DESMOSTEROL is a lipid of Sterol Lipids (ST) class. Desmosterol is associated with abnormalities such as Cataract, Congenital Abnormality, Liver diseases, Erectile dysfunction and Multiple congenital anomalies. The involved functions are known as Bulla, Methylation, cholesterol biosynthetic process, Process and cholesterol efflux. Desmosterol often locates in Body tissue, Tissue membrane, Plasma membrane, Pore and Endoplasmic Reticulum. The associated genes with DESMOSTEROL are P4HTM gene, SHH gene, WDR48 gene, CFLAR gene and SLC33A1 gene. The related lipids are Sterols, androstanol, Steroids, Unilamellar Vesicles and 7-dehydrocholesterol. The related experimental models are Transgenic Model and Rodent Model.
To understand associated biological information of DESMOSTEROL, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
DESMOSTEROL is suspected in Atherosclerosis, Congenital Abnormality, Liver diseases, Fatty Streak, Arterial, Senile Plaques, Coronary Arteriosclerosis and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with DESMOSTEROL
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Limb Deformities, Congenital | D017880 | 4 associated lipids |
| Celiac Disease | D002446 | 16 associated lipids |
| Xanthomatosis | D014973 | 17 associated lipids |
| Coronary Disease | D003327 | 70 associated lipids |
| Insulin Resistance | D007333 | 99 associated lipids |
| Hemolysis | D006461 | 131 associated lipids |
Lipid pathways are not clear in current pathway databases. We organized associated pathways with DESMOSTEROL through full-text articles, including metabolic pathways or pathways of biological mechanisms.
| Pathway name | Related literatures |
|---|
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
|---|
Transgenic Model are used in the study 'Cellular production of n-3 PUFAs and reduction of n-6-to-n-3 ratios in the pancreatic beta-cells and islets enhance insulin secretion and confer protection against cytokine-induced cell death.' (Wei D et al., 2010).
Rodent Model are used in the study 'Oxidation of 7-dehydrocholesterol and desmosterol by human cytochrome P450 46A1.' (Goyal S et al., 2014).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Yoder CA et al. | Feeding of grey squirrels (Sciurus carolinensis) with the contraceptive agent DiazaConâ„¢: effect on cholesterol, hematology, and blood chemistry. | 2011 | Integr Zool | pmid:22182332 |
| Singh P et al. | Desmosterol replaces cholesterol for ligand binding function of the serotonin(1A) receptor in solubilized hippocampal membranes: support for nonannular binding sites for cholesterol? | 2011 | Biochim. Biophys. Acta | pmid:21763272 |
| Vanmierlo T et al. | Cerebral accumulation of dietary derivable plant sterols does not interfere with memory and anxiety related behavior in Abcg5-/- mice. | 2011 | Plant Foods Hum Nutr | pmid:21431910 |
| Ramos SC et al. | The role of soluble fiber intake in patients under highly effective lipid-lowering therapy. | 2011 | Nutr J | pmid:21810257 |
| Nasir M et al. | Sterols from the red algae, Gracilaria salicornia and Hypnea flagelliformis, from Persian Gulf. | 2011 | Pharmacogn Mag | pmid:21716930 |
| Elias PM et al. | Pathogenesis of the cutaneous phenotype in inherited disorders of cholesterol metabolism: Therapeutic implications for topical treatment of these disorders. | 2011 | Dermatoendocrinol | pmid:21695019 |
| Nagata S and Nagasawa H | Sterol composition in larvae of the silkworm, Bombyx mori. | 2011 | Biosci. Biotechnol. Biochem. | pmid:21597175 |
| Wolff E et al. | Cholesterol absorption status and fasting plasma cholesterol are modulated by the microsomal triacylglycerol transfer protein -493 G/T polymorphism and the usual diet in women. | 2011 | Genes Nutr | pmid:21437032 |
| Cheng D et al. | Lipid pathway alterations in Parkinson's disease primary visual cortex. | 2011 | PLoS ONE | pmid:21387008 |
| Soh J et al. | Hepatic gene expression profiles are altered by dietary unsalted korean fermented soybean (chongkukjang) consumption in mice with diet-induced obesity. | 2011 | J Nutr Metab | pmid:21437188 |