DESMOSTEROL

DESMOSTEROL is a lipid of Sterol Lipids (ST) class. Desmosterol is associated with abnormalities such as Cataract, Congenital Abnormality, Liver diseases, Erectile dysfunction and Multiple congenital anomalies. The involved functions are known as Bulla, Methylation, cholesterol biosynthetic process, Process and cholesterol efflux. Desmosterol often locates in Body tissue, Tissue membrane, Plasma membrane, Pore and Endoplasmic Reticulum. The associated genes with DESMOSTEROL are P4HTM gene, SHH gene, WDR48 gene, CFLAR gene and SLC33A1 gene. The related lipids are Sterols, androstanol, Steroids, Unilamellar Vesicles and 7-dehydrocholesterol. The related experimental models are Transgenic Model and Rodent Model.

Cross Reference

Introduction

To understand associated biological information of DESMOSTEROL, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with DESMOSTEROL?

DESMOSTEROL is suspected in Atherosclerosis, Congenital Abnormality, Liver diseases, Fatty Streak, Arterial, Senile Plaques, Coronary Arteriosclerosis and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with DESMOSTEROL

MeSH term MeSH ID Detail
Limb Deformities, Congenital D017880 4 associated lipids
Celiac Disease D002446 16 associated lipids
Xanthomatosis D014973 17 associated lipids
Coronary Disease D003327 70 associated lipids
Insulin Resistance D007333 99 associated lipids
Hemolysis D006461 131 associated lipids
Total 6

PubChem Associated disorders and diseases

What pathways are associated with DESMOSTEROL

Lipid pathways are not clear in current pathway databases. We organized associated pathways with DESMOSTEROL through full-text articles, including metabolic pathways or pathways of biological mechanisms.

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Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with DESMOSTEROL?

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Location Cross reference Weighted score Related literatures
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What functions are associated with DESMOSTEROL?


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Function Cross reference Weighted score Related literatures

What lipids are associated with DESMOSTEROL?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with DESMOSTEROL?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with DESMOSTEROL?

Transgenic Model

Transgenic Model are used in the study 'Cellular production of n-3 PUFAs and reduction of n-6-to-n-3 ratios in the pancreatic beta-cells and islets enhance insulin secretion and confer protection against cytokine-induced cell death.' (Wei D et al., 2010).

Rodent Model

Rodent Model are used in the study 'Oxidation of 7-dehydrocholesterol and desmosterol by human cytochrome P450 46A1.' (Goyal S et al., 2014).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with DESMOSTEROL

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Authors Title Published Journal PubMed Link
pmid:
Villareal VA et al. Hepatitis C Virus Selectively Alters the Intracellular Localization of Desmosterol. 2016 ACS Chem. Biol. pmid:27128812
Costello DA et al. Desmosterol Increases Lipid Bilayer Fluidity during Hepatitis C Virus Infection. 2016 ACS Infect Dis pmid:27933788
Huijmans JG et al. Effects of 22S-hydroxy-cholesterol and other hydroxylated sterols on the ACTH-stimulated steroid production in rat adrenal cells. 1981 Acta Endocrinol. pmid:6263029
Fumagalli R et al. [Desmosterol test in the diagnosis of recurrent brain neoplasms]. 1973 May-Jun Acta Neurol (Napoli) pmid:4732487
Mirza R et al. Requirement of DHCR24 for postnatal development of epidermis and hair follicles in mice. 2009 Am J Dermatopathol pmid:19542918
SACHS BA and WOLFMAN L Studies of serum desmosterol levels in hypercholesteremic subjects treated with triparanol (MER-29). 1961 Nov-Dec Am. J. Clin. Nutr. pmid:14495832
Hallikainen M et al. Interaction between cholesterol and glucose metabolism during dietary carbohydrate modification in subjects with the metabolic syndrome. 2006 Am. J. Clin. Nutr. pmid:17158421
Waterham HR et al. Mutations in the 3beta-hydroxysterol Delta24-reductase gene cause desmosterolosis, an autosomal recessive disorder of cholesterol biosynthesis. 2001 Am. J. Hum. Genet. pmid:11519011
FitzPatrick DR et al. Clinical phenotype of desmosterolosis. 1998 Am. J. Med. Genet. pmid:9450875
Andersson HC et al. Desmosterolosis presenting with multiple congenital anomalies and profound developmental delay. 2002 Am. J. Med. Genet. pmid:12457401
Schaaf CP et al. Desmosterolosis-phenotypic and molecular characterization of a third case and review of the literature. 2011 Am. J. Med. Genet. A pmid:21671375
Tedde A et al. Mutational screening analysis of DHCR24/seladin-1 gene in Italian familial Alzheimer's disease. 2008 Am. J. Med. Genet. B Neuropsychiatr. Genet. pmid:17579359
Domeño C et al. Determination of sterols in biological samples by SPME with on-fiber derivatization and GC/FID. 2005 Anal Bioanal Chem pmid:15827725
Igarashi F et al. A highly specific and sensitive quantification analysis of the sterols in silkworm larvae by high performance liquid chromatography-atmospheric pressure chemical ionization-tandem mass spectrometry. 2011 Anal. Biochem. pmid:21925474
Lu B et al. Separation and determination of diversiform phytosterols in food materials using supercritical carbon dioxide extraction and ultraperformance liquid chromatography-atmospheric pressure chemical ionization-mass spectrometry. 2007 Anal. Chim. Acta pmid:17386793
Moraes EA et al. Delivering cholesterol or cholestanol to bull sperm membranes improves cryosurvival. 2010 Anim. Reprod. Sci. pmid:19733986
Leboeuf M et al. [Steroid alkaloids. 138(12). Chemical composition of the fruits and grains of Holarrhena mitis R. Br. (Apocynacea): alkaloids and unsaponifiable material]. 1972 Ann Pharm Fr pmid:4668289
Wasserstrom WR et al. Cerebrospinal fluid biochemical markers in central nervous system tumors: a review. 1981 May-Jun Ann. Clin. Lab. Sci. pmid:6166240
Seidenfeld J and Marton LJ Biochemical markers of central nervous system tumors in cerebrospinal fluid. 1978 Nov-Dec Ann. Clin. Lab. Sci. pmid:736510
Svoboda JA et al. Recent developments in insect steroid metabolism. 1975 Annu. Rev. Entomol. pmid:1091201
Zhang S et al. Identification of a sterol Delta7 reductase gene involved in desmosterol biosynthesis in Mortierella alpina 1S-4. 2007 Appl. Environ. Microbiol. pmid:17220261
Johnson RC and Shah SN Microsomal synthesis of cholesterol from squalene, Lanosterol, and desmosterol. Evidence for the presence of two noncatalytic activator proteins in the 105,000 g supernatant fraction from brain, heart, and kidney. 1974 Arch. Biochem. Biophys. pmid:4460877
Pikuleva I and Javitt NB Novel sterols synthesized via the CYP27A1 metabolic pathway. 2003 Arch. Biochem. Biophys. pmid:14622972
Clayton PT Disorders of cholesterol biosynthesis. 1998 Arch. Dis. Child. pmid:9579167
Weiss JF et al. Desmosterol in human and experimental brain tumors in tissue culture. 1976 Arch. Neurol. pmid:1252160
Marton LJ et al. Faliure to demonstrate desmosterol in spinal fluid of brain tumor patients. 1973 Arch. Neurol. pmid:4345665
Miettinen TA et al. Noncholesterol sterols and cholesterol lowering by long-term simvastatin treatment in coronary patients: relation to basal serum cholestanol. 2000 Arterioscler. Thromb. Vasc. Biol. pmid:10807752
van Himbergen TM et al. Familial combined hyperlipidemia is associated with alterations in the cholesterol synthesis pathway. 2010 Arterioscler. Thromb. Vasc. Biol. pmid:19834104
Heverin M et al. Studies on the cholesterol-free mouse: strong activation of LXR-regulated hepatic genes when replacing cholesterol with desmosterol. 2007 Arterioscler. Thromb. Vasc. Biol. pmid:17761942
Burgess B et al. Overexpression of human ABCG1 does not affect atherosclerosis in fat-fed ApoE-deficient mice. 2008 Arterioscler. Thromb. Vasc. Biol. pmid:18599800
Mourvaki E et al. Desmosterol, the main sterol in rabbit semen: distribution among semen subfractions and its role in the in vitro spermatozoa acrosome reaction and motility. 2010 Asian J. Androl. pmid:20729867
Hallikainen M et al. Endothelial function in hypercholesterolemic subjects: Effects of plant stanol and sterol esters. 2006 Atherosclerosis pmid:16386259
Arnold A et al. Triparanol-induced desmoterol accumulation in clofibrate-effected hypocholesterolemia. 1974 Sep-Oct Atherosclerosis pmid:4416741
Simonen PP et al. The distribution of squalene and non-cholesterol sterols in lipoproteins in type 2 diabetes. 2007 Atherosclerosis pmid:16963050
Bhattacharyya AK and Eggen DA Relationships between dietary cholesterol, cholesterol absorption, cholesterol synthesis, and plasma cholesterol in rhesus monkeys. 1987 Atherosclerosis pmid:3675704
Hoenig MR and Sellke FW Insulin resistance is associated with increased cholesterol synthesis, decreased cholesterol absorption and enhanced lipid response to statin therapy. 2010 Atherosclerosis pmid:20356594
Miettinen TA and Gylling H Ineffective decrease of serum cholesterol by simvastatin in a subgroup of hypercholesterolemic coronary patients. 2002 Atherosclerosis pmid:12119203
Strandberg TE et al. Serum plant and other noncholesterol sterols, cholesterol metabolism and 22-year mortality among middle-aged men. 2010 Atherosclerosis pmid:19962145
Fassbender K et al. Moderately elevated plant sterol levels are associated with reduced cardiovascular risk--the LASA study. 2008 Atherosclerosis pmid:17137582
Niesor EJ et al. Effect of dalcetrapib, a CETP modulator, on non-cholesterol sterol markers of cholesterol homeostasis in healthy subjects. 2011 Atherosclerosis pmid:21982411
Imai Y and Shimamoto K Biological studies of AT-308. 1. Hypocholesterolemic effect of 1,2,4-oxadiazole derivatives in rats. 1973 Jan-Feb Atherosclerosis pmid:4696738
Hietter H et al. Antagonist action of cholesterol towards the toxicity of hydroxysterols on cultured hepatoma cells. 1984 Biochem. Biophys. Res. Commun. pmid:6732777
Johnson RC and Shah SN Evidence for the participation of two soluble noncatalytic proteins in hepatic microsomal cholesterol synthesis. 1973 Biochem. Biophys. Res. Commun. pmid:4741538
Wang JH and Tuohimaa P Regulation of cholesterol 25-hydroxylase expression by vitamin D3 metabolites in human prostate stromal cells. 2006 Biochem. Biophys. Res. Commun. pmid:16696936
Rodríguez-Acebes S et al. Dose-dependent dual effects of cholesterol and desmosterol on J774 macrophage proliferation. 2008 Biochem. Biophys. Res. Commun. pmid:18851952
Miquel K et al. Farnesol and geranylgeraniol induce actin cytoskeleton disorganization and apoptosis in A549 lung adenocarcinoma cells. 1996 Biochem. Biophys. Res. Commun. pmid:8780704
Awata N et al. Carbon-carbon bond cleavage of fucosterol-24, 28-oxide by cell-free extracts of silkworm Bombyx mori. 1975 Biochem. Biophys. Res. Commun. pmid:167728
Ortiz de Montellano PR et al. Regulation of sterol biosynthesis and lysis of cultured hepatoma cells: inhibition of lanosterol demethylation by hydroxysterols. 1979 Biochem. Biophys. Res. Commun. pmid:508352
Baila-Rueda L et al. Bile acid synthesis precursors in familial combined hyperlipidemia: the oxysterols 24S-hydroxycholesterol and 27-hydroxycholesterol. 2014 Biochem. Biophys. Res. Commun. pmid:24406166
Kojima H et al. Increased plasma post-heparin diamine oxidase activity and plant sterol levels in streptozotocin diabetic rat. 1992 Biochem. Biophys. Res. Commun. pmid:1632778
Rosenblum ER et al. Effect of 20,25-diazacholesterol on viability and steroid synthesis capability of cultured chick embryo pectoral muscle cells. 1979 Biochem. Biophys. Res. Commun. pmid:572680
Schroeder F et al. Correlation of tumor metastasis with sterol carrier protein and plasma membrane sterol levels. 1984 Biochem. Biophys. Res. Commun. pmid:6497882
Smith AG and Goad LJ Sterol biosynthesis by the sea urchin Echinus esculentus. 1974 Biochem. J. pmid:4441383
Goh EH Transfer of exogenous cholesterol to microsomes of hepatocytes investigated with [3H]desmosterol tracer. 1983 Biochem. J. pmid:6651772
Slotte JP and Bierman EL Movement of plasma-membrane sterols to the endoplasmic reticulum in cultured cells. 1987 Biochem. J. pmid:3435441
Fernández C et al. Inhibition of cholesterol biosynthesis by Delta22-unsaturated phytosterols via competitive inhibition of sterol Delta24-reductase in mammalian cells. 2002 Biochem. J. pmid:12162789
Pettler PJ et al. Mechanism of dealkylation of clionasterol in the insect Tenebrio molitor. 1978 Biochem. J. pmid:708391
Patel DD et al. The absolute rate of cholesterol biosynthesis in monocyte-macrophages from normal and familial hypercholesterolaemic subjects. 1984 Biochem. J. pmid:6743229
Watson KC and Kerr EJ Sterol structural requirements for inhibition of streptolysin O activity. 1974 Biochem. J. pmid:4451554
Rodríguez-Acebes S et al. Desmosterol can replace cholesterol in sustaining cell proliferation and regulating the SREBP pathway in a sterol-Delta24-reductase-deficient cell line. 2009 Biochem. J. pmid:19260826
Akhtar M et al. A novel olefinic rearrangement. The enzymic conversion of cholesta-7,9-dien-3 -ol into cholesta-8,14-dien-3 -ol. 1972 Biochem. J. pmid:4404936
Gibbons GF and Pullinger CR Measurement of the absolute rates of cholesterol biosynthesis in isolated rat liver cells. 1977 Biochem. J. pmid:849287
Arthur JR et al. Oxidation of cholesterol and cholesterol analogues by mitochondrial preparations of steroid-hormone-producing tissue. 1976 Biochem. J. pmid:986816
Gibbons GF and Pullinger CR Utilization of endogenous and exogenous sources of substrate for cholesterol biosynthesis by isolated hepatocytes. 1979 Biochem. J. pmid:426772
Stevenson J and Brown AJ How essential is cholesterol? 2009 Biochem. J. pmid:19426142
Meljon A et al. Analysis by liquid chromatography-mass spectrometry of sterols and oxysterols in brain of the newborn Dhcr7(Δ3-5/T93M) mouse: a model of Smith-Lemli-Opitz syndrome. 2013 Biochem. Pharmacol. pmid:23500538
Jeng I et al. Effect of a hypocholesterolemic agent on cholesteryl ester metabolism in glioblastoma cells. 1985 Biochem. Pharmacol. pmid:3994747
Abernethy DR and Azarnoff DL Effect of drugs which alter microsomal drug-metabolizing enzyme activity on rat hepatic cholesterol biosynthesis. 1977 Biochem. Pharmacol. pmid:849344
Gibbons GF and Pullinger CR Cholesterol biosynthesis in hepatocytes. 1978 Biochem. Soc. Trans. pmid:744335
Shrivastava S et al. Differential effects of cholesterol and its immediate biosynthetic precursors on membrane organization. 2008 Biochemistry pmid:18442257
HÄ…c-Wydro K et al. The influence of cholesterol precursor--desmosterol--on artificial lipid membranes. 2015 Biochim. Biophys. Acta pmid:25960185
Kölsch H et al. Alterations of cholesterol precursor levels in Alzheimer's disease. 2010 Biochim. Biophys. Acta pmid:20226877
Sokoloff L and Rothblat GH Regulation of sterol synthesis in L cells: steady-state and transitional responses. 1972 Biochim. Biophys. Acta pmid:5070653
Surpuriya V and Higuchi WI Two-step interfacial barrier mechanism for the transport of micelle-solubilized solute across an oil-water interface. 1972 Biochim. Biophys. Acta pmid:4640769
Zerenturk EJ et al. The endogenous regulator 24(S),25-epoxycholesterol inhibits cholesterol synthesis at DHCR24 (Seladin-1). 2012 Biochim. Biophys. Acta pmid:22178193
Bojesen I and Roepstorff P Identification of C sterols produced by rat renal inner medulla in vitro. 1973 Biochim. Biophys. Acta pmid:4722467
Singh P et al. Desmosterol replaces cholesterol for ligand binding function of the serotonin(1A) receptor in solubilized hippocampal membranes: support for nonannular binding sites for cholesterol? 2011 Biochim. Biophys. Acta pmid:21763272
Bourre JM et al. Alterations of cholesterol synthesis precursors (7-dehydrocholesterol, 7-dehydrodesmosterol, desmosterol) in dysmyelinating neurological mutant mouse (quaking, shiverer and trembler) in the PNS and the CNS. 1989 Biochim. Biophys. Acta pmid:2547434
Bates SR and Rothblat GH Regulation of cellular sterol flux and synthesis by human serum lipoproteins. 1974 Biochim. Biophys. Acta pmid:4369129
Sauer SW et al. Severe dysfunction of respiratory chain and cholesterol metabolism in Atp7b(-/-) mice as a model for Wilson disease. 2011 Biochim. Biophys. Acta pmid:21920437
Singh P et al. Differential effects of cholesterol and desmosterol on the ligand binding function of the hippocampal serotonin(1A) receptor: implications in desmosterolosis. 2009 Biochim. Biophys. Acta pmid:19616511
Volpe JJ et al. Regulation of cholesterol ester synthesis in cultured glial and neuronal cells. Relation to control of cholesterol synthesis. 1978 Biochim. Biophys. Acta pmid:205252
Chau IY and Geyer RP The effects of serum albumin and phospholipid on sterol excretion in tissue culture cells. 1978 Biochim. Biophys. Acta pmid:687659
Serfis AB et al. Comparative behavior of sterols in phosphatidylcholine-sterol monolayer films. 2001 Biochim. Biophys. Acta pmid:11286977
Collignon-Thiennot F et al. [Demonstration of 2 pathways for cholesterol synthesis in the mollusk: patella Patella vulgata L., (Gasteropoda, Prosobranches, Archeogasteropoda)]. 1973 Biochimie pmid:4754188
Bouthillier M et al. Distribution of steroid sulfotransferase in the male hamster reproductive tract. 1984 Biol. Reprod. pmid:6240284
Cross NL Decrease in order of human sperm lipids during capacitation. 2003 Biol. Reprod. pmid:12700200
Nimmo MR and Cross NL Structural features of sterols required to inhibit human sperm capacitation. 2003 Biol. Reprod. pmid:12606419
Bogan RL et al. Liver x receptor modulation of gene expression leading to proluteolytic effects in primate luteal cells. 2012 Biol. Reprod. pmid:22156476
Boerke A et al. Involvement of bicarbonate-induced radical signaling in oxysterol formation and sterol depletion of capacitating mammalian sperm during in vitro fertilization. 2013 Biol. Reprod. pmid:23115269
Sánchez-Machado DI et al. An HPLC method for the quantification of sterols in edible seaweeds. 2004 Biomed. Chromatogr. pmid:15103705
Khripach VA et al. [Synthesis of C24-functionalized hydroxysterols]. 2002 May-Jun Bioorg. Khim. pmid:12077856
Saini R et al. Synthesis and biological activity of (24E)- and (24Z)-26-hydroxydesmosterol. 2013 Bioorg. Med. Chem. pmid:23910990
Fujimoto Y et al. Stereochemistry of the reduction of 24-ethyldesmosterol to sitosterol in tissue cultures of Oryza sativa. 1998 Bioorg. Med. Chem. Lett. pmid:9871655
Haldar S et al. Differential effect of cholesterol and its biosynthetic precursors on membrane dipole potential. 2012 Biophys. J. pmid:22500756
Scheidt HA et al. Diffusion of cholesterol and its precursors in lipid membranes studied by 1H pulsed field gradient magic angle spinning NMR. 2005 Biophys. J. pmid:16085761
Huster D et al. Desmosterol may replace cholesterol in lipid membranes. 2005 Biophys. J. pmid:15596512
Stottrup BL and Keller SL Phase behavior of lipid monolayers containing DPPC and cholesterol analogs. 2006 Biophys. J. pmid:16461392
Nagata S and Nagasawa H Sterol composition in larvae of the silkworm, Bombyx mori. 2011 Biosci. Biotechnol. Biochem. pmid:21597175