DESMOSTEROL is a lipid of Sterol Lipids (ST) class. Desmosterol is associated with abnormalities such as Cataract, Congenital Abnormality, Liver diseases, Erectile dysfunction and Multiple congenital anomalies. The involved functions are known as Bulla, Methylation, cholesterol biosynthetic process, Process and cholesterol efflux. Desmosterol often locates in Body tissue, Tissue membrane, Plasma membrane, Pore and Endoplasmic Reticulum. The associated genes with DESMOSTEROL are P4HTM gene, SHH gene, WDR48 gene, CFLAR gene and SLC33A1 gene. The related lipids are Sterols, androstanol, Steroids, Unilamellar Vesicles and 7-dehydrocholesterol. The related experimental models are Transgenic Model and Rodent Model.
To understand associated biological information of DESMOSTEROL, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
DESMOSTEROL is suspected in Atherosclerosis, Congenital Abnormality, Liver diseases, Fatty Streak, Arterial, Senile Plaques, Coronary Arteriosclerosis and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with DESMOSTEROL
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Insulin Resistance | D007333 | 99 associated lipids |
| Coronary Disease | D003327 | 70 associated lipids |
| Xanthomatosis | D014973 | 17 associated lipids |
| Celiac Disease | D002446 | 16 associated lipids |
| Limb Deformities, Congenital | D017880 | 4 associated lipids |
Lipid pathways are not clear in current pathway databases. We organized associated pathways with DESMOSTEROL through full-text articles, including metabolic pathways or pathways of biological mechanisms.
| Pathway name | Related literatures |
|---|
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
| Gene | Cross reference | Weighted score | Related literatures |
|---|
Transgenic Model are used in the study 'Cellular production of n-3 PUFAs and reduction of n-6-to-n-3 ratios in the pancreatic beta-cells and islets enhance insulin secretion and confer protection against cytokine-induced cell death.' (Wei D et al., 2010).
Rodent Model are used in the study 'Oxidation of 7-dehydrocholesterol and desmosterol by human cytochrome P450 46A1.' (Goyal S et al., 2014).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Nagy K et al. | Analysis of sterols by high-performance liquid chromatography/mass spectrometry combined with chemometrics. | 2006 | Rapid Commun. Mass Spectrom. | pmid:16841361 |
| Legg RL et al. | Diets high in selenium and isoflavones decrease androgen-regulated gene expression in healthy rat dorsolateral prostate. | 2008 | Reprod. Biol. Endocrinol. | pmid:19025659 |
| Sanocka D and Kurpisz M | Reactive oxygen species and sperm cells. | 2004 | Reprod. Biol. Endocrinol. | pmid:15038829 |
| Peter JB and Fiehn W | Diazacholesterol myotonia: accumulation of desmosterol and increased adenosine triphosphatase activity of sarcolemma. | 1973 | Science | pmid:4265797 |
| Wechsler A et al. | Generation of viable cholesterol-free mice. | 2003 | Science | pmid:14684813 |
| Zhao Q et al. | A highly stereoselective synthesis of C-24 and C-25 oxysterols from desmosterol. | 2016 | Steroids | pmid:26968128 |
| Zhao Q et al. | Investigation on the synthesis of 25-hydroxycholesterol. | 2014 | Steroids | pmid:24582707 |
| Chitwood DJ et al. | Novel nuclear methylation of sterols by the nematode Caenorhabditis elegans. | 1983 | Steroids | pmid:6673193 |
| Ochi K et al. | Synthesis of desmosterol and epidesmosterol from hyodeoxycholic acid. | 1977 | Steroids | pmid:611642 |
| Pedretti A et al. | Homology modelling of human DHCR24 (seladin-1) and analysis of its binding properties through molecular docking and dynamics simulations. | 2008 | Steroids | pmid:18394665 |