DESMOSTEROL

DESMOSTEROL is a lipid of Sterol Lipids (ST) class. Desmosterol is associated with abnormalities such as Cataract, Congenital Abnormality, Liver diseases, Erectile dysfunction and Multiple congenital anomalies. The involved functions are known as Bulla, Methylation, cholesterol biosynthetic process, Process and cholesterol efflux. Desmosterol often locates in Body tissue, Tissue membrane, Plasma membrane, Pore and Endoplasmic Reticulum. The associated genes with DESMOSTEROL are P4HTM gene, SHH gene, WDR48 gene, CFLAR gene and SLC33A1 gene. The related lipids are Sterols, androstanol, Steroids, Unilamellar Vesicles and 7-dehydrocholesterol. The related experimental models are Transgenic Model and Rodent Model.

Cross Reference

Introduction

To understand associated biological information of DESMOSTEROL, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with DESMOSTEROL?

DESMOSTEROL is suspected in Atherosclerosis, Congenital Abnormality, Liver diseases, Fatty Streak, Arterial, Senile Plaques, Coronary Arteriosclerosis and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with DESMOSTEROL

MeSH term MeSH ID Detail
Limb Deformities, Congenital D017880 4 associated lipids
Celiac Disease D002446 16 associated lipids
Xanthomatosis D014973 17 associated lipids
Coronary Disease D003327 70 associated lipids
Insulin Resistance D007333 99 associated lipids
Hemolysis D006461 131 associated lipids
Total 6

PubChem Associated disorders and diseases

What pathways are associated with DESMOSTEROL

Lipid pathways are not clear in current pathway databases. We organized associated pathways with DESMOSTEROL through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with DESMOSTEROL?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with DESMOSTEROL?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with DESMOSTEROL?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with DESMOSTEROL?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with DESMOSTEROL?

Transgenic Model

Transgenic Model are used in the study 'Cellular production of n-3 PUFAs and reduction of n-6-to-n-3 ratios in the pancreatic beta-cells and islets enhance insulin secretion and confer protection against cytokine-induced cell death.' (Wei D et al., 2010).

Rodent Model

Rodent Model are used in the study 'Oxidation of 7-dehydrocholesterol and desmosterol by human cytochrome P450 46A1.' (Goyal S et al., 2014).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with DESMOSTEROL

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Authors Title Published Journal PubMed Link
Pasanen MK et al. Polymorphism of the hepatic influx transporter organic anion transporting polypeptide 1B1 is associated with increased cholesterol synthesis rate. 2008 Pharmacogenet. Genomics pmid:18794729
Rodríguez-Acebes S et al. Dose-dependent dual effects of cholesterol and desmosterol on J774 macrophage proliferation. 2008 Biochem. Biophys. Res. Commun. pmid:18851952
de Sain-van der Velden MG et al. Elevated cholesterol precursors other than cholestanol can also be a hallmark for CTX. 2008 J. Inherit. Metab. Dis. pmid:18949577
Laitinen K et al. Plant stanol ester spreads as components of a balanced diet for pregnant and breast-feeding women: evaluation of clinical safety. 2009 Br. J. Nutr. pmid:19017423
Kervizic G and Corcos L Dynamical modeling of the cholesterol regulatory pathway with Boolean networks. 2008 BMC Syst Biol pmid:19025648
Legg RL et al. Diets high in selenium and isoflavones decrease androgen-regulated gene expression in healthy rat dorsolateral prostate. 2008 Reprod. Biol. Endocrinol. pmid:19025659
Peri A and Serio M Estrogen receptor-mediated neuroprotection: The role of the Alzheimer's disease-related gene seladin-1. 2008 Neuropsychiatr Dis Treat pmid:19043524
Róg T et al. Comparison of cholesterol and its direct precursors along the biosynthetic pathway: effects of cholesterol, desmosterol and 7-dehydrocholesterol on saturated and unsaturated lipid bilayers. 2008 J Chem Phys pmid:19045210
Kuehnle K et al. Age-dependent increase in desmosterol restores DRM formation and membrane-related functions in cholesterol-free DHCR24-/- mice. 2009 Neurochem. Res. pmid:19115107
Miettinen TA et al. Twenty-one year tracking of serum non-cholesterol sterols. The Cardiovascular Risk in Young Finns study. 2009 Nutr Metab Cardiovasc Dis pmid:19185477
Fumagalli R and Paoletti P Radioimmunoassay of glioma associated antigen in CSF and its usefulness for the diagnosis and monitoring of human glioma. 1991 J. Neurooncol. pmid:1919650
Rodríguez-Acebes S et al. Desmosterol can replace cholesterol in sustaining cell proliferation and regulating the SREBP pathway in a sterol-Delta24-reductase-deficient cell line. 2009 Biochem. J. pmid:19260826
Buffone MG et al. High cholesterol content and decreased membrane fluidity in human spermatozoa are associated with protein tyrosine phosphorylation and functional deficiencies. 2009 Sep-Oct J. Androl. pmid:19269935
Peri A et al. New insights on the neuroprotective role of sterols and sex steroids: the seladin-1/DHCR24 paradigm. 2009 Front Neuroendocrinol pmid:19351544
Stevenson J and Brown AJ How essential is cholesterol? 2009 Biochem. J. pmid:19426142
Matthan NR et al. Alterations in cholesterol absorption/synthesis markers characterize Framingham offspring study participants with CHD. 2009 J. Lipid Res. pmid:19436064
Kuehnle K Age-dependent increase in desmosterol restores DRM formation and membrane-related functions in cholesterol-free DHCR24(-/-) mice. Neurochemical Research (34, 1167-82). 2009 Neurochem. Res. pmid:19475506
Zalata A et al. Cholesterol and desmosterol in two sperm populations separated on Sil-Select gradient. 2010 Int. J. Androl. pmid:19490187
Acimovic J et al. Combined gas chromatographic/mass spectrometric analysis of cholesterol precursors and plant sterols in cultured cells. 2009 J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. pmid:19525158
Mirza R et al. Requirement of DHCR24 for postnatal development of epidermis and hair follicles in mice. 2009 Am J Dermatopathol pmid:19542918