DESMOSTEROL is a lipid of Sterol Lipids (ST) class. Desmosterol is associated with abnormalities such as Cataract, Congenital Abnormality, Liver diseases, Erectile dysfunction and Multiple congenital anomalies. The involved functions are known as Bulla, Methylation, cholesterol biosynthetic process, Process and cholesterol efflux. Desmosterol often locates in Body tissue, Tissue membrane, Plasma membrane, Pore and Endoplasmic Reticulum. The associated genes with DESMOSTEROL are P4HTM gene, SHH gene, WDR48 gene, CFLAR gene and SLC33A1 gene. The related lipids are Sterols, androstanol, Steroids, Unilamellar Vesicles and 7-dehydrocholesterol. The related experimental models are Transgenic Model and Rodent Model.
To understand associated biological information of DESMOSTEROL, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
DESMOSTEROL is suspected in Atherosclerosis, Congenital Abnormality, Liver diseases, Fatty Streak, Arterial, Senile Plaques, Coronary Arteriosclerosis and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with DESMOSTEROL
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Celiac Disease | D002446 | 16 associated lipids |
| Coronary Disease | D003327 | 70 associated lipids |
| Hemolysis | D006461 | 131 associated lipids |
| Insulin Resistance | D007333 | 99 associated lipids |
| Xanthomatosis | D014973 | 17 associated lipids |
| Limb Deformities, Congenital | D017880 | 4 associated lipids |
Lipid pathways are not clear in current pathway databases. We organized associated pathways with DESMOSTEROL through full-text articles, including metabolic pathways or pathways of biological mechanisms.
| Pathway name | Related literatures |
|---|
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
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Transgenic Model are used in the study 'Cellular production of n-3 PUFAs and reduction of n-6-to-n-3 ratios in the pancreatic beta-cells and islets enhance insulin secretion and confer protection against cytokine-induced cell death.' (Wei D et al., 2010).
Rodent Model are used in the study 'Oxidation of 7-dehydrocholesterol and desmosterol by human cytochrome P450 46A1.' (Goyal S et al., 2014).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Serra M et al. | Hair and skin sterols in normal mice and those with deficient dehydrosterol reductase (DHCR7), the enzyme associated with Smith-Lemli-Opitz syndrome. | 2010 | J. Steroid Biochem. Mol. Biol. | pmid:20804844 |
| Fon Tacer K et al. | Adaptation of cholesterol synthesis to fasting and TNF-alpha: profiling cholesterol intermediates in the liver, brain, and testis. | 2010 | J. Steroid Biochem. Mol. Biol. | pmid:20206258 |
| Samuli Ollila OH et al. | Role of sterol type on lateral pressure profiles of lipid membranes affecting membrane protein functionality: Comparison between cholesterol, desmosterol, 7-dehydrocholesterol and ketosterol. | 2007 | J. Struct. Biol. | pmid:17369050 |
| Wudiri GA et al. | Molecular requirement for sterols in herpes simplex virus entry and infectivity. | 2014 | J. Virol. | pmid:25231306 |
| Doi O and Endo A | Specific inhibition of desmosterol synthesis by ML--236B in mouse LM cells grown in suspension in a lipid-free medium. | 1978 | Jpn. J. Med. Sci. Biol. | pmid:732030 |
| Choi HS and Kim YW | [Oxysterol (3,5-cholestadien-7-one, 5 beta-cholestan-3-one, 5,24-cholestadien-3 beta-OL) induced cytotoxicity and apoptosis in gallbladder epithelial cells]. | 2004 | Korean J Gastroenterol | pmid:15665577 |
| AVIGAN J and STEINBERG D | Deposition of desmosterol in the lesions of experimental atherosclerosis. | 1962 | Lancet | pmid:13863404 |
| Clayton P et al. | Desmosterolosis: a new inborn error of cholesterol biosynthesis. | 1996 | Lancet | pmid:8709748 |
| Fleisher JH et al. | Cholesterol in cerebrospinal fluid of brain tumor patients. | 1973 | Life Sci. | pmid:4358663 |
| Barbosa SP et al. | Effects of ezetimibe on markers of synthesis and absorption of cholesterol in high-risk patients with elevated C-reactive protein. | 2013 | Life Sci. | pmid:23507424 |