DESMOSTEROL

DESMOSTEROL is a lipid of Sterol Lipids (ST) class. Desmosterol is associated with abnormalities such as Cataract, Congenital Abnormality, Liver diseases, Erectile dysfunction and Multiple congenital anomalies. The involved functions are known as Bulla, Methylation, cholesterol biosynthetic process, Process and cholesterol efflux. Desmosterol often locates in Body tissue, Tissue membrane, Plasma membrane, Pore and Endoplasmic Reticulum. The associated genes with DESMOSTEROL are P4HTM gene, SHH gene, WDR48 gene, CFLAR gene and SLC33A1 gene. The related lipids are Sterols, androstanol, Steroids, Unilamellar Vesicles and 7-dehydrocholesterol. The related experimental models are Transgenic Model and Rodent Model.

Cross Reference

Introduction

To understand associated biological information of DESMOSTEROL, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with DESMOSTEROL?

DESMOSTEROL is suspected in Atherosclerosis, Congenital Abnormality, Liver diseases, Fatty Streak, Arterial, Senile Plaques, Coronary Arteriosclerosis and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with DESMOSTEROL

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Coronary Disease D003327 70 associated lipids
Celiac Disease D002446 16 associated lipids
Xanthomatosis D014973 17 associated lipids
Insulin Resistance D007333 99 associated lipids
Limb Deformities, Congenital D017880 4 associated lipids
Total 6

PubChem Associated disorders and diseases

What pathways are associated with DESMOSTEROL

Lipid pathways are not clear in current pathway databases. We organized associated pathways with DESMOSTEROL through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with DESMOSTEROL?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with DESMOSTEROL?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with DESMOSTEROL?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with DESMOSTEROL?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with DESMOSTEROL?

Transgenic Model

Transgenic Model are used in the study 'Cellular production of n-3 PUFAs and reduction of n-6-to-n-3 ratios in the pancreatic beta-cells and islets enhance insulin secretion and confer protection against cytokine-induced cell death.' (Wei D et al., 2010).

Rodent Model

Rodent Model are used in the study 'Oxidation of 7-dehydrocholesterol and desmosterol by human cytochrome P450 46A1.' (Goyal S et al., 2014).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with DESMOSTEROL

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Authors Title Published Journal PubMed Link
Sion B et al. Quantitative analysis of desmosterol, cholesterol and cholesterol sulfate in semen by high-performance liquid chromatography. 2001 J Chromatogr A pmid:11762778
Hoenig MR et al. The C3435T polymorphism in ABCB1 influences atorvastatin efficacy and muscle symptoms in a high-risk vascular cohort. J Clin Lipidol pmid:21392722
Shay CM et al. Do plant sterol concentrations correlate with coronary artery disease in type 1 diabetes? A report from the Pittsburgh Epidemiology of Diabetes Complications Study. 2009 J Diabetes pmid:20827426
Sheriff DS and Ali EF Perspective on plasma membrane cholesterol efflux and spermatozoal function. 2010 J Hum Reprod Sci pmid:21209749
Soh J et al. Hepatic gene expression profiles are altered by dietary unsalted korean fermented soybean (chongkukjang) consumption in mice with diet-induced obesity. 2011 J Nutr Metab pmid:21437188
Turi JS et al. Systems approach to study of solute transport across membranes using suspension cultures of mammalian cells IV: Uptake and release kinetics of sterols. 1975 J Pharm Sci pmid:1170314
Harris PA and Harris KL Quantitative GLC analysis of plasma cholesterol. 1974 J Pharm Sci pmid:4830004
Johnston JJ et al. Desmosterol: a biomarker for the efficient development of 20,25-diazacholesterol as a contraceptive for pest wildlife. 2003 J. Agric. Food Chem. pmid:12502398
Wisniewski T et al. Alzheimer's disease: brain desmosterol levels. 2013 J. Alzheimers Dis. pmid:23042211
Vanmierlo T et al. Alterations in brain cholesterol metabolism in the APPSLxPS1mut mouse, a model for Alzheimer's disease. 2010 J. Alzheimers Dis. pmid:20061631
Javitt NB Alzheimer's disease: neuroprogesterone, epoxycholesterol, and ABC transporters as determinants of neurodesmosterol tissue levels and its role in amyloid protein processing. 2013 J. Alzheimers Dis. pmid:23455994
Rodgers MA et al. Lipid metabolite profiling identifies desmosterol metabolism as a new antiviral target for hepatitis C virus. 2012 J. Am. Chem. Soc. pmid:22480142
Chen SM et al. Letter: Stereospecificity in the conversion of fucosterol 24,28-epoxide to desmosterol in the silkworm, Bombyx mori. 1975 J. Am. Chem. Soc. pmid:1165366
Rajaratnam RA et al. Independent association of serum squalene and noncholesterol sterols with coronary artery disease in postmenopausal women. 2000 J. Am. Coll. Cardiol. pmid:10758959
Buffone MG et al. High cholesterol content and decreased membrane fluidity in human spermatozoa are associated with protein tyrosine phosphorylation and functional deficiencies. 2009 Sep-Oct J. Androl. pmid:19269935
Albers-Schönberg G et al. Dihydromevinolin, a potent hypocholesterolemic metabolite produced by Aspergillus terreus. 1981 J. Antibiot. pmid:7275832
Feio CA et al. Euterpe oleracea (açai) modifies sterol metabolism and attenuates experimentally-induced atherosclerosis. 2012 J. Atheroscler. Thromb. pmid:22139433
Leonard DA and Chen HW Aphidicolin, a specific inhibitor of DNA polymerase alpha, inhibits conversion of lanosterol to C-27 sterols in mouse L cells. 1984 J. Biol. Chem. pmid:6425279
FISH WA et al. Metabolism of cholesterol in the chick embryo. III. Localization and turnover of desmosterol (24-dehydrocholesterol). 1962 J. Biol. Chem. pmid:13893200
Pentchev PG et al. The cholesterol storage disorder of the mutant BALB/c mouse. A primary genetic lesion closely linked to defective esterification of exogenously derived cholesterol and its relationship to human type C Niemann-Pick disease. 1986 J. Biol. Chem. pmid:3949747