DESMOSTEROL is a lipid of Sterol Lipids (ST) class. Desmosterol is associated with abnormalities such as Cataract, Congenital Abnormality, Liver diseases, Erectile dysfunction and Multiple congenital anomalies. The involved functions are known as Bulla, Methylation, cholesterol biosynthetic process, Process and cholesterol efflux. Desmosterol often locates in Body tissue, Tissue membrane, Plasma membrane, Pore and Endoplasmic Reticulum. The associated genes with DESMOSTEROL are P4HTM gene, SHH gene, WDR48 gene, CFLAR gene and SLC33A1 gene. The related lipids are Sterols, androstanol, Steroids, Unilamellar Vesicles and 7-dehydrocholesterol. The related experimental models are Transgenic Model and Rodent Model.
To understand associated biological information of DESMOSTEROL, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
DESMOSTEROL is suspected in Atherosclerosis, Congenital Abnormality, Liver diseases, Fatty Streak, Arterial, Senile Plaques, Coronary Arteriosclerosis and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with DESMOSTEROL
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Limb Deformities, Congenital | D017880 | 4 associated lipids |
| Celiac Disease | D002446 | 16 associated lipids |
| Xanthomatosis | D014973 | 17 associated lipids |
| Coronary Disease | D003327 | 70 associated lipids |
| Insulin Resistance | D007333 | 99 associated lipids |
| Hemolysis | D006461 | 131 associated lipids |
Lipid pathways are not clear in current pathway databases. We organized associated pathways with DESMOSTEROL through full-text articles, including metabolic pathways or pathways of biological mechanisms.
| Pathway name | Related literatures |
|---|
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
|---|
Transgenic Model are used in the study 'Cellular production of n-3 PUFAs and reduction of n-6-to-n-3 ratios in the pancreatic beta-cells and islets enhance insulin secretion and confer protection against cytokine-induced cell death.' (Wei D et al., 2010).
Rodent Model are used in the study 'Oxidation of 7-dehydrocholesterol and desmosterol by human cytochrome P450 46A1.' (Goyal S et al., 2014).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Parks LW et al. | Sterol transmethylation during aerobic adaptation of yeast. | 1974 | Eur. J. Biochem. | pmid:4598750 |
| Watson KC and Kerr EJ | Sterol structural requirements for inhibition of streptolysin O activity. | 1974 | Biochem. J. | pmid:4451554 |
| Fumagalli R et al. | [Desmosterol test in the diagnosis of recurrent brain neoplasms]. | 1973 May-Jun | Acta Neurol (Napoli) | pmid:4732487 |
| Imai Y and Shimamoto K | Biological studies of AT-308. 1. Hypocholesterolemic effect of 1,2,4-oxadiazole derivatives in rats. | 1973 Jan-Feb | Atherosclerosis | pmid:4696738 |
| Fiehn W et al. | ATPases of erythrocytes from rats with 20, 25-diazacholesterol induced myotonia. | 1973 | FEBS Lett. | pmid:4270614 |
| Bojesen I and Roepstorff P | Identification of C sterols produced by rat renal inner medulla in vitro. | 1973 | Biochim. Biophys. Acta | pmid:4722467 |
| Dennick RG et al. | Desmosterol levels in human foetal brain--a reassessment. | 1973 | J. Neurochem. | pmid:4697890 |
| Ener MA and Frantz ID | Chemical synthesis of delta 7,24-(3alpha-3H)cholestadien-3beta-ol and its conversion to cholesterol in the rat. | 1973 | J. Biol. Chem. | pmid:4355504 |
| Norton WT and Poduslo SE | Myelination in rat brain: changes in myelin composition during brain maturation. | 1973 | J. Neurochem. | pmid:4754856 |
| Collignon-Thiennot F et al. | [Demonstration of 2 pathways for cholesterol synthesis in the mollusk: patella Patella vulgata L., (Gasteropoda, Prosobranches, Archeogasteropoda)]. | 1973 | Biochimie | pmid:4754188 |