DESMOSTEROL is a lipid of Sterol Lipids (ST) class. Desmosterol is associated with abnormalities such as Cataract, Congenital Abnormality, Liver diseases, Erectile dysfunction and Multiple congenital anomalies. The involved functions are known as Bulla, Methylation, cholesterol biosynthetic process, Process and cholesterol efflux. Desmosterol often locates in Body tissue, Tissue membrane, Plasma membrane, Pore and Endoplasmic Reticulum. The associated genes with DESMOSTEROL are P4HTM gene, SHH gene, WDR48 gene, CFLAR gene and SLC33A1 gene. The related lipids are Sterols, androstanol, Steroids, Unilamellar Vesicles and 7-dehydrocholesterol. The related experimental models are Transgenic Model and Rodent Model.
To understand associated biological information of DESMOSTEROL, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
DESMOSTEROL is suspected in Atherosclerosis, Congenital Abnormality, Liver diseases, Fatty Streak, Arterial, Senile Plaques, Coronary Arteriosclerosis and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with DESMOSTEROL
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Limb Deformities, Congenital | D017880 | 4 associated lipids |
| Celiac Disease | D002446 | 16 associated lipids |
| Xanthomatosis | D014973 | 17 associated lipids |
| Coronary Disease | D003327 | 70 associated lipids |
| Insulin Resistance | D007333 | 99 associated lipids |
| Hemolysis | D006461 | 131 associated lipids |
Lipid pathways are not clear in current pathway databases. We organized associated pathways with DESMOSTEROL through full-text articles, including metabolic pathways or pathways of biological mechanisms.
| Pathway name | Related literatures |
|---|
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
| Gene | Cross reference | Weighted score | Related literatures |
|---|
Transgenic Model are used in the study 'Cellular production of n-3 PUFAs and reduction of n-6-to-n-3 ratios in the pancreatic beta-cells and islets enhance insulin secretion and confer protection against cytokine-induced cell death.' (Wei D et al., 2010).
Rodent Model are used in the study 'Oxidation of 7-dehydrocholesterol and desmosterol by human cytochrome P450 46A1.' (Goyal S et al., 2014).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Mirza R et al. | Increased expression of aquaporin-3 in the epidermis of DHCR24 knockout mice. | 2008 | Br. J. Dermatol. | pmid:18241265 |
| Tedde A et al. | Mutational screening analysis of DHCR24/seladin-1 gene in Italian familial Alzheimer's disease. | 2008 | Am. J. Med. Genet. B Neuropsychiatr. Genet. | pmid:17579359 |
| Luciani P et al. | Seladin-1 is a fundamental mediator of the neuroprotective effects of estrogen in human neuroblast long-term cell cultures. | 2008 | Endocrinology | pmid:18499757 |
| RodrÃguez-Acebes S et al. | Dose-dependent dual effects of cholesterol and desmosterol on J774 macrophage proliferation. | 2008 | Biochem. Biophys. Res. Commun. | pmid:18851952 |
| Fassbender K et al. | Moderately elevated plant sterol levels are associated with reduced cardiovascular risk--the LASA study. | 2008 | Atherosclerosis | pmid:17137582 |
| Berthold HK et al. | SREBP-1c gene polymorphism is associated with increased inhibition of cholesterol-absorption in response to ezetimibe treatment. | 2008 | Exp. Clin. Endocrinol. Diabetes | pmid:18072016 |
| Assmann G et al. | Effects of ezetimibe, simvastatin, atorvastatin, and ezetimibe-statin therapies on non-cholesterol sterols in patients with primary hypercholesterolemia. | 2008 | Curr Med Res Opin | pmid:18053317 |
| Shrivastava S et al. | Differential effects of cholesterol and its immediate biosynthetic precursors on membrane organization. | 2008 | Biochemistry | pmid:18442257 |
| Wang N et al. | ATP-binding cassette transporters G1 and G4 mediate cholesterol and desmosterol efflux to HDL and regulate sterol accumulation in the brain. | 2008 | FASEB J. | pmid:18039927 |
| Pedretti A et al. | Homology modelling of human DHCR24 (seladin-1) and analysis of its binding properties through molecular docking and dynamics simulations. | 2008 | Steroids | pmid:18394665 |