DESMOSTEROL

DESMOSTEROL is a lipid of Sterol Lipids (ST) class. Desmosterol is associated with abnormalities such as Cataract, Congenital Abnormality, Liver diseases, Erectile dysfunction and Multiple congenital anomalies. The involved functions are known as Bulla, Methylation, cholesterol biosynthetic process, Process and cholesterol efflux. Desmosterol often locates in Body tissue, Tissue membrane, Plasma membrane, Pore and Endoplasmic Reticulum. The associated genes with DESMOSTEROL are P4HTM gene, SHH gene, WDR48 gene, CFLAR gene and SLC33A1 gene. The related lipids are Sterols, androstanol, Steroids, Unilamellar Vesicles and 7-dehydrocholesterol. The related experimental models are Transgenic Model and Rodent Model.

Cross Reference

Introduction

To understand associated biological information of DESMOSTEROL, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with DESMOSTEROL?

DESMOSTEROL is suspected in Atherosclerosis, Congenital Abnormality, Liver diseases, Fatty Streak, Arterial, Senile Plaques, Coronary Arteriosclerosis and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with DESMOSTEROL

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Coronary Disease D003327 70 associated lipids
Celiac Disease D002446 16 associated lipids
Xanthomatosis D014973 17 associated lipids
Insulin Resistance D007333 99 associated lipids
Limb Deformities, Congenital D017880 4 associated lipids
Total 6

PubChem Associated disorders and diseases

What pathways are associated with DESMOSTEROL

Lipid pathways are not clear in current pathway databases. We organized associated pathways with DESMOSTEROL through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
Loading... please refresh the page if content is not showing up.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with DESMOSTEROL?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with DESMOSTEROL?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with DESMOSTEROL?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with DESMOSTEROL?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with DESMOSTEROL?

Transgenic Model

Transgenic Model are used in the study 'Cellular production of n-3 PUFAs and reduction of n-6-to-n-3 ratios in the pancreatic beta-cells and islets enhance insulin secretion and confer protection against cytokine-induced cell death.' (Wei D et al., 2010).

Rodent Model

Rodent Model are used in the study 'Oxidation of 7-dehydrocholesterol and desmosterol by human cytochrome P450 46A1.' (Goyal S et al., 2014).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

NCBI Entrez Crosslinks

All references with DESMOSTEROL

Download all related citations
Per page 10 20 50 100 | Total 433
Authors Title Published Journal PubMed Link
Lütjohann D et al. Profile of cholesterol-related sterols in aged amyloid precursor protein transgenic mouse brain. 2002 J. Lipid Res. pmid:12091492
Murphy KJ et al. Lipid, FA, and sterol composition of New Zealand green lipped mussel (Perna canaliculus) and Tasmanian blue mussel (Mytilus edulis). 2002 Lipids pmid:12120958
Lindenthal B et al. Influence of simvastatin, pravastatin, and BM 15.766 on neutral sterols in liver and testis of guinea pigs. 2002 Metab. Clin. Exp. pmid:11912560
Chevy F et al. Limb malformations of rat fetuses exposed to a distal inhibitor of cholesterol biosynthesis. 2002 J. Lipid Res. pmid:12177163
Fernández C et al. Inhibition of cholesterol biosynthesis by Delta22-unsaturated phytosterols via competitive inhibition of sterol Delta24-reductase in mammalian cells. 2002 Biochem. J. pmid:12162789
Berge KE et al. Heritability of plasma noncholesterol sterols and relationship to DNA sequence polymorphism in ABCG5 and ABCG8. 2002 J. Lipid Res. pmid:11893785
Simonen P et al. Acute effects of weight reduction on cholesterol metabolism in obese type 2 diabetes. 2002 Clin. Chim. Acta pmid:11750274
Hallikainen M et al. Short-term LDL cholesterol-lowering efficacy of plant stanol esters. 2002 BMC Cardiovasc Disord pmid:12197945
Khripach VA et al. [Synthesis of C24-functionalized hydroxysterols]. 2002 May-Jun Bioorg. Khim. pmid:12077856
Cross NL Decrease in order of human sperm lipids during capacitation. 2003 Biol. Reprod. pmid:12700200
Westover EJ and Covey DF First synthesis of ent-desmosterol and its conversion to ent-deuterocholesterol. 2003 Steroids pmid:12606007
Nimmo MR and Cross NL Structural features of sterols required to inhibit human sperm capacitation. 2003 Biol. Reprod. pmid:12606419
Juvet LK et al. On the role of liver X receptors in lipid accumulation in adipocytes. 2003 Mol. Endocrinol. pmid:12554745
Okumura K et al. Formal synthesis of squalamine from desmosterol. 2003 Chem. Pharm. Bull. pmid:14519925
Miettinen TA and Gylling H Synthesis and absorption markers of cholesterol in serum and lipoproteins during a large dose of statin treatment. 2003 Eur. J. Clin. Invest. pmid:14636301
Pikuleva I and Javitt NB Novel sterols synthesized via the CYP27A1 metabolic pathway. 2003 Arch. Biochem. Biophys. pmid:14622972
Otte K et al. Identification of farnesoid X receptor beta as a novel mammalian nuclear receptor sensing lanosterol. 2003 Mol. Cell. Biol. pmid:12529392
Wechsler A et al. Generation of viable cholesterol-free mice. 2003 Science pmid:14684813
Lusa S et al. Differential mobilization of newly synthesized cholesterol and biosynthetic sterol precursors from cells. 2003 J. Biol. Chem. pmid:12657643
Matthan NR et al. Impact of simvastatin, niacin, and/or antioxidants on cholesterol metabolism in CAD patients with low HDL. 2003 J. Lipid Res. pmid:12562840