DESMOSTEROL is a lipid of Sterol Lipids (ST) class. Desmosterol is associated with abnormalities such as Cataract, Congenital Abnormality, Liver diseases, Erectile dysfunction and Multiple congenital anomalies. The involved functions are known as Bulla, Methylation, cholesterol biosynthetic process, Process and cholesterol efflux. Desmosterol often locates in Body tissue, Tissue membrane, Plasma membrane, Pore and Endoplasmic Reticulum. The associated genes with DESMOSTEROL are P4HTM gene, SHH gene, WDR48 gene, CFLAR gene and SLC33A1 gene. The related lipids are Sterols, androstanol, Steroids, Unilamellar Vesicles and 7-dehydrocholesterol. The related experimental models are Transgenic Model and Rodent Model.
To understand associated biological information of DESMOSTEROL, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
DESMOSTEROL is suspected in Atherosclerosis, Congenital Abnormality, Liver diseases, Fatty Streak, Arterial, Senile Plaques, Coronary Arteriosclerosis and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with DESMOSTEROL
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Celiac Disease | D002446 | 16 associated lipids |
| Coronary Disease | D003327 | 70 associated lipids |
| Hemolysis | D006461 | 131 associated lipids |
| Insulin Resistance | D007333 | 99 associated lipids |
| Xanthomatosis | D014973 | 17 associated lipids |
| Limb Deformities, Congenital | D017880 | 4 associated lipids |
Lipid pathways are not clear in current pathway databases. We organized associated pathways with DESMOSTEROL through full-text articles, including metabolic pathways or pathways of biological mechanisms.
| Pathway name | Related literatures |
|---|
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
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Transgenic Model are used in the study 'Cellular production of n-3 PUFAs and reduction of n-6-to-n-3 ratios in the pancreatic beta-cells and islets enhance insulin secretion and confer protection against cytokine-induced cell death.' (Wei D et al., 2010).
Rodent Model are used in the study 'Oxidation of 7-dehydrocholesterol and desmosterol by human cytochrome P450 46A1.' (Goyal S et al., 2014).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Seidenfeld J and Marton LJ | Biochemical markers of central nervous system tumors in cerebrospinal fluid. | 1978 Nov-Dec | Ann. Clin. Lab. Sci. | pmid:736510 |
| Hidaka K et al. | Growth of amphotericin B-resistant hamster cell line requires exogenous cholesterol. | 1980 | Exp. Cell Res. | pmid:7408982 |
| Gibbons GF and Pullinger CR | Cholesterol biosynthesis in hepatocytes. | 1978 | Biochem. Soc. Trans. | pmid:744335 |
| Lewis D et al. | Enzyme inhibition during the conversion of squalene to cholesterol. | 1995 | Steroids | pmid:7482633 |
| Jurevics H and Morell P | Cholesterol for synthesis of myelin is made locally, not imported into brain. | 1995 | J. Neurochem. | pmid:7830084 |
| Yagi T et al. | Stereochemistry of hydrogen addition to C-25 of desmosterol by sterol-delta 24-reductase of rat liver homogenate. | 1994 | Chem. Pharm. Bull. | pmid:8004717 |
| Zeeck E et al. | Sex pheromones in marine polychaetes: steroids from ripe Nereis succinea. | 1994 | Steroids | pmid:8073448 |
| Awano M et al. | Lipid composition of hamster epididymal spermatozoa. | 1993 | J. Reprod. Fertil. | pmid:8107019 |
| Lin DS et al. | Unique lipids of primate spermatozoa: desmosterol and docosahexaenoic acid. | 1993 | J. Lipid Res. | pmid:8468532 |
| Gibbons GF and Pullinger CR | Measurement of the absolute rates of cholesterol biosynthesis in isolated rat liver cells. | 1977 | Biochem. J. | pmid:849287 |