| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Ooi LG and Liong MT | Cholesterol-lowering effects of probiotics and prebiotics: a review of in vivo and in vitro findings. | 2010 | Int J Mol Sci | pmid:20640165 |
| Ismail SI and Mazen IA | A study of gender outcome of Egyptian patients with 46,XY disorder of sex development. | 2010 | Sex Dev | pmid:20664246 |
| Martin LJ | Olesoxime, a cholesterol-like neuroprotectant for the potential treatment of amyotrophic lateral sclerosis. | 2010 | IDrugs | pmid:20721828 |
| Wang X et al. | Establishment of a novel model for studying the effects of extracts of Chinese herb medicine on human type II 5alpha-reductase in vitro. | 2010 | Yakugaku Zasshi | pmid:20823678 |
| Johnston JB et al. | Functional redundancy of steroid C26-monooxygenase activity in Mycobacterium tuberculosis revealed by biochemical and genetic analyses. | 2010 | J. Biol. Chem. | pmid:20843794 |
| Driscoll MD et al. | Structural and biochemical characterization of Mycobacterium tuberculosis CYP142: evidence for multiple cholesterol 27-hydroxylase activities in a human pathogen. | 2010 | J. Biol. Chem. | pmid:20889498 |
| Edrees MM et al. | Antimicrobial, antitumor and 5α-reductase inhibitor activities of some hydrazonoyl substituted pyrimidinones. | 2010 | Eur J Med Chem | pmid:20933305 |
| Roth MY et al. | Steady-state pharmacokinetics of oral testosterone undecanoate with concomitant inhibition of 5α-reductase by finasteride. | 2011 | Int. J. Androl. | pmid:20969601 |
| Aloisi AM et al. | Aromatase and 5-alpha reductase gene expression: modulation by pain and morphine treatment in male rats. | 2010 | Mol Pain | pmid:20977699 |
| Lin AS et al. | Structure and biological evaluation of novel cytotoxic sterol glycosides from the marine red alga Peyssonnelia sp. | 2010 | Bioorg. Med. Chem. | pmid:21036050 |
| DuÅ¡ková M and PospÃÅ¡ilová H | The role of non-aromatizable testosterone metabolite in metabolic pathways. | 2011 | Physiol Res | pmid:21114370 |
| DeBarber AE et al. | Profiling sterols in cerebrotendinous xanthomatosis: utility of Girard derivatization and high resolution exact mass LC-ESI-MS(n) analysis. | 2011 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:21168372 |
| UhÃa I et al. | Initial step in the catabolism of cholesterol by Mycobacterium smegmatis mc2 155. | 2011 | Environ. Microbiol. | pmid:21208358 |
| Martin LJ et al. | The mitochondrial permeability transition pore regulates nitric oxide-mediated apoptosis of neurons induced by target deprivation. | 2011 | J. Neurosci. | pmid:21209222 |
| Finelli A et al. | Impact of 5α-reductase inhibitors on men followed by active surveillance for prostate cancer. | 2011 | Eur. Urol. | pmid:21211899 |
| Ho CK and Habib FK | Estrogen and androgen signaling in the pathogenesis of BPH. | 2011 | Nat Rev Urol | pmid:21228820 |
| Bortolato M et al. | Isolation rearing-induced reduction of brain 5α-reductase expression: relevance to dopaminergic impairments. | 2011 | Neuropharmacology | pmid:21256141 |
| Wu YG et al. | Testosterone, not 5α-dihydrotestosterone, stimulates LRH-1 leading to FSH-independent expression of Cyp19 and P450scc in granulosa cells. | 2011 | Mol. Endocrinol. | pmid:21273442 |
| Cha EK and Shariat SF | The use of 5α-reductase inhibitors for the prevention and treatment of prostate cancer. | 2011 | Eur. Urol. | pmid:21277077 |
| Sato K et al. | Increased muscular dehydroepiandrosterone levels are associated with improved hyperglycemia in obese rats. | 2011 | Am. J. Physiol. Endocrinol. Metab. | pmid:21285401 |
| Niu Y et al. | Reduced levels of 5-α reductase 2 in adult prostate tissue and implications for BPH therapy. | 2011 | Prostate | pmid:21308715 |
| Kang HJ et al. | The first successful paternity through in vitro fertilization-intracytoplasmic sperm injection with a man homozygous for the 5α-reductase-2 gene mutation. | 2011 | Fertil. Steril. | pmid:21334614 |
| Guardiola-Serrano F et al. | Palmitoylation of human FasL modulates its cell death-inducing function. | 2010 | Cell Death Dis | pmid:21368861 |
| Jusakul A et al. | Mechanisms of oxysterol-induced carcinogenesis. | 2011 | Lipids Health Dis | pmid:21388551 |
| Graupp M et al. | Association of genetic variants in the two isoforms of 5α-reductase, SRD5A1 and SRD5A2, in lean patients with polycystic ovary syndrome. | 2011 | Eur. J. Obstet. Gynecol. Reprod. Biol. | pmid:21530059 |
| Askarova S et al. | Impacts of membrane biophysics in Alzheimer's disease: from amyloid precursor protein processing to aβ Peptide-induced membrane changes. | 2011 | Int J Alzheimers Dis | pmid:21547213 |
| Nicholson TM and Ricke WA | Androgens and estrogens in benign prostatic hyperplasia: past, present and future. | 2011 Nov-Dec | Differentiation | pmid:21620560 |
| Aggarwal S et al. | QSAR studies on human 5alpha-reductase inhibitors: unsaturated 3-carboxysteroids. | 2011 May-Jun | Acta Pol Pharm | pmid:21648201 |
| Baudrand R et al. | Overexpression of hepatic 5α-reductase and 11β-hydroxysteroid dehydrogenase type 1 in visceral adipose tissue is associated with hyperinsulinemia in morbidly obese patients. | 2011 | Metab. Clin. Exp. | pmid:21704348 |
| Mohler JL et al. | Potential prostate cancer drug target: bioactivation of androstanediol by conversion to dihydrotestosterone. | 2011 | Clin. Cancer Res. | pmid:21705451 |
| Arellano Y et al. | New ester derivatives of dehydroepiandrosterone as 5α-reductase inhibitors. | 2011 | Steroids | pmid:21729714 |
| Lei H et al. | [Sterols of marine bryozoan Bugula neritina from the South China Sea]. | 2011 | Zhong Yao Cai | pmid:21823470 |
| de Almeida CL et al. | Bioactivities from marine algae of the genus Gracilaria. | 2011 | Int J Mol Sci | pmid:21845096 |
| Chen L et al. | [Active ingredients of Plastrum Testudinis inhibit epidermal stem cell apoptosis in serum-deprived culture]. | 2011 | Zhong Xi Yi Jie He Xue Bao | pmid:21849150 |
| Cai LQ et al. | 17α-Estradiol and genistein inhibit high fat diet induced prostate gene expression and prostate growth in the rat. | 2011 | J. Urol. | pmid:21855913 |
| Le Lay S et al. | Caveolin-1-mediated apolipoprotein A-I membrane binding sites are not required for cholesterol efflux. | 2011 | PLoS ONE | pmid:21858084 |
| Paris JJ et al. | Inhibition of 5α-reductase activity in late pregnancy decreases gestational length and fecundity and impairs object memory and central progestogen milieu of juvenile rat offspring. | 2011 | J. Neuroendocrinol. | pmid:21914008 |
| Sen S et al. | Restoration of IFNγR subunit assembly, IFNγ signaling and parasite clearance in Leishmania donovani infected macrophages: role of membrane cholesterol. | 2011 | PLoS Pathog. | pmid:21931549 |
| Griffin JE et al. | High-resolution phenotypic profiling defines genes essential for mycobacterial growth and cholesterol catabolism. | 2011 | PLoS Pathog. | pmid:21980284 |
| Yarrow JF et al. | Intracrine and myotrophic roles of 5α-reductase and androgens: a review. | 2012 | Med Sci Sports Exerc | pmid:21988936 |
| Marques MP et al. | Continuous steroid biotransformations in microchannel reactors. | 2012 | N Biotechnol | pmid:22008387 |
| Jusakul A et al. | Liver fluke-induced hepatic oxysterols stimulate DNA damage and apoptosis in cultured human cholangiocytes. | 2012 | Mutat. Res. | pmid:22044627 |
| Husain GM et al. | Hypolipidemic and Antiobesity-Like Activity of Standardised Extract of Hypericum perforatum L. in Rats. | 2011 | ISRN Pharmacol | pmid:22084716 |
| Djavan B et al. | Testosterone in prostate cancer: the Bethesda consensus. | 2012 | BJU Int. | pmid:22129242 |
| Joo SH et al. | Biosynthesis of a cholesterol-derived brassinosteroid, 28-norcastasterone, in Arabidopsis thaliana. | 2012 | J. Exp. Bot. | pmid:22170941 |
| Li J et al. | Androgen regulation of 5α-reductase isoenzymes in prostate cancer: implications for prostate cancer prevention. | 2011 | PLoS ONE | pmid:22194926 |
| Lange Y et al. | Activation mobilizes the cholesterol in the late endosomes-lysosomes of Niemann Pick type C cells. | 2012 | PLoS ONE | pmid:22276143 |
| Mieczkowska J et al. | Changes in the activity of connective tissue matrix enzymes in the metabolic syndrome. | 2011 | Arch Med Sci | pmid:22291799 |
| Magalon K et al. | Olesoxime accelerates myelination and promotes repair in models of demyelination. | 2012 | Ann. Neurol. | pmid:22367994 |
| Chen DM et al. | [The relationship of serum testosterone and its related index with the metabolism syndrome in women at perimenopausal or postmenopausal periods]. | 2012 | Zhonghua Fu Chan Ke Za Zhi | pmid:22455743 |
| Kasashima S et al. | Expression of 5α-reductase in apocrine carcinoma of the breast and its correlation with clinicopathological aggressiveness. | 2012 | Histopathology | pmid:22486281 |
| Wollam J et al. | A novel 3-hydroxysteroid dehydrogenase that regulates reproductive development and longevity. | 2012 | PLoS Biol. | pmid:22505847 |
| Kumar M et al. | Cholesterol-lowering probiotics as potential biotherapeutics for metabolic diseases. | 2012 | Exp Diabetes Res | pmid:22611376 |
| Martel C et al. | Inhibition of the Mitochondrial Permeability Transition for Cytoprotection: Direct versus Indirect Mechanisms. | 2012 | Biochem Res Int | pmid:22675634 |
| Muto A et al. | Detection of Δ4-3-oxo-steroid 5β-reductase deficiency by LC-ESI-MS/MS measurement of urinary bile acids. | 2012 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:22695323 |
| Biswas A et al. | Influence of pioglitazone on experimental heart failure and hyperlipidemia in rats. | 2012 | Indian J Pharmacol | pmid:22701242 |
| Pan L et al. | Sterols with antileishmanial activity isolated from the roots of Pentalinon andrieuxii. | 2012 | Phytochemistry | pmid:22840389 |
| Cieślak J et al. | Convenient and efficient approach to the permanent or reversible conjugation of RNA and DNA sequences with functional groups. | 2012 | Curr Protoc Nucleic Acid Chem | pmid:22956458 |
| Gupta Y et al. | Kinetic analysis of LDL oxidation in IHD and IHD risk subjects in Indian population. | 2003 | Indian J Clin Biochem | pmid:23105369 |
| GarcÃa-Fernández E et al. | A highly conserved mycobacterial cholesterol catabolic pathway. | 2013 | Environ. Microbiol. | pmid:23489718 |
| Benesch MG et al. | A DSC and FTIR spectroscopic study of the effects of the epimeric 4-cholesten-3-ols and 4-cholesten-3-one on the thermotropic phase behaviour and organization of dipalmitoylphosphatidylcholine bilayer membranes: comparison with their 5-cholesten analogues. | 2014 | Chem. Phys. Lipids | pmid:24296232 |
| Bouvaine S et al. | A dietary test of putative deleterious sterols for the aphid Myzus persicae. | 2014 | PLoS ONE | pmid:24465993 |
| Neuvonen M et al. | Enzymatic oxidation of cholesterol: properties and functional effects of cholestenone in cell membranes. | 2014 | PLoS ONE | pmid:25157633 |
| Walters JR et al. | The response of patients with bile acid diarrhoea to the farnesoid X receptor agonist obeticholic acid. | 2015 | Aliment. Pharmacol. Ther. | pmid:25329562 |
| Lin CW et al. | Substrate uptake and subcellular compartmentation of anoxic cholesterol catabolism in Sterolibacterium denitrificans. | 2015 | J. Biol. Chem. | pmid:25418128 |
| Chen M et al. | The rate-determining steps of aldo-keto reductases (AKRs), a study on human steroid 5β-reductase (AKR1D1). | 2015 | Chem. Biol. Interact. | pmid:25500266 |
| Wijnberg JB and de Groot A | Synthesis and 13C-NMR analysis of 5 alpha- and 5 beta-cholestane-3,6-dione. | 1989 | Steroids | pmid:2588307 |
| Chen L et al. | A new ent-kaurane diterpenoid from Ixora amplexicaulis. | 2016 | Nat. Prod. Res. | pmid:25941744 |
| Sugano S et al. | Sensitive assay of cytochrome P450scc activity by high-performance liquid chromatography. | 1989 | Anal. Biochem. | pmid:2610350 |
| Mouzaki M et al. | Bile Acids and Dysbiosis in Non-Alcoholic Fatty Liver Disease. | 2016 | PLoS ONE | pmid:27203081 |
| Chen CL et al. | Cholest-4-en-3-one attenuates TGF-β responsiveness by inducing TGF-β receptors degradation in Mv1Lu cells and colorectal adenocarcinoma cells. | 2017 | J. Recept. Signal Transduct. Res. | pmid:27401208 |
| Ma J et al. | 4-cholesten-3-one suppresses lung adenocarcinoma metastasis by regulating translocation of HMGB1, HIF1α and Caveolin-1. | 2016 | Cell Death Dis | pmid:27899819 |
| Donato LJ et al. | Description of analytical method and clinical utility of measuring serum 7-alpha-hydroxy-4-cholesten-3-one (7aC4) by mass spectrometry. | 2018 | Clin. Biochem. | pmid:29051033 |
| Ghosh S et al. | Cholesterol-oxidase-magnetic nanobioconjugates for the production of 4-cholesten-3-one and 4-cholesten-3, 7-dione. | 2018 | Bioresour. Technol. | pmid:29413944 |
| Batta AK et al. | Chromatographic separation of putative precursors of cholestanol. | 1988 Jul-Aug | Steroids | pmid:3247666 |
| Kaul HK et al. | Genotoxicity of two fecal steroids in murine colonic epithelium assessed by the sister chromatid exchange technique. | 1987 | Mutagenesis | pmid:3328036 |
| Yoshimoto T et al. | Polyethylene glycol derivative-modified cholesterol oxidase soluble and active in benzene. | 1987 | Biochem. Biophys. Res. Commun. | pmid:3479986 |
| Buchmann MS et al. | Metabolism of the cholestanol precursor cholesta-4,6-dien-3-one in different tissues. | 1987 | Biochim. Biophys. Acta | pmid:3676336 |
| Suzuki K et al. | Characterization of cytotoxic steroids in human faeces and their putative role in the etiology of human colonic cancer. | 1986 | Cancer Lett. | pmid:3802059 |
| Stokes NA and Hylemon PB | Characterization of delta 4-3-ketosteroid-5 beta-reductase and 3 beta-hydroxysteroid dehydrogenase in cell extracts of Clostridium innocuum. | 1985 | Biochim. Biophys. Acta | pmid:3861198 |
| Murphy PR et al. | Binding of oxygenated cholesterol metabolites to antiestrogen binding sites from chicken liver. | 1985 | Biochem. Biophys. Res. Commun. | pmid:3985957 |
| Schuster RE and Bennett RD | A direct low temperature 1H and 19F nuclear magnetic resonance study of boron trifluoride complexes with 4-cholesten-3-one, 1(5beta)-androstene-3,17-dione, 5beta-androstane-3,17-dione, and obacunone. | 1973 | J. Org. Chem. | pmid:4733449 |
| MotlÃk K and Stárka L | 4-Cholesten-3-one-induced lipoid hyperplasia of the adrenal cortex in rats. | 1983 | Acta Univ Carol Med (Praha) | pmid:6637679 |
| Nakagawa Y et al. | Transfer of steroids and alpha-tocopherol between liposomal membranes. | 1980 | J. Biochem. | pmid:6892636 |
| Trinder P | Oxidase determination of plasma cholesterol as cholest-4-en-3-one using iso-octane extraction. | 1981 | Ann. Clin. Biochem. | pmid:6942786 |
| Skrede S and Björkhem I | Biosynthesis of cholestanol from intestinal 7 alpha-hydroxy-4-cholesten-3-one. | 1982 | J. Biol. Chem. | pmid:7045120 |
| Gallo LL et al. | Enzymatic assay for cholesterol ester hydrolase activity. | 1978 | J. Lipid Res. | pmid:712250 |
| Aringer L | 7-Hydroxylation of 3-oxygenated C27-, C28-, and C29-steroids in rat liver 18,000 g supernate. | 1978 | J. Lipid Res. | pmid:731128 |
| Slotte JP | Direct observation of the action of cholesterol oxidase in monolayers. | 1995 | Biochim. Biophys. Acta | pmid:7488639 |
| Suzuki K | Anti-obesity effect of cholest-4-en-3-one, an intestinal catabolite of cholesterol, on mice. | 1993 | J. Nutr. Sci. Vitaminol. | pmid:8120678 |
| Slotte JP and Ostman AL | Oxidation/isomerization of 5-cholesten-3 beta-ol and 5-cholesten-3-one to 4-cholesten-3-one in pure sterol and mixed phospholipid-containing monolayers by cholesterol oxidase. | 1993 | Biochim. Biophys. Acta | pmid:8431456 |
| Molnár I et al. | Bacterial cholesterol oxidases are able to act as flavoprotein-linked ketosteroid monooxygenases that catalyse the hydroxylation of cholesterol to 4-cholesten-6-ol-3-one. | 1993 | Mol. Microbiol. | pmid:8459768 |
| Plemenitas A et al. | Identification of progesterone binding sites in the plasma membrane of the filamentous fungus Cochliobolus lunatus. | 1993 | J. Steroid Biochem. Mol. Biol. | pmid:8499335 |
| Bartram HP et al. | Effects of fish oil on fecal bacterial enzymes and steroid excretion in healthy volunteers: implications for colon cancer prevention. | 1996 | Nutr Cancer | pmid:8837863 |
| Smith AG and Brooks CJ | The mechanism of the isomerization of Cholest-5-en-3-one to cholest-4-en-3-one by cholesterol oxidase [proceedings]. | 1977 | Biochem. Soc. Trans. | pmid:913789 |
| Lin HS et al. | Synthesis of 4 alpha-(2-propenyl)-5,6-secocholestan-3 alpha-ol, a novel B-ring seco analog of the hypocholesterolemic agent 4 alpha-(2-propenyl)-5 alpha-cholestan-3 alpha-ol. | 1998 | Steroids | pmid:9589554 |
| Suzuki K et al. | The cholesterol metabolite cholest-4-en-3-one and its 3-oxo derivatives suppress body weight gain, body fat accumulation and serum lipid concentration in mice. | 1998 | Bioorg. Med. Chem. Lett. | pmid:9873500 |
4-Cholesten-3-one
4-Cholesten-3-one is a lipid of Sterol Lipids (ST) class. 4-cholesten-3-one is associated with abnormalities such as Dehydration, Xanthomatosis, Cerebrotendinous, Peripheral Neuropathy, L.mexicana and Xanthoma. The involved functions are known as CYP27A1activity, 25-hydroxycholesterol 7alpha-hydroxylase activity, Biochemical Pathway, Anabolism and Oxidation. 4-cholesten-3-one often locates in Mitochondria, Liver, Body tissue, Hepatic, Mitochondria and Endothelium of artery. The associated genes with 4-Cholesten-3-one are P4HTM gene, tryptones and Regulon. The related lipids are Cholestenones, 7-hydroxy-4-cholesten-3-one, cholest-4-en-3-one, 25-hydroxycholesterol and 24-hydroxycholesterol.
Cross Reference
Introduction
To understand associated biological information of 4-Cholesten-3-one, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with 4-Cholesten-3-one?
4-Cholesten-3-one is suspected in Dehydration, Xanthomatosis, Cerebrotendinous, Peripheral Neuropathy, L.mexicana, Xanthoma, Rare Diseases and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Biochem. J. (1)
- J. Biol. Chem. (1)
- J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. (1)
- Others (3)
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
No disease MeSH terms mapped to the current reference collection.
PubChem Associated disorders and diseases
What pathways are associated with 4-Cholesten-3-one
Lipid pathways are not clear in current pathway databases. We organized associated pathways with 4-Cholesten-3-one through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with 4-Cholesten-3-one?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
- J. Biol. Chem. (2)
- J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. (1)
- J. Lipid Res. (1)
- Others (2)
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with 4-Cholesten-3-one?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with 4-Cholesten-3-one?
Related references are published most in these journals:
- J. Biol. Chem. (2)
- J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. (1)
- J. Lipid Res. (1)
- Others (3)
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with 4-Cholesten-3-one?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with 4-Cholesten-3-one?
There are no associated biomedical information in the current reference collection.