DESMOSTEROL

DESMOSTEROL is a lipid of Sterol Lipids (ST) class. Desmosterol is associated with abnormalities such as Cataract, Congenital Abnormality, Liver diseases, Erectile dysfunction and Multiple congenital anomalies. The involved functions are known as Bulla, Methylation, cholesterol biosynthetic process, Process and cholesterol efflux. Desmosterol often locates in Body tissue, Tissue membrane, Plasma membrane, Pore and Endoplasmic Reticulum. The associated genes with DESMOSTEROL are P4HTM gene, SHH gene, WDR48 gene, CFLAR gene and SLC33A1 gene. The related lipids are Sterols, androstanol, Steroids, Unilamellar Vesicles and 7-dehydrocholesterol. The related experimental models are Transgenic Model and Rodent Model.

Cross Reference

Introduction

To understand associated biological information of DESMOSTEROL, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with DESMOSTEROL?

DESMOSTEROL is suspected in Atherosclerosis, Congenital Abnormality, Liver diseases, Fatty Streak, Arterial, Senile Plaques, Coronary Arteriosclerosis and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with DESMOSTEROL

MeSH term MeSH ID Detail
Celiac Disease D002446 16 associated lipids
Coronary Disease D003327 70 associated lipids
Hemolysis D006461 131 associated lipids
Insulin Resistance D007333 99 associated lipids
Xanthomatosis D014973 17 associated lipids
Limb Deformities, Congenital D017880 4 associated lipids
Total 6

PubChem Associated disorders and diseases

What pathways are associated with DESMOSTEROL

Lipid pathways are not clear in current pathway databases. We organized associated pathways with DESMOSTEROL through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
Loading... please refresh the page if content is not showing up.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with DESMOSTEROL?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with DESMOSTEROL?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with DESMOSTEROL?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with DESMOSTEROL?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with DESMOSTEROL?

Transgenic Model

Transgenic Model are used in the study 'Cellular production of n-3 PUFAs and reduction of n-6-to-n-3 ratios in the pancreatic beta-cells and islets enhance insulin secretion and confer protection against cytokine-induced cell death.' (Wei D et al., 2010).

Rodent Model

Rodent Model are used in the study 'Oxidation of 7-dehydrocholesterol and desmosterol by human cytochrome P450 46A1.' (Goyal S et al., 2014).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

NCBI Entrez Crosslinks

All references with DESMOSTEROL

Download all related citations
Per page 10 20 50 100 | Total 433
Authors Title Published Journal PubMed Link
Furtula V et al. Inorganic nitrogen, sterols and bacterial source tracking as tools to characterize water quality and possible contamination sources in surface water. 2012 Water Res. pmid:22197263
Weeks AC et al. Identification and potency of cyclodextrin-lipid inhibitors of Staphylococcus aureus α-toxin. 2012 Curr. Eye Res. pmid:22050601
Feio CA et al. Euterpe oleracea (açai) modifies sterol metabolism and attenuates experimentally-induced atherosclerosis. 2012 J. Atheroscler. Thromb. pmid:22139433
Zerenturk EJ et al. The endogenous regulator 24(S),25-epoxycholesterol inhibits cholesterol synthesis at DHCR24 (Seladin-1). 2012 Biochim. Biophys. Acta pmid:22178193
Swaminathan S et al. Amyloid pathway-based candidate gene analysis of [(11)C]PiB-PET in the Alzheimer's Disease Neuroimaging Initiative (ADNI) cohort. 2012 Brain Imaging Behav pmid:21901424
Sato Y et al. Identification of a new plasma biomarker of Alzheimer's disease using metabolomics technology. 2012 J. Lipid Res. pmid:22203775
Rodgers MA et al. Lipid metabolite profiling identifies desmosterol metabolism as a new antiviral target for hepatitis C virus. 2012 J. Am. Chem. Soc. pmid:22480142
Bogan RL et al. Liver x receptor modulation of gene expression leading to proluteolytic effects in primate luteal cells. 2012 Biol. Reprod. pmid:22156476
Min HK et al. Increased hepatic synthesis and dysregulation of cholesterol metabolism is associated with the severity of nonalcoholic fatty liver disease. 2012 Cell Metab. pmid:22560219
Lim L et al. Lanosterol induces mitochondrial uncoupling and protects dopaminergic neurons from cell death in a model for Parkinson's disease. 2012 Cell Death Differ. pmid:21818119
Yoder CA et al. Feeding of grey squirrels (Sciurus carolinensis) with the contraceptive agent DiazaConâ„¢: effect on cholesterol, hematology, and blood chemistry. 2011 Integr Zool pmid:22182332
Igarashi F et al. A highly specific and sensitive quantification analysis of the sterols in silkworm larvae by high performance liquid chromatography-atmospheric pressure chemical ionization-tandem mass spectrometry. 2011 Anal. Biochem. pmid:21925474
Nunes VS et al. HDL-C concentration is related to markers of absorption and of cholesterol synthesis: Study in subjects with low vs. high HDL-C. 2011 Clin. Chim. Acta pmid:20932966
Nes WD Biosynthesis of cholesterol and other sterols. 2011 Chem. Rev. pmid:21902244
Wang L et al. Genome characterization of the oleaginous fungus Mortierella alpina. 2011 PLoS ONE pmid:22174787
Simonen P et al. Cholesterol synthesis is increased and absorption decreased in non-alcoholic fatty liver disease independent of obesity. 2011 J. Hepatol. pmid:20947198
Singh P et al. Desmosterol replaces cholesterol for ligand binding function of the serotonin(1A) receptor in solubilized hippocampal membranes: support for nonannular binding sites for cholesterol? 2011 Biochim. Biophys. Acta pmid:21763272
Hong C et al. Constitutive activation of LXR in macrophages regulates metabolic and inflammatory gene expression: identification of ARL7 as a direct target. 2011 J. Lipid Res. pmid:21187453
de Almeida CL et al. Bioactivities from marine algae of the genus Gracilaria. 2011 Int J Mol Sci pmid:21845096
Stottmann RW et al. Cholesterol metabolism is required for intracellular hedgehog signal transduction in vivo. 2011 PLoS Genet. pmid:21912524
Pfeifer T et al. Synthetic LXR agonist suppresses endogenous cholesterol biosynthesis and efficiently lowers plasma cholesterol. 2011 Curr Pharm Biotechnol pmid:21190543
Steinberg D Chance and serendipity in science: two examples from my own career. 2011 J. Biol. Chem. pmid:21908608
Saraiva D et al. Selection of the derivatization reagent--the case of human blood cholesterol, its precursors and phytosterols GC-MS analyses. 2011 J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. pmid:22088355
Vanmierlo T et al. Cerebral accumulation of dietary derivable plant sterols does not interfere with memory and anxiety related behavior in Abcg5-/- mice. 2011 Plant Foods Hum Nutr pmid:21431910
Schaaf CP et al. Desmosterolosis-phenotypic and molecular characterization of a third case and review of the literature. 2011 Am. J. Med. Genet. A pmid:21671375
Zolotushko J et al. The desmosterolosis phenotype: spasticity, microcephaly and micrognathia with agenesis of corpus callosum and loss of white matter. 2011 Eur. J. Hum. Genet. pmid:21559050
Hoenig MR et al. Low density lipoprotein cholesterol is inversely correlated with abdominal visceral fat area: a magnetic resonance imaging study. 2011 Lipids Health Dis pmid:21247428
Ramos SC et al. The role of soluble fiber intake in patients under highly effective lipid-lowering therapy. 2011 Nutr J pmid:21810257
Christophersen OA and Haug A Animal products, diseases and drugs: a plea for better integration between agricultural sciences, human nutrition and human pharmacology. 2011 Lipids Health Dis pmid:21247506
Hajar R Statins: past and present. 2011 Heart Views pmid:22567201
Ciufo LF et al. Characterisation of a desmosterol reductase involved in phytosterol dealkylation in the silkworm, Bombyx mori. 2011 PLoS ONE pmid:21738635
Lin HY et al. Molecular basis for certain neuroprotective effects of thyroid hormone. 2011 Front Mol Neurosci pmid:22016721
Orsi M and Essex JW The ELBA force field for coarse-grain modeling of lipid membranes. 2011 PLoS ONE pmid:22194874
Nasir M et al. Sterols from the red algae, Gracilaria salicornia and Hypnea flagelliformis, from Persian Gulf. 2011 Pharmacogn Mag pmid:21716930
Sauer SW et al. Severe dysfunction of respiratory chain and cholesterol metabolism in Atp7b(-/-) mice as a model for Wilson disease. 2011 Biochim. Biophys. Acta pmid:21920437
Elias PM et al. Pathogenesis of the cutaneous phenotype in inherited disorders of cholesterol metabolism: Therapeutic implications for topical treatment of these disorders. 2011 Dermatoendocrinol pmid:21695019
Nagata S and Nagasawa H Sterol composition in larvae of the silkworm, Bombyx mori. 2011 Biosci. Biotechnol. Biochem. pmid:21597175
Wolff E et al. Cholesterol absorption status and fasting plasma cholesterol are modulated by the microsomal triacylglycerol transfer protein -493 G/T polymorphism and the usual diet in women. 2011 Genes Nutr pmid:21437032
Cheng D et al. Lipid pathway alterations in Parkinson's disease primary visual cortex. 2011 PLoS ONE pmid:21387008
Peri A et al. Membrane cholesterol as a mediator of the neuroprotective effects of estrogens. 2011 Neuroscience pmid:21396986
Niesor EJ et al. Effect of dalcetrapib, a CETP modulator, on non-cholesterol sterol markers of cholesterol homeostasis in healthy subjects. 2011 Atherosclerosis pmid:21982411
Soh J et al. Hepatic gene expression profiles are altered by dietary unsalted korean fermented soybean (chongkukjang) consumption in mice with diet-induced obesity. 2011 J Nutr Metab pmid:21437188
Kaddurah-Daouk R et al. Enteric microbiome metabolites correlate with response to simvastatin treatment. 2011 PLoS ONE pmid:22022402
Pihlajamäki J et al. Cholesterol absorption decreases after Roux-en-Y gastric bypass but not after gastric banding. 2010 Metab. Clin. Exp. pmid:20015521
Zalata A et al. Cholesterol and desmosterol in two sperm populations separated on Sil-Select gradient. 2010 Int. J. Androl. pmid:19490187
Moraes EA et al. Delivering cholesterol or cholestanol to bull sperm membranes improves cryosurvival. 2010 Anim. Reprod. Sci. pmid:19733986
Strandberg TE et al. Serum plant and other noncholesterol sterols, cholesterol metabolism and 22-year mortality among middle-aged men. 2010 Atherosclerosis pmid:19962145
Aknin M et al. Sterols from the Madagascar sponge Fascaplysinopsis sp. 2010 Mar Drugs pmid:21339959
Sheriff DS and Ali EF Perspective on plasma membrane cholesterol efflux and spermatozoal function. 2010 J Hum Reprod Sci pmid:21209749
Nissinen MJ et al. Applicability of non-cholesterol sterols in predicting response in cholesterol metabolism to simvastatin and fluvastatin treatment among hypercholesterolemic men. 2010 Nutr Metab Cardiovasc Dis pmid:19695854