DESMOSTEROL is a lipid of Sterol Lipids (ST) class. Desmosterol is associated with abnormalities such as Cataract, Congenital Abnormality, Liver diseases, Erectile dysfunction and Multiple congenital anomalies. The involved functions are known as Bulla, Methylation, cholesterol biosynthetic process, Process and cholesterol efflux. Desmosterol often locates in Body tissue, Tissue membrane, Plasma membrane, Pore and Endoplasmic Reticulum. The associated genes with DESMOSTEROL are P4HTM gene, SHH gene, WDR48 gene, CFLAR gene and SLC33A1 gene. The related lipids are Sterols, androstanol, Steroids, Unilamellar Vesicles and 7-dehydrocholesterol. The related experimental models are Transgenic Model and Rodent Model.
To understand associated biological information of DESMOSTEROL, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
DESMOSTEROL is suspected in Atherosclerosis, Congenital Abnormality, Liver diseases, Fatty Streak, Arterial, Senile Plaques, Coronary Arteriosclerosis and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with DESMOSTEROL
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Celiac Disease | D002446 | 16 associated lipids |
| Coronary Disease | D003327 | 70 associated lipids |
| Hemolysis | D006461 | 131 associated lipids |
| Insulin Resistance | D007333 | 99 associated lipids |
| Xanthomatosis | D014973 | 17 associated lipids |
| Limb Deformities, Congenital | D017880 | 4 associated lipids |
Lipid pathways are not clear in current pathway databases. We organized associated pathways with DESMOSTEROL through full-text articles, including metabolic pathways or pathways of biological mechanisms.
| Pathway name | Related literatures |
|---|
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
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Transgenic Model are used in the study 'Cellular production of n-3 PUFAs and reduction of n-6-to-n-3 ratios in the pancreatic beta-cells and islets enhance insulin secretion and confer protection against cytokine-induced cell death.' (Wei D et al., 2010).
Rodent Model are used in the study 'Oxidation of 7-dehydrocholesterol and desmosterol by human cytochrome P450 46A1.' (Goyal S et al., 2014).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Miettinen TA et al. | Noncholesterol sterols and cholesterol lowering by long-term simvastatin treatment in coronary patients: relation to basal serum cholestanol. | 2000 | Arterioscler. Thromb. Vasc. Biol. | pmid:10807752 |
| Mourvaki E et al. | Desmosterol, the main sterol in rabbit semen: distribution among semen subfractions and its role in the in vitro spermatozoa acrosome reaction and motility. | 2010 | Asian J. Androl. | pmid:20729867 |
| Hallikainen M et al. | Endothelial function in hypercholesterolemic subjects: Effects of plant stanol and sterol esters. | 2006 | Atherosclerosis | pmid:16386259 |
| Arnold A et al. | Triparanol-induced desmoterol accumulation in clofibrate-effected hypocholesterolemia. | 1974 Sep-Oct | Atherosclerosis | pmid:4416741 |
| Bhattacharyya AK and Eggen DA | Relationships between dietary cholesterol, cholesterol absorption, cholesterol synthesis, and plasma cholesterol in rhesus monkeys. | 1987 | Atherosclerosis | pmid:3675704 |
| Miettinen TA and Gylling H | Ineffective decrease of serum cholesterol by simvastatin in a subgroup of hypercholesterolemic coronary patients. | 2002 | Atherosclerosis | pmid:12119203 |
| Strandberg TE et al. | Serum plant and other noncholesterol sterols, cholesterol metabolism and 22-year mortality among middle-aged men. | 2010 | Atherosclerosis | pmid:19962145 |
| Fassbender K et al. | Moderately elevated plant sterol levels are associated with reduced cardiovascular risk--the LASA study. | 2008 | Atherosclerosis | pmid:17137582 |
| Niesor EJ et al. | Effect of dalcetrapib, a CETP modulator, on non-cholesterol sterol markers of cholesterol homeostasis in healthy subjects. | 2011 | Atherosclerosis | pmid:21982411 |
| Imai Y and Shimamoto K | Biological studies of AT-308. 1. Hypocholesterolemic effect of 1,2,4-oxadiazole derivatives in rats. | 1973 Jan-Feb | Atherosclerosis | pmid:4696738 |