4-Cholesten-3-one

4-Cholesten-3-one is a lipid of Sterol Lipids (ST) class. 4-cholesten-3-one is associated with abnormalities such as Dehydration, Xanthomatosis, Cerebrotendinous, Peripheral Neuropathy, L.mexicana and Xanthoma. The involved functions are known as CYP27A1activity, 25-hydroxycholesterol 7alpha-hydroxylase activity, Biochemical Pathway, Anabolism and Oxidation. 4-cholesten-3-one often locates in Mitochondria, Liver, Body tissue, Hepatic, Mitochondria and Endothelium of artery. The associated genes with 4-Cholesten-3-one are P4HTM gene, tryptones and Regulon. The related lipids are Cholestenones, 7-hydroxy-4-cholesten-3-one, cholest-4-en-3-one, 25-hydroxycholesterol and 24-hydroxycholesterol.

Cross Reference

Introduction

To understand associated biological information of 4-Cholesten-3-one, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with 4-Cholesten-3-one?

4-Cholesten-3-one is suspected in Dehydration, Xanthomatosis, Cerebrotendinous, Peripheral Neuropathy, L.mexicana, Xanthoma, Rare Diseases and other diseases in descending order of the highest number of associated sentences.

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Disease Cross reference Weighted score Related literature
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No disease MeSH terms mapped to the current reference collection.

PubChem Associated disorders and diseases

What pathways are associated with 4-Cholesten-3-one

Lipid pathways are not clear in current pathway databases. We organized associated pathways with 4-Cholesten-3-one through full-text articles, including metabolic pathways or pathways of biological mechanisms.

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PubChem Biomolecular Interactions and Pathways

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What cellular locations are associated with 4-Cholesten-3-one?

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What functions are associated with 4-Cholesten-3-one?


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What lipids are associated with 4-Cholesten-3-one?

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What genes are associated with 4-Cholesten-3-one?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with 4-Cholesten-3-one?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with 4-Cholesten-3-one

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Authors Title Published Journal PubMed Link
Kaul HK et al. Genotoxicity of two fecal steroids in murine colonic epithelium assessed by the sister chromatid exchange technique. 1987 Mutagenesis pmid:3328036
Batta AK et al. Chromatographic separation of putative precursors of cholestanol. 1988 Jul-Aug Steroids pmid:3247666
Sugano S et al. Sensitive assay of cytochrome P450scc activity by high-performance liquid chromatography. 1989 Anal. Biochem. pmid:2610350
Wijnberg JB and de Groot A Synthesis and 13C-NMR analysis of 5 alpha- and 5 beta-cholestane-3,6-dione. 1989 Steroids pmid:2588307
Liu KZ et al. Oxidative status of lipoproteins in coronary disease patients. 1992 Am. Heart J. pmid:1736561
Contreras JA et al. Combination of an enzymatic method and HPLC for the quantitation of cholesterol in cultured cells. 1992 J. Lipid Res. pmid:1512516
Suzuki K Anti-obesity effect of cholest-4-en-3-one, an intestinal catabolite of cholesterol, on mice. 1993 J. Nutr. Sci. Vitaminol. pmid:8120678
Plemenitas A et al. Identification of progesterone binding sites in the plasma membrane of the filamentous fungus Cochliobolus lunatus. 1993 J. Steroid Biochem. Mol. Biol. pmid:8499335
Molnár I et al. Bacterial cholesterol oxidases are able to act as flavoprotein-linked ketosteroid monooxygenases that catalyse the hydroxylation of cholesterol to 4-cholesten-6-ol-3-one. 1993 Mol. Microbiol. pmid:8459768
Slotte JP and Ostman AL Oxidation/isomerization of 5-cholesten-3 beta-ol and 5-cholesten-3-one to 4-cholesten-3-one in pure sterol and mixed phospholipid-containing monolayers by cholesterol oxidase. 1993 Biochim. Biophys. Acta pmid:8431456