DESMOSTEROL

DESMOSTEROL is a lipid of Sterol Lipids (ST) class. Desmosterol is associated with abnormalities such as Cataract, Congenital Abnormality, Liver diseases, Erectile dysfunction and Multiple congenital anomalies. The involved functions are known as Bulla, Methylation, cholesterol biosynthetic process, Process and cholesterol efflux. Desmosterol often locates in Body tissue, Tissue membrane, Plasma membrane, Pore and Endoplasmic Reticulum. The associated genes with DESMOSTEROL are P4HTM gene, SHH gene, WDR48 gene, CFLAR gene and SLC33A1 gene. The related lipids are Sterols, androstanol, Steroids, Unilamellar Vesicles and 7-dehydrocholesterol. The related experimental models are Transgenic Model and Rodent Model.

Cross Reference

Introduction

To understand associated biological information of DESMOSTEROL, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with DESMOSTEROL?

DESMOSTEROL is suspected in Atherosclerosis, Congenital Abnormality, Liver diseases, Fatty Streak, Arterial, Senile Plaques, Coronary Arteriosclerosis and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with DESMOSTEROL

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Coronary Disease D003327 70 associated lipids
Celiac Disease D002446 16 associated lipids
Xanthomatosis D014973 17 associated lipids
Insulin Resistance D007333 99 associated lipids
Limb Deformities, Congenital D017880 4 associated lipids
Total 6

PubChem Associated disorders and diseases

What pathways are associated with DESMOSTEROL

Lipid pathways are not clear in current pathway databases. We organized associated pathways with DESMOSTEROL through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with DESMOSTEROL?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with DESMOSTEROL?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with DESMOSTEROL?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with DESMOSTEROL?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with DESMOSTEROL?

Transgenic Model

Transgenic Model are used in the study 'Cellular production of n-3 PUFAs and reduction of n-6-to-n-3 ratios in the pancreatic beta-cells and islets enhance insulin secretion and confer protection against cytokine-induced cell death.' (Wei D et al., 2010).

Rodent Model

Rodent Model are used in the study 'Oxidation of 7-dehydrocholesterol and desmosterol by human cytochrome P450 46A1.' (Goyal S et al., 2014).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with DESMOSTEROL

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Authors Title Published Journal PubMed Link
Simonen P et al. Desmosterol accumulation in users of amiodarone. 2018 J. Intern. Med. pmid:28861933
Müller C et al. New chemotype of selective and potent inhibitors of human delta 24-dehydrocholesterol reductase. 2017 Eur J Med Chem pmid:28964935
Mouritsen OG et al. Effects of seaweed sterols fucosterol and desmosterol on lipid membranes. 2017 Chem. Phys. Lipids pmid:28365392
Hamdan IJA et al. Sterols in infant formulas: validation of a gas chromatographic method. 2017 Int J Food Sci Nutr pmid:28276904
Kazkayasi I et al. Lack of insulin results in reduced seladin-1 expression in primary cultured neurons and in cerebral cortex of STZ-induced diabetic rats. 2016 Neurosci. Lett. pmid:27639960
Zhao Q et al. A highly stereoselective synthesis of C-24 and C-25 oxysterols from desmosterol. 2016 Steroids pmid:26968128
Andrade I et al. Cholesterol absorption and synthesis markers in Portuguese hypercholesterolemic adults: A cross-sectional study. 2016 Eur. J. Intern. Med. pmid:26577223
Yin L et al. Benzyl butyl phthalate promotes adipogenesis in 3T3-L1 preadipocytes: A High Content Cellomics and metabolomic analysis. 2016 Toxicol In Vitro pmid:26820058
Villareal VA et al. Hepatitis C Virus Selectively Alters the Intracellular Localization of Desmosterol. 2016 ACS Chem. Biol. pmid:27128812
Costello DA et al. Desmosterol Increases Lipid Bilayer Fluidity during Hepatitis C Virus Infection. 2016 ACS Infect Dis pmid:27933788
HÄ…c-Wydro K et al. The influence of cholesterol precursor--desmosterol--on artificial lipid membranes. 2015 Biochim. Biophys. Acta pmid:25960185
Benesch MG et al. A calorimetric and spectroscopic comparison of the effects of cholesterol and its immediate biosynthetic precursors 7-dehydrocholesterol and desmosterol on the thermotropic phase behavior and organization of dipalmitoylphosphatidylcholine bilayer membranes. 2015 Chem. Phys. Lipids pmid:26368000
Altunayar C et al. A comparative study of the effects of cholesterol and desmosterol on zwitterionic DPPC model membranes. 2015 Chem. Phys. Lipids pmid:25847673
Hu X et al. Sterol metabolism controls T(H)17 differentiation by generating endogenous RORγ agonists. 2015 Nat. Chem. Biol. pmid:25558972
Mendiara I et al. Online solid-phase extraction-liquid chromatography-mass spectrometry to determine free sterols in human serum. 2015 Talanta pmid:25476366
Kiyotake R et al. Human Mincle Binds to Cholesterol Crystals and Triggers Innate Immune Responses. 2015 J. Biol. Chem. pmid:26296894
Luu W et al. Signaling regulates activity of DHCR24, the final enzyme in cholesterol synthesis. 2014 J. Lipid Res. pmid:24363437
Nakano-Ito K et al. E2012-induced cataract and its predictive biomarkers. 2014 Toxicol. Sci. pmid:24085193
Zhao Q et al. Investigation on the synthesis of 25-hydroxycholesterol. 2014 Steroids pmid:24582707
Plat J et al. Protective role of plant sterol and stanol esters in liver inflammation: insights from mice and humans. 2014 PLoS ONE pmid:25356831
Wudiri GA et al. Molecular requirement for sterols in herpes simplex virus entry and infectivity. 2014 J. Virol. pmid:25231306
Goyal S et al. Oxidation of 7-dehydrocholesterol and desmosterol by human cytochrome P450 46A1. 2014 J. Lipid Res. pmid:25017465
Tint GS et al. Desmosterol in brain is elevated because DHCR24 needs REST for Robust Expression but REST is poorly expressed. 2014 Dev. Neurosci. pmid:24861183
Sugiyama K et al. Prominent steatosis with hypermetabolism of the cell line permissive for years of infection with hepatitis C virus. 2014 PLoS ONE pmid:24718268
Baila-Rueda L et al. Bile acid synthesis precursors in familial combined hyperlipidemia: the oxysterols 24S-hydroxycholesterol and 27-hydroxycholesterol. 2014 Biochem. Biophys. Res. Commun. pmid:24406166
Meljon A et al. Analysis by liquid chromatography-mass spectrometry of sterols and oxysterols in brain of the newborn Dhcr7(Δ3-5/T93M) mouse: a model of Smith-Lemli-Opitz syndrome. 2013 Biochem. Pharmacol. pmid:23500538
Brouwers MC et al. Plasma proprotein convertase subtilisin kexin type 9 levels are related to markers of cholesterol synthesis in familial combined hyperlipidemia. 2013 Nutr Metab Cardiovasc Dis pmid:23333725
Wisniewski T et al. Alzheimer's disease: brain desmosterol levels. 2013 J. Alzheimers Dis. pmid:23042211
Ozyurt G et al. Comparative seasonal sterol profiles in edible parts of Mediterranean fish and shellfish species. 2013 Int J Food Sci Nutr pmid:23216341
Jansen M et al. What dictates the accumulation of desmosterol in the developing brain? 2013 FASEB J. pmid:23230282
Saini R et al. Synthesis and biological activity of (24E)- and (24Z)-26-hydroxydesmosterol. 2013 Bioorg. Med. Chem. pmid:23910990
Simonen M et al. Desmosterol in human nonalcoholic steatohepatitis. 2013 Hepatology pmid:23447451
Javitt NB Alzheimer's disease: neuroprogesterone, epoxycholesterol, and ABC transporters as determinants of neurodesmosterol tissue levels and its role in amyloid protein processing. 2013 J. Alzheimers Dis. pmid:23455994
Boerke A et al. Involvement of bicarbonate-induced radical signaling in oxysterol formation and sterol depletion of capacitating mammalian sperm during in vitro fertilization. 2013 Biol. Reprod. pmid:23115269
Zerenturk EJ et al. Desmosterol and DHCR24: unexpected new directions for a terminal step in cholesterol synthesis. 2013 Prog. Lipid Res. pmid:24095826
Barbosa SP et al. Effects of ezetimibe on markers of synthesis and absorption of cholesterol in high-risk patients with elevated C-reactive protein. 2013 Life Sci. pmid:23507424
Koeth RA et al. Intestinal microbiota metabolism of L-carnitine, a nutrient in red meat, promotes atherosclerosis. 2013 Nat. Med. pmid:23563705
Haldar S et al. Differential effect of cholesterol and its biosynthetic precursors on membrane dipole potential. 2012 Biophys. J. pmid:22500756
Tansley G et al. Sterol lipid metabolism in down syndrome revisited: down syndrome is associated with a selective reduction in serum brassicasterol levels. 2012 Curr Gerontol Geriatr Res pmid:22649448
Meljon A et al. Analysis of bioactive oxysterols in newborn mouse brain by LC/MS. 2012 J. Lipid Res. pmid:22891291
Bieghs V et al. Internalization of modified lipids by CD36 and SR-A leads to hepatic inflammation and lysosomal cholesterol storage in Kupffer cells. 2012 PLoS ONE pmid:22470565
Kasmas SH et al. Differences in synthesis and absorption of cholesterol of two effective lipid-lowering therapies. 2012 Braz. J. Med. Biol. Res. pmid:22801416
McDonald JG et al. A comprehensive method for extraction and quantitative analysis of sterols and secosteroids from human plasma. 2012 J. Lipid Res. pmid:22517925
Cacabelos R et al. Genomics of Dementia: APOE- and CYP2D6-Related Pharmacogenetics. 2012 Int J Alzheimers Dis pmid:22482072
Khanavi M et al. Cytotoxicity of fucosterol containing fraction of marine algae against breast and colon carcinoma cell line. 2012 Pharmacogn Mag pmid:22438665
Rodgers MA et al. Lipid metabolite profiling identifies desmosterol metabolism as a new antiviral target for hepatitis C virus. 2012 J. Am. Chem. Soc. pmid:22480142
Silbernagel G et al. Cholesterol synthesis is associated with hepatic lipid content and dependent on fructose/glucose intake in healthy humans. 2012 Exp Diabetes Res pmid:22203835
Spann NJ et al. Regulated accumulation of desmosterol integrates macrophage lipid metabolism and inflammatory responses. 2012 Cell pmid:23021221
Matysik S et al. Gas chromatography-tandem mass spectrometry method for the simultaneous determination of oxysterols, plant sterols, and cholesterol precursors. 2012 Clin. Chem. pmid:22997279
Lim L et al. Lanosterol induces mitochondrial uncoupling and protects dopaminergic neurons from cell death in a model for Parkinson's disease. 2012 Cell Death Differ. pmid:21818119