DESMOSTEROL is a lipid of Sterol Lipids (ST) class. Desmosterol is associated with abnormalities such as Cataract, Congenital Abnormality, Liver diseases, Erectile dysfunction and Multiple congenital anomalies. The involved functions are known as Bulla, Methylation, cholesterol biosynthetic process, Process and cholesterol efflux. Desmosterol often locates in Body tissue, Tissue membrane, Plasma membrane, Pore and Endoplasmic Reticulum. The associated genes with DESMOSTEROL are P4HTM gene, SHH gene, WDR48 gene, CFLAR gene and SLC33A1 gene. The related lipids are Sterols, androstanol, Steroids, Unilamellar Vesicles and 7-dehydrocholesterol. The related experimental models are Transgenic Model and Rodent Model.
To understand associated biological information of DESMOSTEROL, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
DESMOSTEROL is suspected in Atherosclerosis, Congenital Abnormality, Liver diseases, Fatty Streak, Arterial, Senile Plaques, Coronary Arteriosclerosis and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with DESMOSTEROL
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Limb Deformities, Congenital | D017880 | 4 associated lipids |
| Celiac Disease | D002446 | 16 associated lipids |
| Xanthomatosis | D014973 | 17 associated lipids |
| Coronary Disease | D003327 | 70 associated lipids |
| Insulin Resistance | D007333 | 99 associated lipids |
| Hemolysis | D006461 | 131 associated lipids |
Lipid pathways are not clear in current pathway databases. We organized associated pathways with DESMOSTEROL through full-text articles, including metabolic pathways or pathways of biological mechanisms.
| Pathway name | Related literatures |
|---|
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
|---|
Transgenic Model are used in the study 'Cellular production of n-3 PUFAs and reduction of n-6-to-n-3 ratios in the pancreatic beta-cells and islets enhance insulin secretion and confer protection against cytokine-induced cell death.' (Wei D et al., 2010).
Rodent Model are used in the study 'Oxidation of 7-dehydrocholesterol and desmosterol by human cytochrome P450 46A1.' (Goyal S et al., 2014).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Tedde A et al. | Mutational screening analysis of DHCR24/seladin-1 gene in Italian familial Alzheimer's disease. | 2008 | Am. J. Med. Genet. B Neuropsychiatr. Genet. | pmid:17579359 |
| RodrÃguez-Acebes S et al. | Dose-dependent dual effects of cholesterol and desmosterol on J774 macrophage proliferation. | 2008 | Biochem. Biophys. Res. Commun. | pmid:18851952 |
| Jansen M et al. | Cholesterol substitution increases the structural heterogeneity of caveolae. | 2008 | J. Biol. Chem. | pmid:18353778 |
| Fassbender K et al. | Moderately elevated plant sterol levels are associated with reduced cardiovascular risk--the LASA study. | 2008 | Atherosclerosis | pmid:17137582 |
| Burgess B et al. | Overexpression of human ABCG1 does not affect atherosclerosis in fat-fed ApoE-deficient mice. | 2008 | Arterioscler. Thromb. Vasc. Biol. | pmid:18599800 |
| Matthan NR et al. | Alterations in cholesterol absorption/synthesis markers characterize Framingham offspring study participants with CHD. | 2009 | J. Lipid Res. | pmid:19436064 |
| Shay CM et al. | Do plant sterol concentrations correlate with coronary artery disease in type 1 diabetes? A report from the Pittsburgh Epidemiology of Diabetes Complications Study. | 2009 | J Diabetes | pmid:20827426 |
| Laitinen K et al. | Plant stanol ester spreads as components of a balanced diet for pregnant and breast-feeding women: evaluation of clinical safety. | 2009 | Br. J. Nutr. | pmid:19017423 |
| Drzewińska J et al. | [Seladin-1/DHCR24: a key protein of cell homeostasis and cholesterol biosynthesis]. | 2009 | Postepy Hig Med Dosw (Online) | pmid:19597241 |
| Kuehnle K | Age-dependent increase in desmosterol restores DRM formation and membrane-related functions in cholesterol-free DHCR24(-/-) mice. Neurochemical Research (34, 1167-82). | 2009 | Neurochem. Res. | pmid:19475506 |