DESMOSTEROL is a lipid of Sterol Lipids (ST) class. Desmosterol is associated with abnormalities such as Cataract, Congenital Abnormality, Liver diseases, Erectile dysfunction and Multiple congenital anomalies. The involved functions are known as Bulla, Methylation, cholesterol biosynthetic process, Process and cholesterol efflux. Desmosterol often locates in Body tissue, Tissue membrane, Plasma membrane, Pore and Endoplasmic Reticulum. The associated genes with DESMOSTEROL are P4HTM gene, SHH gene, WDR48 gene, CFLAR gene and SLC33A1 gene. The related lipids are Sterols, androstanol, Steroids, Unilamellar Vesicles and 7-dehydrocholesterol. The related experimental models are Transgenic Model and Rodent Model.
To understand associated biological information of DESMOSTEROL, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
DESMOSTEROL is suspected in Atherosclerosis, Congenital Abnormality, Liver diseases, Fatty Streak, Arterial, Senile Plaques, Coronary Arteriosclerosis and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with DESMOSTEROL
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Limb Deformities, Congenital | D017880 | 4 associated lipids |
| Celiac Disease | D002446 | 16 associated lipids |
| Xanthomatosis | D014973 | 17 associated lipids |
| Coronary Disease | D003327 | 70 associated lipids |
| Insulin Resistance | D007333 | 99 associated lipids |
| Hemolysis | D006461 | 131 associated lipids |
Lipid pathways are not clear in current pathway databases. We organized associated pathways with DESMOSTEROL through full-text articles, including metabolic pathways or pathways of biological mechanisms.
| Pathway name | Related literatures |
|---|
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
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Transgenic Model are used in the study 'Cellular production of n-3 PUFAs and reduction of n-6-to-n-3 ratios in the pancreatic beta-cells and islets enhance insulin secretion and confer protection against cytokine-induced cell death.' (Wei D et al., 2010).
Rodent Model are used in the study 'Oxidation of 7-dehydrocholesterol and desmosterol by human cytochrome P450 46A1.' (Goyal S et al., 2014).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Sokoloff L and Rothblat GH | Regulation of sterol synthesis in L cells: steady-state and transitional responses. | 1972 | Biochim. Biophys. Acta | pmid:5070653 |
| Siperstein MD | The relationship of cholesterol biosynthesis to cancer. | 1972 | Trans. Am. Clin. Climatol. Assoc. | pmid:4340647 |
| Shah SN | Effect of neonatal food restriction and hyperphenylalaninemia on desmosterol to cholesterol (D-C) ratio in developing rat brain. | 1972 | Lipids | pmid:5084158 |
| Wakamatsu H et al. | Concentration and fatty acid composition of serum lipids in myotonia dystrophica. With special reference to pathogenesis. | 1972 | Horm. Metab. Res. | pmid:4655500 |
| Grossi-Paoletti E et al. | Tumors of the nervous system induced by ethylnitrosourea administered either intracerebrally of subcutaneously to newborn rats. Morphological and biochemical characteristics. | 1972 | J. Neurosurg. | pmid:5076376 |
| Ikan R et al. | Synthesis of steroidal cyclopropanes. | 1972 | J. Chem. Soc. Perkin Trans. I | pmid:4674538 |
| Leboeuf M et al. | [Steroid alkaloids. 138(12). Chemical composition of the fruits and grains of Holarrhena mitis R. Br. (Apocynacea): alkaloids and unsaponifiable material]. | 1972 | Ann Pharm Fr | pmid:4668289 |
| Svoboda JA and Thompson MJ | Separation of 24- and 25-dehydrocholesterols; and the impure state of commercial desmosterol preparations. | 1967 | J. Lipid Res. | pmid:14564725 |
| CHOBANIAN AV and HOLLANDER W | TISSUE DISTRIBUTION OF CHOLESTEROL AND 24-DEHYDROCHOLESTEROL DURING CHRONIC TRIPARANOL THERAPY. | 1965 | J. Lipid Res. | pmid:14280470 |
| WHITBY LG et al. | THE ESTIMATION OF DESMOSTEROL AND CHOLESTEROL IN PLASMA. | 1964 | Br Heart J | pmid:14132032 |