| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Moinpour CM et al. | Longitudinal analysis of sexual function reported by men in the Prostate Cancer Prevention Trial. | 2007 | J. Natl. Cancer Inst. | pmid:17596576 |
| Barat P et al. | Effects of gonadectomy on glucocorticoid metabolism in obese Zucker rats. | 2007 | Endocrinology | pmid:17628001 |
| Dixon J et al. | Prolonged human chorionic gonadotrophin stimulation as a tool for investigating and managing undescended testes. | 2007 | Clin. Endocrinol. (Oxf) | pmid:17645564 |
| Jang S et al. | Establishment of type II 5alpha-reductase over-expressing cell line as an inhibitor screening model. | J. Steroid Biochem. Mol. Biol. | pmid:17646096 | |
| Andersson KE | LUTS treatment: future treatment options. | 2007 | Neurourol. Urodyn. | pmid:17696154 |
| Yassin AA and Saad F | Plasma levels of dihydrotestosterone remain in the normal range in men treated with long-acting parenteral testosterone undecanoate. | 2007 | Andrologia | pmid:17714216 |
| Carneiro MM et al. | Androgen receptor and 5alpha-reductase are expressed in pelvic endometriosis. | 2008 | BJOG | pmid:17983420 |
| Chiang YR et al. | Cholest-4-en-3-one-delta 1-dehydrogenase, a flavoprotein catalyzing the second step in anoxic cholesterol metabolism. | 2008 | Appl. Environ. Microbiol. | pmid:17993555 |
| Assinder SJ | Oxytocin increases 5alpha-reductase activity of human prostate epithelial cells, but not stromal cells. | 2008 | Prostate | pmid:18008328 |
| Hannemann F et al. | Biocatalytic synthesis of 4-pregnen-20,21-diol-3-one, a selective inhibitor of human 5alpha-reductase type II. | 2007 | J Enzyme Inhib Med Chem | pmid:18035825 |
| Wheeler RE | Is it necessary to cure prostate cancer when it is possible? (Understanding the role of prostate inflammation resolution to prostate cancer evolution). | 2007 | Clin Interv Aging | pmid:18044088 |
| Araki M et al. | Decreased efficiency of potassium-titanyl-phosphate laser photoselective vaporization prostatectomy with long-term 5 alpha-reductase inhibition therapy: is it true? | 2007 | Urology | pmid:18068449 |
| Wilt TJ and N'Dow J | Benign prostatic hyperplasia. Part 2--management. | 2008 | BMJ | pmid:18219042 |
| Palermo M et al. | Human Delta4-3-oxosteroid 5beta-reductase (AKR1D1) deficiency and steroid metabolism. | 2008 | Steroids | pmid:18243262 |
| Liu S and Yamauchi H | Different patterns of 5alpha-reductase expression, cellular distribution, and testosterone metabolism in human follicular dermal papilla cells. | 2008 | Biochem. Biophys. Res. Commun. | pmid:18258185 |
| Gallegos PJ and Frazee LA | Anticholinergic therapy for lower urinary tract symptoms associated with benign prostatic hyperplasia. | 2008 | Pharmacotherapy | pmid:18294115 |
| Koltz L and Clarke N | Open to debate. The Motion: all men over the age of 50 should be encouraged to take a 5alpha-reductase inhibitor to prevent prostate cancer. | 2008 | Eur. Urol. | pmid:18308462 |
| Tomlinson JW et al. | Reduced glucocorticoid production rate, decreased 5alpha-reductase activity, and adipose tissue insulin sensitization after weight loss. | 2008 | Diabetes | pmid:18340018 |
| Golbano JM et al. | Finasteride induces apoptosis via Bcl-2, Bcl-xL, Bax and caspase-3 proteins in LNCaP human prostate cancer cell line. | 2008 | Int. J. Oncol. | pmid:18360719 |
| Grinthal A and Guidotti G | CD39, NTPDase 1, is attached to the plasma membrane by two transmembrane domains. Why? | 2006 | Purinergic Signal. | pmid:18404478 |
| Amory JK et al. | The effect of 5alpha-reductase inhibition with dutasteride and finasteride on bone mineral density, serum lipoproteins, hemoglobin, prostate specific antigen and sexual function in healthy young men. | 2008 | J. Urol. | pmid:18423697 |
| Khan SA | Synthesis, characterization and in vitro antibacterial activity of new steroidal 5-en-3-oxazolo and thiazoloquinoxaline. | 2008 | Eur J Med Chem | pmid:18455270 |
| Bordet T et al. | Specific antinociceptive activity of cholest-4-en-3-one, oxime (TRO19622) in experimental models of painful diabetic and chemotherapy-induced neuropathy. | 2008 | J. Pharmacol. Exp. Ther. | pmid:18492948 |
| Ford MM et al. | Inhibition of 5alpha-reduced steroid biosynthesis impedes acquisition of ethanol drinking in male C57BL/6J mice. | 2008 | Alcohol. Clin. Exp. Res. | pmid:18565155 |
| Holzgrabe U and Sinz A | [Alpha blockers and 5-alpha reductase inhibitors]. | 2008 | Pharm Unserer Zeit | pmid:18615868 |
| Faucher F et al. | The crystal structure of human Delta4-3-ketosteroid 5beta-reductase defines the functional role of the residues of the catalytic tetrad in the steroid double bond reduction mechanism. | 2008 | Biochemistry | pmid:18624455 |
| Tomlinson JW et al. | Impaired glucose tolerance and insulin resistance are associated with increased adipose 11beta-hydroxysteroid dehydrogenase type 1 expression and elevated hepatic 5alpha-reductase activity. | 2008 | Diabetes | pmid:18633104 |
| Hadziselimovic F and Dessouky N | Differences in testicular development between 5alpha-reductase 2 deficiency and isolated bilateral cryptorchidism. | 2008 | J. Urol. | pmid:18639287 |
| Gooren LJ et al. | Decline of plasma 5alpha-dihydrotestosterone (DHT) levels upon testosterone administration to elderly men with subnormal plasma testosterone and high DHT levels. | 2008 | Andrologia | pmid:18811920 |
| Kolasa A et al. | Expression of E-SOD, GPX5 mRNAs and immunoexpression of Cu/ZnSOD in epididymal epithelial cells of finasteride-treated rats. | 2008 | Andrologia | pmid:18811921 |
| Masserini B et al. | The limited role of midnight salivary cortisol levels in the diagnosis of subclinical hypercortisolism in patients with adrenal incidentaloma. | 2009 | Eur. J. Endocrinol. | pmid:18835977 |
| Lemus AE et al. | Bioconversion of norethisterone, a progesterone receptor agonist into estrogen receptor agonists in osteoblastic cells. | 2009 | J. Endocrinol. | pmid:19008332 |
| Ditscheid B et al. | Faecal steroid excretion in humans is affected by calcium supplementation and shows gender-specific differences. | 2009 | Eur J Nutr | pmid:19009227 |
| Bhasin S and Storer TW | Anabolic applications of androgens for functional limitations associated with aging and chronic illness. | 2009 | Front Horm Res | pmid:19011296 |
| Le Lay S et al. | Caveolin-1-dependent and -independent membrane domains. | 2009 | J. Lipid Res. | pmid:19074371 |
| Veldhuis JD et al. | Aromatase and 5alpha-reductase inhibition during an exogenous testosterone clamp unveils selective sex steroid modulation of somatostatin and growth hormone secretagogue actions in healthy older men. | 2009 | J. Clin. Endocrinol. Metab. | pmid:19088159 |
| Yehuda R et al. | Enduring effects of severe developmental adversity, including nutritional deprivation, on cortisol metabolism in aging Holocaust survivors. | 2009 | J Psychiatr Res | pmid:19162277 |
| Ueki I et al. | SRD5B1 gene analysis needed for the accurate diagnosis of primary 3-oxo-Delta4-steroid 5beta-reductase deficiency. | 2009 | J. Gastroenterol. Hepatol. | pmid:19175828 |
| Jeong YB et al. | Effect of discontinuation of 5alpha-reductase inhibitors on prostate volume and symptoms in men with BPH: a prospective study. | 2009 | Urology | pmid:19193422 |
| Schröder FH et al. | Can dutasteride delay or prevent the progression of prostate cancer in patients with biochemical failure after radical therapy? Rationale and design of the Avodart after Radical Therapy for Prostate Cancer Study. | 2009 | BJU Int. | pmid:19226424 |
| Zhou C et al. | The steroid and xenobiotic receptor (SXR), beyond xenobiotic metabolism. | 2009 | Nucl Recept Signal | pmid:19240808 |
| Kramer BS et al. | Use of 5alpha-reductase inhibitors for prostate cancer chemoprevention: American Society of Clinical Oncology/American Urological Association 2008 Clinical Practice Guideline. | 2009 | J. Urol. | pmid:19249063 |
| Droller MJ | A guideline for discussion and some thoughts. | 2009 | J. Urol. | pmid:19249064 |
| Kotłowska A et al. | The urinary steroid profile in patients diagnosed with adrenal incidentaloma. | 2009 | Clin. Biochem. | pmid:19297679 |
| Sillat T et al. | Intracrine androgenic apparatus in human bone marrow stromal cells. | 2009 | J. Cell. Mol. Med. | pmid:19298521 |
| Fitzpatrick JM et al. | Prostate cancer: a serious disease suitable for prevention. | 2009 | BJU Int. | pmid:19302133 |
| Kuo HC and Liu HT | Therapeutic effects of add-on botulinum toxin A on patients with large benign prostatic hyperplasia and unsatisfactory response to combined medical therapy. | 2009 | Scand. J. Urol. Nephrol. | pmid:19308807 |
| Fujii T et al. | Efficient biotransformations using Escherichia coli with tolC acrAB mutations expressing cytochrome P450 genes. | 2009 | Biosci. Biotechnol. Biochem. | pmid:19352031 |
| Liu J et al. | Anti-androgenic activity of fatty acids. | 2009 | Chem. Biodivers. | pmid:19353546 |
| Abe M et al. | Isolation and pharmacological characterization of fatty acids from saw palmetto extract. | 2009 | Anal Sci | pmid:19359798 |
| Cabeza M et al. | Novel C-6 substituted and unsubstituted pregnane derivatives as 5alpha-reductase inhibitors and their effect on hamster flank organs diameter size. | 2009 | Steroids | pmid:19406144 |
| Colciago A et al. | Chronic treatment with polychlorinated biphenyls (PCB) during pregnancy and lactation in the rat Part 2: Effects on reproductive parameters, on sex behavior, on memory retention and on hypothalamic expression of aromatase and 5alpha-reductases in the offspring. | 2009 | Toxicol. Appl. Pharmacol. | pmid:19464308 |
| Corradi LS et al. | Increased androgen receptor and remodeling in the prostatic stroma after the inhibition of 5-alpha reductase and aromatase in gerbil ventral prostate. | 2009 | Microsc. Res. Tech. | pmid:19484778 |
| Castro BM et al. | Cholesterol-rich fluid membranes solubilize ceramide domains: implications for the structure and dynamics of mammalian intracellular and plasma membranes. | 2009 | J. Biol. Chem. | pmid:19520848 |
| Zhou X et al. | High abundance of testosterone and salivary androgen-binding protein in the lateral nasal gland of male mice. | 2009 | J. Steroid Biochem. Mol. Biol. | pmid:19524040 |
| Lintker KB et al. | A comparison of the packing behavior of egg phosphatidylcholine with cholesterol and biogenically related sterols in Langmuir monolayer films. | 2009 | Chem. Phys. Lipids | pmid:19524563 |
| Miller J and Tarter TH | Combination therapy with dutasteride and tamsulosin for the treatment of symptomatic enlarged prostate. | 2009 | Clin Interv Aging | pmid:19554096 |
| Vassiliadi DA et al. | Increased 5 alpha-reductase activity and adrenocortical drive in women with polycystic ovary syndrome. | 2009 | J. Clin. Endocrinol. Metab. | pmid:19567518 |
| Yawno T et al. | Role of neurosteroids in regulating cell death and proliferation in the late gestation fetal brain. | 2009 | Neuroscience | pmid:19591903 |
| Biggio G et al. | GABA(A) receptor function and gene expression during pregnancy and postpartum. | 2009 | Int. Rev. Neurobiol. | pmid:19607962 |
| Gonzales E et al. | Oral cholic acid for hereditary defects of primary bile acid synthesis: a safe and effective long-term therapy. | 2009 | Gastroenterology | pmid:19622360 |
| Schmidt LJ et al. | Effects of the 5 alpha-reductase inhibitor dutasteride on gene expression in prostate cancer xenografts. | 2009 | Prostate | pmid:19676081 |
| Reismann P et al. | Pharmacological options for treatment of hyperandrogenic disorders. | 2009 | Mini Rev Med Chem | pmid:19689407 |
| Frankel PH and Twardowski P | Guideline for 5-alpha-reductase inhibitors in the prevention of prostate cancer is premature. | 2009 | J. Clin. Oncol. | pmid:19738114 |
| Osborne DM and Frye CA | Estrogen increases latencies to seizures and levels of 5alpha-pregnan-3alpha-ol-20-one in hippocampus of wild-type, but not 5alpha-reductase knockout, mice. | 2009 | Epilepsy Behav | pmid:19782646 |
| Hong SK et al. | Effect of the dual 5alpha-reductase inhibitor, dutasteride, on serum testosterone and body mass index in men with benign prostatic hyperplasia. | 2010 | BJU Int. | pmid:19793378 |
| Xiao WH et al. | Olesoxime (cholest-4-en-3-one, oxime): analgesic and neuroprotective effects in a rat model of painful peripheral neuropathy produced by the chemotherapeutic agent, paclitaxel. | 2009 | Pain | pmid:19833436 |
| Pollegioni L et al. | Cholesterol oxidase: biotechnological applications. | 2009 | FEBS J. | pmid:19843167 |
| Rosłoniec KZ et al. | Cytochrome P450 125 (CYP125) catalyses C26-hydroxylation to initiate sterol side-chain degradation in Rhodococcus jostii RHA1. | 2009 | Mol. Microbiol. | pmid:19843222 |
| Capyk JK et al. | Mycobacterial cytochrome p450 125 (cyp125) catalyzes the terminal hydroxylation of c27 steroids. | 2009 | J. Biol. Chem. | pmid:19846551 |
| Perlmutter JD and Sachs JN | Inhibiting lateral domain formation in lipid bilayers: simulations of alternative steroid headgroup chemistries. | 2009 | J. Am. Chem. Soc. | pmid:19860442 |
| Hollingsworth JM and Wei JT | Does the combination of an alpha1-adrenergic antagonist with a 5alpha-reductase inhibitor improve urinary symptoms more than either monotherapy? | 2010 | Curr Opin Urol | pmid:19881352 |
| Campino C et al. | 11β-Hydroxysteroid dehydrogenase type-2 and type-1 (11β-HSD2 and 11β-HSD1) and 5β-reductase activities in the pathogenia of essential hypertension. | 2010 | Endocrine | pmid:19882252 |
| Taplin ME et al. | Phase II study of androgen synthesis inhibition with ketoconazole, hydrocortisone, and dutasteride in asymptomatic castration-resistant prostate cancer. | 2009 | Clin. Cancer Res. | pmid:19887483 |
| Aggarwal S et al. | 3D-QSAR studies on unsaturated 4-azasteroids as human 5alpha-reductase inhibitors: a self organizing molecular field analysis approach. | 2010 | Eur J Med Chem | pmid:19906465 |
| Cohen RE and Wade J | Testosterone selectively affects aromatase and 5alpha-reductase activities in the green anole lizard brain. | 2010 | Gen. Comp. Endocrinol. | pmid:19917285 |
| Juan Escudero JU et al. | [Green light laser efficacy in patients with prostatic hyperplasia treatment with 5-alpha reductase inhibitors]. | 2009 | Actas Urol Esp | pmid:19925759 |
| Shimoda H et al. | The hypocholesterolemic effects of Cistanche tubulosa extract, a Chinese traditional crude medicine, in mice. | 2009 | Am. J. Chin. Med. | pmid:19938221 |
| Tibolla G et al. | Increased atherosclerosis and vascular inflammation in APP transgenic mice with apolipoprotein E deficiency. | 2010 | Atherosclerosis | pmid:19945109 |
| Gravas S and Oelke M | Current status of 5alpha-reductase inhibitors in the management of lower urinary tract symptoms and BPH. | 2010 | World J Urol | pmid:19956956 |
| Zoccolella S et al. | Current and emerging treatments for amyotrophic lateral sclerosis. | 2009 | Neuropsychiatr Dis Treat | pmid:19966906 |
| Kasashima S et al. | Androgen receptor and 5alpha-reductase immunohistochemical profiles in extramammary Paget disease. | 2010 | Br. J. Dermatol. | pmid:19995364 |
| Verhovshek T et al. | Testosterone metabolites differentially maintain adult morphology in a sexually dimorphic neuromuscular system. | 2010 | Dev Neurobiol | pmid:20024940 |
| Shore N | NX-1207: a novel investigational drug for the treatment of benign prostatic hyperplasia. | 2010 | Expert Opin Investig Drugs | pmid:20050813 |
| Li L et al. | Selective induction of apoptosis in the hamster flank sebaceous gland organ by a topical liposome 5-alpha-reductase inhibitor: a treatment strategy for acne. | 2010 | J. Dermatol. | pmid:20175850 |
| Oh CY et al. | Korean urologist's view of practice patterns in diagnosis and management of benign prostatic hyperplasia: a nationwide survey. | 2010 | Yonsei Med. J. | pmid:20191018 |
| Cohen P | Do 5-alpha reductase inhibitors influence the severity of brain injury in men after a stroke? | 2010 | Med. Hypotheses | pmid:20202761 |
| Bühler P et al. | Comparison of gene expression in LNCaP prostate cancer cells after treatment with bicalutamide or 5-alpha-reductase inhibitors. | 2010 | Urol. Int. | pmid:20215827 |
| Elterman DS et al. | Investigating contamination of phytotherapy products for benign prostatic hyperplasia with alpha-blockers and 5alpha-reductase inhibitors. | 2010 | J. Urol. | pmid:20303529 |
| Dovbnya DV et al. | Microbial side-chain degradation of ergosterol and its 3-substituted derivatives: a new route for obtaining of deltanoids. | 2010 | Steroids | pmid:20385161 |
| Volontè F et al. | Production of recombinant cholesterol oxidase containing covalently bound FAD in Escherichia coli. | 2010 | BMC Biotechnol. | pmid:20409334 |
| Rovini A et al. | Olesoxime prevents microtubule-targeting drug neurotoxicity: selective preservation of EB comets in differentiated neuronal cells. | 2010 | Biochem. Pharmacol. | pmid:20417191 |
| Helfand BT et al. | Consequences of switching 5alpha-reductase inhibitors on prostate specific antigen velocity. | 2010 | J. Urol. | pmid:20483154 |
| Trüeb RM | [Hormones and hair growth]. | 2010 | Hautarzt | pmid:20502852 |
| Brun EM et al. | Enzyme-linked immunosorbent assays for doping control of 5alpha-reductase inhibitors finasteride and dutasteride. | 2010 | Anal. Chim. Acta | pmid:20541645 |
| Ouellet H et al. | Mycobacterium tuberculosis CYP125A1, a steroid C27 monooxygenase that detoxifies intracellularly generated cholest-4-en-3-one. | 2010 | Mol. Microbiol. | pmid:20545858 |
| Gupta S et al. | Inhibition of 5alpha-reductase enhances testosterone-induced expression of U19/Eaf2 tumor suppressor during the regrowth of LNCaP xenograft tumor in nude mice. | 2010 | Prostate | pmid:20564326 |
| Chung DE and Kaplan SA | Current role for combination therapy in male LUTS. | 2010 | Arch. Esp. Urol. | pmid:20587837 |
| van Gorselen EO et al. | Artifactual measurement of low serum HDL-cholesterol due to paraproteinemia. | 2010 | Clin Res Cardiol | pmid:20593189 |
| Cho CH et al. | 5alpha-reductase inhibitory components as antiandrogens from herbal medicine. | 2010 | J Acupunct Meridian Stud | pmid:20633525 |
4-Cholesten-3-one
4-Cholesten-3-one is a lipid of Sterol Lipids (ST) class. 4-cholesten-3-one is associated with abnormalities such as Dehydration, Xanthomatosis, Cerebrotendinous, Peripheral Neuropathy, L.mexicana and Xanthoma. The involved functions are known as CYP27A1activity, 25-hydroxycholesterol 7alpha-hydroxylase activity, Biochemical Pathway, Anabolism and Oxidation. 4-cholesten-3-one often locates in Mitochondria, Liver, Body tissue, Hepatic, Mitochondria and Endothelium of artery. The associated genes with 4-Cholesten-3-one are P4HTM gene, tryptones and Regulon. The related lipids are Cholestenones, 7-hydroxy-4-cholesten-3-one, cholest-4-en-3-one, 25-hydroxycholesterol and 24-hydroxycholesterol.
Cross Reference
Introduction
To understand associated biological information of 4-Cholesten-3-one, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with 4-Cholesten-3-one?
4-Cholesten-3-one is suspected in Dehydration, Xanthomatosis, Cerebrotendinous, Peripheral Neuropathy, L.mexicana, Xanthoma, Rare Diseases and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Biochem. J. (1)
- J. Biol. Chem. (1)
- J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. (1)
- Others (3)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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No disease MeSH terms mapped to the current reference collection.
PubChem Associated disorders and diseases
What pathways are associated with 4-Cholesten-3-one
Lipid pathways are not clear in current pathway databases. We organized associated pathways with 4-Cholesten-3-one through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with 4-Cholesten-3-one?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
- J. Biol. Chem. (2)
- J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. (1)
- J. Lipid Res. (1)
- Others (2)
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with 4-Cholesten-3-one?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with 4-Cholesten-3-one?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with 4-Cholesten-3-one?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with 4-Cholesten-3-one?
There are no associated biomedical information in the current reference collection.