiol. | pmid:16270175 |
| Haeffner F et al. | Model studies of cholesterol and ascorbate oxidation by copper complexes: relevance to Alzheimer's disease beta-amyloid metallochemistry. | 2005 | J. Inorg. Biochem. | pmid:16271394 |
| Paris F et al. | Increased serum estrogenic bioactivity in three male newborns with ambiguous genitalia: a potential consequence of prenatal exposure to environmental endocrine disruptors. | 2006 | Environ. Res. | pmid:16274687 |
| Andriole G et al. | The effects of 5alpha-reductase inhibitors on the natural history, detection and grading of prostate cancer: current state of knowledge. | 2005 | J. Urol. | pmid:16280736 |
| Barocas DA et al. | Five-alpha-reductase expression in benign and malignant urothelium: correlation with disease characteristics and outcome. | 2005 | Urology | pmid:16286153 |
| Sandhu JS and Vaughan ED | Combination therapy for the pharmacological management of benign prostatic hyperplasia: rationale and treatment options. | 2005 | Drugs Aging | pmid:16323969 |
| Luchetti S et al. | Comparative non-radioactive RT-PCR assay: an approach to study the neurosteroids biosynthetic pathway in humans. | 2006 | J. Neurosci. Methods | pmid:16378642 |
| Wakisaka N et al. | Effectiveness of finasteride on patients with male pattern baldness who have different androgen receptor gene polymorphism. | 2005 | J. Investig. Dermatol. Symp. Proc. | pmid:16382684 |
| Woollett LA et al. | Micellar solubilisation of cholesterol is essential for absorption in humans. | 2006 | Gut | pmid:16407385 |
| Fox SA et al. | Identifying putative contraceptive targets by dissecting signal transduction networks in the epididymis using an in vivo electroporation (electrotransfer) approach. | 2006 | Mol. Cell. Endocrinol. | pmid:16423449 |
| Gilliver SC et al. | Androgens modulate the inflammatory response during acute wound healing. | 2006 | J. Cell. Sci. | pmid:16449322 |
| Stottrup BL and Keller SL | Phase behavior of lipid monolayers containing DPPC and cholesterol analogs. | 2006 | Biophys. J. | pmid:16461392 |
| Liu J et al. | 5alpha-reductase inhibitory effect of triterpenoids isolated from Ganoderma lucidum. | 2006 | Biol. Pharm. Bull. | pmid:16462054 |
| Robaire B and Henderson NA | Actions of 5alpha-reductase inhibitors on the epididymis. | 2006 | Mol. Cell. Endocrinol. | pmid:16476520 |
| Marszalek M and Madersbacher S | [Epidemiology of BPH and medication approaches]. | 2006 | Ther Umsch | pmid:16514964 |
| Tarter TH and Vaughan ED | Inhibitors of 5alpha-reductase in the treatment of benign prostatic hyperplasia. | 2006 | Curr. Pharm. Des. | pmid:16515494 |
| Motola DL et al. | Identification of ligands for DAF-12 that govern dauer formation and reproduction in C. elegans. | 2006 | Cell | pmid:16529801 |
| Dolder CR | Dutasteride: a dual 5-alpha reductase inhibitor for the treatment of symptomatic benign prostatic hyperplasia. | 2006 | Ann Pharmacother | pmid:16569804 |
| Andriole GL et al. | Clinical usefulness of serum prostate specific antigen for the detection of prostate cancer is preserved in men receiving the dual 5alpha-reductase inhibitor dutasteride. | 2006 | J. Urol. | pmid:16600723 |
| Patel S and Mishra BK | Oxidation of cholesterol by a biomimetic oxidant, cetyltrimethylammonium dichromate. | 2006 | J. Org. Chem. | pmid:16626135 |
| Maria McCrohan A et al. | Effects of the dual 5 alpha-reductase inhibitor dutasteride on apoptosis in primary cultures of prostate cancer epithelial cells and cell lines. | 2006 | Cancer | pmid:16703599 |
| Zhu YS and Cai LQ | Effects of male sex hormones on gender identity, sexual behavior, and cognitive function. | 2006 | Zhong Nan Da Xue Xue Bao Yi Xue Ban | pmid:16706106 |
| Frye SV | Discovery and clinical development of dutasteride, a potent dual 5alpha-reductase inhibitor. | 2006 | Curr Top Med Chem | pmid:16719800 |
| Sobel V et al. | Bone mineral density in the complete androgen insensitivity and 5alpha-reductase-2 deficiency syndromes. | 2006 | J. Clin. Endocrinol. Metab. | pmid:16735493 |
| Pitts WR | Re: The effects of 5alpha-reductase inhibitors on the natural history, detection and grading of prostate cancer: current state of knowledge. | 2006 | J. Urol. | pmid:16753453 |
| Sánchez P et al. | Effects of testosterone on brain mRNA levels of steroid 5alpha-reductase isozymes in early postnatal life of rat. | 2006 | Neurochem. Int. | pmid:16828201 |
| Olanrewaju HA et al. | Stress and acid-base balance in chickens. | 2006 | Poult. Sci. | pmid:16830868 |
| Finn DA et al. | A new look at the 5alpha-reductase inhibitor finasteride. | 2006 | CNS Drug Rev | pmid:16834758 |
| Lim L et al. | Structural and kinetic analyses of the H121A mutant of cholesterol oxidase. | 2006 | Biochem. J. | pmid:16856877 |
| Rebolj K et al. | Steroid structural requirements for interaction of ostreolysin, a lipid-raft binding cytolysin, with lipid monolayers and bilayers. | 2006 | Biochim. Biophys. Acta | pmid:16857161 |
| Randall VA et al. | New dimensions in Hirsutism. | 2006 | Lasers Med Sci | pmid:16874541 |
| Marks LS et al. | The interpretation of serum prostate specific antigen in men receiving 5alpha-reductase inhibitors: a review and clinical recommendations. | 2006 | J. Urol. | pmid:16890642 |
| Ekinci S et al. | Sigmoid colon vaginoplasty in children. | 2006 | Eur J Pediatr Surg | pmid:16909357 |
| Norg RJ et al. | A decision aid for GPs for the treatment of elderly male patients with lower urinary tract symptoms (LUTS). | 2006 | Fam Pract | pmid:16971394 |
| Hall MC | The effect of oxysterols, individually and as a representative mixture from food, on in vitro cultured bovine ovarian granulosa cells. | 2006 | Mol. Cell. Biochem. | pmid:16983501 |
| Rojo L et al. | Roles of cholesterol and lipids in the etiopathogenesis of Alzheimer's disease. | 2006 | J. Biomed. Biotechnol. | pmid:17047312 |
| Cabeza M et al. | New progesterone derivatives as inhibitors of 5alpha-reductase enzyme and prostate cancer cell growth. | 2006 | J Enzyme Inhib Med Chem | pmid:17059168 |
| Santillo VM and Lowe FC | Treatment of benign prostatic hyperplasia in patients with cardiovascular disease. | 2006 | Drugs Aging | pmid:17067183 |
| Stine KJ et al. | Interaction of the glycoalkaloid tomatine with DMPC and sterol monolayers studied by surface pressure measurements and Brewster angle microscopy. | 2006 | J Phys Chem B | pmid:17078662 |
| Kim CI et al. | Long-term results of medical treatment in benign prostatic hyperplasia. | 2006 | Urology | pmid:17095071 |
| Naslund MJ et al. | Managing enlarged prostate in primary care. | 2006 | Int. J. Clin. Pract. | pmid:17109668 |
| GarcÃa CI et al. | Differential gene expression during development in two oligodendroglial cell lines overexpressing transferrin: a cDNA array analysis. | 2007 | Dev. Neurosci. | pmid:17119318 |
| Huang YF et al. | One new anthraquinone from marine Streptomyces sp. FX-58. | 2006 | Nat. Prod. Res. | pmid:17127510 |
| Petraki CD and Sfikas CP | Histopathological changes induced by therapies in the benign prostate and prostate adenocarcinoma. | 2007 | Histol. Histopathol. | pmid:17128417 |
| Seiffert K et al. | Inhibition of 5alpha-reductase activity in SZ95 sebocytes and HaCaT keratinocytes in vitro. | 2007 | Horm. Metab. Res. | pmid:17326010 |
| Liu KZ et al. | Oxidative status of lipoproteins in coronary disease patients. | 1992 | Am. Heart J. | pmid:1736561 |
| Chai TC | Treatment of men with lower urinary tract symptoms and overactive bladder. | 2007 | JAMA | pmid:17374808 |
| Thevis M et al. | Doping-control analysis of the 5alpha-reductase inhibitor finasteride: determination of its influence on urinary steroid profiles and detection of its major urinary metabolite. | 2007 | Ther Drug Monit | pmid:17417080 |
| Morgentaler A | Re: The interpretation of serum prostate specific antigen in men receiving 5alpha-reductase inhibitors: a review and clinical recommendations. | 2007 | J. Urol. | pmid:17437855 |
| Maier C | Editorial comment on: Low-activity V89L variant in SRD5A2 is associated with aggressive prostate cancer risk: an explanation for the adverse effects observed in chemoprevention trials using 5-alpha-reductase inhibitors. | 2007 | Eur. Urol. | pmid:17448591 |
| Cussenot O et al. | Low-activity V89L variant in SRD5A2 is associated with aggressive prostate cancer risk: an explanation for the adverse effects observed in chemoprevention trials using 5-alpha-reductase inhibitors. | 2007 | Eur. Urol. | pmid:17448593 |
| Prayer-Galetti T | Editorial comment on: Low-activity V89L variant in SRD5A2 is associated with aggressive prostate cancer risk: an explanation for the adverse effects observed in chemoprevention trials using 5-alpha-reductase inhibitors. | 2007 | Eur. Urol. | pmid:17448594 |
| Schmidt LJ et al. | Inhibition of fatty acid synthase activity in prostate cancer cells by dutasteride. | 2007 | Prostate | pmid:17477363 |
| Borst SE et al. | Anabolic effects of testosterone are preserved during inhibition of 5alpha-reductase. | 2007 | Am. J. Physiol. Endocrinol. Metab. | pmid:17488806 |
| Bordet T et al. | Identification and characterization of cholest-4-en-3-one, oxime (TRO19622), a novel drug candidate for amyotrophic lateral sclerosis. | 2007 | J. Pharmacol. Exp. Ther. | pmid:17496168 |
| Kibel AS | Optimizing prostate biopsy techniques. | 2007 | J. Urol. | pmid:17509275 |
| Lunacek A et al. | Fetal distribution of 5alpha-reductase 1 and 5alpha-reductase 2, and their input on human prostate development. | 2007 | J. Urol. | pmid:17574609 |
4-Cholesten-3-one
4-Cholesten-3-one is a lipid of Sterol Lipids (ST) class. 4-cholesten-3-one is associated with abnormalities such as Dehydration, Xanthomatosis, Cerebrotendinous, Peripheral Neuropathy, L.mexicana and Xanthoma. The involved functions are known as CYP27A1activity, 25-hydroxycholesterol 7alpha-hydroxylase activity, Biochemical Pathway, Anabolism and Oxidation. 4-cholesten-3-one often locates in Mitochondria, Liver, Body tissue, Hepatic, Mitochondria and Endothelium of artery. The associated genes with 4-Cholesten-3-one are P4HTM gene, tryptones and Regulon. The related lipids are Cholestenones, 7-hydroxy-4-cholesten-3-one, cholest-4-en-3-one, 25-hydroxycholesterol and 24-hydroxycholesterol.
Cross Reference
Introduction
To understand associated biological information of 4-Cholesten-3-one, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with 4-Cholesten-3-one?
4-Cholesten-3-one is suspected in Dehydration, Xanthomatosis, Cerebrotendinous, Peripheral Neuropathy, L.mexicana, Xanthoma, Rare Diseases and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Biochem. J. (1)
- J. Biol. Chem. (1)
- J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. (1)
- Others (3)
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
No disease MeSH terms mapped to the current reference collection.
PubChem Associated disorders and diseases
What pathways are associated with 4-Cholesten-3-one
Lipid pathways are not clear in current pathway databases. We organized associated pathways with 4-Cholesten-3-one through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with 4-Cholesten-3-one?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
- J. Biol. Chem. (2)
- J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. (1)
- J. Lipid Res. (1)
- Others (2)
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with 4-Cholesten-3-one?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with 4-Cholesten-3-one?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with 4-Cholesten-3-one?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with 4-Cholesten-3-one?
There are no associated biomedical information in the current reference collection.