4-Cholesten-3-one

4-Cholesten-3-one is a lipid of Sterol Lipids (ST) class. 4-cholesten-3-one is associated with abnormalities such as Dehydration, Xanthomatosis, Cerebrotendinous, Peripheral Neuropathy, L.mexicana and Xanthoma. The involved functions are known as CYP27A1activity, 25-hydroxycholesterol 7alpha-hydroxylase activity, Biochemical Pathway, Anabolism and Oxidation. 4-cholesten-3-one often locates in Mitochondria, Liver, Body tissue, Hepatic, Mitochondria and Endothelium of artery. The associated genes with 4-Cholesten-3-one are P4HTM gene, tryptones and Regulon. The related lipids are Cholestenones, 7-hydroxy-4-cholesten-3-one, cholest-4-en-3-one, 25-hydroxycholesterol and 24-hydroxycholesterol.

Cross Reference

Introduction

To understand associated biological information of 4-Cholesten-3-one, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with 4-Cholesten-3-one?

4-Cholesten-3-one is suspected in Dehydration, Xanthomatosis, Cerebrotendinous, Peripheral Neuropathy, L.mexicana, Xanthoma, Rare Diseases and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

No disease MeSH terms mapped to the current reference collection.

PubChem Associated disorders and diseases

What pathways are associated with 4-Cholesten-3-one

Lipid pathways are not clear in current pathway databases. We organized associated pathways with 4-Cholesten-3-one through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
Loading... please refresh the page if content is not showing up.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with 4-Cholesten-3-one?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with 4-Cholesten-3-one?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with 4-Cholesten-3-one?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with 4-Cholesten-3-one?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with 4-Cholesten-3-one?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with 4-Cholesten-3-one

Download all related citations
Per page 10 20 50 100 | Total 397
Authors Title Published Journal PubMed Link
Beattie ME et al. Sterol structure determines miscibility versus melting transitions in lipid vesicles. 2005 Biophys. J. pmid:15951379
Iranmanesh A and Veldhuis JD Combined inhibition of types I and II 5 alpha-reductase selectively augments the basal (nonpulsatile) mode of testosterone secretion in young men. 2005 J. Clin. Endocrinol. Metab. pmid:15811930
Bratoeff E et al. Recent advances in the chemistry and pharmacological activity of new steroidal antiandrogens and 5 alpha-reductase inhibitors. 2005 Curr. Med. Chem. pmid:15853706
Pérez-Ornelas V et al. New 5alpha-reductase inhibitors: in vitro and in vivo effects. 2005 Steroids pmid:15763601
Pucadyil TJ et al. Membrane cholesterol oxidation inhibits ligand binding function of hippocampal serotonin(1A) receptors. 2005 Biochem. Biophys. Res. Commun. pmid:15850776
Borst SE et al. Inhibition of 5alpha-reductase blocks prostate effects of testosterone without blocking anabolic effects. 2005 Am. J. Physiol. Endocrinol. Metab. pmid:15367394
Hammer F et al. Sex steroid metabolism in human peripheral blood mononuclear cells changes with aging. 2005 J. Clin. Endocrinol. Metab. pmid:16091484
Wakisaka N et al. Effectiveness of finasteride on patients with male pattern baldness who have different androgen receptor gene polymorphism. 2005 J. Investig. Dermatol. Symp. Proc. pmid:16382684
Livingstone DE et al. Increased A-ring reduction of glucocorticoids in obese Zucker rats: effects of insulin sensitization. 2005 Obes. Res. pmid:16222053
Caldinelli L et al. Dissecting the structural determinants of the stability of cholesterol oxidase containing covalently bound flavin. 2005 J. Biol. Chem. pmid:15817448
Evans CP et al. An evidence-based approach to understanding the pharmacological class effect in the management of prostatic diseases. 2005 BJU Int. pmid:15794775
Wiebe JP et al. The role of progesterone metabolites in breast cancer: potential for new diagnostics and therapeutics. 2005 J. Steroid Biochem. Mol. Biol. pmid:15860263
Panter BU et al. 5alpha-reductase in human embryonic kidney cell line HEK293: evidence for type II enzyme expression and activity. 2005 Mol. Cell. Biochem. pmid:15792368
Puglielli L et al. Alzheimer disease beta-amyloid activity mimics cholesterol oxidase. 2005 J. Clin. Invest. pmid:16127459
Sandhu JS and Vaughan ED Combination therapy for the pharmacological management of benign prostatic hyperplasia: rationale and treatment options. 2005 Drugs Aging pmid:16323969
Fujita R et al. Anti-androgenic activities of Ganoderma lucidum. 2005 J Ethnopharmacol pmid:16029938
Rosati F et al. 5alpha-Reductase activity in Lycopersicon esculentum: cloning and functional characterization of LeDET2 and evidence of the presence of two isoenzymes. 2005 J. Steroid Biochem. Mol. Biol. pmid:15993049
Gorin RE et al. Effects of finasteride on chronic and acute ethanol withdrawal severity in the WSP and WSR selected lines. 2005 Alcohol. Clin. Exp. Res. pmid:15976519
Monte MJ et al. Transient changes in the expression pattern of key enzymes for bile acid synthesis during rat liver regeneration. 2005 Biochim. Biophys. Acta pmid:15904869
Vallarino M et al. Ontogeny of 3 beta-hydroxysteroid dehydrogenase and 5 alpha-reductase in the frog brain. 2005 Ann. N. Y. Acad. Sci. pmid:15891098
Rho SS et al. The hair growth promoting effect of Asiasari radix extract and its molecular regulation. 2005 J. Dermatol. Sci. pmid:15862941
Luu-The V et al. Quantitative appreciation of steroidogenic gene expression in mouse tissues: new roles for type 2 5alpha-reductase, 20alpha-hydroxysteroid dehydrogenase and estrogen sulfotransferase. 2005 J. Steroid Biochem. Mol. Biol. pmid:15860270
Monte MJ et al. Changes in the expression of genes related to bile acid synthesis and transport by the rat liver during hepatocarcinogenesis. 2005 Clin. Sci. pmid:15853769
Souverein PC et al. Treatment of benign prostatic hyperplasia and occurrence of prostatic surgery and acute urinary retention: a population-based cohort study in the Netherlands. 2005 Eur. Urol. pmid:15774250
Papanikolaou A et al. Cholesterol-dependent lipid assemblies regulate the activity of the ecto-nucleotidase CD39. 2005 J. Biol. Chem. pmid:15890655
Guzmán DC et al. Effect of testosterone and steroids homologues on indolamines and lipid peroxidation in rat brain. 2005 J. Steroid Biochem. Mol. Biol. pmid:15857756
Cabeza M et al. New progesterone derivatives as inhibitors of 5alpha-reductase enzyme and prostate cancer cell growth. 2006 J Enzyme Inhib Med Chem pmid:17059168
Stine KJ et al. Interaction of the glycoalkaloid tomatine with DMPC and sterol monolayers studied by surface pressure measurements and Brewster angle microscopy. 2006 J Phys Chem B pmid:17078662
Gilliver SC et al. Androgens modulate the inflammatory response during acute wound healing. 2006 J. Cell. Sci. pmid:16449322
Huang YF et al. One new anthraquinone from marine Streptomyces sp. FX-58. 2006 Nat. Prod. Res. pmid:17127510
Woollett LA et al. Micellar solubilisation of cholesterol is essential for absorption in humans. 2006 Gut pmid:16407385
Rebolj K et al. Steroid structural requirements for interaction of ostreolysin, a lipid-raft binding cytolysin, with lipid monolayers and bilayers. 2006 Biochim. Biophys. Acta pmid:16857161
Rojo L et al. Roles of cholesterol and lipids in the etiopathogenesis of Alzheimer's disease. 2006 J. Biomed. Biotechnol. pmid:17047312
Motola DL et al. Identification of ligands for DAF-12 that govern dauer formation and reproduction in C. elegans. 2006 Cell pmid:16529801
Lim L et al. Structural and kinetic analyses of the H121A mutant of cholesterol oxidase. 2006 Biochem. J. pmid:16856877
Finn DA et al. A new look at the 5alpha-reductase inhibitor finasteride. 2006 CNS Drug Rev pmid:16834758
Zhu YS and Cai LQ Effects of male sex hormones on gender identity, sexual behavior, and cognitive function. 2006 Zhong Nan Da Xue Xue Bao Yi Xue Ban pmid:16706106
Maria McCrohan A et al. Effects of the dual 5 alpha-reductase inhibitor dutasteride on apoptosis in primary cultures of prostate cancer epithelial cells and cell lines. 2006 Cancer pmid:16703599
Rouquette-Jazdanian AK et al. Revaluation of the role of cholesterol in stabilizing rafts implicated in T cell receptor signaling. 2006 Cell. Signal. pmid:15925486
Liu J et al. 5alpha-reductase inhibitory effect of triterpenoids isolated from Ganoderma lucidum. 2006 Biol. Pharm. Bull. pmid:16462054
Robaire B and Henderson NA Actions of 5alpha-reductase inhibitors on the epididymis. 2006 Mol. Cell. Endocrinol. pmid:16476520
Naslund MJ et al. Managing enlarged prostate in primary care. 2006 Int. J. Clin. Pract. pmid:17109668
Kim CI et al. Long-term results of medical treatment in benign prostatic hyperplasia. 2006 Urology pmid:17095071
Hall MC The effect of oxysterols, individually and as a representative mixture from food, on in vitro cultured bovine ovarian granulosa cells. 2006 Mol. Cell. Biochem. pmid:16983501
Norg RJ et al. A decision aid for GPs for the treatment of elderly male patients with lower urinary tract symptoms (LUTS). 2006 Fam Pract pmid:16971394
Ekinci S et al. Sigmoid colon vaginoplasty in children. 2006 Eur J Pediatr Surg pmid:16909357
Stottrup BL and Keller SL Phase behavior of lipid monolayers containing DPPC and cholesterol analogs. 2006 Biophys. J. pmid:16461392
Fox SA et al. Identifying putative contraceptive targets by dissecting signal transduction networks in the epididymis using an in vivo electroporation (electrotransfer) approach. 2006 Mol. Cell. Endocrinol. pmid:16423449
Luchetti S et al. Comparative non-radioactive RT-PCR assay: an approach to study the neurosteroids biosynthetic pathway in humans. 2006 J. Neurosci. Methods pmid:16378642
Paris F et al. Increased serum estrogenic bioactivity in three male newborns with ambiguous genitalia: a potential consequence of prenatal exposure to environmental endocrine disruptors. 2006 Environ. Res. pmid:16274687