DESMOSTEROL

DESMOSTEROL is a lipid of Sterol Lipids (ST) class. Desmosterol is associated with abnormalities such as Cataract, Congenital Abnormality, Liver diseases, Erectile dysfunction and Multiple congenital anomalies. The involved functions are known as Bulla, Methylation, cholesterol biosynthetic process, Process and cholesterol efflux. Desmosterol often locates in Body tissue, Tissue membrane, Plasma membrane, Pore and Endoplasmic Reticulum. The associated genes with DESMOSTEROL are P4HTM gene, SHH gene, WDR48 gene, CFLAR gene and SLC33A1 gene. The related lipids are Sterols, androstanol, Steroids, Unilamellar Vesicles and 7-dehydrocholesterol. The related experimental models are Transgenic Model and Rodent Model.

Cross Reference

Introduction

To understand associated biological information of DESMOSTEROL, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with DESMOSTEROL?

DESMOSTEROL is suspected in Atherosclerosis, Congenital Abnormality, Liver diseases, Fatty Streak, Arterial, Senile Plaques, Coronary Arteriosclerosis and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with DESMOSTEROL

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Coronary Disease D003327 70 associated lipids
Celiac Disease D002446 16 associated lipids
Xanthomatosis D014973 17 associated lipids
Insulin Resistance D007333 99 associated lipids
Limb Deformities, Congenital D017880 4 associated lipids
Total 6

PubChem Associated disorders and diseases

What pathways are associated with DESMOSTEROL

Lipid pathways are not clear in current pathway databases. We organized associated pathways with DESMOSTEROL through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
Loading... please refresh the page if content is not showing up.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with DESMOSTEROL?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with DESMOSTEROL?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with DESMOSTEROL?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with DESMOSTEROL?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with DESMOSTEROL?

Transgenic Model

Transgenic Model are used in the study 'Cellular production of n-3 PUFAs and reduction of n-6-to-n-3 ratios in the pancreatic beta-cells and islets enhance insulin secretion and confer protection against cytokine-induced cell death.' (Wei D et al., 2010).

Rodent Model

Rodent Model are used in the study 'Oxidation of 7-dehydrocholesterol and desmosterol by human cytochrome P450 46A1.' (Goyal S et al., 2014).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

NCBI Entrez Crosslinks

All references with DESMOSTEROL

Download all related citations
Per page 10 20 50 100 | Total 433
Authors Title Published Journal PubMed Link
Johnson RC and Shah SN Binding of squalene, lanosterol, desmosterol, and cholesterol to proteins in brain and liver 105,000 g supernatant fractions: evidence for specific binding sites. 1976 Lipids pmid:994754
Fujimoto Y et al. Stereochemistry of the reduction of 24-ethyldesmosterol to sitosterol in tissue cultures of Oryza sativa. 1998 Bioorg. Med. Chem. Lett. pmid:9871655
Arthur JR et al. Oxidation of cholesterol and cholesterol analogues by mitochondrial preparations of steroid-hormone-producing tissue. 1976 Biochem. J. pmid:986816
Phillips JE et al. Basis for rapid efflux of biosynthetic desmosterol from cells. 1998 J. Lipid Res. pmid:9831635
Kuksis A et al. Identification of plant sterols in plasma and red blood cells of man and experimental animals. 1976 Lipids pmid:972575
Connor WE et al. Uneven distribution of desmosterol and docosahexaenoic acid in the heads and tails of monkey sperm. 1998 J. Lipid Res. pmid:9684743
Sweasey D et al. Biphasic myelination and the fatty acid composition of cerebrosides and cholesterol esters in the developing central nervous system of the domestic pig. 1976 J. Neurochem. pmid:965978
Gylling H et al. Oral guar gum treatment of intrahepatic cholestasis and pruritus in pregnant women: effects on serum cholestanol and other non-cholesterol sterols. 1998 Eur. J. Clin. Invest. pmid:9650008
Clayton PT Disorders of cholesterol biosynthesis. 1998 Arch. Dis. Child. pmid:9579167
Bagshawe KD and Harland S Detection of intracranial tumours with special reference to immunodiagnosis. 1976 Proc. R. Soc. Med. pmid:945577
FitzPatrick DR et al. Clinical phenotype of desmosterolosis. 1998 Am. J. Med. Genet. pmid:9450875
Weete JD and Gandhi SR Sterols of the phylum zygomycota: phylogenetic implications. 1997 Lipids pmid:9438242
Connor WE et al. Biochemical markers for puberty in the monkey testis: desmosterol and docosahexaenoic acid. 1997 J. Clin. Endocrinol. Metab. pmid:9177405
Svoboda JA et al. Reduction of blood and liver cholesterol in the rat by straight and branched chain alkyl amines. 1977 Lipids pmid:909356
Sheu JH et al. Cytotoxic oxygenated desmosterols of the red alga Galaxaura marginata. 1996 J. Nat. Prod. pmid:8984148
Hakala K et al. Serum cholesterol, cholesterol precursors and plant sterols in different inflammatory bowel diseases. 1996 Digestion pmid:8786005
Miquel K et al. Farnesol and geranylgeraniol induce actin cytoskeleton disorganization and apoptosis in A549 lung adenocarcinoma cells. 1996 Biochem. Biophys. Res. Commun. pmid:8780704
Ramsey RB et al. Effect of zuclomiphene on cholesterol formation in the developing central nervous system of the rat. 1977 J. Neurochem. pmid:874494
Clayton P et al. Desmosterolosis: a new inborn error of cholesterol biosynthesis. 1996 Lancet pmid:8709748
Palamarchuk VI and Koval' VG [Isolation and identification of desmosterol and its concentration in animal brain tissue]. 1977 Mar-Apr Ukr Biokhim Zh pmid:867530
Stranberg TE et al. Associations of fasting blood glucose with cholesterol absorption and synthesis in nondiabetic middle-aged men. 1996 Diabetes pmid:8635649
Likhodii SS and Cunnane SC Utilization of carbon from dietary polyunsaturates for brain cholesterol synthesis during early postnatal development in the rat: a 13C NMR study. 1995 Magn Reson Med pmid:8598807
Abernethy DR and Azarnoff DL Effect of drugs which alter microsomal drug-metabolizing enzyme activity on rat hepatic cholesterol biosynthesis. 1977 Biochem. Pharmacol. pmid:849344
Gibbons GF and Pullinger CR Measurement of the absolute rates of cholesterol biosynthesis in isolated rat liver cells. 1977 Biochem. J. pmid:849287
Lin DS et al. Unique lipids of primate spermatozoa: desmosterol and docosahexaenoic acid. 1993 J. Lipid Res. pmid:8468532
Awano M et al. Lipid composition of hamster epididymal spermatozoa. 1993 J. Reprod. Fertil. pmid:8107019
Zeeck E et al. Sex pheromones in marine polychaetes: steroids from ripe Nereis succinea. 1994 Steroids pmid:8073448
Yagi T et al. Stereochemistry of hydrogen addition to C-25 of desmosterol by sterol-delta 24-reductase of rat liver homogenate. 1994 Chem. Pharm. Bull. pmid:8004717
Jurevics H and Morell P Cholesterol for synthesis of myelin is made locally, not imported into brain. 1995 J. Neurochem. pmid:7830084
Lewis D et al. Enzyme inhibition during the conversion of squalene to cholesterol. 1995 Steroids pmid:7482633
Gibbons GF and Pullinger CR Cholesterol biosynthesis in hepatocytes. 1978 Biochem. Soc. Trans. pmid:744335
Hidaka K et al. Growth of amphotericin B-resistant hamster cell line requires exogenous cholesterol. 1980 Exp. Cell Res. pmid:7408982
Seidenfeld J and Marton LJ Biochemical markers of central nervous system tumors in cerebrospinal fluid. 1978 Nov-Dec Ann. Clin. Lab. Sci. pmid:736510
Legault Y et al. 5alpha-Cholesta-7,24-dien-3beta-ol as a major sterol of the male hamster reproductive tract. 1978 Steroids pmid:734699
Doi O and Endo A Specific inhibition of desmosterol synthesis by ML--236B in mouse LM cells grown in suspension in a lipid-free medium. 1978 Jpn. J. Med. Sci. Biol. pmid:732030
Albers-Schönberg G et al. Dihydromevinolin, a potent hypocholesterolemic metabolite produced by Aspergillus terreus. 1981 J. Antibiot. pmid:7275832
Ramsey RB Effect of extended hypocholesterolemic drug treatment on peripheral and central nervous system sterol content of the rat. 1977 Lipids pmid:72342
Bhattacharyya AK and Eggen DA Feedback regulation of cholesterol biosynthesis in rhesus monkeys with variable hypercholesterolemic response to dietary cholesterol. 1981 J. Lipid Res. pmid:7217781
Evans RW and Tinoco J Monolayers of sterols and phosphatidylcholines containing a 20-carbon chain. 1978 Chem. Phys. Lipids pmid:719817
Paoletti P Desmosterol in CSF. 1981 Neurology pmid:7194986
Long TT et al. The sources of rat biliary cholesterol and bile acid. 1978 J. Lipid Res. pmid:712246
D'Alonzo AJ and McArdle JJ An evaluation of fast- and slow-twitch muscle from rats treated with 20,25-diazacholesterol. 1982 Exp. Neurol. pmid:7117485
Svoboda JA et al. Utilization and metabolism of dietary sterols in the honey bee and the yellow fever mosquito. 1982 Lipids pmid:7087696
Sarkar CP et al. Studies on the mechanisms of the epileptiform activity induced by U186661. I Gross alteration of the lipids of synaptosomes and myelin. 1982 Epilepsia pmid:7084136
Pettler PJ et al. Mechanism of dealkylation of clionasterol in the insect Tenebrio molitor. 1978 Biochem. J. pmid:708391
Chalikian DM and Barchi RL Sarcolemmal desmosterol accumulation and membrane physical properties in 20,25-diazacholesterol myotonia. 1982 Muscle Nerve pmid:7070392
Kwieciński H Myotonia induced by chemical agents. 1981 Crit. Rev. Toxicol. pmid:7026172
Sekula BC and Nes WR Metabolism of sterols by anaerobic Saccharomyces cerevisiae. 1981 Lipids pmid:7012521
Burck PJ and Zimmerman RE The inhibition of acrosin by sterol sulphates. 1980 J. Reprod. Fertil. pmid:6987395
Hansbury E and Scallen TJ Resolution of desmosterol, cholesterol, and other sterol intermediates by reverse-phase high-pressure liquid chromatography. 1978 J. Lipid Res. pmid:690514