DESMOSTEROL

DESMOSTEROL is a lipid of Sterol Lipids (ST) class. Desmosterol is associated with abnormalities such as Cataract, Congenital Abnormality, Liver diseases, Erectile dysfunction and Multiple congenital anomalies. The involved functions are known as Bulla, Methylation, cholesterol biosynthetic process, Process and cholesterol efflux. Desmosterol often locates in Body tissue, Tissue membrane, Plasma membrane, Pore and Endoplasmic Reticulum. The associated genes with DESMOSTEROL are P4HTM gene, SHH gene, WDR48 gene, CFLAR gene and SLC33A1 gene. The related lipids are Sterols, androstanol, Steroids, Unilamellar Vesicles and 7-dehydrocholesterol. The related experimental models are Transgenic Model and Rodent Model.

Cross Reference

Introduction

To understand associated biological information of DESMOSTEROL, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with DESMOSTEROL?

DESMOSTEROL is suspected in Atherosclerosis, Congenital Abnormality, Liver diseases, Fatty Streak, Arterial, Senile Plaques, Coronary Arteriosclerosis and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with DESMOSTEROL

MeSH term MeSH ID Detail
Limb Deformities, Congenital D017880 4 associated lipids
Celiac Disease D002446 16 associated lipids
Xanthomatosis D014973 17 associated lipids
Coronary Disease D003327 70 associated lipids
Insulin Resistance D007333 99 associated lipids
Hemolysis D006461 131 associated lipids
Total 6

PubChem Associated disorders and diseases

What pathways are associated with DESMOSTEROL

Lipid pathways are not clear in current pathway databases. We organized associated pathways with DESMOSTEROL through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with DESMOSTEROL?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with DESMOSTEROL?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with DESMOSTEROL?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with DESMOSTEROL?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with DESMOSTEROL?

Transgenic Model

Transgenic Model are used in the study 'Cellular production of n-3 PUFAs and reduction of n-6-to-n-3 ratios in the pancreatic beta-cells and islets enhance insulin secretion and confer protection against cytokine-induced cell death.' (Wei D et al., 2010).

Rodent Model

Rodent Model are used in the study 'Oxidation of 7-dehydrocholesterol and desmosterol by human cytochrome P450 46A1.' (Goyal S et al., 2014).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with DESMOSTEROL

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Authors Title Published Journal PubMed Link
Nes WD Biosynthesis of cholesterol and other sterols. 2011 Chem. Rev. pmid:21902244
Wang L et al. Genome characterization of the oleaginous fungus Mortierella alpina. 2011 PLoS ONE pmid:22174787
Hong C et al. Constitutive activation of LXR in macrophages regulates metabolic and inflammatory gene expression: identification of ARL7 as a direct target. 2011 J. Lipid Res. pmid:21187453
Stottmann RW et al. Cholesterol metabolism is required for intracellular hedgehog signal transduction in vivo. 2011 PLoS Genet. pmid:21912524
Pfeifer T et al. Synthetic LXR agonist suppresses endogenous cholesterol biosynthesis and efficiently lowers plasma cholesterol. 2011 Curr Pharm Biotechnol pmid:21190543
Steinberg D Chance and serendipity in science: two examples from my own career. 2011 J. Biol. Chem. pmid:21908608
Schaaf CP et al. Desmosterolosis-phenotypic and molecular characterization of a third case and review of the literature. 2011 Am. J. Med. Genet. A pmid:21671375
Zolotushko J et al. The desmosterolosis phenotype: spasticity, microcephaly and micrognathia with agenesis of corpus callosum and loss of white matter. 2011 Eur. J. Hum. Genet. pmid:21559050
Hoenig MR et al. Low density lipoprotein cholesterol is inversely correlated with abdominal visceral fat area: a magnetic resonance imaging study. 2011 Lipids Health Dis pmid:21247428
Lin HY et al. Molecular basis for certain neuroprotective effects of thyroid hormone. 2011 Front Mol Neurosci pmid:22016721
Orsi M and Essex JW The ELBA force field for coarse-grain modeling of lipid membranes. 2011 PLoS ONE pmid:22194874
Sauer SW et al. Severe dysfunction of respiratory chain and cholesterol metabolism in Atp7b(-/-) mice as a model for Wilson disease. 2011 Biochim. Biophys. Acta pmid:21920437
Kaddurah-Daouk R et al. Enteric microbiome metabolites correlate with response to simvastatin treatment. 2011 PLoS ONE pmid:22022402
Matthan NR et al. Cholesterol absorption and synthesis markers in individuals with and without a CHD event during pravastatin therapy: insights from the PROSPER trial. 2010 J. Lipid Res. pmid:19578163
Hoenig MR et al. Markers of cholesterol absorption and synthesis predict the low-density lipoprotein cholesterol response to atorvastatin. 2010 J. Cardiovasc. Pharmacol. pmid:20625310
Pakarinen MP et al. Cholesterol metabolism in pediatric short bowel syndrome after weaning off parenteral nutrition. 2010 Dig Liver Dis pmid:20538532
Amaral C et al. Quantitative analysis of five sterols in amniotic fluid by GC-MS: application to the diagnosis of cholesterol biosynthesis defects. 2010 J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. pmid:20630811
Hoenig MR and Sellke FW Insulin resistance is associated with increased cholesterol synthesis, decreased cholesterol absorption and enhanced lipid response to statin therapy. 2010 Atherosclerosis pmid:20356594
Aknin M et al. Sterols from the Madagascar sponge Fascaplysinopsis sp. 2010 Mar Drugs pmid:21339959
Sheriff DS and Ali EF Perspective on plasma membrane cholesterol efflux and spermatozoal function. 2010 J Hum Reprod Sci pmid:21209749