DESMOSTEROL

DESMOSTEROL is a lipid of Sterol Lipids (ST) class. Desmosterol is associated with abnormalities such as Cataract, Congenital Abnormality, Liver diseases, Erectile dysfunction and Multiple congenital anomalies. The involved functions are known as Bulla, Methylation, cholesterol biosynthetic process, Process and cholesterol efflux. Desmosterol often locates in Body tissue, Tissue membrane, Plasma membrane, Pore and Endoplasmic Reticulum. The associated genes with DESMOSTEROL are P4HTM gene, SHH gene, WDR48 gene, CFLAR gene and SLC33A1 gene. The related lipids are Sterols, androstanol, Steroids, Unilamellar Vesicles and 7-dehydrocholesterol. The related experimental models are Transgenic Model and Rodent Model.

Cross Reference

Introduction

To understand associated biological information of DESMOSTEROL, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with DESMOSTEROL?

DESMOSTEROL is suspected in Atherosclerosis, Congenital Abnormality, Liver diseases, Fatty Streak, Arterial, Senile Plaques, Coronary Arteriosclerosis and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with DESMOSTEROL

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Insulin Resistance D007333 99 associated lipids
Coronary Disease D003327 70 associated lipids
Xanthomatosis D014973 17 associated lipids
Celiac Disease D002446 16 associated lipids
Limb Deformities, Congenital D017880 4 associated lipids
Total 6

PubChem Associated disorders and diseases

What pathways are associated with DESMOSTEROL

Lipid pathways are not clear in current pathway databases. We organized associated pathways with DESMOSTEROL through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with DESMOSTEROL?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with DESMOSTEROL?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with DESMOSTEROL?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with DESMOSTEROL?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with DESMOSTEROL?

Transgenic Model

Transgenic Model are used in the study 'Cellular production of n-3 PUFAs and reduction of n-6-to-n-3 ratios in the pancreatic beta-cells and islets enhance insulin secretion and confer protection against cytokine-induced cell death.' (Wei D et al., 2010).

Rodent Model

Rodent Model are used in the study 'Oxidation of 7-dehydrocholesterol and desmosterol by human cytochrome P450 46A1.' (Goyal S et al., 2014).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with DESMOSTEROL

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Authors Title Published Journal PubMed Link
Samuli Ollila OH et al. Role of sterol type on lateral pressure profiles of lipid membranes affecting membrane protein functionality: Comparison between cholesterol, desmosterol, 7-dehydrocholesterol and ketosterol. 2007 J. Struct. Biol. pmid:17369050
Serra M et al. Hair and skin sterols in normal mice and those with deficient dehydrosterol reductase (DHCR7), the enzyme associated with Smith-Lemli-Opitz syndrome. 2010 J. Steroid Biochem. Mol. Biol. pmid:20804844
Fon Tacer K et al. Adaptation of cholesterol synthesis to fasting and TNF-alpha: profiling cholesterol intermediates in the liver, brain, and testis. 2010 J. Steroid Biochem. Mol. Biol. pmid:20206258
Roberts KD Sterol sulfates in the epididymis; synthesis and possible function in the reproductive process. 1987 J. Steroid Biochem. pmid:3480393
Awano M et al. Lipid composition of hamster epididymal spermatozoa. 1993 J. Reprod. Fertil. pmid:8107019
Burck PJ and Zimmerman RE The inhibition of acrosin by sterol sulphates. 1980 J. Reprod. Fertil. pmid:6987395
Bleau G et al. Desmosteryl sulphate of hamster spermatozoa, a potent inhibitor of capacitation in vitro. 1975 J. Reprod. Fertil. pmid:1127634
Griffiths WJ et al. Discovering oxysterols in plasma: a window on the metabolome. 2008 J. Proteome Res. pmid:18605750
Arnold A et al. Triparanol-effected accumulation of desmosterol in oestrone-induced hypocholesterolaemia. 1974 J. Pharm. Pharmacol. pmid:4156546
Hedman M et al. Serum noncholesterol sterols in children with heterozygous familial hypercholesterolemia undergoing pravastatin therapy. 2006 J. Pediatr. pmid:16492436
Dasgupta SK et al. New preparation of desmosterol. 1974 J. Org. Chem. pmid:4853344
Tammi A et al. Dietary plant sterols alter the serum plant sterol concentration but not the cholesterol precursor sterol concentrations in young children (the STRIP Study). Special Turku Coronary Risk Factor Intervention Project. 2001 J. Nutr. pmid:11435511
Grossi-Paoletti E et al. Tumors of the nervous system induced by ethylnitrosourea administered either intracerebrally of subcutaneously to newborn rats. Morphological and biochemical characteristics. 1972 J. Neurosurg. pmid:5076376
Fumagalli R and Paoletti P Radioimmunoassay of glioma associated antigen in CSF and its usefulness for the diagnosis and monitoring of human glioma. 1991 J. Neurooncol. pmid:1919650
Bernini F et al. Selected ion monitoring technique for the evaluation of sterols in cerebrospinal fluid: a new approach to desmosterol test for central nervous system tumors. 1986 J. Neurooncol. pmid:3746383
Ramsey RB et al. Effect of zuclomiphene on cholesterol formation in the developing central nervous system of the rat. 1977 J. Neurochem. pmid:874494
Kim JH et al. Changes in cholesterol biosynthetic and transport pathways after excitotoxicity. 2010 J. Neurochem. pmid:19860851
Norton WT and Poduslo SE Myelination in rat brain: changes in myelin composition during brain maturation. 1973 J. Neurochem. pmid:4754856
Sweasey D et al. Biphasic myelination and the fatty acid composition of cerebrosides and cholesterol esters in the developing central nervous system of the domestic pig. 1976 J. Neurochem. pmid:965978
Jurevics H and Morell P Cholesterol for synthesis of myelin is made locally, not imported into brain. 1995 J. Neurochem. pmid:7830084