DESMOSTEROL

DESMOSTEROL is a lipid of Sterol Lipids (ST) class. Desmosterol is associated with abnormalities such as Cataract, Congenital Abnormality, Liver diseases, Erectile dysfunction and Multiple congenital anomalies. The involved functions are known as Bulla, Methylation, cholesterol biosynthetic process, Process and cholesterol efflux. Desmosterol often locates in Body tissue, Tissue membrane, Plasma membrane, Pore and Endoplasmic Reticulum. The associated genes with DESMOSTEROL are P4HTM gene, SHH gene, WDR48 gene, CFLAR gene and SLC33A1 gene. The related lipids are Sterols, androstanol, Steroids, Unilamellar Vesicles and 7-dehydrocholesterol. The related experimental models are Transgenic Model and Rodent Model.

Cross Reference

Introduction

To understand associated biological information of DESMOSTEROL, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with DESMOSTEROL?

DESMOSTEROL is suspected in Atherosclerosis, Congenital Abnormality, Liver diseases, Fatty Streak, Arterial, Senile Plaques, Coronary Arteriosclerosis and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with DESMOSTEROL

MeSH term MeSH ID Detail
Celiac Disease D002446 16 associated lipids
Coronary Disease D003327 70 associated lipids
Hemolysis D006461 131 associated lipids
Insulin Resistance D007333 99 associated lipids
Xanthomatosis D014973 17 associated lipids
Limb Deformities, Congenital D017880 4 associated lipids
Total 6

PubChem Associated disorders and diseases

What pathways are associated with DESMOSTEROL

Lipid pathways are not clear in current pathway databases. We organized associated pathways with DESMOSTEROL through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with DESMOSTEROL?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with DESMOSTEROL?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with DESMOSTEROL?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with DESMOSTEROL?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with DESMOSTEROL?

Transgenic Model

Transgenic Model are used in the study 'Cellular production of n-3 PUFAs and reduction of n-6-to-n-3 ratios in the pancreatic beta-cells and islets enhance insulin secretion and confer protection against cytokine-induced cell death.' (Wei D et al., 2010).

Rodent Model

Rodent Model are used in the study 'Oxidation of 7-dehydrocholesterol and desmosterol by human cytochrome P450 46A1.' (Goyal S et al., 2014).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with DESMOSTEROL

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Authors Title Published Journal PubMed Link
Mutka AL et al. Secretion of sterols and the NPC2 protein from primary astrocytes. 2004 J. Biol. Chem. pmid:15355983
AVIGAN J and STEINBERG D Studies of cholesterol biosynthesis. III. The desmosterol reductase system in liver. 1961 J. Biol. Chem. pmid:13863405
AVIGAN J et al. Studies of cholesterol biosynthesis. I. The identification of desmosterol in serum and tissues of animals and man treated with MER-29. 1960 J. Biol. Chem. pmid:13685286
STOKES WM et al. Sterol metabolism. I. The occurrence of desmosterol (24-dehydrocholesterol) in rat skin and its conversion in vivo to cholesterol. 1958 J. Biol. Chem. pmid:13549424
Megha O et al. Cholesterol precursors stabilize ordinary and ceramide-rich ordered lipid domains (lipid rafts) to different degrees. Implications for the Bloch hypothesis and sterol biosynthesis disorders. 2006 J. Biol. Chem. pmid:16735517
Ener MA and Frantz ID Chemical synthesis of delta 7,24-(3alpha-3H)cholestadien-3beta-ol and its conversion to cholesterol in the rat. 1973 J. Biol. Chem. pmid:4355504
FISH WA et al. Metabolism of cholesterol in the chick embryo. III. Localization and turnover of desmosterol (24-dehydrocholesterol). 1962 J. Biol. Chem. pmid:13893200
Yang C et al. Sterol intermediates from cholesterol biosynthetic pathway as liver X receptor ligands. 2006 J. Biol. Chem. pmid:16857673
Steinberg D Chance and serendipity in science: two examples from my own career. 2011 J. Biol. Chem. pmid:21908608
Ramsey RB et al. Formation of methyl sterols in brain cholesterol biosynthesis. Sterol formation in vitro in actively myelinating rat brain. 1972 J. Biol. Chem. pmid:5030627
Ohyama Y et al. Studies on the transcriptional regulation of cholesterol 24-hydroxylase (CYP46A1): marked insensitivity toward different regulatory axes. 2006 J. Biol. Chem. pmid:16321981
Kiyotake R et al. Human Mincle Binds to Cholesterol Crystals and Triggers Innate Immune Responses. 2015 J. Biol. Chem. pmid:26296894
Vainio S et al. Significance of sterol structural specificity. Desmosterol cannot replace cholesterol in lipid rafts. 2006 J. Biol. Chem. pmid:16249181
Clejan S and Bittman R Distribution and movement of sterols with different side chain structures between the two leaflets of the membrane bilayer of mycoplasma cells. 1984 J. Biol. Chem. pmid:6706946
James MJ and Kandutsch AA Inter-relationships between dolichol and sterol synthesis in mammalian cell cultures. 1979 J. Biol. Chem. pmid:468837
Lusa S et al. Differential mobilization of newly synthesized cholesterol and biosynthetic sterol precursors from cells. 2003 J. Biol. Chem. pmid:12657643
Feio CA et al. Euterpe oleracea (açai) modifies sterol metabolism and attenuates experimentally-induced atherosclerosis. 2012 J. Atheroscler. Thromb. pmid:22139433
Albers-Schönberg G et al. Dihydromevinolin, a potent hypocholesterolemic metabolite produced by Aspergillus terreus. 1981 J. Antibiot. pmid:7275832
Buffone MG et al. High cholesterol content and decreased membrane fluidity in human spermatozoa are associated with protein tyrosine phosphorylation and functional deficiencies. 2009 Sep-Oct J. Androl. pmid:19269935
Rajaratnam RA et al. Independent association of serum squalene and noncholesterol sterols with coronary artery disease in postmenopausal women. 2000 J. Am. Coll. Cardiol. pmid:10758959
Rodgers MA et al. Lipid metabolite profiling identifies desmosterol metabolism as a new antiviral target for hepatitis C virus. 2012 J. Am. Chem. Soc. pmid:22480142
Chen SM et al. Letter: Stereospecificity in the conversion of fucosterol 24,28-epoxide to desmosterol in the silkworm, Bombyx mori. 1975 J. Am. Chem. Soc. pmid:1165366
Wisniewski T et al. Alzheimer's disease: brain desmosterol levels. 2013 J. Alzheimers Dis. pmid:23042211
Vanmierlo T et al. Alterations in brain cholesterol metabolism in the APPSLxPS1mut mouse, a model for Alzheimer's disease. 2010 J. Alzheimers Dis. pmid:20061631
Javitt NB Alzheimer's disease: neuroprogesterone, epoxycholesterol, and ABC transporters as determinants of neurodesmosterol tissue levels and its role in amyloid protein processing. 2013 J. Alzheimers Dis. pmid:23455994
Johnston JJ et al. Desmosterol: a biomarker for the efficient development of 20,25-diazacholesterol as a contraceptive for pest wildlife. 2003 J. Agric. Food Chem. pmid:12502398
Turi JS et al. Systems approach to study of solute transport across membranes using suspension cultures of mammalian cells IV: Uptake and release kinetics of sterols. 1975 J Pharm Sci pmid:1170314
Harris PA and Harris KL Quantitative GLC analysis of plasma cholesterol. 1974 J Pharm Sci pmid:4830004
Soh J et al. Hepatic gene expression profiles are altered by dietary unsalted korean fermented soybean (chongkukjang) consumption in mice with diet-induced obesity. 2011 J Nutr Metab pmid:21437188
Sheriff DS and Ali EF Perspective on plasma membrane cholesterol efflux and spermatozoal function. 2010 J Hum Reprod Sci pmid:21209749
Shay CM et al. Do plant sterol concentrations correlate with coronary artery disease in type 1 diabetes? A report from the Pittsburgh Epidemiology of Diabetes Complications Study. 2009 J Diabetes pmid:20827426
Hoenig MR et al. The C3435T polymorphism in ABCB1 influences atorvastatin efficacy and muscle symptoms in a high-risk vascular cohort. J Clin Lipidol pmid:21392722
Sion B et al. Quantitative analysis of desmosterol, cholesterol and cholesterol sulfate in semen by high-performance liquid chromatography. 2001 J Chromatogr A pmid:11762778
Róg T et al. Comparison of cholesterol and its direct precursors along the biosynthetic pathway: effects of cholesterol, desmosterol and 7-dehydrocholesterol on saturated and unsaturated lipid bilayers. 2008 J Chem Phys pmid:19045210
Schmelzer C et al. The reduced form of coenzyme Q10 mediates distinct effects on cholesterol metabolism at the transcriptional and metabolite level in SAMP1 mice. 2010 IUBMB Life pmid:21086475
Yoder CA et al. Feeding of grey squirrels (Sciurus carolinensis) with the contraceptive agent DiazaConâ„¢: effect on cholesterol, hematology, and blood chemistry. 2011 Integr Zool pmid:22182332
Zalata A et al. Cholesterol and desmosterol in two sperm populations separated on Sil-Select gradient. 2010 Int. J. Androl. pmid:19490187
de Almeida CL et al. Bioactivities from marine algae of the genus Gracilaria. 2011 Int J Mol Sci pmid:21845096
Hamdan IJA et al. Sterols in infant formulas: validation of a gas chromatographic method. 2017 Int J Food Sci Nutr pmid:28276904
Ozyurt G et al. Comparative seasonal sterol profiles in edible parts of Mediterranean fish and shellfish species. 2013 Int J Food Sci Nutr pmid:23216341
Cacabelos R et al. Genomics of Dementia: APOE- and CYP2D6-Related Pharmacogenetics. 2012 Int J Alzheimers Dis pmid:22482072
Wakamatsu H et al. Concentration and fatty acid composition of serum lipids in myotonia dystrophica. With special reference to pathogenesis. 1972 Horm. Metab. Res. pmid:4655500
Stojakovic T et al. Atorvastatin in patients with primary biliary cirrhosis and incomplete biochemical response to ursodeoxycholic acid. 2007 Hepatology pmid:17668874
Simonen M et al. Desmosterol in human nonalcoholic steatohepatitis. 2013 Hepatology pmid:23447451
Hajar R Statins: past and present. 2011 Heart Views pmid:22567201
Vuoristo M and Miettinen TA Serum cholesterol precursor sterols in coeliac disease: effects of gluten free diet and cholestyramine. 1986 Gut pmid:3792914
Wolff E et al. Cholesterol absorption status and fasting plasma cholesterol are modulated by the microsomal triacylglycerol transfer protein -493 G/T polymorphism and the usual diet in women. 2011 Genes Nutr pmid:21437032
Peri A et al. New insights on the neuroprotective role of sterols and sex steroids: the seladin-1/DHCR24 paradigm. 2009 Front Neuroendocrinol pmid:19351544
Lin HY et al. Molecular basis for certain neuroprotective effects of thyroid hormone. 2011 Front Mol Neurosci pmid:22016721
Dennick RG et al. The occurrence of desmosterol in neuronal and glial fractions from developing rat brain. 1974 FEBS Lett. pmid:4213464