DESMOSTEROL

DESMOSTEROL is a lipid of Sterol Lipids (ST) class. Desmosterol is associated with abnormalities such as Cataract, Congenital Abnormality, Liver diseases, Erectile dysfunction and Multiple congenital anomalies. The involved functions are known as Bulla, Methylation, cholesterol biosynthetic process, Process and cholesterol efflux. Desmosterol often locates in Body tissue, Tissue membrane, Plasma membrane, Pore and Endoplasmic Reticulum. The associated genes with DESMOSTEROL are P4HTM gene, SHH gene, WDR48 gene, CFLAR gene and SLC33A1 gene. The related lipids are Sterols, androstanol, Steroids, Unilamellar Vesicles and 7-dehydrocholesterol. The related experimental models are Transgenic Model and Rodent Model.

Cross Reference

Introduction

To understand associated biological information of DESMOSTEROL, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with DESMOSTEROL?

DESMOSTEROL is suspected in Atherosclerosis, Congenital Abnormality, Liver diseases, Fatty Streak, Arterial, Senile Plaques, Coronary Arteriosclerosis and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with DESMOSTEROL

MeSH term MeSH ID Detail
Limb Deformities, Congenital D017880 4 associated lipids
Celiac Disease D002446 16 associated lipids
Xanthomatosis D014973 17 associated lipids
Coronary Disease D003327 70 associated lipids
Insulin Resistance D007333 99 associated lipids
Hemolysis D006461 131 associated lipids
Total 6

PubChem Associated disorders and diseases

What pathways are associated with DESMOSTEROL

Lipid pathways are not clear in current pathway databases. We organized associated pathways with DESMOSTEROL through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with DESMOSTEROL?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with DESMOSTEROL?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with DESMOSTEROL?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with DESMOSTEROL?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with DESMOSTEROL?

Transgenic Model

Transgenic Model are used in the study 'Cellular production of n-3 PUFAs and reduction of n-6-to-n-3 ratios in the pancreatic beta-cells and islets enhance insulin secretion and confer protection against cytokine-induced cell death.' (Wei D et al., 2010).

Rodent Model

Rodent Model are used in the study 'Oxidation of 7-dehydrocholesterol and desmosterol by human cytochrome P450 46A1.' (Goyal S et al., 2014).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with DESMOSTEROL

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Authors Title Published Journal PubMed Link
Legault Y et al. The binding of sterol sulfates to hamster spermatozoa. 1979 Steroids pmid:483338
Harris PA and Harris KL Quantitative GLC analysis of plasma cholesterol. 1974 J Pharm Sci pmid:4830004
Jurgelski W et al. Induction of a chronic somatosensory epilepsy in the opossum (Didelphis virginiana Kerr) with an inhibitor of cholesterol biosynthesis. 1973 Brain Res. pmid:4798641
Herz JE and Cruz Montalvo S Fluorinated sterols. 1. 26,26,26,27,27,27-Hexafluorodesmosterol. 1973 J. Chem. Soc. Perkin Trans. I pmid:4795247
Norton WT and Poduslo SE Myelination in rat brain: changes in myelin composition during brain maturation. 1973 J. Neurochem. pmid:4754856
Collignon-Thiennot F et al. [Demonstration of 2 pathways for cholesterol synthesis in the mollusk: patella Patella vulgata L., (Gasteropoda, Prosobranches, Archeogasteropoda)]. 1973 Biochimie pmid:4754188
Johnson RC and Shah SN Evidence for the participation of two soluble noncatalytic proteins in hepatic microsomal cholesterol synthesis. 1973 Biochem. Biophys. Res. Commun. pmid:4741538
Fumagalli R et al. [Desmosterol test in the diagnosis of recurrent brain neoplasms]. 1973 May-Jun Acta Neurol (Napoli) pmid:4732487
Bojesen I and Roepstorff P Identification of C sterols produced by rat renal inner medulla in vitro. 1973 Biochim. Biophys. Acta pmid:4722467
Dennick RG et al. Desmosterol levels in human foetal brain--a reassessment. 1973 J. Neurochem. pmid:4697890
Imai Y and Shimamoto K Biological studies of AT-308. 1. Hypocholesterolemic effect of 1,2,4-oxadiazole derivatives in rats. 1973 Jan-Feb Atherosclerosis pmid:4696738
James MJ and Kandutsch AA Inter-relationships between dolichol and sterol synthesis in mammalian cell cultures. 1979 J. Biol. Chem. pmid:468837
Cenedella RJ and Bierkamper GG Mechanism of cataract production by 3-beta(2-diethylaminoethoxy) androst-5-en-17-one hydrochloride, U18666A: an inhibitor of cholesterol biosynthesis. 1979 Exp. Eye Res. pmid:467524
Ikan R et al. Synthesis of steroidal cyclopropanes. 1972 J. Chem. Soc. Perkin Trans. I pmid:4674538
Leboeuf M et al. [Steroid alkaloids. 138(12). Chemical composition of the fruits and grains of Holarrhena mitis R. Br. (Apocynacea): alkaloids and unsaponifiable material]. 1972 Ann Pharm Fr pmid:4668289
Wakamatsu H et al. Concentration and fatty acid composition of serum lipids in myotonia dystrophica. With special reference to pathogenesis. 1972 Horm. Metab. Res. pmid:4655500
Singh RA et al. Effect of azasterols on sterol metabolism in the laying hen. 1972 Poult. Sci. pmid:4643119
Surpuriya V and Higuchi WI Two-step interfacial barrier mechanism for the transport of micelle-solubilized solute across an oil-water interface. 1972 Biochim. Biophys. Acta pmid:4640769
Brennan PJ et al. The lipids of fungi. 1974 Prog Chem Fats Other Lipids pmid:4610639
Parks LW et al. Sterol transmethylation during aerobic adaptation of yeast. 1974 Eur. J. Biochem. pmid:4598750