| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
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| Maria McCrohan A et al. | Effects of the dual 5 alpha-reductase inhibitor dutasteride on apoptosis in primary cultures of prostate cancer epithelial cells and cell lines. | 2006 | Cancer | pmid:16703599 |
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| Hall MC | The effect of oxysterols, individually and as a representative mixture from food, on in vitro cultured bovine ovarian granulosa cells. | 2006 | Mol. Cell. Biochem. | pmid:16983501 |
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| Borst SE et al. | Inhibition of 5alpha-reductase blocks prostate effects of testosterone without blocking anabolic effects. | 2005 | Am. J. Physiol. Endocrinol. Metab. | pmid:15367394 |
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| Panter BU et al. | 5alpha-reductase in human embryonic kidney cell line HEK293: evidence for type II enzyme expression and activity. | 2005 | Mol. Cell. Biochem. | pmid:15792368 |
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| Ordyan NE and Pivina SG | Effects of prenatal stress on the activity of an enzyme involved in neurosteroid synthesis during the "critical period" of sexual differentiation of the brain in male rats. | 2005 | Neurosci. Behav. Physiol. | pmid:16270175 |
| Kiyokage E et al. | Localization of 5alpha-reductase in the rat main olfactory bulb. | 2005 | J. Comp. Neurol. | pmid:16261538 |
| Tiwari A et al. | Benign prostatic hyperplasia: an insight into current investigational medical therapies. | 2005 | Expert Opin Investig Drugs | pmid:16255676 |
| Fujita R et al. | Anti-androgenic activities of Ganoderma lucidum. | 2005 | J Ethnopharmacol | pmid:16029938 |
| Rosati F et al. | 5alpha-Reductase activity in Lycopersicon esculentum: cloning and functional characterization of LeDET2 and evidence of the presence of two isoenzymes. | 2005 | J. Steroid Biochem. Mol. Biol. | pmid:15993049 |
| Gorin RE et al. | Effects of finasteride on chronic and acute ethanol withdrawal severity in the WSP and WSR selected lines. | 2005 | Alcohol. Clin. Exp. Res. | pmid:15976519 |
| Monte MJ et al. | Transient changes in the expression pattern of key enzymes for bile acid synthesis during rat liver regeneration. | 2005 | Biochim. Biophys. Acta | pmid:15904869 |
| Vallarino M et al. | Ontogeny of 3 beta-hydroxysteroid dehydrogenase and 5 alpha-reductase in the frog brain. | 2005 | Ann. N. Y. Acad. Sci. | pmid:15891098 |
| Rho SS et al. | The hair growth promoting effect of Asiasari radix extract and its molecular regulation. | 2005 | J. Dermatol. Sci. | pmid:15862941 |
| Luu-The V et al. | Quantitative appreciation of steroidogenic gene expression in mouse tissues: new roles for type 2 5alpha-reductase, 20alpha-hydroxysteroid dehydrogenase and estrogen sulfotransferase. | 2005 | J. Steroid Biochem. Mol. Biol. | pmid:15860270 |
| Monte MJ et al. | Changes in the expression of genes related to bile acid synthesis and transport by the rat liver during hepatocarcinogenesis. | 2005 | Clin. Sci. | pmid:15853769 |
| Souverein PC et al. | Treatment of benign prostatic hyperplasia and occurrence of prostatic surgery and acute urinary retention: a population-based cohort study in the Netherlands. | 2005 | Eur. Urol. | pmid:15774250 |
| Haeffner F et al. | Model studies of cholesterol and ascorbate oxidation by copper complexes: relevance to Alzheimer's disease beta-amyloid metallochemistry. | 2005 | J. Inorg. Biochem. | pmid:16271394 |
| Festuccia C et al. | Effects of 5 alpha reductase inhibitors on androgen-dependent human prostatic carcinoma cells. | 2005 | J. Cancer Res. Clin. Oncol. | pmid:15650886 |
| Papanikolaou A et al. | Cholesterol-dependent lipid assemblies regulate the activity of the ecto-nucleotidase CD39. | 2005 | J. Biol. Chem. | pmid:15890655 |
| Guzmán DC et al. | Effect of testosterone and steroids homologues on indolamines and lipid peroxidation in rat brain. | 2005 | J. Steroid Biochem. Mol. Biol. | pmid:15857756 |
| Al-Mutair A et al. | Cytogenetics and etiology of ambiguous genitalia in 120 pediatric patients. | 2004 Sep-Oct | Ann Saudi Med | pmid:15573851 |
| Schmidt LJ et al. | Gene expression in prostate cancer cells treated with the dual 5 alpha-reductase inhibitor dutasteride. | 2004 Nov-Dec | J. Androl. | pmid:15477368 |
| Bairamov AA and Sapronov NS | Effect of dehydroepiandrosterone on radioligand binding of [3H]-testosterone by androgen receptors in rat hypothalamus. | 2004 | Bull. Exp. Biol. Med. | pmid:15665952 |
| Finn DA et al. | The role of pregnane neurosteroids in ethanol withdrawal: behavioral genetic approaches. | 2004 | Pharmacol. Ther. | pmid:14761701 |
| Namazi MR | Further insight into the pathomechanism of acne by considering the 5-alpha-reductase inhibitory effect of linoleic acid. | 2004 | Int. J. Dermatol. | pmid:15357760 |
| Nguyen PN et al. | Increased allopregnanolone levels in the fetal sheep brain following umbilical cord occlusion. | 2004 | J. Physiol. (Lond.) | pmid:15331682 |
| Lee HH et al. | Theaflavin-3,3'-digallate and penta-O-galloyl-beta-D-glucose inhibit rat liver microsomal 5alpha-reductase activity and the expression of androgen receptor in LNCaP prostate cancer cells. | 2004 | Carcinogenesis | pmid:14963012 |
| Siler U et al. | Lycopene and vitamin E interfere with autocrine/paracrine loops in the Dunning prostate cancer model. | 2004 | FASEB J. | pmid:15084515 |
| Assinder SJ et al. | Regulation of 5alpha-reductase isoforms by oxytocin in the rat ventral prostate. | 2004 | Endocrinology | pmid:15358676 |
| Ahn KW and Sampson NS | Cholesterol oxidase senses subtle changes in lipid bilayer structure. | 2004 | Biochemistry | pmid:14730988 |
| Seo DW et al. | Oxysterols from human bile induce apoptosis of canine gallbladder epithelial cells in monolayer culture. | 2004 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:15246959 |
| Rontani JF and Aubert C | Electron ionization mass spectral fragmentation of derivatized 4,5- and 5,6-epoxysterols. | 2004 | Rapid Commun. Mass Spectrom. | pmid:15116422 |
| Chapple CR | Pharmacological therapy of benign prostatic hyperplasia/lower urinary tract symptoms: an overview for the practising clinician. | 2004 | BJU Int. | pmid:15329091 |
| McInnes KJ et al. | 5alpha-reduced glucocorticoids, novel endogenous activators of the glucocorticoid receptor. | 2004 | J. Biol. Chem. | pmid:15044432 |
| Frye CA et al. | Progesterone enhances motor, anxiolytic, analgesic, and antidepressive behavior of wild-type mice, but not those deficient in type 1 5 alpha-reductase. | 2004 | Brain Res. | pmid:15033426 |
| Dalla Valle L et al. | Expression of cytochrome P450c17 and other steroid-converting enzymes in the rat kidney throughout the life-span. | 2004 | J. Steroid Biochem. Mol. Biol. | pmid:15261307 |
| Clark RV et al. | Marked suppression of dihydrotestosterone in men with benign prostatic hyperplasia by dutasteride, a dual 5alpha-reductase inhibitor. | 2004 | J. Clin. Endocrinol. Metab. | pmid:15126539 |
| McVey MJ et al. | Altered testicular microsomal steroidogenic enzyme activities in rats with lifetime exposure to soy isoflavones. | 2004 | J. Steroid Biochem. Mol. Biol. | pmid:15698548 |
| Mathur S et al. | Evaluation of cell permeation of a potent 5alpha-reductase inhibitor using MALDI-TOF MS. | 2004 | J Enzyme Inhib Med Chem | pmid:15648657 |
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4-Cholesten-3-one
4-Cholesten-3-one is a lipid of Sterol Lipids (ST) class. 4-cholesten-3-one is associated with abnormalities such as Dehydration, Xanthomatosis, Cerebrotendinous, Peripheral Neuropathy, L.mexicana and Xanthoma. The involved functions are known as CYP27A1activity, 25-hydroxycholesterol 7alpha-hydroxylase activity, Biochemical Pathway, Anabolism and Oxidation. 4-cholesten-3-one often locates in Mitochondria, Liver, Body tissue, Hepatic, Mitochondria and Endothelium of artery. The associated genes with 4-Cholesten-3-one are P4HTM gene, tryptones and Regulon. The related lipids are Cholestenones, 7-hydroxy-4-cholesten-3-one, cholest-4-en-3-one, 25-hydroxycholesterol and 24-hydroxycholesterol.
Cross Reference
Introduction
To understand associated biological information of 4-Cholesten-3-one, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with 4-Cholesten-3-one?
4-Cholesten-3-one is suspected in Dehydration, Xanthomatosis, Cerebrotendinous, Peripheral Neuropathy, L.mexicana, Xanthoma, Rare Diseases and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Biochem. J. (1)
- J. Biol. Chem. (1)
- J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. (1)
- Others (3)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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No disease MeSH terms mapped to the current reference collection.
PubChem Associated disorders and diseases
What pathways are associated with 4-Cholesten-3-one
Lipid pathways are not clear in current pathway databases. We organized associated pathways with 4-Cholesten-3-one through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with 4-Cholesten-3-one?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
- J. Biol. Chem. (2)
- J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. (1)
- J. Lipid Res. (1)
- Others (2)
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with 4-Cholesten-3-one?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with 4-Cholesten-3-one?
Related references are published most in these journals:
- J. Biol. Chem. (2)
- J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. (1)
- J. Lipid Res. (1)
- Others (3)
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with 4-Cholesten-3-one?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with 4-Cholesten-3-one?
There are no associated biomedical information in the current reference collection.