DESMOSTEROL

DESMOSTEROL is a lipid of Sterol Lipids (ST) class. Desmosterol is associated with abnormalities such as Cataract, Congenital Abnormality, Liver diseases, Erectile dysfunction and Multiple congenital anomalies. The involved functions are known as Bulla, Methylation, cholesterol biosynthetic process, Process and cholesterol efflux. Desmosterol often locates in Body tissue, Tissue membrane, Plasma membrane, Pore and Endoplasmic Reticulum. The associated genes with DESMOSTEROL are P4HTM gene, SHH gene, WDR48 gene, CFLAR gene and SLC33A1 gene. The related lipids are Sterols, androstanol, Steroids, Unilamellar Vesicles and 7-dehydrocholesterol. The related experimental models are Transgenic Model and Rodent Model.

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Introduction

To understand associated biological information of DESMOSTEROL, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with DESMOSTEROL?

DESMOSTEROL is suspected in Atherosclerosis, Congenital Abnormality, Liver diseases, Fatty Streak, Arterial, Senile Plaques, Coronary Arteriosclerosis and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with DESMOSTEROL

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Coronary Disease D003327 70 associated lipids
Celiac Disease D002446 16 associated lipids
Xanthomatosis D014973 17 associated lipids
Insulin Resistance D007333 99 associated lipids
Limb Deformities, Congenital D017880 4 associated lipids
Total 6

PubChem Associated disorders and diseases

What pathways are associated with DESMOSTEROL

Lipid pathways are not clear in current pathway databases. We organized associated pathways with DESMOSTEROL through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with DESMOSTEROL?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with DESMOSTEROL?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with DESMOSTEROL?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with DESMOSTEROL?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with DESMOSTEROL?

Transgenic Model

Transgenic Model are used in the study 'Cellular production of n-3 PUFAs and reduction of n-6-to-n-3 ratios in the pancreatic beta-cells and islets enhance insulin secretion and confer protection against cytokine-induced cell death.' (Wei D et al., 2010).

Rodent Model

Rodent Model are used in the study 'Oxidation of 7-dehydrocholesterol and desmosterol by human cytochrome P450 46A1.' (Goyal S et al., 2014).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with DESMOSTEROL

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Authors Title Published Journal PubMed Link
Hoenig MR et al. The C3435T polymorphism in ABCB1 influences atorvastatin efficacy and muscle symptoms in a high-risk vascular cohort. J Clin Lipidol pmid:21392722
pmid:
STOKES WM et al. Sterol metabolism. I. The occurrence of desmosterol (24-dehydrocholesterol) in rat skin and its conversion in vivo to cholesterol. 1958 J. Biol. Chem. pmid:13549424
AVIGAN J et al. Studies of cholesterol biosynthesis. I. The identification of desmosterol in serum and tissues of animals and man treated with MER-29. 1960 J. Biol. Chem. pmid:13685286
STEINBERG D et al. Identification of 24-dehydrocholesterol in the serum of patients treated with MER-29. 1960 Prog Cardiovasc Dis pmid:13834161
AVIGAN J and STEINBERG D Studies of cholesterol biosynthesis. III. The desmosterol reductase system in liver. 1961 J. Biol. Chem. pmid:13863405
SACHS BA and WOLFMAN L Studies of serum desmosterol levels in hypercholesteremic subjects treated with triparanol (MER-29). 1961 Nov-Dec Am. J. Clin. Nutr. pmid:14495832
GOODMAN DS et al. The in vitro metabolism of desmosterol with adrenal and liver preparations. 1962 J. Clin. Invest. pmid:13949087
AVIGAN J and STEINBERG D Deposition of desmosterol in the lesions of experimental atherosclerosis. 1962 Lancet pmid:13863404
FISH WA et al. Metabolism of cholesterol in the chick embryo. III. Localization and turnover of desmosterol (24-dehydrocholesterol). 1962 J. Biol. Chem. pmid:13893200
GOODMAN DS et al. The metabolism of desmosterol in human subjects during triparanol administration. 1962 J. Clin. Invest. pmid:13900301
HERNDON JH and SIPERSTEIN MD Desmosterol deposition in human and experimental atherosclerosis. 1963 Circ. Res. pmid:13953991
WHITBY LG et al. THE ESTIMATION OF DESMOSTEROL AND CHOLESTEROL IN PLASMA. 1964 Br Heart J pmid:14132032
POTTIER J and BUSIGNY M [DETERMINATION OF DESMOSTEROL IN SERUM]. 1964 Clin. Chim. Acta pmid:14231926
CHOBANIAN AV and HOLLANDER W TISSUE DISTRIBUTION OF CHOLESTEROL AND 24-DEHYDROCHOLESTEROL DURING CHRONIC TRIPARANOL THERAPY. 1965 J. Lipid Res. pmid:14280470
Svoboda JA and Thompson MJ Separation of 24- and 25-dehydrocholesterols; and the impure state of commercial desmosterol preparations. 1967 J. Lipid Res. pmid:14564725
Sokoloff L and Rothblat GH Regulation of sterol synthesis in L cells: steady-state and transitional responses. 1972 Biochim. Biophys. Acta pmid:5070653
Surpuriya V and Higuchi WI Two-step interfacial barrier mechanism for the transport of micelle-solubilized solute across an oil-water interface. 1972 Biochim. Biophys. Acta pmid:4640769
Siperstein MD The relationship of cholesterol biosynthesis to cancer. 1972 Trans. Am. Clin. Climatol. Assoc. pmid:4340647
Singh RA et al. Effect of azasterols on sterol metabolism in the laying hen. 1972 Poult. Sci. pmid:4643119
Ramsey RB et al. Formation of methyl sterols in brain cholesterol biosynthesis. Sterol formation in vitro in actively myelinating rat brain. 1972 J. Biol. Chem. pmid:5030627
Akhtar M et al. A novel olefinic rearrangement. The enzymic conversion of cholesta-7,9-dien-3 -ol into cholesta-8,14-dien-3 -ol. 1972 Biochem. J. pmid:4404936
Shah SN Effect of neonatal food restriction and hyperphenylalaninemia on desmosterol to cholesterol (D-C) ratio in developing rat brain. 1972 Lipids pmid:5084158
Wakamatsu H et al. Concentration and fatty acid composition of serum lipids in myotonia dystrophica. With special reference to pathogenesis. 1972 Horm. Metab. Res. pmid:4655500
Grossi-Paoletti E et al. Tumors of the nervous system induced by ethylnitrosourea administered either intracerebrally of subcutaneously to newborn rats. Morphological and biochemical characteristics. 1972 J. Neurosurg. pmid:5076376
Ikan R et al. Synthesis of steroidal cyclopropanes. 1972 J. Chem. Soc. Perkin Trans. I pmid:4674538
Leboeuf M et al. [Steroid alkaloids. 138(12). Chemical composition of the fruits and grains of Holarrhena mitis R. Br. (Apocynacea): alkaloids and unsaponifiable material]. 1972 Ann Pharm Fr pmid:4668289
Fiehn W et al. ATPases of erythrocytes from rats with 20, 25-diazacholesterol induced myotonia. 1973 FEBS Lett. pmid:4270614
Peter JB and Fiehn W Diazacholesterol myotonia: accumulation of desmosterol and increased adenosine triphosphatase activity of sarcolemma. 1973 Science pmid:4265797
Johnson RC and Shah SN Evidence for the participation of two soluble noncatalytic proteins in hepatic microsomal cholesterol synthesis. 1973 Biochem. Biophys. Res. Commun. pmid:4741538
Bojesen I and Roepstorff P Identification of C sterols produced by rat renal inner medulla in vitro. 1973 Biochim. Biophys. Acta pmid:4722467
Dennick RG et al. Desmosterol levels in human foetal brain--a reassessment. 1973 J. Neurochem. pmid:4697890
Ener MA and Frantz ID Chemical synthesis of delta 7,24-(3alpha-3H)cholestadien-3beta-ol and its conversion to cholesterol in the rat. 1973 J. Biol. Chem. pmid:4355504
Fleisher JH et al. Cholesterol in cerebrospinal fluid of brain tumor patients. 1973 Life Sci. pmid:4358663
Jurgelski W et al. Induction of a chronic somatosensory epilepsy in the opossum (Didelphis virginiana Kerr) with an inhibitor of cholesterol biosynthesis. 1973 Brain Res. pmid:4798641
Norton WT and Poduslo SE Myelination in rat brain: changes in myelin composition during brain maturation. 1973 J. Neurochem. pmid:4754856
Marton LJ et al. Faliure to demonstrate desmosterol in spinal fluid of brain tumor patients. 1973 Arch. Neurol. pmid:4345665
Herz JE and Cruz Montalvo S Fluorinated sterols. 1. 26,26,26,27,27,27-Hexafluorodesmosterol. 1973 J. Chem. Soc. Perkin Trans. I pmid:4795247
Collignon-Thiennot F et al. [Demonstration of 2 pathways for cholesterol synthesis in the mollusk: patella Patella vulgata L., (Gasteropoda, Prosobranches, Archeogasteropoda)]. 1973 Biochimie pmid:4754188
Imai Y and Shimamoto K Biological studies of AT-308. 1. Hypocholesterolemic effect of 1,2,4-oxadiazole derivatives in rats. 1973 Jan-Feb Atherosclerosis pmid:4696738
Fumagalli R et al. [Desmosterol test in the diagnosis of recurrent brain neoplasms]. 1973 May-Jun Acta Neurol (Napoli) pmid:4732487
Johnson RC and Shah SN Microsomal synthesis of cholesterol from squalene, Lanosterol, and desmosterol. Evidence for the presence of two noncatalytic activator proteins in the 105,000 g supernatant fraction from brain, heart, and kidney. 1974 Arch. Biochem. Biophys. pmid:4460877
Kobayashi M and Mitsuhashi H Marine sterols. V. Isolation and structure of occelasterol, a new 27-norergostane-type sterol, from an annelida, Pseudopotamilla occelata. 1974 Steroids pmid:4370183
Smith AG and Goad LJ Sterol biosynthesis by the sea urchin Echinus esculentus. 1974 Biochem. J. pmid:4441383
Ramsey RB and Davison AN Steryl esters and their relationship to normal and diseased human central nervous system. 1974 J. Lipid Res. pmid:4363969
Parks LW et al. Sterol transmethylation during aerobic adaptation of yeast. 1974 Eur. J. Biochem. pmid:4598750
Morisaki M et al. Nutritional effect of possible intermediates of phytosterol dealkylation in the silkworm, Bombyx mori. 1974 Steroids pmid:4421556
Dennick RG et al. Sterol content and squaline-2(3)-epoxide-lanosterol cyclase activity in human foetal brain during early and mid-gestation. 1974 J. Neurochem. pmid:4854410
Watson KC and Kerr EJ Sterol structural requirements for inhibition of streptolysin O activity. 1974 Biochem. J. pmid:4451554
Dennick RG et al. The occurrence of desmosterol in neuronal and glial fractions from developing rat brain. 1974 FEBS Lett. pmid:4213464
Bleau G and VandenHeuvel WJ Desmosteryl sulfate and desmosterol in hamster epididymal spermatozoa. 1974 Steroids pmid:4423229
Brennan PJ et al. The lipids of fungi. 1974 Prog Chem Fats Other Lipids pmid:4610639
Bates SR and Rothblat GH Regulation of cellular sterol flux and synthesis by human serum lipoproteins. 1974 Biochim. Biophys. Acta pmid:4369129
Croce CM et al. Restoration of the conversion of desmosterol to cholesterol in L-cells after hybridization with human fibroblasts. 1974 Proc. Natl. Acad. Sci. U.S.A. pmid:4359325
Harris PA and Harris KL Quantitative GLC analysis of plasma cholesterol. 1974 J Pharm Sci pmid:4830004
Arnold A et al. Triparanol-effected accumulation of desmosterol in oestrone-induced hypocholesterolaemia. 1974 J. Pharm. Pharmacol. pmid:4156546
Dasgupta SK et al. New preparation of desmosterol. 1974 J. Org. Chem. pmid:4853344
Arnold A et al. Triparanol-induced desmoterol accumulation in clofibrate-effected hypocholesterolemia. 1974 Sep-Oct Atherosclerosis pmid:4416741
Awata N et al. Carbon-carbon bond cleavage of fucosterol-24, 28-oxide by cell-free extracts of silkworm Bombyx mori. 1975 Biochem. Biophys. Res. Commun. pmid:167728
Seiler D et al. [Effect of sterol composition on the activity of transport-ATPase of the erythrocyte membrane]. 1975 Verh Dtsch Ges Inn Med pmid:132802
Nagatomo T and Peter JB (Na+ + K+)-ATPase activity in rats with 20, 25-diazacholesterol-induced myotonia. 1975 Exp. Neurol. pmid:123512
Svoboda JA et al. Recent developments in insect steroid metabolism. 1975 Annu. Rev. Entomol. pmid:1091201
Fiehn W et al. Transport ATPases of cardiac sarcolemma in 20,25-diazacholesterol induced myopathy. 1975 Eur. J. Clin. Invest. pmid:126165
Peter JB et al. The effect of a high cholesterol diet on 20,25-diazacholesterol-induced myotonia. 1975 Exp. Neurol. pmid:127722
Chen SM et al. Letter: Stereospecificity in the conversion of fucosterol 24,28-epoxide to desmosterol in the silkworm, Bombyx mori. 1975 J. Am. Chem. Soc. pmid:1165366
Turi JS et al. Systems approach to study of solute transport across membranes using suspension cultures of mammalian cells IV: Uptake and release kinetics of sterols. 1975 J Pharm Sci pmid:1170314
Bleau G et al. Desmosteryl sulphate of hamster spermatozoa, a potent inhibitor of capacitation in vitro. 1975 J. Reprod. Fertil. pmid:1127634
Fujimoto Y et al. Studies on steroids. Part XXIX. Synthesis of allenic analogues fucosterol and desmosterol. 1975 J. Chem. Soc. Perkin Trans. I pmid:1239449
Kuksis A et al. Identification of plant sterols in plasma and red blood cells of man and experimental animals. 1976 Lipids pmid:972575
Lalumière G et al. Cholesteryl sulfate and sterol sulfatase in the human reproductive tract. 1976 Steroids pmid:1273889
Pleasure D and Kim SU Sterol synthesis by myelinating cultures of mouse spinal cord. 1976 Brain Res. pmid:175882
Weiss JF et al. Desmosterol in human and experimental brain tumors in tissue culture. 1976 Arch. Neurol. pmid:1252160
Bagshawe KD and Harland S Detection of intracranial tumours with special reference to immunodiagnosis. 1976 Proc. R. Soc. Med. pmid:945577
Arthur JR et al. Oxidation of cholesterol and cholesterol analogues by mitochondrial preparations of steroid-hormone-producing tissue. 1976 Biochem. J. pmid:986816
Sweasey D et al. Biphasic myelination and the fatty acid composition of cerebrosides and cholesterol esters in the developing central nervous system of the domestic pig. 1976 J. Neurochem. pmid:965978
Johnson RC and Shah SN Binding of squalene, lanosterol, desmosterol, and cholesterol to proteins in brain and liver 105,000 g supernatant fractions: evidence for specific binding sites. 1976 Lipids pmid:994754
Svoboda JA et al. Reduction of blood and liver cholesterol in the rat by straight and branched chain alkyl amines. 1977 Lipids pmid:909356
Saito Y et al. Animal cell mutants defective in sterol metabolism: a specific selection procedure and partial characterization of defects. 1977 Proc. Natl. Acad. Sci. U.S.A. pmid:269426
Ramsey RB et al. Effect of zuclomiphene on cholesterol formation in the developing central nervous system of the rat. 1977 J. Neurochem. pmid:874494
Gibbons GF and Pullinger CR Measurement of the absolute rates of cholesterol biosynthesis in isolated rat liver cells. 1977 Biochem. J. pmid:849287
Abernethy DR and Azarnoff DL Effect of drugs which alter microsomal drug-metabolizing enzyme activity on rat hepatic cholesterol biosynthesis. 1977 Biochem. Pharmacol. pmid:849344
Ochi K et al. Synthesis of desmosterol and epidesmosterol from hyodeoxycholic acid. 1977 Steroids pmid:611642
Ramsey RB Effect of extended hypocholesterolemic drug treatment on peripheral and central nervous system sterol content of the rat. 1977 Lipids pmid:72342
Palamarchuk VI and Koval' VG [Isolation and identification of desmosterol and its concentration in animal brain tissue]. 1977 Mar-Apr Ukr Biokhim Zh pmid:867530
Legault Y et al. 5alpha-Cholesta-7,24-dien-3beta-ol as a major sterol of the male hamster reproductive tract. 1978 Steroids pmid:734699
Pettler PJ et al. Mechanism of dealkylation of clionasterol in the insect Tenebrio molitor. 1978 Biochem. J. pmid:708391
Long TT et al. The sources of rat biliary cholesterol and bile acid. 1978 J. Lipid Res. pmid:712246
Gibbons GF and Pullinger CR Cholesterol biosynthesis in hepatocytes. 1978 Biochem. Soc. Trans. pmid:744335
Bierkamper GG and Cenedella RJ Induction of chronic epileptiform activity in the rat by an inhibitor of cholesterol synthesis, U18666A. 1978 Brain Res. pmid:678974
Albers HK et al. [The problem of characterization of sterins in the gingiva by means of gas chromatography--mass spectrometry]. 1978 Dtsch Zahnarztl Z pmid:280451
Volpe JJ et al. Regulation of cholesterol ester synthesis in cultured glial and neuronal cells. Relation to control of cholesterol synthesis. 1978 Biochim. Biophys. Acta pmid:205252
Chau IY and Geyer RP The effects of serum albumin and phospholipid on sterol excretion in tissue culture cells. 1978 Biochim. Biophys. Acta pmid:687659
Evans RW and Tinoco J Monolayers of sterols and phosphatidylcholines containing a 20-carbon chain. 1978 Chem. Phys. Lipids pmid:719817
Doi O and Endo A Specific inhibition of desmosterol synthesis by ML--236B in mouse LM cells grown in suspension in a lipid-free medium. 1978 Jpn. J. Med. Sci. Biol. pmid:732030
Hansbury E and Scallen TJ Resolution of desmosterol, cholesterol, and other sterol intermediates by reverse-phase high-pressure liquid chromatography. 1978 J. Lipid Res. pmid:690514
Seidenfeld J and Marton LJ Biochemical markers of central nervous system tumors in cerebrospinal fluid. 1978 Nov-Dec Ann. Clin. Lab. Sci. pmid:736510
Bentzen CL and Brendel K Synthesis of [24, 25-3H]cholesterol: a new substrate for determining the rate of cholesterol side chain oxidation. 1979 J. Lipid Res. pmid:438651
Legault Y et al. The binding of sterol sulfates to hamster spermatozoa. 1979 Steroids pmid:483338
James MJ and Kandutsch AA Inter-relationships between dolichol and sterol synthesis in mammalian cell cultures. 1979 J. Biol. Chem. pmid:468837
Seidenfeld J and Marton LJ Biochemical markers of central nervous system tumors measured in cerebrospinal fluid and their potential use in diagnosis and patient management: a review. 1979 J. Natl. Cancer Inst. pmid:384010