DESMOSTEROL

DESMOSTEROL is a lipid of Sterol Lipids (ST) class. Desmosterol is associated with abnormalities such as Cataract, Congenital Abnormality, Liver diseases, Erectile dysfunction and Multiple congenital anomalies. The involved functions are known as Bulla, Methylation, cholesterol biosynthetic process, Process and cholesterol efflux. Desmosterol often locates in Body tissue, Tissue membrane, Plasma membrane, Pore and Endoplasmic Reticulum. The associated genes with DESMOSTEROL are P4HTM gene, SHH gene, WDR48 gene, CFLAR gene and SLC33A1 gene. The related lipids are Sterols, androstanol, Steroids, Unilamellar Vesicles and 7-dehydrocholesterol. The related experimental models are Transgenic Model and Rodent Model.

Cross Reference

Introduction

To understand associated biological information of DESMOSTEROL, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with DESMOSTEROL?

DESMOSTEROL is suspected in Atherosclerosis, Congenital Abnormality, Liver diseases, Fatty Streak, Arterial, Senile Plaques, Coronary Arteriosclerosis and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with DESMOSTEROL

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Coronary Disease D003327 70 associated lipids
Celiac Disease D002446 16 associated lipids
Xanthomatosis D014973 17 associated lipids
Insulin Resistance D007333 99 associated lipids
Limb Deformities, Congenital D017880 4 associated lipids
Total 6

PubChem Associated disorders and diseases

What pathways are associated with DESMOSTEROL

Lipid pathways are not clear in current pathway databases. We organized associated pathways with DESMOSTEROL through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with DESMOSTEROL?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with DESMOSTEROL?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with DESMOSTEROL?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with DESMOSTEROL?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with DESMOSTEROL?

Transgenic Model

Transgenic Model are used in the study 'Cellular production of n-3 PUFAs and reduction of n-6-to-n-3 ratios in the pancreatic beta-cells and islets enhance insulin secretion and confer protection against cytokine-induced cell death.' (Wei D et al., 2010).

Rodent Model

Rodent Model are used in the study 'Oxidation of 7-dehydrocholesterol and desmosterol by human cytochrome P450 46A1.' (Goyal S et al., 2014).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with DESMOSTEROL

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Authors Title Published Journal PubMed Link
Simonen P et al. Cholesterol synthesis is increased and absorption decreased in non-alcoholic fatty liver disease independent of obesity. 2011 J. Hepatol. pmid:20947198
Moghadasian MH et al. Specificity of the commonly used enzymatic assay for plasma cholesterol determination. 2002 J. Clin. Pathol. pmid:12401826
GOODMAN DS et al. The in vitro metabolism of desmosterol with adrenal and liver preparations. 1962 J. Clin. Invest. pmid:13949087
GOODMAN DS et al. The metabolism of desmosterol in human subjects during triparanol administration. 1962 J. Clin. Invest. pmid:13900301
Tabas I et al. The reactivity of desmosterol and other shellfish- and xanthomatosis-associated sterols in the macrophage sterol esterification reaction. 1989 J. Clin. Invest. pmid:2592557
Connor WE et al. Biochemical markers for puberty in the monkey testis: desmosterol and docosahexaenoic acid. 1997 J. Clin. Endocrinol. Metab. pmid:9177405
Luciani P et al. Expression of the novel adrenocorticotropin-responsive gene selective Alzheimer's disease indicator-1 in the normal adrenal cortex and in adrenocortical adenomas and carcinomas. 2004 J. Clin. Endocrinol. Metab. pmid:15001630
Amaral C et al. Quantitative analysis of five sterols in amniotic fluid by GC-MS: application to the diagnosis of cholesterol biosynthesis defects. 2010 J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. pmid:20630811
Saraiva D et al. Selection of the derivatization reagent--the case of human blood cholesterol, its precursors and phytosterols GC-MS analyses. 2011 J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. pmid:22088355
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Acimovic J et al. Combined gas chromatographic/mass spectrometric analysis of cholesterol precursors and plant sterols in cultured cells. 2009 J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. pmid:19525158
Fujimoto Y et al. Studies on steroids. Part XXIX. Synthesis of allenic analogues fucosterol and desmosterol. 1975 J. Chem. Soc. Perkin Trans. I pmid:1239449
Herz JE and Cruz Montalvo S Fluorinated sterols. 1. 26,26,26,27,27,27-Hexafluorodesmosterol. 1973 J. Chem. Soc. Perkin Trans. I pmid:4795247
Ikan R et al. Synthesis of steroidal cyclopropanes. 1972 J. Chem. Soc. Perkin Trans. I pmid:4674538
Burger BV et al. Mammalian exocrine secretions XVI. Constitutents of secretion of supplementary sacculi of dwarf hamster, Phodopus sungorus sungorus. 2001 J. Chem. Ecol. pmid:11504028
Martin-Creuzburg D and Von Elert E Impact of 10 dietary sterols on growth and reproduction of Daphnia galeata. 2004 J. Chem. Ecol. pmid:15139303
Hoenig MR et al. Markers of cholesterol absorption and synthesis predict the low-density lipoprotein cholesterol response to atorvastatin. 2010 J. Cardiovasc. Pharmacol. pmid:20625310
Mutka AL et al. Secretion of sterols and the NPC2 protein from primary astrocytes. 2004 J. Biol. Chem. pmid:15355983
Steinberg D Chance and serendipity in science: two examples from my own career. 2011 J. Biol. Chem. pmid:21908608
Lusa S et al. Differential mobilization of newly synthesized cholesterol and biosynthetic sterol precursors from cells. 2003 J. Biol. Chem. pmid:12657643