DESMOSTEROL is a lipid of Sterol Lipids (ST) class. Desmosterol is associated with abnormalities such as Cataract, Congenital Abnormality, Liver diseases, Erectile dysfunction and Multiple congenital anomalies. The involved functions are known as Bulla, Methylation, cholesterol biosynthetic process, Process and cholesterol efflux. Desmosterol often locates in Body tissue, Tissue membrane, Plasma membrane, Pore and Endoplasmic Reticulum. The associated genes with DESMOSTEROL are P4HTM gene, SHH gene, WDR48 gene, CFLAR gene and SLC33A1 gene. The related lipids are Sterols, androstanol, Steroids, Unilamellar Vesicles and 7-dehydrocholesterol. The related experimental models are Transgenic Model and Rodent Model.
To understand associated biological information of DESMOSTEROL, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
DESMOSTEROL is suspected in Atherosclerosis, Congenital Abnormality, Liver diseases, Fatty Streak, Arterial, Senile Plaques, Coronary Arteriosclerosis and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with DESMOSTEROL
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Celiac Disease | D002446 | 16 associated lipids |
| Coronary Disease | D003327 | 70 associated lipids |
| Hemolysis | D006461 | 131 associated lipids |
| Insulin Resistance | D007333 | 99 associated lipids |
| Xanthomatosis | D014973 | 17 associated lipids |
| Limb Deformities, Congenital | D017880 | 4 associated lipids |
Lipid pathways are not clear in current pathway databases. We organized associated pathways with DESMOSTEROL through full-text articles, including metabolic pathways or pathways of biological mechanisms.
| Pathway name | Related literatures |
|---|
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
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Transgenic Model are used in the study 'Cellular production of n-3 PUFAs and reduction of n-6-to-n-3 ratios in the pancreatic beta-cells and islets enhance insulin secretion and confer protection against cytokine-induced cell death.' (Wei D et al., 2010).
Rodent Model are used in the study 'Oxidation of 7-dehydrocholesterol and desmosterol by human cytochrome P450 46A1.' (Goyal S et al., 2014).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Fumagalli R et al. | [Desmosterol test in the diagnosis of recurrent brain neoplasms]. | 1973 May-Jun | Acta Neurol (Napoli) | pmid:4732487 |
| Smith AG and Goad LJ | Sterol biosynthesis by the sea urchin Echinus esculentus. | 1974 | Biochem. J. | pmid:4441383 |
| Dennick RG et al. | Sterol content and squaline-2(3)-epoxide-lanosterol cyclase activity in human foetal brain during early and mid-gestation. | 1974 | J. Neurochem. | pmid:4854410 |
| Dennick RG et al. | The occurrence of desmosterol in neuronal and glial fractions from developing rat brain. | 1974 | FEBS Lett. | pmid:4213464 |
| Bleau G and VandenHeuvel WJ | Desmosteryl sulfate and desmosterol in hamster epididymal spermatozoa. | 1974 | Steroids | pmid:4423229 |
| Brennan PJ et al. | The lipids of fungi. | 1974 | Prog Chem Fats Other Lipids | pmid:4610639 |
| Bates SR and Rothblat GH | Regulation of cellular sterol flux and synthesis by human serum lipoproteins. | 1974 | Biochim. Biophys. Acta | pmid:4369129 |
| Harris PA and Harris KL | Quantitative GLC analysis of plasma cholesterol. | 1974 | J Pharm Sci | pmid:4830004 |
| Arnold A et al. | Triparanol-effected accumulation of desmosterol in oestrone-induced hypocholesterolaemia. | 1974 | J. Pharm. Pharmacol. | pmid:4156546 |
| Dasgupta SK et al. | New preparation of desmosterol. | 1974 | J. Org. Chem. | pmid:4853344 |