| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Sampson NS | Dissection of a flavoenzyme active site: the reaction catalyzed by cholesterol oxidase. | 2001 | Antioxid. Redox Signal. | pmid:11761331 |
| Samy TS et al. | Divergent immune responses in male and female mice after trauma-hemorrhage: dimorphic alterations in T lymphocyte steroidogenic enzyme activities. | 2001 | Endocrinology | pmid:11459798 |
| Asada Y et al. | 5 alpha-reductase type 2 is constitutively expressed in the dermal papilla and connective tissue sheath of the hair follicle in vivo but not during culture in vitro. | 2001 | J. Clin. Endocrinol. Metab. | pmid:11397903 |
| Charbonneau A and The VL | Genomic organization of a human 5beta-reductase and its pseudogene and substrate selectivity of the expressed enzyme. | 2001 | Biochim. Biophys. Acta | pmid:11342103 |
| DellaGreca M et al. | Solid-state photodimerization of cholest-4-en-3-one. | 2001 | J. Org. Chem. | pmid:11300900 |
| Platz EA | Basic Science. | 2001 | Urology | pmid:11273573 |
| Nam RK et al. | V89L polymorphism of type-2, 5-alpha reductase enzyme gene predicts prostate cancer presence and progression. | 2001 | Urology | pmid:11164181 |
| Melcangi RC and Panzica G | Steroids in the nervous system: a Pandora's box? | 2001 | Trends Neurosci. | pmid:11421230 |
| Haigh WG and Lee SP | Identification of oxysterols in human bile and pigment gallstones. | 2001 | Gastroenterology | pmid:11438500 |
| Fritsch M et al. | Sebocytes are the key regulators of androgen homeostasis in human skin. | 2001 | J. Invest. Dermatol. | pmid:11348472 |
| Shaw JC | Hormonal therapies in acne. | 2002 | Expert Opin Pharmacother | pmid:12083987 |
| Yin Y et al. | Construction of a catalytically inactive cholesterol oxidase mutant: investigation of the interplay between active site-residues glutamate 361 and histidine 447. | 2002 | Arch. Biochem. Biophys. | pmid:12051668 |
| Huynh H | Induction of apoptosis in rat ventral prostate by finasteride is associated with alteration in MAP kinase pathways and Bcl-2 related family of proteins. | 2002 | Int. J. Oncol. | pmid:12012013 |
| Itoh K et al. | Mutation screening for the 5alpha-reductase type 2 gene in Japanese men with idiopathic azoospermia. | 2002 | Fertil. Steril. | pmid:12009375 |
| Brady BM and Anderson RA | Advances in male contraception. | 2002 | Expert Opin Investig Drugs | pmid:11866663 |
| Malik V and Pundir CS | Determination of total cholesterol in serum by cholesterol esterase and cholesterol oxidase immobilized and co-immobilized on to arylamine glass. | 2002 | Biotechnol. Appl. Biochem. | pmid:12074697 |
| Wolfreys AM and Hepburn PA | Safety evaluation of phytosterol esters. Part 7. Assessment of mutagenic activity of phytosterols, phytosterol esters and the cholesterol derivative, 4-cholesten-3-one. | 2002 | Food Chem. Toxicol. | pmid:11893405 |
| Hiort O et al. | A novel homozygous disruptive mutation in the SRD5A2-gene in a partially virilized patient with 5alpha-reductase deficiency. | 2002 | Int. J. Androl. | pmid:11869378 |
| Silfen ME et al. | 5 alpha-reductase and 11 beta-hydroxysteroid dehydrogenase activity in prepubertal Hispanic girls with premature adrenarche. | 2002 | J. Clin. Endocrinol. Metab. | pmid:12364451 |
| Nguyen DH and Taub D | Cholesterol is essential for macrophage inflammatory protein 1 beta binding and conformational integrity of CC chemokine receptor 5. | 2002 | Blood | pmid:12036855 |
| Azzouzi AR et al. | Impact of constitutional genetic variation in androgen/oestrogen-regulating genes on age-related changes in human prostate. | 2002 | Eur. J. Endocrinol. | pmid:12370109 |
| Yang C et al. | A49T, V89L and TA repeat polymorphisms of steroid 5alpha-reductase type II and breast cancer risk in Japanese women. | 2002 | Breast Cancer Res. | pmid:12100746 |
| Sojo MM et al. | Rhodococcus erythropolis ATCC 25544 as a suitable source of cholesterol oxidase: cell-linked and extracellular enzyme synthesis, purification and concentration. | 2002 | BMC Biotechnol. | pmid:11914155 |
| Ribeiro ML et al. | Allelic frequencies of six polymorphic markers for risk of prostate cancer. | 2002 | Braz. J. Med. Biol. Res. | pmid:11847524 |
| Schatzl G et al. | Association of polymorphisms within androgen receptor, 5alpha-reductase, and PSA genes with prostate volume, clinical parameters, and endocrine status in elderly men. | 2002 | Prostate | pmid:12111704 |
| Raynaud JP et al. | Inhibition of type 1 and type 2 5alpha-reductase activity by free fatty acids, active ingredients of Permixon. | 2002 | J. Steroid Biochem. Mol. Biol. | pmid:12477490 |
| Carmina E | Anti-androgens for the treatment of hirsutism. | 2002 | Expert Opin Investig Drugs | pmid:11866665 |
| Maeda Y et al. | A simple, accurate, and sensitive assay method of dehydroepiandrosterone sulfate: application for quantitative determination in human breast cyst and duct fluids. | 2002 | Steroids | pmid:11958788 |
| Campbell SM et al. | Virion-associated cholesterol is critical for the maintenance of HIV-1 structure and infectivity. | 2002 | AIDS | pmid:12441796 |
| Prager N et al. | A randomized, double-blind, placebo-controlled trial to determine the effectiveness of botanically derived inhibitors of 5-alpha-reductase in the treatment of androgenetic alopecia. | 2002 | J Altern Complement Med | pmid:12006122 |
| Pham H and Ziboh VA | 5 alpha-reductase-catalyzed conversion of testosterone to dihydrotestosterone is increased in prostatic adenocarcinoma cells: suppression by 15-lipoxygenase metabolites of gamma-linolenic and eicosapentaenoic acids. | 2002 | J. Steroid Biochem. Mol. Biol. | pmid:12589947 |
| Zeigler-Johnson CM et al. | Ethnic differences in the frequency of prostate cancer susceptibility alleles at SRD5A2 and CYP3A4. | 2002 | Hum. Hered. | pmid:12446983 |
| Shibata A et al. | Polymorphisms in the androgen receptor and type II 5 alpha-reductase genes and prostate cancer prognosis. | 2002 | Prostate | pmid:12210487 |
| Suzuki Y et al. | 5Alpha-reductase type 2 genes in Japanese males do not appear to be associated with cryptorchidism. | 2002 | Fertil. Steril. | pmid:12137870 |
| Lemonde HA et al. | Mutations in SRD5B1 (AKR1D1), the gene encoding delta(4)-3-oxosteroid 5beta-reductase, in hepatitis and liver failure in infancy. | 2003 | Gut | pmid:12970144 |
| Nguyen PN et al. | Changes in 5alpha-pregnane steroids and neurosteroidogenic enzyme expression in the perinatal sheep. | 2003 | Pediatr. Res. | pmid:12646725 |
| Nguyen DH and Taub DD | Inhibition of chemokine receptor function by membrane cholesterol oxidation. | 2003 | Exp. Cell Res. | pmid:14597406 |
| Mazen I et al. | Molecular analysis of 5alpha-reductase type 2 gene in eight unrelated egyptian children with suspected 5alpha-reductase deficiency: prevalence of the G34R mutation. | 2003 | Clin. Endocrinol. (Oxf) | pmid:12699446 |
| Sung YM et al. | Re: Hormonal markers and hepatitis B virus-related hepatocellular carcinoma risk: a nested case-control study among men. | 2003 | J. Natl. Cancer Inst. | pmid:12671025 |
| Norlin M et al. | On the substrate specificity of human CYP27A1: implications for bile acid and cholestanol formation. | 2003 | J. Lipid Res. | pmid:12777473 |
| Liu XC and Kayser L | New approach to regioselective synthesis: using proteins in vitro as guidance-regioselective reduction of steroids with guidance from bovine serum albumin. | 2003 | Biotechnol. Bioeng. | pmid:12701153 |
| Martin RM et al. | Familial hyperestrogenism in both sexes: clinical, hormonal, and molecular studies of two siblings. | 2003 | J. Clin. Endocrinol. Metab. | pmid:12843139 |
| Johnson DC and Widlanski TS | Cerium(III) chloride-mediated reactions of sulfonamide dianions. | 2003 | J. Org. Chem. | pmid:12816492 |
| Ji Q et al. | Selective reduction of AKR1C2 in prostate cancer and its role in DHT metabolism. | 2003 | Prostate | pmid:12539226 |
| Fassnacht M et al. | Beyond adrenal and ovarian androgen generation: Increased peripheral 5 alpha-reductase activity in women with polycystic ovary syndrome. | 2003 | J. Clin. Endocrinol. Metab. | pmid:12788885 |
| Yoshida T et al. | Origin of oxysterols in hepatic bile of patients with biliary infection. | 2003 | Am. J. Gastroenterol. | pmid:14572579 |
| Sasaki G et al. | Micropenis and the 5alpha-reductase-2 (SRD5A2) gene: mutation and V89L polymorphism analysis in 81 Japanese patients. | 2003 | J. Clin. Endocrinol. Metab. | pmid:12843198 |
| Faragalla J et al. | Comparative pharmacophore development for inhibitors of human and rat 5-alpha-reductase. | 2003 | J. Mol. Graph. Model. | pmid:12798393 |
| Li Z et al. | Association of V89L SRD5A2 polymorphism with prostate cancer development in a Japanese population. | 2003 | J. Urol. | pmid:12771801 |
| Chang BL et al. | Evaluation of SRD5A2 sequence variants in susceptibility to hereditary and sporadic prostate cancer. | 2003 | Prostate | pmid:12746845 |
4-Cholesten-3-one
4-Cholesten-3-one is a lipid of Sterol Lipids (ST) class. 4-cholesten-3-one is associated with abnormalities such as Dehydration, Xanthomatosis, Cerebrotendinous, Peripheral Neuropathy, L.mexicana and Xanthoma. The involved functions are known as CYP27A1activity, 25-hydroxycholesterol 7alpha-hydroxylase activity, Biochemical Pathway, Anabolism and Oxidation. 4-cholesten-3-one often locates in Mitochondria, Liver, Body tissue, Hepatic, Mitochondria and Endothelium of artery. The associated genes with 4-Cholesten-3-one are P4HTM gene, tryptones and Regulon. The related lipids are Cholestenones, 7-hydroxy-4-cholesten-3-one, cholest-4-en-3-one, 25-hydroxycholesterol and 24-hydroxycholesterol.
Cross Reference
Introduction
To understand associated biological information of 4-Cholesten-3-one, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with 4-Cholesten-3-one?
4-Cholesten-3-one is suspected in Dehydration, Xanthomatosis, Cerebrotendinous, Peripheral Neuropathy, L.mexicana, Xanthoma, Rare Diseases and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- J. Biol. Chem. (1)
- J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. (1)
- J. Lipid Res. (1)
- Others (3)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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No disease MeSH terms mapped to the current reference collection.
PubChem Associated disorders and diseases
What pathways are associated with 4-Cholesten-3-one
Lipid pathways are not clear in current pathway databases. We organized associated pathways with 4-Cholesten-3-one through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with 4-Cholesten-3-one?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
- J. Biol. Chem. (2)
- J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. (1)
- J. Lipid Res. (1)
- Others (2)
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with 4-Cholesten-3-one?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with 4-Cholesten-3-one?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with 4-Cholesten-3-one?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with 4-Cholesten-3-one?
There are no associated biomedical information in the current reference collection.