DESMOSTEROL is a lipid of Sterol Lipids (ST) class. Desmosterol is associated with abnormalities such as Cataract, Congenital Abnormality, Liver diseases, Erectile dysfunction and Multiple congenital anomalies. The involved functions are known as Bulla, Methylation, cholesterol biosynthetic process, Process and cholesterol efflux. Desmosterol often locates in Body tissue, Tissue membrane, Plasma membrane, Pore and Endoplasmic Reticulum. The associated genes with DESMOSTEROL are P4HTM gene, SHH gene, WDR48 gene, CFLAR gene and SLC33A1 gene. The related lipids are Sterols, androstanol, Steroids, Unilamellar Vesicles and 7-dehydrocholesterol. The related experimental models are Transgenic Model and Rodent Model.
To understand associated biological information of DESMOSTEROL, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
DESMOSTEROL is suspected in Atherosclerosis, Congenital Abnormality, Liver diseases, Fatty Streak, Arterial, Senile Plaques, Coronary Arteriosclerosis and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with DESMOSTEROL
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Coronary Disease | D003327 | 70 associated lipids |
| Celiac Disease | D002446 | 16 associated lipids |
| Xanthomatosis | D014973 | 17 associated lipids |
| Insulin Resistance | D007333 | 99 associated lipids |
| Limb Deformities, Congenital | D017880 | 4 associated lipids |
Lipid pathways are not clear in current pathway databases. We organized associated pathways with DESMOSTEROL through full-text articles, including metabolic pathways or pathways of biological mechanisms.
| Pathway name | Related literatures |
|---|
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
| Gene | Cross reference | Weighted score | Related literatures |
|---|
Transgenic Model are used in the study 'Cellular production of n-3 PUFAs and reduction of n-6-to-n-3 ratios in the pancreatic beta-cells and islets enhance insulin secretion and confer protection against cytokine-induced cell death.' (Wei D et al., 2010).
Rodent Model are used in the study 'Oxidation of 7-dehydrocholesterol and desmosterol by human cytochrome P450 46A1.' (Goyal S et al., 2014).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Nagy K et al. | Analysis of sterols by high-performance liquid chromatography/mass spectrometry combined with chemometrics. | 2006 | Rapid Commun. Mass Spectrom. | pmid:16841361 |
| Yang C et al. | Sterol intermediates from cholesterol biosynthetic pathway as liver X receptor ligands. | 2006 | J. Biol. Chem. | pmid:16857673 |
| Simonen PP et al. | The distribution of squalene and non-cholesterol sterols in lipoproteins in type 2 diabetes. | 2007 | Atherosclerosis | pmid:16963050 |
| Mazalli MR et al. | HPLC method for quantification and characterization of cholesterol and its oxidation products in eggs. | 2006 | Lipids | pmid:16981439 |
| Fassbender K et al. | Moderately elevated plant sterol levels are associated with reduced cardiovascular risk--the LASA study. | 2008 | Atherosclerosis | pmid:17137582 |
| Hallikainen M et al. | Interaction between cholesterol and glucose metabolism during dietary carbohydrate modification in subjects with the metabolic syndrome. | 2006 | Am. J. Clin. Nutr. | pmid:17158421 |
| Solcà C et al. | Loss of apolipoprotein E exacerbates the neonatal lethality of the Smith-Lemli-Opitz syndrome mouse. | 2007 | Mol. Genet. Metab. | pmid:17197219 |
| Zhang S et al. | Identification of a sterol Delta7 reductase gene involved in desmosterol biosynthesis in Mortierella alpina 1S-4. | 2007 | Appl. Environ. Microbiol. | pmid:17220261 |
| Niemelä PS et al. | Assessing the nature of lipid raft membranes. | 2007 | PLoS Comput. Biol. | pmid:17319738 |
| Samuli Ollila OH et al. | Role of sterol type on lateral pressure profiles of lipid membranes affecting membrane protein functionality: Comparison between cholesterol, desmosterol, 7-dehydrocholesterol and ketosterol. | 2007 | J. Struct. Biol. | pmid:17369050 |