DESMOSTEROL

DESMOSTEROL is a lipid of Sterol Lipids (ST) class. Desmosterol is associated with abnormalities such as Cataract, Congenital Abnormality, Liver diseases, Erectile dysfunction and Multiple congenital anomalies. The involved functions are known as Bulla, Methylation, cholesterol biosynthetic process, Process and cholesterol efflux. Desmosterol often locates in Body tissue, Tissue membrane, Plasma membrane, Pore and Endoplasmic Reticulum. The associated genes with DESMOSTEROL are P4HTM gene, SHH gene, WDR48 gene, CFLAR gene and SLC33A1 gene. The related lipids are Sterols, androstanol, Steroids, Unilamellar Vesicles and 7-dehydrocholesterol. The related experimental models are Transgenic Model and Rodent Model.

Cross Reference

Introduction

To understand associated biological information of DESMOSTEROL, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with DESMOSTEROL?

DESMOSTEROL is suspected in Atherosclerosis, Congenital Abnormality, Liver diseases, Fatty Streak, Arterial, Senile Plaques, Coronary Arteriosclerosis and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with DESMOSTEROL

MeSH term MeSH ID Detail
Limb Deformities, Congenital D017880 4 associated lipids
Celiac Disease D002446 16 associated lipids
Xanthomatosis D014973 17 associated lipids
Coronary Disease D003327 70 associated lipids
Insulin Resistance D007333 99 associated lipids
Hemolysis D006461 131 associated lipids
Total 6

PubChem Associated disorders and diseases

What pathways are associated with DESMOSTEROL

Lipid pathways are not clear in current pathway databases. We organized associated pathways with DESMOSTEROL through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with DESMOSTEROL?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with DESMOSTEROL?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with DESMOSTEROL?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with DESMOSTEROL?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with DESMOSTEROL?

Transgenic Model

Transgenic Model are used in the study 'Cellular production of n-3 PUFAs and reduction of n-6-to-n-3 ratios in the pancreatic beta-cells and islets enhance insulin secretion and confer protection against cytokine-induced cell death.' (Wei D et al., 2010).

Rodent Model

Rodent Model are used in the study 'Oxidation of 7-dehydrocholesterol and desmosterol by human cytochrome P450 46A1.' (Goyal S et al., 2014).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with DESMOSTEROL

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Authors Title Published Journal PubMed Link
Jurgelski W et al. Induction of a chronic somatosensory epilepsy in the opossum (Didelphis virginiana Kerr) with an inhibitor of cholesterol biosynthesis. 1973 Brain Res. pmid:4798641
Harris PA and Harris KL Quantitative GLC analysis of plasma cholesterol. 1974 J Pharm Sci pmid:4830004
Legault Y et al. The binding of sterol sulfates to hamster spermatozoa. 1979 Steroids pmid:483338
Dasgupta SK et al. New preparation of desmosterol. 1974 J. Org. Chem. pmid:4853344
Dennick RG et al. Sterol content and squaline-2(3)-epoxide-lanosterol cyclase activity in human foetal brain during early and mid-gestation. 1974 J. Neurochem. pmid:4854410
Francisco C et al. Side chain-hydroxylated sterols of the red alga Asparagopsis armata: significant products or artifacts due to autoxidation? 1979 Steroids pmid:494359
Ramsey RB et al. Formation of methyl sterols in brain cholesterol biosynthesis. Sterol formation in vitro in actively myelinating rat brain. 1972 J. Biol. Chem. pmid:5030627
Sokoloff L and Rothblat GH Regulation of sterol synthesis in L cells: steady-state and transitional responses. 1972 Biochim. Biophys. Acta pmid:5070653
Grossi-Paoletti E et al. Tumors of the nervous system induced by ethylnitrosourea administered either intracerebrally of subcutaneously to newborn rats. Morphological and biochemical characteristics. 1972 J. Neurosurg. pmid:5076376
Ortiz de Montellano PR et al. Regulation of sterol biosynthesis and lysis of cultured hepatoma cells: inhibition of lanosterol demethylation by hydroxysterols. 1979 Biochem. Biophys. Res. Commun. pmid:508352
Shah SN Effect of neonatal food restriction and hyperphenylalaninemia on desmosterol to cholesterol (D-C) ratio in developing rat brain. 1972 Lipids pmid:5084158
Rosenblum ER et al. Effect of 20,25-diazacholesterol on viability and steroid synthesis capability of cultured chick embryo pectoral muscle cells. 1979 Biochem. Biophys. Res. Commun. pmid:572680
Ochi K et al. Synthesis of desmosterol and epidesmosterol from hyodeoxycholic acid. 1977 Steroids pmid:611642
Wasserstrom WR et al. Cerebrospinal fluid biochemical markers in central nervous system tumors: a review. 1981 May-Jun Ann. Clin. Lab. Sci. pmid:6166240
Sarkar CP and Cenedella RJ Reactivity of key metabolic sterols in standard colorimetric assays for cholesterol. 1982 Lipids pmid:6177997
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Bouthillier M et al. Distribution of steroid sulfotransferase in the male hamster reproductive tract. 1984 Biol. Reprod. pmid:6240284
Huijmans JG et al. Effects of 22S-hydroxy-cholesterol and other hydroxylated sterols on the ACTH-stimulated steroid production in rat adrenal cells. 1981 Acta Endocrinol. pmid:6263029
Leonard DA and Chen HW Aphidicolin, a specific inhibitor of DNA polymerase alpha, inhibits conversion of lanosterol to C-27 sterols in mouse L cells. 1984 J. Biol. Chem. pmid:6425279
Schroeder F et al. Correlation of tumor metastasis with sterol carrier protein and plasma membrane sterol levels. 1984 Biochem. Biophys. Res. Commun. pmid:6497882
Pullinger CR and Gibbons GF The relationship between the rate of hepatic sterol synthesis and the incorporation of [3H]water. 1983 J. Lipid Res. pmid:6644182
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Chitwood DJ et al. Novel nuclear methylation of sterols by the nematode Caenorhabditis elegans. 1983 Steroids pmid:6673193
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Clejan S and Bittman R Distribution and movement of sterols with different side chain structures between the two leaflets of the membrane bilayer of mycoplasma cells. 1984 J. Biol. Chem. pmid:6706946
Ashraf J et al. Membrane fluidity and myotonia: effects of cholesterol and desmosterol on erythrocyte membrane fluidity in rats with 20,25-diazacholesterol-induced myotonia and on phospholipid liposomes. 1984 Biosci. Rep. pmid:6713083
Hietter H et al. Antagonist action of cholesterol towards the toxicity of hydroxysterols on cultured hepatoma cells. 1984 Biochem. Biophys. Res. Commun. pmid:6732777
Patel DD et al. The absolute rate of cholesterol biosynthesis in monocyte-macrophages from normal and familial hypercholesterolaemic subjects. 1984 Biochem. J. pmid:6743229
Bierkamper GG and Cenedella RJ Induction of chronic epileptiform activity in the rat by an inhibitor of cholesterol synthesis, U18666A. 1978 Brain Res. pmid:678974
Nes WR et al. Steric effects at C-20 and C-24 on the metabolism of sterols by Tetrahymena pyriformis. 1981 J. Lipid Res. pmid:6793681
Kling D and Gamble W Cholesterol biosynthesis in polychlorinated biphenyl-treated rats. 1982 Environ. Res. pmid:6802634
Clark RM et al. Desmosterol in human milk. 1983 Lipids pmid:6855485
Chau IY and Geyer RP The effects of serum albumin and phospholipid on sterol excretion in tissue culture cells. 1978 Biochim. Biophys. Acta pmid:687659
Hansbury E and Scallen TJ Resolution of desmosterol, cholesterol, and other sterol intermediates by reverse-phase high-pressure liquid chromatography. 1978 J. Lipid Res. pmid:690514
Burck PJ and Zimmerman RE The inhibition of acrosin by sterol sulphates. 1980 J. Reprod. Fertil. pmid:6987395
Sekula BC and Nes WR Metabolism of sterols by anaerobic Saccharomyces cerevisiae. 1981 Lipids pmid:7012521
Kwieciński H Myotonia induced by chemical agents. 1981 Crit. Rev. Toxicol. pmid:7026172
Chalikian DM and Barchi RL Sarcolemmal desmosterol accumulation and membrane physical properties in 20,25-diazacholesterol myotonia. 1982 Muscle Nerve pmid:7070392
Pettler PJ et al. Mechanism of dealkylation of clionasterol in the insect Tenebrio molitor. 1978 Biochem. J. pmid:708391
Sarkar CP et al. Studies on the mechanisms of the epileptiform activity induced by U186661. I Gross alteration of the lipids of synaptosomes and myelin. 1982 Epilepsia pmid:7084136
Svoboda JA et al. Utilization and metabolism of dietary sterols in the honey bee and the yellow fever mosquito. 1982 Lipids pmid:7087696
D'Alonzo AJ and McArdle JJ An evaluation of fast- and slow-twitch muscle from rats treated with 20,25-diazacholesterol. 1982 Exp. Neurol. pmid:7117485
Long TT et al. The sources of rat biliary cholesterol and bile acid. 1978 J. Lipid Res. pmid:712246
Paoletti P Desmosterol in CSF. 1981 Neurology pmid:7194986
Evans RW and Tinoco J Monolayers of sterols and phosphatidylcholines containing a 20-carbon chain. 1978 Chem. Phys. Lipids pmid:719817
Bhattacharyya AK and Eggen DA Feedback regulation of cholesterol biosynthesis in rhesus monkeys with variable hypercholesterolemic response to dietary cholesterol. 1981 J. Lipid Res. pmid:7217781
Ramsey RB Effect of extended hypocholesterolemic drug treatment on peripheral and central nervous system sterol content of the rat. 1977 Lipids pmid:72342
Albers-Schönberg G et al. Dihydromevinolin, a potent hypocholesterolemic metabolite produced by Aspergillus terreus. 1981 J. Antibiot. pmid:7275832
Doi O and Endo A Specific inhibition of desmosterol synthesis by ML--236B in mouse LM cells grown in suspension in a lipid-free medium. 1978 Jpn. J. Med. Sci. Biol. pmid:732030
Legault Y et al. 5alpha-Cholesta-7,24-dien-3beta-ol as a major sterol of the male hamster reproductive tract. 1978 Steroids pmid:734699