| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Soma KK et al. | Brain aromatase, 5 alpha-reductase, and 5 beta-reductase change seasonally in wild male song sparrows: relationship to aggressive and sexual behavior. | 2003 | J. Neurobiol. | pmid:12884261 |
| Ntais C et al. | SRD5A2 gene polymorphisms and the risk of prostate cancer: a meta-analysis. | 2003 | Cancer Epidemiol. Biomarkers Prev. | pmid:12869400 |
| Gupta Y et al. | Kinetic analysis of LDL oxidation in IHD and IHD risk subjects in Indian population. | 2003 | Indian J Clin Biochem | pmid:23105369 |
| Nguyen PN et al. | Changes in 5alpha-pregnane steroids and neurosteroidogenic enzyme expression in fetal sheep with umbilicoplacental embolization. | 2003 | Pediatr. Res. | pmid:12930920 |
| Torres JM et al. | Semiquantitative RT-PCR method coupled to capillary electrophoresis to study 5alpha-reductase mRNA isozymes in rat ventral prostate in different androgen status. | 2003 | Mol. Cell. Biochem. | pmid:12962150 |
| Yoshida T et al. | Origin of oxysterols in hepatic bile of patients with biliary infection. | 2003 | Am. J. Gastroenterol. | pmid:14572579 |
| Wang GM et al. | Effects of insulin-like growth factor I on steroidogenic enzyme expression levels in mouse leydig cells. | 2003 | Endocrinology | pmid:12959969 |
| Wiebe JP and Lewis MJ | Activity and expression of progesterone metabolizing 5alpha-reductase, 20alpha-hydroxysteroid oxidoreductase and 3alpha(beta)-hydroxysteroid oxidoreductases in tumorigenic (MCF-7, MDA-MB-231, T-47D) and nontumorigenic (MCF-10A) human breast cancer cells. | 2003 | BMC Cancer | pmid:12659654 |
| Luo J et al. | Decreased gene expression of steroid 5 alpha-reductase 2 in human prostate cancer: implications for finasteride therapy of prostate carcinoma. | 2003 | Prostate | pmid:12949937 |
| Abbiati G et al. | Sequential amination/annulation/aromatization reaction of carbonyl compounds and propargylamine: a new one-pot approach to functionalized pyridines. | 2003 | J. Org. Chem. | pmid:12946136 |
| Bairamov AA and Sapronov NS | Effect of dehydroepiandrosterone on radioligand binding of [3H]-testosterone by androgen receptors in rat hypothalamus. | 2004 | Bull. Exp. Biol. Med. | pmid:15665952 |
| Finn DA et al. | The role of pregnane neurosteroids in ethanol withdrawal: behavioral genetic approaches. | 2004 | Pharmacol. Ther. | pmid:14761701 |
| Namazi MR | Further insight into the pathomechanism of acne by considering the 5-alpha-reductase inhibitory effect of linoleic acid. | 2004 | Int. J. Dermatol. | pmid:15357760 |
| Nguyen PN et al. | Increased allopregnanolone levels in the fetal sheep brain following umbilical cord occlusion. | 2004 | J. Physiol. (Lond.) | pmid:15331682 |
| Lee HH et al. | Theaflavin-3,3'-digallate and penta-O-galloyl-beta-D-glucose inhibit rat liver microsomal 5alpha-reductase activity and the expression of androgen receptor in LNCaP prostate cancer cells. | 2004 | Carcinogenesis | pmid:14963012 |
| Siler U et al. | Lycopene and vitamin E interfere with autocrine/paracrine loops in the Dunning prostate cancer model. | 2004 | FASEB J. | pmid:15084515 |
| Assinder SJ et al. | Regulation of 5alpha-reductase isoforms by oxytocin in the rat ventral prostate. | 2004 | Endocrinology | pmid:15358676 |
| Ahn KW and Sampson NS | Cholesterol oxidase senses subtle changes in lipid bilayer structure. | 2004 | Biochemistry | pmid:14730988 |
| Seo DW et al. | Oxysterols from human bile induce apoptosis of canine gallbladder epithelial cells in monolayer culture. | 2004 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:15246959 |
| Rontani JF and Aubert C | Electron ionization mass spectral fragmentation of derivatized 4,5- and 5,6-epoxysterols. | 2004 | Rapid Commun. Mass Spectrom. | pmid:15116422 |
| Chapple CR | Pharmacological therapy of benign prostatic hyperplasia/lower urinary tract symptoms: an overview for the practising clinician. | 2004 | BJU Int. | pmid:15329091 |
| McInnes KJ et al. | 5alpha-reduced glucocorticoids, novel endogenous activators of the glucocorticoid receptor. | 2004 | J. Biol. Chem. | pmid:15044432 |
| Frye CA et al. | Progesterone enhances motor, anxiolytic, analgesic, and antidepressive behavior of wild-type mice, but not those deficient in type 1 5 alpha-reductase. | 2004 | Brain Res. | pmid:15033426 |
| Dalla Valle L et al. | Expression of cytochrome P450c17 and other steroid-converting enzymes in the rat kidney throughout the life-span. | 2004 | J. Steroid Biochem. Mol. Biol. | pmid:15261307 |
| Clark RV et al. | Marked suppression of dihydrotestosterone in men with benign prostatic hyperplasia by dutasteride, a dual 5alpha-reductase inhibitor. | 2004 | J. Clin. Endocrinol. Metab. | pmid:15126539 |
| McVey MJ et al. | Altered testicular microsomal steroidogenic enzyme activities in rats with lifetime exposure to soy isoflavones. | 2004 | J. Steroid Biochem. Mol. Biol. | pmid:15698548 |
| Mathur S et al. | Evaluation of cell permeation of a potent 5alpha-reductase inhibitor using MALDI-TOF MS. | 2004 | J Enzyme Inhib Med Chem | pmid:15648657 |
| Palusinski R and Barud W | Proscar and propecia--a therapeutic perspective. | 2004 | J. Clin. Endocrinol. Metab. | pmid:15579805 |
| Aissaoui A et al. | Novel cationic lipids incorporating an acid-sensitive acylhydrazone linker: synthesis and transfection properties. | 2004 | J. Med. Chem. | pmid:15456264 |
| Zhu HJ and Sacchetti M | Solubilization and solid-state characterization of a poorly soluble 5-alpha reductase inhibitor. | 2004 | Drug Dev Ind Pharm | pmid:15285330 |
| Foley CL et al. | An update on the use of 5alpha-reductase inhibitors. | 2004 | Drugs Today | pmid:15148530 |
| Hernandez J et al. | The potential role of cyclooxygenase-2 inhibitors and 5alpha-reductase inhibitors in the prevention of urologic conditions. | 2004 | Urol. Clin. North Am. | pmid:15123401 |
| Libecco JF and Bergfeld WF | Finasteride in the treatment of alopecia. | 2004 | Expert Opin Pharmacother | pmid:15102575 |
| Marberger M et al. | Optimising the medical management of benign prostatic hyperplasia. | 2004 | Eur. Urol. | pmid:15041103 |
| Brown GA and Sussman DO | A current review of medical therapy for benign prostatic hyperplasia. | 2004 | J Am Osteopath Assoc | pmid:15038398 |
| Gonzales E et al. | SRD5B1 (AKR1D1) gene analysis in delta(4)-3-oxosteroid 5beta-reductase deficiency: evidence for primary genetic defect. | 2004 | J. Hepatol. | pmid:15030995 |
| Goodman PJ et al. | Implementation of the Prostate Cancer Prevention Trial (PCPT). | 2004 | Control Clin Trials | pmid:15020037 |
| Leyden J et al. | A systemic type I 5 alpha-reductase inhibitor is ineffective in the treatment of acne vulgaris. | 2004 | J. Am. Acad. Dermatol. | pmid:14988688 |
| Schmidt LJ et al. | Gene expression in prostate cancer cells treated with the dual 5 alpha-reductase inhibitor dutasteride. | 2004 Nov-Dec | J. Androl. | pmid:15477368 |
| Al-Mutair A et al. | Cytogenetics and etiology of ambiguous genitalia in 120 pediatric patients. | 2004 Sep-Oct | Ann Saudi Med | pmid:15573851 |
| Wakisaka N et al. | Effectiveness of finasteride on patients with male pattern baldness who have different androgen receptor gene polymorphism. | 2005 | J. Investig. Dermatol. Symp. Proc. | pmid:16382684 |
| Livingstone DE et al. | Increased A-ring reduction of glucocorticoids in obese Zucker rats: effects of insulin sensitization. | 2005 | Obes. Res. | pmid:16222053 |
| Matthiesson KL et al. | Novel male hormonal contraceptive combinations: the hormonal and spermatogenic effects of testosterone and levonorgestrel combined with a 5alpha-reductase inhibitor or gonadotropin-releasing hormone antagonist. | 2005 | J. Clin. Endocrinol. Metab. | pmid:15509637 |
| Sandhu JS and Vaughan ED | Combination therapy for the pharmacological management of benign prostatic hyperplasia: rationale and treatment options. | 2005 | Drugs Aging | pmid:16323969 |
| Barocas DA et al. | Five-alpha-reductase expression in benign and malignant urothelium: correlation with disease characteristics and outcome. | 2005 | Urology | pmid:16286153 |
| Andriole G et al. | The effects of 5alpha-reductase inhibitors on the natural history, detection and grading of prostate cancer: current state of knowledge. | 2005 | J. Urol. | pmid:16280736 |
| Ordyan NE and Pivina SG | Effects of prenatal stress on the activity of an enzyme involved in neurosteroid synthesis during the "critical period" of sexual differentiation of the brain in male rats. | 2005 | Neurosci. Behav. Physiol. | pmid:16270175 |
| Kiyokage E et al. | Localization of 5alpha-reductase in the rat main olfactory bulb. | 2005 | J. Comp. Neurol. | pmid:16261538 |
| Haeffner F et al. | Model studies of cholesterol and ascorbate oxidation by copper complexes: relevance to Alzheimer's disease beta-amyloid metallochemistry. | 2005 | J. Inorg. Biochem. | pmid:16271394 |
| Festuccia C et al. | Effects of 5 alpha reductase inhibitors on androgen-dependent human prostatic carcinoma cells. | 2005 | J. Cancer Res. Clin. Oncol. | pmid:15650886 |
4-Cholesten-3-one
4-Cholesten-3-one is a lipid of Sterol Lipids (ST) class. 4-cholesten-3-one is associated with abnormalities such as Dehydration, Xanthomatosis, Cerebrotendinous, Peripheral Neuropathy, L.mexicana and Xanthoma. The involved functions are known as CYP27A1activity, 25-hydroxycholesterol 7alpha-hydroxylase activity, Biochemical Pathway, Anabolism and Oxidation. 4-cholesten-3-one often locates in Mitochondria, Liver, Body tissue, Hepatic, Mitochondria and Endothelium of artery. The associated genes with 4-Cholesten-3-one are P4HTM gene, tryptones and Regulon. The related lipids are Cholestenones, 7-hydroxy-4-cholesten-3-one, cholest-4-en-3-one, 25-hydroxycholesterol and 24-hydroxycholesterol.
Cross Reference
Introduction
To understand associated biological information of 4-Cholesten-3-one, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with 4-Cholesten-3-one?
4-Cholesten-3-one is suspected in Dehydration, Xanthomatosis, Cerebrotendinous, Peripheral Neuropathy, L.mexicana, Xanthoma, Rare Diseases and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Biochem. J. (1)
- J. Biol. Chem. (1)
- J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. (1)
- Others (3)
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
No disease MeSH terms mapped to the current reference collection.
PubChem Associated disorders and diseases
What pathways are associated with 4-Cholesten-3-one
Lipid pathways are not clear in current pathway databases. We organized associated pathways with 4-Cholesten-3-one through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with 4-Cholesten-3-one?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
- J. Biol. Chem. (2)
- J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. (1)
- J. Lipid Res. (1)
- Others (2)
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with 4-Cholesten-3-one?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with 4-Cholesten-3-one?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with 4-Cholesten-3-one?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with 4-Cholesten-3-one?
There are no associated biomedical information in the current reference collection.